36 Works

Sample Size Calculation and Timing of Dose Selection in a Multiple-Dose Clinical Trial

Liji Shen, Jin Zhang & Paul DeLucca
In a two-stage design for multiple-dose clinical trial, a dose that has the highest observed response rate is often chosen to carry to the next stage, then to compare against the control group. The observed response rate could overestimate the true response rate of the selected dose. If it is used to compare with the response rate of the control group without any adjustment, the Type I error of this statistical inference will not be...

One new triterpenoids from Momordica charantia L

Yue Jiang, Bing Liang, Qiong Wu, Jing-Ru Wang & Bing Liu
Momordica charantia L. (M. charantia) is an annual climbing herb in Cucurbitaceae. It is not only a food, but also a drug with a long history of application. This study aims to isolate and identify the chemical constituents form M. charantia and evaluate their inhibiting effect on Hcy-induced proliferation of VSMCs. Silica column chromatography, ODS silica column chromatography, Sephadex LH-20 column chromatography and semi-preparative HPLC were used to obtain one new compound (1). The inhibition...

Supplementary document for Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation - 6094077.pdf

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
1. Transformation of the quadratic nonlinear system into the cubic nonlinear system in the regime of cascading limit;2. Doubly-periodic waves from the cubic nonlinearity

Supplementary document for Spatio-temporal doubly periodic waves in phase-mismatched second-harmonic generation - 6094077.pdf

Zhixiang Deng, Jin Zhang, Dianyuan Fan & LIFU ZHANG
1. Transformation of the quadratic nonlinear system into the cubic nonlinear system in the regime of cascading limit;2. Doubly-periodic waves from the cubic nonlinearity

Adsorption Behavior of Vanadium Using Supported 1-Butyl-3-Methylimidazolium Chloride Ionic Liquid

Yu Liang, Shenxu Bao, Yimin Zhang, Bo Chen & Chen Yu
Imidazole-based ionic liquid 1-Butyl-3-methylimidazolium chloride was immobilized on polymer support by chemical grafting and utilized to separate vanadium (V) from a vanadium-containing solution. Characterizations with elementary analysis, Fourier transform infrared (FTIR), 13C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) proved the successful loading of the ionic liquid on the surface of the support. The adsorption capacity toward V(V) reached 222.42 mg/g under experimental conditions, which was significantly higher than...

Additional file 2 of Genetic analysis of 55 cases with fetal skeletal dysplasia

Ying Bai, Yue Sun, Ning Liu, Li Wang, Zhihui Jiao, Yaqin Hou, Huikun Duan, Qianqian Li, Xiaofan Zhu, Jingjing Meng & Xiangdong Kong
Additional file 2. Images of US examination of some fetuses in this study.

Transition-metal-free mono- or dinitration of protected anilines

Enrui Dai, Yongrui Dong, Rui Kong, Guangzhang Liu, Ying Dong, Qiong Wu, Deqiang Liang & Yinhai Ma
An amide-assisted arene nitration is presented, and both mono- and dinitration of protected anilines could be effected by using NaNO2 and NaNO3 as the mono- and bisnitrating agents, respectively. This divergent synthesis is transition-metal- and acid-free, and features a broad substrate scope, low cost, and ortho–para selectivity.

Two new cycloartane triterpenoid glycosides from the rhizomes of Actaea vaginata

Shunqin Zeng, Xiangyuan Li, Zixuan Zhao, Yan Lin, Yindi Zhu, Guoxu Ma, Xiaohong Zhao, Xudong Xu, Meichun Wu, Haifeng Wu, Qiongyu Zou & Yongtao Li
Two new cycloartane triterpenoid glycosides, soulieoside V (1) and 15-deacetylbeesioside O (2), together with one known compound, beesioside J (3), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. All the compounds were tested for their cytotoxic activities against human cancer cell lines.

Sample Size Calculation and Timing of Dose Selection in a Multiple-Dose Clinical Trial

Liji Shen, Jin Zhang & Paul DeLucca
In a two-stage design for multiple-dose clinical trial, a dose that has the highest observed response rate is often chosen to carry to the next stage, then to compare against the control group. The observed response rate could overestimate the true response rate of the selected dose. If it is used to compare with the response rate of the control group without any adjustment, the Type I error of this statistical inference will not be...

Sample size calculation and timing of dose selection in an adaptive multiple-dose clinical trial

Liji Shen, Jin Zhang & Paul DeLucca
In a two-stage design for multiple-dose clinical trial, a dose that has the highest observed response rate is often chosen to carry to the next stage, then to compare against the control group. The observed response rate could overestimate the true response rate of the selected dose. If it is used to compare with the response rate of the control group without any adjustment, the Type I error of this statistical inference will not be...

