410 Works

Single-machine scheduling with energy generation and storage systems

Hyun-Jung Kim, Eun-Seok Kim, Jun-Ho Lee, Lixin Tang & Yang Yang
This paper considers a single-machine scheduling problem with sequence-dependent setup times and energy-generation and storage systems. Each job requires a sequence-dependent setup to be processed on the machine, and both setup and processing of the job require job-dependent amounts of energy. The energy consumed by the machine can be bought from an Electric Power Company (EPC) or generated by own Distributed Energy Resource (DER), such as solar photovoltaic or wind, and the energy can be...

The predictive value of diabetic retinopathy on subsequent diabetic nephropathy in patients with type 2 diabetes: a systematic review and meta-analysis of prospective studies

Yu Li, Xiaoxuan Su, Qing Ye, Xiaodan Guo, Bo Xu, Tianjun Guan & Anqun Chen
This systematic review and meta-analysis aimed to assess the predictive value of diabetic retinopathy (DR) on further diabetic nephropathy (DN) risk in patients with type 2 diabetes (T2D) based on the prospective cohort studies. PubMed, Embase, and the Cochrane Library were systematically searched for eligible prospective cohort studies through March 2020. The predictive value of DR was assessed using sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and...

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes

Lan-Qing Li, Jing Li, Hong-Ping Long, Ji-Kai Liu & Xian Wang
Four new resorcinol derivatives, namely (−)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (−)-1 by chiral HPLC. The neuroprotective effects of 1–3 against the damage of PC12...

Structure, antioxidant property and protection on PC12 of a polysaccharide isolated and screened from Abelmoschus esculentus L.Moench (okra)

Li-Chao Pan, Yang-Yang Sun, Xiao-Ling Zhang, Zhen-Yuan Zhu, Chun-Yu Liu, Hui-Qing Sun, Xue-Qing Geng, Wei Jiang & Jia-He Wang
AeP-P-2, a pectic polysaccharide, was extracted from the fruit pod of okra. It composed of rhamnose (Rha), arabinose (Ara), glucose (Glc), galactose (Gal) and galacturonic acid (GalA) with the ratio of 4.75:2.01:1.00:4.91:7.24. The main structural feature of AeP-P-2 are 1,4-linked galacturonan units (homogalacturonan backbone) and (1 → 2) and (1 → 2,4) linked Rha (rhamnogalacturonan I region). And the other side chains contained →1)-linked Ara, (1 → 5)-linked Ara, (1 → 4)-linked Glc, (1 →...

Phenoxychromone and 4-hydroxyisoflavans from the roots of Glycyrrhiza uralensis

Zulfiqar Ali, Mohammed Hawwal, Bharathi Avula, Amar G. Chittiboyina, Jing Li, Charles Wu & Ikhlas A. Khan
In an attempt to find species specific markers, a phenoxychromone (1) and eight isoflavonoids including six isoflavans (2-7) and two isoflavanones (8 and 9) were isolated from the root of Glycyrrhiza uralensis. Among the isolated phenolic compounds, glycyurelone (1), glycyurelvanins A and B (2 and 3) were found to be undescribed while others, (−)-vestitol (4), conferol A (5), glyasperin C (6), glyasperin D (7), (−)-licoisoflavanone (8), and (−)-3'-(γ,γ-dimethylallyl)kievitone (9) were previously reported. All compounds except...

Two new pyrone derivatives from the mangrove-derived endophytic fungus Aspergillus sydowii #2B

Yuhui Wang, Zhiwei Zhong, Fei Zhao, Junxia Zheng, Xi Zheng, Kun Zhang & Huarong Huang
Two new pyrone derivatives, 2-(12S-hydroxypropyl)-3-hydroxy-methyl-6-hydroxy-7-methoxychromone (1), and (±)-pyrenocine S (5), together with five known compounds xanthoradone A (2), (+)-3,3′,7,7′,8,8′-hexahydroxy-5,5′-dimethyl-bianthra-quinone (3), butyrolactone-I (4), pyrenocine A (6), and (±)-pyrenocine E (7) were obtained from the mangrove endophytic fungus Aspergillus sydowii #2B. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis and comparison data with of literatures. Compounds 2, 3, 4, 5, 6 and 7 showed cytotoxicities against prostate cancer VCaP cells with...

Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress

Jing-Yuan Cao, Li-lu Ling, Wei-Jie Ni, Hong-Lei Guo & Min Yang
Aldosterone exerts an enormous function on proximal tubular cells (PTC) senescence, which is a common pathomechanism contributing to renal dysfunction. Numerous studies have shown that oxidative stress is deeply involved in the pathophysiologic processes of chronic kidney diseases. The study aims to investigate whether autophagy could regulate the process of senescence through oxidative stress in PTC both in vivo and ex vivo. Our results suggested that aldosterone treatment increased the senescence and oxidative stress as...

Combining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee

Xiaoyu Li, Zheting Liao, Zhonghao Deng, Nachun Chen & Liang Zhao
Osteoarthritis (OA) occurs mostly in the knees, hips, finger interphalangeal joints, and spinal facet joints, and is characterized by cartilage degeneration. The existing bulk RNA sequencing (bulk RNA-seq) and single-cell sequencing (scRNA-seq) data for chondrocytes in the osteoarthritic knee joint provide the expression profiles of entire cell populations and individual cells, respectively. Here, we aimed to analyze these two types of sequencing data in order to obtain a more comprehensive understanding of OA. We compared...

Association between gestational weight gain and perinatal outcomes among twin gestations based on the 2009 Institute of Medicine (IOM) guidelines: a systematic review

Dongxin Lin, Zheng Huang, Dazhi Fan, Gengdong Chen, Shaoxin Ye, Shuzhen Wu, Xiaoling Guo, Caihong Luo & Zhengping Liu
Gestational weight gain (GWG) has been understudied among twin pregnancies. This systematic review aimed to review the data on the associations between GWG, based on the 2009 Institute of Medicine (IOM) guidelines and pregnancy outcomes among twin gestations. A systematic review was performed according to the PRISMA guidelines. A search for eligible studies published from January 2010 to August 2020 was conducted in the EMBASE, PubMed, Web of Science, ScienceDirect, and Cochrane databases. The methodological...

Molecular characterization and function analysis of the rice OsDUF1664 family

Lin Zhang, Dejia Hou, Chunliu Li, Xiaohong Li, Jiangbo Fan, Yilun Dong, Jianqing Zhu, Zhengjian Huang, Zhengjun Xu & Lihua Li
The functions of a large number of genes, including gene families with domains of unknown functions (DUF), still remain unclear. In this study, we analyzed four members of OsDUF1664 (OsDUF1664.1-OsDUF1664.4) in rice Nipponbare. By phylogenetic analysis, DUF1664 members in rice and Arabidopsis were classified into three major groups (I, II, III). Under drought conditions, the expression level of OsDUF1664.3 in rice was significantly elevated. Overexpression of OsDUF1664.3 in Escherichia coli led to a significant enhancement...

Additional file 2 of Transcriptional dynamics of transposable elements when converting fibroblast cells of Macaca mulatta to neuroepithelial stem cells

Dahai Liu, Li Liu, Kui Duan, Junqiang Guo, Shipeng Li, Zhigang Zhao, Xiaotuo Zhang, Nan Zhou & Yun Zheng
Additional file 2 Supplementary Figure S1. The expression levels of LTRs in the Cluster L4 of Figure 3A. Supplementary Figure S2. The primers used to validate the expressions of 13 MacERV3 LTRs. (A) The alignment of the forward primer MacERV3_LTR2_34_F and the 13 MacERV3 LTRs. (B) The alignment of the reverse primer MacERV3_LTR2_34_R and the 13 MacERV3 LTRs. (C) The precise loci of the two primers in one of the selected MacERV3 LTRs, MacERV3_LTR2_34. Supplementary...

Testing independence between discrete random variables

Adriano Z. Zambom & Qing Wang
In this paper we develop a likelihood ratio test for independence between multivariate discrete random vectors whose components may be dependent or may have different marginal distributions. A special case that tests independence between two discrete random variables is also discussed. The model under the null hypothesis is constructed based on the marginal distributions of the random variables, while the model under the alternative is built by adding a common random effect which is not...

Post-translational knockdown and post-secretional modification of EsxA determine contribution of EsxA membrane permeabilizing activity for mycobacterial intracellular survival

Yanqing Bao, Lin Wang & Jianjun Sun
Current genetic studies (e.g. gene knockout) have suggested that EsxA and EsxB function as secreted virulence factors that are essential for Mycobaterium tuberculosis (Mtb) intracellular survival, specifically in mediating phagosome rupture and translocation of Mtb to the cytosol of host cells, which further facilitates Mtb intracellular replicating and cell-to-cell spreading. The EsxA-mediated intracellular survival is presumably achieved by its pH-dependent membrane-permeabilizing activity (MPA). However, the data from other studies have generated a discrepancy regarding the...

