Additional file 2: Supplemental Table 2. The kappa coefficients of categorical variables between three radiologists.

The demonstration of batch-to-batch consistency is indispensable for quality control of vaccines. We conducted a randomized, double-blind, parallel-controlled trial to evaluate the immunogenicity consistency of a single shot of Ad5-nCoV in healthy adults who had not previously received any COVID-19 vaccine. All eligible participants were randomly assigned equally to receive one of the three consecutive batches of Ad5-nCoV (5 × 1010 viral particles/vial, 0.5 mL). The primary endpoint was geometric mean titers (GMTs) of serum...

The potential for effector functions of therapeutic antibodies, including antibody-dependent cell-mediated cytotoxicity (ADCC), is a biological activity of interest for characterization, regardless of if ADCC is an intended primary pharmacological effect. The composition of the conserved antibody Fc glycan can vary as a function of post-translational processing which may affect the binding affinity to Fc receptors, leading to a change of effector activity. Ordesekimab (AMG 714 or PRV-015), a fully human immunoglobulin G1-kappa anti-interleukin (IL)-15...

The reduction of CO2 into valuable chemicals through electrocatalytic techniques provides a potential strategy to alleviate energy crises and environmental pollution. In this study, 2D M3(THT)2 (M = Fe, Co, Ni, Ru, Rh, Pd, THT = 2,3,6,7,10,11-triphenylenehexathiolate) framework as CO2 reduction reaction (CO2RR) electrocatalysts was investigated by using the density functional method. The results showed that the studied catalysts are stable both thermodynamically and electrochemically. Rh3(THT)2 exhibits the best catalytic performance to produce CH4 with...

Chronic stress is a well-established risk factor for cardiometabolic disease. Caregiving for individuals with cancer is perceived as a chronic stressor yet research on the risk for cardiometabolic disease in this population, opposed to the elderly and those with Alzheimer’s disease, is limited. Additionally, few studies have explored the early physiological changes that occur in family caregivers suggesting an elevated risk for illness. This cross-sectional study was designed to examine levels of cardiometabolic risk biomarkers...

It has been discovered that many plants accumulate proline in response to osmotic stress. However, the interaction between salinity stress and proline metabolism-related genes has not been unequivocally identified in Spartina alterniflora. In our research, we successfully cloned key genes: SaP5CS1 and SaP5CS2, SaOAT, SaProT and correlated with expression profiles including SaPDH were also investigated. As the key enzyme genes for proline metabolism, the up-regulated expression of SaP5CS2 played a leading part under salt stress....

This century’s planning challenge is one of retrofitting suburbia. As relatively compact suburban forms, edge cities may be the most amenable to retrofit. In the 30 years since the publication of Garreau’s Edge City, to what extent and in what ways have planning intentions changed to favor greater urbanity in edge cities? Across 10 indicators, we examined planning intentions covering 117 of 123 edge cities identified in 1991. Content analysis of plans revealed the mixed...

Additional file 2.

Additional file 1. Original images for western blot.

Additional file 8.

Additional file 2.

Researchers have investigated miR-130b-3p in lung disease pathology, such as lung fibrosis. The present study was performed to elucidate the miR-130b-3p-involved mechanism in acute lung injury (ALI) through delivery by mesenchymal stem cells-derived exosomes (MSCs-Exo). ALI mouse models were induced via intratracheal administration of lipopolysaccharide (LPS) and treated with MSCs-Exo. Lung dry-wet (W/D) ratio, inflammatory factors in the bronchoalveolar lavage fluid, pathological damage and apoptosis in the lung tissues were analyzed. Expression levels of miR-130b-3p...

Supplementary Material containing S1, S2 and S3.