One new triterpenoids from Momordica charantia L

Yue Jiang, Bing Liang, Qiong Wu, Jing-Ru Wang & Bing Liu
Momordica charantia L. (M. charantia) is an annual climbing herb in Cucurbitaceae. It is not only a food, but also a drug with a long history of application. This study aims to isolate and identify the chemical constituents form M. charantia and evaluate their inhibiting effect on Hcy-induced proliferation of VSMCs. Silica column chromatography, ODS silica column chromatography, Sephadex LH-20 column chromatography and semi-preparative HPLC were used to obtain one new compound (1). The inhibition...

Effects of encapsulated thymol and carvacrol mixture on growth performance, antioxidant capacity, immune function and intestinal health of broilers

Zhen Li, Xu Jin, Qiong Wu, Lingbo Long, Yang Li, Qingyue Zhang, Aidong Liu, Xingyong Chen, Zhaoyu Geng & Cheng Zhang
This study evaluated the effect of encapsulated thymol and carvacrol mixture (ETCM) on the growth performance, antioxidant capacity, immune function and intestinal health of broilers. In total, 400 one-day-old male Arbour Acres broilers were randomly allocated to two groups with eight replicates of 25 birds each and fed a basal diet (control) or a basal diet supplemented with 150 mg/kg ETCM. The trial lasted 42 days. ETCM supplementation significantly increased (p < .05) average daily...

Effects of encapsulated thymol and carvacrol mixture on growth performance, antioxidant capacity, immune function and intestinal health of broilers

Zhen Li, Xu Jin, Qiong Wu, Lingbo Long, Yang Li, Qingyue Zhang, Aidong Liu, Xingyong Chen, Zhaoyu Geng & Cheng Zhang
This study evaluated the effect of encapsulated thymol and carvacrol mixture (ETCM) on the growth performance, antioxidant capacity, immune function and intestinal health of broilers. In total, 400 one-day-old male Arbour Acres broilers were randomly allocated to two groups with eight replicates of 25 birds each and fed a basal diet (control) or a basal diet supplemented with 150 mg/kg ETCM. The trial lasted 42 days. ETCM supplementation significantly increased (p < .05) average daily...

Two new cycloartane triterpenoid glycosides from the rhizomes of Actaea vaginata

Shunqin Zeng, Xiangyuan Li, Zixuan Zhao, Yan Lin, Yindi Zhu, Guoxu Ma, Xiaohong Zhao, Xudong Xu, Meichun Wu, Haifeng Wu, Qiongyu Zou & Yongtao Li
Two new cycloartane triterpenoid glycosides, soulieoside V (1) and 15-deacetylbeesioside O (2), together with one known compound, beesioside J (3), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. All the compounds were tested for their cytotoxic activities against human cancer cell lines.

Adsorption Behavior of Vanadium Using Supported 1-Butyl-3-Methylimidazolium Chloride Ionic Liquid

Yu Liang, Shenxu Bao, Yimin Zhang, Bo Chen & Chen Yu
Imidazole-based ionic liquid 1-Butyl-3-methylimidazolium chloride was immobilized on polymer support by chemical grafting and utilized to separate vanadium (V) from a vanadium-containing solution. Characterizations with elementary analysis, Fourier transform infrared (FTIR), 13C nuclear magnetic resonance (NMR), scanning electron microscopy (SEM) and energy dispersive spectrometer (EDS) proved the successful loading of the ionic liquid on the surface of the support. The adsorption capacity toward V(V) reached 222.42 mg/g under experimental conditions, which was significantly higher than...

sj-docx-1-eso-10.1177_23969873221126000 – Supplemental material for Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke

Yueyang Wu, Xiaomeng Yang, Jing Jing, Xia Meng, Zixiao Li, Yuesong Pan, Yong Jiang, Hongyi Yan, Xinying Huang, Liping Liu, Xingquan Zhao, Yilong Wang, Hao Li & Yongjun Wang
Supplemental material, sj-docx-1-eso-10.1177_23969873221126000 for Prognostic significance of atrial cardiopathy in patients with acute ischemic stroke by Yueyang Wu, Xiaomeng Yang, Jing Jing, Xia Meng, Zixiao Li, Yuesong Pan, Yong Jiang, Hongyi Yan, Xinying Huang, Liping Liu, Xingquan Zhao, Yilong Wang, Hao Li and Yongjun Wang in European Stroke Journal

Additional file 1 of Effective hospital readmission prediction models using machine-learned features

Sacha Davis, Jin Zhang, Ilbin Lee, Mostafa Rezaei, Russell Greiner, Finlay A. McAlister & Raj Padwal
Supplementary Material 1

Low serum 25-hydroxyvitamin D levels are associated with increased cardiovascular morbidity and mortality

Wei Luo, Dan Xu, Jin Zhang, Yao Zhou, Qin Yang, Qiuju Lv & Zhen Qu
There is controversy about the association between vitamin D and cardiovascular disease (CVD). This article aims to explore the association of serum 25-hydroxyvitaminD (25 OHD) with the risk of CVD. PubMed, EMBASE, Web of Science database, OVID, and Cochrane Library databases (last updated in August 2022) were systematically searched. The relationship between 25OHD and the risk of CVD was assessed by using the 95% confidence intervals (CI) and hazard ratio (HR). The effect model was...

