522 Works

Determinants of Sedentary Behaviour in Individuals with COPD: A Qualitative Exploration Guided by the Theoretical Domains Framework

Adnan Wshah, Anne-Marie Selzler, Kylie Hill, Dina Brooks & Roger Goldstein
In people with chronic obstructive pulmonary disease (COPD), there is increasing recognition that the prolonged accumulation of sedentary time (ST) is associated with adverse cardio-metabolic health outcomes. Nevertheless, changing this lifestyle, which has evolved over several decades, is likely to be challenging. This study reports the determinants, perceived by individuals with COPD, as being important for reducing ST. An in-depth understanding of this information is essential when planning an intervention to reduce ST. Fourteen individuals...

Prolonged shedding of severe acute respiratory syndrome coronavirus 2 in patients with COVID-19

Qian Li, Xiao-Shuang Zheng, Xu-Rui Shen, Hao-Rui Si, Xi Wang, Qi Wang, Bei Li, Wei Zhang, Yan Zhu, Ren-Di Jiang, Kai Zhao, Hui Wang, Zheng-Li Shi, Hui-Lan Zhang, Rong-Hui Du & Peng Zhou
Following acute infection, individuals COVID-19 may still shed SARS-CoV-2 RNA. However, limited information is available regarding the active shedding period or whether infectious virus is also shed. Here, we monitored the clinical characteristics and virological features of 38 patients with COVID-19 (long-term carriers) who recovered from the acute disease, but still shed viral RNA for over 3 months. The median carrying history of the long-term carriers was 92 days after the first admission, and the...

Prolonged shedding of severe acute respiratory syndrome coronavirus 2 in patients with COVID-19

Qian Li, Xiao-Shuang Zheng, Xu-Rui Shen, Hao-Rui Si, Xi Wang, Qi Wang, Bei Li, Wei Zhang, Yan Zhu, Ren-Di Jiang, Kai Zhao, Hui Wang, Zheng-Li Shi, Hui-Lan Zhang, Rong-Hui Du & Peng Zhou
Following acute infection, individuals COVID-19 may still shed SARS-CoV-2 RNA. However, limited information is available regarding the active shedding period or whether infectious virus is also shed. Here, we monitored the clinical characteristics and virological features of 38 patients with COVID-19 (long-term carriers) who recovered from the acute disease, but still shed viral RNA for over 3 months. The median carrying history of the long-term carriers was 92 days after the first admission, and the...

Reducing sedentary behavior in individuals with COPD: healthcare professionals’ perspectives

Adnan Wshah, Anne-Marie Selzler, Lauren Ellerton, Kylie Hill, Dina Brooks & Roger Goldstein
Reducing sedentary behavior (SB) in individuals with chronic obstructive pulmonary disease (COPD) is being increasingly recognized as a novel health target. Understanding healthcare professionals (HCPs) behavior that influences a reduction in SB in this population could facilitate achieving this target. To explore the determinants of behavior related to HCPs targeting a reduction in SB in people with COPD. We used a qualitative semi-structured interview approach informed by the Theoretical Domains Framework (TDF). Sixteen HCPs were...

Β-Cyclodextrin-graft-poly(amidoamine) dendrons as the nitric oxide deliver system for the chronic rhinosinusitis therapy

Tao Liu, Guowei Li, Xidong Wu, Shaohua Chen, Siyi Zhang, Hong Han, Hongbin Zhang, Xiaoning Luo, Xiang Cai & Dong Ma
Chronic rhinosinusitis (CRS) is a rather prevalent condition with a chronic inflammatory process, which is hard to cure. Herein, a new antibacterial drug, nitric oxide (NO), was used for the attempt on CRS therapy. To achieve this, a star copolymer (β-CD-PAMAM) consisting of the β-cyclodextrin (β-CD) core and seven PAMAM-G3 arms, which was designed as a low-cytotoxicity and high NO loading carrier, were synthesized and characterizied. The obtained β-CD-PAMAM/NONOate showed the effect in inhibiting and...

Association of soft drink and 100% fruit juice consumption with all-cause mortality, cardiovascular diseases mortality, and cancer mortality: A systematic review and dose-response meta-analysis of prospective cohort studies

Bei Pan, Long Ge, Honghao Lai, Qi Wang, Qian Zhang, Min Yin, Sheng Li, Jinhui Tian, Kehu Yang & Jiancheng Wang
Sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and 100% fruit juices are frequently consumed and have been documented that they could lead to serious disease burden. However, inconsistent evidence on the association between SSBs, ASBs, and 100% fruit juices consumption and mortality have been presented. PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, and PsycINFO were systematically searched. We conducted a random-effects meta-analysis and dose-response meta-analysis to assess the association and calculated...