Supplemental material, sj-pdf-1-imr-10.1177_03000605221126378 for Ultrasonographic analysis of Langerhans cell histiocytosis in children: a report of 55 cases by Lei Liu, Zhouqin Lin, Ruijie Wang, Fusui Xie, Jingran Zhou, Tingting Liu, Shizhe Liu, Cailei Zhao and Bei Xia in Journal of International Medical Research

Supplemental material, sj-pdf-1-imr-10.1177_03000605221126378 for Ultrasonographic analysis of Langerhans cell histiocytosis in children: a report of 55 cases by Lei Liu, Zhouqin Lin, Ruijie Wang, Fusui Xie, Jingran Zhou, Tingting Liu, Shizhe Liu, Cailei Zhao and Bei Xia in Journal of International Medical Research

Supplemental Material for Associations of RPEL1 and miR-1307 gene polymorphisms with disease susceptibility, glucocorticoid efficacy, anxiety, depression, and health-related quality of life in Chinese systemic lupus erythematosus patients by Zi-Ye Yan, Wan-Qin Hu, Qi-Qun Zong, Guang-Hui Yu, Chun-Xia Zhai, Lin-Lin Wang, Yu-Hua Wang, Ting-Yu Zhang, Zhen Li, Ying Teng, Jing Cai, Yang-Fan Chen, Mu Li, Zhou-Zhou Xu, Fa-Ming Pan, Hai-Feng Pan, Hong Su, and Yan-Feng Zou in Lupus.

RAS protein activator like 2 (Rasal2) exerts pro-proliferative effect in several types of cells. However, whether Rasal2 is involved in the regulation of pulmonary artery smooth muscle cell (PASMC) remains unclear. In the current study, we explored the role of Rasal2 in proliferation and migration of PASMC during the development of pulmonary arterial hypertension (PAH). We found that the protein level of Rasal2 was increased in both pulmonary arteries of chronic hypoxia-induced pulmonary hypertension (CH-PH)...

Supplemental Material, sj-docx-1-ptd-10.1177_08968608211064192 for Serum vancomycin levels predict the short-term adverse outcomes of peritoneal dialysis–associated peritonitis by Ying Ma, Yingzhou Geng, Li Jin, Xiaopei Wang, Changna Liang, Liyi Xie, Wanhong Lu and Jing Lv in Peritoneal Dialysis International

Supplemental Material, sj-docx-1-ptd-10.1177_08968608211064192 for Serum vancomycin levels predict the short-term adverse outcomes of peritoneal dialysis–associated peritonitis by Ying Ma, Yingzhou Geng, Li Jin, Xiaopei Wang, Changna Liang, Liyi Xie, Wanhong Lu and Jing Lv in Peritoneal Dialysis International

The protection of migratory birds and their habitats is important to the ecological stability of the Qinghai-Tibet Plateau (QTP). Currently protected areas (PAs) were designed in accordance with species distribution patterns under current climatic conditions, thus ignoring climate change will lead to a decrease in the protection efficiency of PAs. In this study, using the flagship species Grus nigricollis, as an example, we used the maximum entropy (MaxEnt) model to simulate the distributions and conservation...

figures of the result of the rest animals and humans

Richmond agitation-sedation scale (RASS) is a simple and widely used tool for evaluating sedation and agitation in adult ICU patients. Early deep sedation has been shown to be an important independent predictor of death, however, studies on the role of RASS in the prognostic assessment of neurocritical patients are lacking. The purpose of this study was to investigate the relationship between RASS and in-hospital mortality in neurocritical patients, and to develop and validate an effective...

The benefits of potent antithrombotic therapy usually come at the expense of a higher risk of bleeding. The efficacy and safety of ticagrelor in elderly East Asian populations remains debated due to the concerns about the imbalance of ischemic and bleeding risks. This study aimed to compare the impact of clopidogrel with ticagrelor on clinical outcomes in East Asian patients aged ≥75 years with acute coronary syndrome (ACS) using data from an institutional registry. We...

Osteoporosis is a worldwide disease that seriously affects the quality of life and survival rate of the elderly. The detection of bone biomarkers will provide supplementary information on bone mineral density, contributing to the accurate diagnosis of osteoporosis and better health care for prevention. This study aimed to investigate the efficacy of oxidative stress markers—8-oxo-7,8-dihydroguanine (8-oxoGsn) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn) in the assessment of osteoporosis. We conducted a cross-sectional study among menopausal women with a mean...

The programmed death ligand 1 (PD-L1) is a pivotal biomarker of immunotherapy in triple negative breast cancer (TNBC). TP53 is reported as a positive regulatory predictor of immune efficacy. The correlation of p53 expression or mutation and PD-L1 expression is explored. By immunohistochemistry, PD-L1 expression between p53 mutation (missense and nonsense) and wild type; p53 no-expression/loss vs. expression were compared. There was a significant association between p53 mutation, especially missense mutation with higher histological grade,...