Double-layer electrowetting-aided spinning for fabrication of metal-core piezoelectric-piezoresistive composite fiber

Yang Wang, Xiangdong Kong & Ping Yu
Metal core piezoelectric fiber (MPF) with excellent dynamic force response performance is a promising coaxial fiber, but its application in numerous occasions requiring simultaneous detecting of static and dynamic forces is limited due to its inability to detect static forces. To overcome this problem, this paper proposes a novel double-layer electrowetting-aided spinning to produce a metal-core piezoelectric piezoresistive composite fiber (MPPCF). The MPPCF is composed of seven layers from inside to outside including a metal...

Exogenous H2S reverses high glucose-induced endothelial progenitor cells dysfunction via regulating autophagy

Wenxue Ma, Tingting Zhong, Junqiu Chen, Xiao Ke, Huihua Zuo & Qiang Liu
This study aims to determine the effect of exogenous hydrogen sulfide (H2S) under high glucose (HG)-induced injury in endothelial progenitor cells (EPCs), and to explore the possible underlying mechanisms. Mononuclear cells were isolated from the peripheral blood of healthy volunteers by density-gradient centrifugation and identified as late EPCs by immunofluorescence and flow cytometry. EPCs were treated with high concentrations of glucose, H2S, Baf-A1, 3-MA or rapamycin. Cell proliferation, cell migration and tube formation were measured...

Additional file 1 of Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi & Jin Hou
Additional file 1: Figure S1. Screening β-farnesene synthase from different plants. A The evolutionary tree of β-farnesene synthase from different plants. B β-Farnesene production and biomass of strains containing different β-farnesene synthase. Data represent the mean ± SD of biological triplicate. Figure S2. The SDS-PAGE electrophoresis analysis of purified protein AanFSK197T/F180H and AanFS. Figure S3. The copy number and relative expression of AanFSK197T/F180H in Q6 and Q7 strains. Data represent the mean ± SD of...

Additional file 1 of Engineering Yarrowia lipolytica for the sustainable production of β-farnesene from waste oil feedstock

Yinghang Liu, Jin Zhang, Qingbin Li, Zhaoxuan Wang, Zhiyong Cui, Tianyuan Su, Xuemei Lu, Qingsheng Qi & Jin Hou
Additional file 1: Figure S1. Screening β-farnesene synthase from different plants. A The evolutionary tree of β-farnesene synthase from different plants. B β-Farnesene production and biomass of strains containing different β-farnesene synthase. Data represent the mean ± SD of biological triplicate. Figure S2. The SDS-PAGE electrophoresis analysis of purified protein AanFSK197T/F180H and AanFS. Figure S3. The copy number and relative expression of AanFSK197T/F180H in Q6 and Q7 strains. Data represent the mean ± SD of...

Additional file 1 of A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots

Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu & Yongzhi Yang
Additional file 1: Fig. S1. The previously reported topologies within eudicots. Fig. S2. 19-Kmer-based analysis to estimate the genome size of Buxus austro-yunnanensis. Fig. S3. Interaction frequency distribution of Hi-C links among chromosomes. Fig. S4. GC contents of five early-diverging eudicot species. Fig. S5. BUSCO results for six eudicots. Fig. S6. LTR insertion time of Buxus austro-yunnanensis. Fig. S7. Gene structures of Aquilegia, Buxus, Nelumbo, Trochodendron and Tetracentron. Fig. S8. The phylogenetic trees of the...

Additional file 1 of A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots

Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu & Yongzhi Yang
Additional file 1: Fig. S1. The previously reported topologies within eudicots. Fig. S2. 19-Kmer-based analysis to estimate the genome size of Buxus austro-yunnanensis. Fig. S3. Interaction frequency distribution of Hi-C links among chromosomes. Fig. S4. GC contents of five early-diverging eudicot species. Fig. S5. BUSCO results for six eudicots. Fig. S6. LTR insertion time of Buxus austro-yunnanensis. Fig. S7. Gene structures of Aquilegia, Buxus, Nelumbo, Trochodendron and Tetracentron. Fig. S8. The phylogenetic trees of the...

Additional file 1 of Effective hospital readmission prediction models using machine-learned features

Sacha Davis, Jin Zhang, Ilbin Lee, Mostafa Rezaei, Russell Greiner, Finlay A. McAlister & Raj Padwal
Supplementary Material 1

Registration Year

  • 2023
    2
  • 2022
    32
  • 2020
    2

Resource Types

  • Text
    36

Affiliations

  • Guangxi Normal University
    36
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    30
  • Sheng Jing Hospital
    22
  • Shandong University
    22
  • Zhejiang Chinese Medical University
    20
  • Lanzhou University
    18
  • Shanghai Jiao Tong University
    18
  • Yangzhou University
    18
  • Fudan University
    15
  • Huazhong University of Science and Technology
    13