Novel mutation in TSPAN12 associated with familial exudative vitreoretinopathy in a Chinese pedigree

Zhen Song, Mo Li, Chang Wang, Yu Wang, Lihua Zhang, Na Li, Ruifang Yang & Ping Sun
Familial exudative vitreoretinopathy (FEVR) is a rare retinal disorder characterised by incomplete retinal vascular development. Symptoms vary widely from none to blindness even within the same family. Multiple genes related to the Wnt pathway have been found to be associated with FEVR. Recent studies identified tetraspanin 12 (TSPAN12) as a cause of the autosomal dominant inheritance form of FEVR. Here, we describe a novel TSPAN12 mutation in a Chinese family with FEVR. Targeted next-generation sequencing...

Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response

Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang & Fei Han
Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs). Aspirin could prevent cardiomyocyte damage by inducing heat shock response. This study investigates the effect of aspirin on alleviating VSMC calcification. An in vitro VSMC calcification model was established by 10-day calcification induction in osteogenic medium. VSMCs were grouped as following: control group (normal medium), calcified...

Abietane diterpenoids with neuroprotective activities from Phlegmariurus carinatus

Yang Liu, Qiang Wang, Dong-Kun Zheng, De Zhang, Zhen Xie, Jia-Wei Hu, Xin-Hua Xie, Jing Li & Shu-Ping Jiang
Two new abietane diterpenoids, phlecarinatone A (1) and phlecarinatone B (2), along with two known analogues (3 and 4), were isolated from Phlegmariurus carinatus. The structures of 1 − 4 were unambiguously elucidated by comprehensive spectroscopic analyses. Abietane diterpenoids were isolated from the plant for the first time. All isolates were tested for their neuroprotective activities against H2O2-induced SH-SY5Y cells injury, and compound 2 showed moderate effect at the concentrations ranging from 5 ∼ 20...

Additional file 5 of Cross-watershed distribution pattern challenging the elimination of Oncomelania hupensis, the intermediate host of Schistosoma japonicum, in Sichuan province, China

Shen Chen, Ding Lu, Lei Duan, Ben Ma, Chao Lv, Yin-long Li, Shen-ning Lu, Lan-hua Li, Liang Xu, Zi-song Wu, Shang Xia, Jing Xu, Yang Liu & Shan Lv
Additional file 5: Figure S4. A Kruskal-Wallis comparison analysis of median distances among different groups.

Supplementary document for Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method - 6063130.pdf

Hao Liang, Qi Wang, Xueguang Yuan, Hao Liu, Jiyu Xu, Yangan Zhang, Kai Liu, Yongqing Huang & Xiaomin Ren
Topological inverse design of fabrication-constrained nanophotonic devices via adaptive projection method: supplemental document

Identifying substitute activities for alcohol consumption: a preliminary analysis

Sarah C. Weinsztok, Derek D. Reed & Michael Amlung
Individuals with alcohol use disorder may excessively value alcohol reinforcement over other types of rewards and may seek out environments supportive of alcohol consumption despite negative consequences. Therefore, examining ways to increase engagement in substance-free activities may be useful in treating alcohol use disorder. Past research has focused on preference and frequency of engagement in alcohol-related versus alcohol-free activities. However, no study to-date has examine the incompatibility of such activities with alcohol consumption, an important...

Additional file 1 of Association between metabolically healthy obesity and risk of atrial fibrillation: taking physical activity into consideration

Ruoting Wang, Ivan Olier, Sandra Ortega-Martorell, Yingxin Liu, Zebing Ye, Gregory YH Lip & Guowei Li
Supplementary Material 1

Additional file 8 of Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes

Weicheng Chen, Feifei Wang, Weijia Zeng, Xinyan Zhang, Libing Shen, Yuan Zhang & Xiangyu Zhou
Additional file 8: Table S4. Primers used for real-time PCR and cDNA amplification of TTC12

Additional file 6 of Screening for prostate cancer: protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update

Alexandria Bennett, Andrew Beck, Nicole Shaver, Roland Grad, Allana LeBlanc, Heather Limburg, Casey Gray, Ahmed Abou-Setta, Scott Klarenbach, Navindra Persaud, Guylène Thériault, Brett D. Thombs, Keith J. Todd, Neil Bell, Philipp Dahm, Andrew Loblaw, Lisa Del Giudice, Xiaomei Yao, Becky Skidmore, Elizabeth Rolland-Harris, Melissa Brouwers, Julian Little & David Moher
Additional file 6. Draft data extraction items.