Tumor heterogeneity in autophagy-dependent ferroptosis

Jingbo Li, Jiao Liu, Yinghua Xu, Runliu Wu, Xin Chen, Xinxin Song, Herbert Zeh, Rui Kang, Daniel J. Klionsky, Xiaoyan Wang & Daolin Tang
Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation process that plays a complex role in cellular stress, either promoting survival or triggering death. Early studies suggest that ferroptosis, an iron-dependent form of regulated cell death, is not related to autophagy. Conversely, recent evidence indicates that the molecular machinery of autophagy facilitates ferroptosis through the selective degradation of anti-ferroptosis regulators. However, the mechanism of autophagy-dependent ferroptosis remains incompletely understood. Here, we examine the early...

Silurian post-orogenic volcanic rocks of the South Kunlun Belt, NW China: links to the Proto- to Paleo-Tethyan tectonic transition

Jing Chen, Bing-Zhang Wang, Bin Li & Fu-Cheng Yu
Newly discovered early Palaeozoic intraplate volcanic rocks within the southern Kunlun Orogen provide an opportunity to examine the middle to late Silurian tectonic setting of this area. This study presents new whole-rock geochemical and zircon U–Pb geochronological and Lu–Hf isotope data for the Silurian volcanic rocks of the Wanbaogou area, South Kunlun Belt. These volcanic rocks are split into trachytic and basaltic groups based on field observations and petrographic and geochemical data. Laser ablation–inductively coupled...

Computerized analysis of fetal heart rate pattern in the third trimester of low-risk pregnancy by long-range electronic fetal monitoring

Shu-Fang Li, Yang-Yu Zhao, Guang-Fei Li, Nan Wang, Song Zhang, Lian Chen & Yan Wang
With computerized analysis of fetal heart rate(FHR) data from long-range monitoring, we aimed to comprehensively clarify the characteristics of FHR with increasing gestational age in low-risk pregnant women during the third trimester of pregnancy. This was an observational study. 85 fetuses of low-risk pregnant women were included. The data covered 28 ∼ 40 weeks of gestation, and 125 cases of FHR monitoring from 85 fetuses were totally collected. The FHR baseline rate, variability, and acceleration...

Computerized analysis of fetal heart rate pattern in the third trimester of low-risk pregnancy by long-range electronic fetal monitoring

Shu-Fang Li, Yang-Yu Zhao, Guang-Fei Li, Nan Wang, Song Zhang, Lian Chen & Yan Wang
With computerized analysis of fetal heart rate(FHR) data from long-range monitoring, we aimed to comprehensively clarify the characteristics of FHR with increasing gestational age in low-risk pregnant women during the third trimester of pregnancy. This was an observational study. 85 fetuses of low-risk pregnant women were included. The data covered 28 ∼ 40 weeks of gestation, and 125 cases of FHR monitoring from 85 fetuses were totally collected. The FHR baseline rate, variability, and acceleration...

Differentially-expressed mRNAs, microRNAs and long noncoding RNAs in intervertebral disc degeneration identified by RNA-sequencing

Zhimin Li, Yu Sun, Maolin He & Jianwei Liu
The underlying molecular mechanisms of intervertebral disc degeneration (IDD) remain unclear. This study aimed to identify the crucial molecules and explore the function of noncoding RNAs and related pathways in IDD. We randomly selected three samples each from an IDD and a spinal cord injury group (control) for RNA-sequencing. We identified 463 differentially-expressed long noncoding RNAs (lncRNAs), 47 differentially-expressed microRNAs (miRNAs), and 1,334 differentially-expressed mRNAs in IDD. Three hundred fifty-eight lncRNAs as cis-regulators could potentially...

Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma

Yong-Fa Zhang, Yi-Xiu Wang, Ning- Zhang, Zhen-Hai Lin, Long-Rong Wang, Yun Feng, Qi Pan & Lu Wang
RNA-binding motif protein 25 (RBM25) is a poorly characterized RNA-binding protein that is involved in several biological processes and regulates the proliferation and metastasis of tumor cells. The regulatory role of RBM25 in hepatocellular carcinoma (HCC) is unknown. Here, RBM25 expression and outcomes in HCC patients were evaluated using The Cancer Genome Atlas database. RBM25 was overexpressed in HCC patients compared with the healthy group. The high expression of RBM25 in tumor tissues was significantly...

Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain

Jian Li, Mouli Tian, Tong Hua, Haowei Wang, Mei Yang, Wenqian Li, Xiaoping Zhang & Hongbin Yuan
Macroautophagy/autophagy, an evolutionarily conserved process, plays an important role in the regulation of immune inflammation and nervous system homeostasis. However, the exact role and mechanism of autophagy in pain is still unclear. Here, we showed that impaired autophagy flux mainly occurred in astrocytes during the maintenance of neuropathic pain. No matter the stage of neuropathic pain induction or maintenance, activation of autophagy relieved the level of pain, whereas inhibition of autophagy aggravated pain. Moreover, the...

Lignans from Bupleurum marginatum and their antioxidant activity

Jian Zhou, Xin He, Rongjin Sun, Zhenlong Yu, Chao Wang, Sa Deng, Baojing Zhang, Shanshan Huang, Chunhui Han & Dawei Li
A new aryltetralin lignan, bupleroid A (1), along with ten known analogues (2–11) were isolated from Bupleurum marginatum. The structures of these isolates were determined by 1D and 2D NMR, HRESIMS, and ECD data analysis. In addition, the DPPH radical scavenging capacities of all compounds were evaluated. Compound 6 exhibited good DPPH radical scavenging activity at a concentration of 50 μM.

Cement Catalyzed Valorization of Rice Straw into Upgraded Bio-Oil and Fuel Gases Using Pyrolysis Reactions

Ikram Uddin, Guijin Wang, Deyang Gao, Ning Li, Zahid Hussain & Baolin Hou
Rice straw is one of the major agricultural residues that is generated enormously in Asian countries. Thus, it is critical to develop an efficient process of converting this residue into valuable compounds in replacing fossil-based products. Herein, we developed an economically viable cement catalyst to pyrolyze the rice straw into bio-oil and fuel gas in a batch-type reactor. Under the optimized conditions, the maximum bio-oil yield of 41.07 wt.%, and gas yield of 30.53 wt.%...

Three new cadinane-type sesquiterpenes from Eupatorium adenophorum spreng.

Xu Liang, Xinzhou Yang, Tongxi Zhou, Yuanren Ma, Yu Peng, Yeerlan Bahetejiang, Yuzhao Li & Jingquan Yuan
Three new cadinane-type sesquiterpenes, eupatorinones A-C (1-3), along with seven known compounds (4-10), were obtained from the petroleum ether fraction of 95% ethanol extract of Eupatorium adenophorum Spreng. The structures of these new compounds were determined by NMR, MS, and ECD spectra analysis. The configuration of compound 3 was established by quantum chemical calculations of NMR chemical shifts and ECD spectra, that matched the experimental data. In addition, compounds 1, 3 and 5 increased the...

Two new cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc (Linn.) Roxb. and their anti-inflammatory activity

Ting Liu, Xiang Li, Zunxi Ning, Shizhou Qi & Huiyuan Gao
In this study, phytochemical investigation on the chloroform soluble fraction of seed kernels of Caesalpinia bonduc led to the isolation of two new cassane-type diterpenoids, norcaesalpinin Q (1) and caesalpinin MR (2), together with seven known compounds (3–9). The structures of the new compounds were elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses, and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. All compounds were evaluated for inhibitory...

Synergy of alanine and gentamicin to reduce nitric oxide for elevating killing efficacy to antibiotic-resistant Vibrio alginolyticus

Su-fang Kuang, Yue-tao Chen, Jia-jie Chen, Xuan-xian Peng, Zhuanggui Chen & Hui Li
The present study explored the cooperative effect of both alanine (Ala) and gentamicin (Gent) on metabolic mechanisms by which exogenous Ala potentiates Gent to kill antibiotic-resistant Vibrio alginolyticus. To test this, GC-MS-based metabolomics was used to characterize Ala-, Gent- and both-induced metabolic profiles, identifying nitric oxide (NO) production pathway as the most key clue to understand metabolic mechanisms. Gent, Ala and both led to low, lower and lowest activity of total nitric oxide synthase (tNOS)...

Registration Year

  • 2021

Resource Types

  • Text


  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Shanghai Jiao Tong University
  • Zhejiang University
  • Sichuan University
  • Fudan University
  • Huazhong University of Science and Technology
  • Chinese Academy of Sciences
  • Capital Medical University
  • Sun Yat-sen University
  • University of Chinese Academy of Sciences