Three new compounds, arneatas A-C (1–3), together with three known compounds (4–6) were isolated from the roots of Arnebia guttata Bunge. The structures were established on the basis of extensive spectroscopic data including NMR and HRESIMS. All the new compounds (1–3) were tested for their cytotoxic activity against two glioma cell lines (U118-MG and U373-MG) in vitro after treatment for 48 h. Compound 1 exhibited moderate cytotoxic activity against U118-MG and U373-MG glioma cell lines,...

Additional file 5.

Additional file 4: Table S2. Performance of the SVM model on tumor types.

Additional file 5: Table S3. Subtypes identified using alternative approaches.

Additional file 9: Table S6. Clinical information of CGGA RNA-seq dataset.

Additional file 13: Figure S5. Methylation levels of DNA methylation driven genes.

Additional file 15: Supplementary methods. Description of normalization methods used data normalization.

Supplemental material, sj-docx-1-jbf-10.1177_22808000221124418 for Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system by Li Gao, Liu Yang, Lixiao Guo, Haibin Wang, Yinghu Zhao, Jun Xie and Nan Shi in Journal of Applied Biomaterials & Functional Materials

Supplemental material, sj-docx-1-jbf-10.1177_22808000221124418 for Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system by Li Gao, Liu Yang, Lixiao Guo, Haibin Wang, Yinghu Zhao, Jun Xie and Nan Shi in Journal of Applied Biomaterials & Functional Materials

Supplementary Material for A data-driven investigation on park visitation and income mixing of visitors in New York City by Hanxue Wei, Xiao Huang, Sicheng Wang, Junyu Lu, Zhenlong Li, Liao Zhu in Environment and Planning B: Urban Analytics and City Science.

Additional file 1: Table S1. Associated risk factors for toxocariasis in shelter workers of São Paulo city, Brazil (N=79).

Additional file 1: Figure S1. Characterization of MSNs. a Transmission electron micrographs of MSNs of different sizes (scale bar = 200 nm). b Corresponding histogram and Gaussian fit of the measured MSN size distribution. Figure S2. Absorption spectroscopy of MSN-Cy3, FITC-Bifidobacterium, and MSNs-Bifidobacterium. Figure S3. Representative images of colonies formed by MSNs-Bi on the culture medium were used to evaluate the activity of Bifidobacterium in Krebs-Henseleit solution. Figure S4. Characterization of MSN-encapsulated Bifidobacterium and E....

Additional file 11: Table S8. Performance of the model based on clinical features.

Additional file 1. Schematic diagram of data collection.

Additional file 1.

Additional file 8.

Additional file 2: Table S1. Interaction analyses between BTBD7_hsa_circ_0000563 and 7 proteins Table S2. Baseline characteristics of the subjects undergoing western blot.

Additional file 11: Supplementary Table 6. Effect of rectal propionate administration on the gut microbiota composition.

Additional file 14: Supplementary Figure 8. Attenuation of macrophage infiltration and TNF-α expression in calcified vessel walls by the propionate-modulated intestinal microbiota. (a) Immunofluorescence staining for macrophages and TNF-α in calcified vessel walls (original magnification×100). (b) Quantitative analysis of the CD68-positive area. (c) Quantitative analysis of the TNF-α-positive area. Data are presented as the mean ± standard deviation (SD). Statistical significance was determined using one-way ANOVA (Tukey post hoc test). NS for P > 0.05,...

Additional file 18: Supplementary Figure 11. Attenuation of macrophage infiltration and TNF-α expression in calcified vessel walls by Akkermansia. (a) Immunofluorescence staining for macrophages and TNF-α in calcified vessel walls (original magnification×100). (b) Quantitative analysis of the CD68-positive area. (c) Quantitative analysis of the TNF-α-positive area. Data are presented as the mean ± standard deviation (SD). Statistical significance was determined using one-way ANOVA (Tukey post hoc test). NS for P > 0.05, ***P< 0.001, ****P<...

Additional file 20: Supplementary Table 9. Questionnaire for China Prime Diet Quality Score.

Additional file 24: Supplementary Table 12. Univariate and multivariate regression analysis of risk factors for vascular calcification in the participants with plasma samples.

Additional file 5: Supplementary Figure 1. Amelioration of VND-induced rat vascular calcification and reduction of inflammation by rectal propionate administration. (a) A flow diagram of the rectal propionate administration experiment. (b) Macroscopic observation of arterial vascular calcification based on alizarin red staining. (c) Quantitative evaluation of calcium content in whole aortas. (d) Observation of vascular calcification of the ascending aorta through alizarin red staining of tissue sections (original magnification ×40). (e) Relative quantification of calcium...

Additional file 9: Supplementary Figure 5. Amelioration of intestinal microbiota imbalance in rats by rectal propionate administration. (a) Principal coordinate analysis (PCoA) diagram showing the β-diversity of the intestinal microbiota among the three groups. (b) and (c) α-diversity of the intestinal microbiota. (d) Relative abundance of intestinal microbiota constituents at the phylum level. (e) Analysis of the differences in the intestinal microbiota by LEfSe. (f) Spearman’s correlation analysis of the relationship of the intestinal microbiota...