Additional file 3 of Optimising a person-centred approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: a realist review

Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Maden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson & Joanne Reeve
Additional file 3. CMOCs with supporting data extracts.

sj-pdf-1-imr-10.1177_03000605221134462 - Supplemental material for Clinical report of delayed recovery after general anaesthesia in elderly patients with cervical spine surgery: A case report

Yang Liu & Huilian Huang
Supplemental material, sj-pdf-1-imr-10.1177_03000605221134462 for Clinical report of delayed recovery after general anaesthesia in elderly patients with cervical spine surgery: A case report by Yang Liu, Huilian Huang in Journal of International Medical Research

Additional file 1 of Mental and physical health and well-being of Canadian employees who were working from home during the COVID-19 pandemic

Kumara G. Somasundram, Amy Hackney, Marcus Yung, Bronson Du, Jodi Oakman, Behdin Nowrouzi-Kia & Amin Yazdani
Supplementary Material 1

Additional file 3 of Mental and physical health and well-being of canadian employees who were working from home during the COVID-19 pandemic

Kumara G. Somasundram, Amy Hackney, Marcus Yung, Bronson Du, Jodi Oakman, Behdin Nowrouzi-Kia & Amin Yazdani
Supplementary Material 3

Additional file 1 of Dietary supplementation of Macleaya cordata extract and Bacillus in combination improve laying performance by regulating reproductive hormones, intestinal microbiota and barrier function of laying hens

Fei Wang, Peng Zou, Shujie Xu, Qi Wang, Yuanhao Zhou, Xiang Li, Li Tang, Baikui Wang, Qian Jin, Dongyou Yu & Weifen Li
Additional file 1: Table S1. Sequences of oligonucleotide primers used for RT-qPCR. Table S2. Organs indices of laying hens fed different biological feed additives1.

Additional file 9 of Machine learning algorithms to identify cluster randomized trials from MEDLINE and EMBASE

Ahmed A. Al-Jaishi, Monica Taljaard, Melissa D. Al-Jaishi, Sheikh S. Abdullah, Lehana Thabane, P. J. Devereaux, Stephanie N. Dixon & Amit X. Garg
Additional file 9. Details and results for applying our model on a dialysis-related dataset. Table S1. Number of relevant articles retrieved with and without machine learning algorithm using the demonstration dataset (n=882 records). The research objective was to review CRTs in the hemodialysis setting to report key methodological and ethical issues.

Additional file 2 of Interventions to address potentially inappropriate prescriptions and over-the-counter medication use among adults 65 years and older in primary care settings: protocol for a systematic review

Andrew Beck, Navindra Persaud, Laure A. Tessier, Roland Grad, Michael R. Kidd, Scott Klarenbach, Christina Korownyk, Ainsley Moore, Brett D. Thombs, Dee Mangin, Rita K. McCracken, Emily G. McDonald, Caroline Sirois, Salmaan Kanji, Frank Molnar, Stuart G. Nicholls, Kednapa Thavorn, Alexandria Bennett, Nicole Shaver, Becky Skidmore, Bradley R. Mitchelmore, Marc Avey, Elizabeth Rolland-Harris, Julian Little & David Moher
Additional file 2. Search strategies.

Additional file 2 of Interventions to address potentially inappropriate prescriptions and over-the-counter medication use among adults 65 years and older in primary care settings: protocol for a systematic review

Andrew Beck, Navindra Persaud, Laure A. Tessier, Roland Grad, Michael R. Kidd, Scott Klarenbach, Christina Korownyk, Ainsley Moore, Brett D. Thombs, Dee Mangin, Rita K. McCracken, Emily G. McDonald, Caroline Sirois, Salmaan Kanji, Frank Molnar, Stuart G. Nicholls, Kednapa Thavorn, Alexandria Bennett, Nicole Shaver, Becky Skidmore, Bradley R. Mitchelmore, Marc Avey, Elizabeth Rolland-Harris, Julian Little & David Moher
Additional file 2. Search strategies.

Additional file 3 of Interventions to address potentially inappropriate prescriptions and over-the-counter medication use among adults 65 years and older in primary care settings: protocol for a systematic review

Andrew Beck, Navindra Persaud, Laure A. Tessier, Roland Grad, Michael R. Kidd, Scott Klarenbach, Christina Korownyk, Ainsley Moore, Brett D. Thombs, Dee Mangin, Rita K. McCracken, Emily G. McDonald, Caroline Sirois, Salmaan Kanji, Frank Molnar, Stuart G. Nicholls, Kednapa Thavorn, Alexandria Bennett, Nicole Shaver, Becky Skidmore, Bradley R. Mitchelmore, Marc Avey, Elizabeth Rolland-Harris, Julian Little & David Moher
Additional file 3. List of grey literature relevant websites.

mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern

Haomeng Wang, Zhao Chen, Zhenghua Wang, Jin Li, Zhihong Yan, Jinbo Yuan, Airu Zhu, Lan Chen, Ye Liu, Chenlong Hu, Ali Zhu, Guowei Li, Yuehu Li, Jie Deng, Liqiao Ma, Xiuwen Sui, Wei Miao, Junqiang Li, Xiuyu Zheng, Jinhua Piao, Yanfeng Yao, Juhong Rao, Chao Shan, Zhiming Yuan, Jincun Zhao … & Tao Zhu
In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against...

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