526 Works

Associations between moral injury, PTSD clusters, and depression among Israeli veterans: a network approach

Yossi Levi-Belz, Talya Greene & Gadi Zerach
Background: Moral Injury (MI) is one of the adverse consequences of combat. Following exposure to potentially morally injurious events (PMIEs)––events perceived as violations of deep moral beliefs by oneself or trusted individuals––a significant minority of veterans could develop posttraumatic stress disorder (PTSD) and depression. Objective: The current study represents the first attempt to apply a network analysis model to examine an exploratory empirical conceptualization of a network of PMIEs during military service, post-traumatic stress disorder...

Unresolved–disorganized attachment adjusted for a general psychopathology factor associated with atypical amygdala resting-state functional connectivity

Marie-José van Hoof, Madelon M. E. Riem, Amy S. Garrett, Nic J. A. van der Wee, Marinus H. van IJzendoorn & Robert R. J. M Vermeiren
Background: Recent research has identified a general psychopathology factor (GPF), which explains overlap in presentation of psychopathological symptoms. Unresolved–disorganized attachment (Ud) is another transdiagnostic risk factor that may be relevant to explain differences in patient characteristics within diagnostic classifications. Objective: In the current study, we examined unique relations of resting-state functional connectivity (RSFC) with Ud and GPF. Method: RSFC data were collected from a mixed group of adolescents (N = 74) with and without psychiatric...

Fire Safety Engineering: Education Report 2 of 8

Jose Torero, David Lange, Mahmut Horasan, Andres Osorio, Cristian Maluk, Juan Hidalgo & Peter Johnson
The Education Report discusses the current status of education and training of fire safety engineers; as well as the competencies which are expected of a fire safety engineering professional

Rail Network Crime and Passenger Travel in the Pandemic

Anthony Dixon, Lara Adamson & Nick Tilley

Fire Safety Engineering: The Methods Report 3 of 8

David Lange, Jose Torero, Andres Osorio, Nate Lobel, Cristian Maluk & Juan P Hidalgo
The Methods Report takes a closer look at international guidelines and methods currently used for Fire Safety Engineering and considers where fundamental change is needed for Australia

Exploring the Impact of Brexit on UK’S Engineering Education Sector from the Perspective of European Students and Staff

Inez Direito, William Williams & Shannon Chance

Understandings of \"Global Responsibility’ Expressed By Civil Engineers Working in London

Shannon Chance, Inez Direito & J. Mitchell

An Introduction to Systematic Literature Reviews In Engineering Education

Inês Direito, Shannon Chance & Manish Malikc

Third Lockdown Crime Effects in England and Wales

Anthony Dixon, Graham Farrell & Shane Johnson
The third national lockdown began early January 2021 and started to ease on 8th March when schools and limited outdoor social contact resumed. Police-recorded crime rates per 10,000 population (in orange) are here compared to expected rates (black lines, with confidence intervals in grey). Crime effects in January and February 2021 were similar to first lockdown (Apr-Jun 2020) but with notable differences. Acquisitive crime except bike theft fell sharply but began to increase in March....

Predictors and rates of PTSD, depression and anxiety in UK frontline health and social care workers during COVID-19

Talya Greene, Jasmine Harju-Seppänen, Mariam Adeniji, Charlotte Steel, Nick Grey, Chris R. Brewin, Michael A. Bloomfield & Jo Billings
Background: Studies have shown that working in frontline healthcare roles during epidemics and pandemics was associated with PTSD, depression, anxiety, and other mental health disorders. Objectives: The objectives of this study were to identify demographic, work-related and other predictors for clinically significant PTSD, depression, and anxiety during the COVID-19 pandemic in UK frontline health and social care workers (HSCWs), and to compare rates of distress across different groups of HCSWs working in different roles and...

Predictors and rates of PTSD, depression and anxiety in UK frontline health and social care workers during COVID-19

Talya Greene, Jasmine Harju-Seppänen, Mariam Adeniji, Charlotte Steel, Nick Grey, Chris R. Brewin, Michael A. Bloomfield & Jo Billings
Background: Studies have shown that working in frontline healthcare roles during epidemics and pandemics was associated with PTSD, depression, anxiety, and other mental health disorders. Objectives: The objectives of this study were to identify demographic, work-related and other predictors for clinically significant PTSD, depression, and anxiety during the COVID-19 pandemic in UK frontline health and social care workers (HSCWs), and to compare rates of distress across different groups of HCSWs working in different roles and...

Energy Modelling in the UK: Strengths and weaknesses of UK energy models

Pei-Hao Li & Neil Strachan
This paper is the second of four to explore results from UKERC’s Modelling Hub survey. It focuses on four key areas, looking at how models deal with time, space, technologies and behaviour.

Black Lives, British Justice: Black People in London Criminal Justice Records, 1720-1841

Adam Crymble & Emma Azid

BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis

Xiaolei Zhou, Yanli Yuan, Hongping Kuang, Bingxiang Tang, Hui Zhang & Manlin Zhang
Lung adenocarcinoma (LUAD) is one of the most common causes of cancer death in men. BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) has been reported to contribute to the initiation and development of several cancers. Here, we aimed to explore the potential role of BUB1B in LUAD. We found BUB1B was upregulated in LUAD, suggesting its potential role as a biomarker for LUAD diagnosis. Significantly, LUAD patients with high BUB1B expression had a shorter survival...

Pathogenicity factors of Phytophthora melonis revealed by comparative proteomics

Aqeel Ahmad, Waheed Akram, Rui Wang, Iqra Shahzadi, Muhammad Umer, Nasim Ahmad Yasin & Tingquan Wu
Deciphering the transcriptional activities of pathogenicity genes is critical to understand pathogenesis mechanisms of Phytophthora melonis, a devastating pathogen of cucurbits. In this study, we have performed comparative proteomics among P. melonis mutants to evaluate the interacting pathogenicity proteins. Structural characterization of all detected proteins discovered the physicochemical factors behind their pathogenic behavior. Results revealed that gamma radiations have an extreme potential to mutate P. melonis spores, and can be a safe alternative of chemical...

Energy Modelling in the UK: Decision making in government and industrys

Pei-Hao Li & Neil Strachan
This paper is the last of four to explore results from UKERC's Modelling Hub survey. It focuses on how models have underpinned decision making on the transition of the energy system.

Adaptación telemática de las actividades grupales de un hospital de día infanto-juvenil: Experiencias de participantes adolescentes

Stefanella Costa Cordella, Karin Borgeaud Carmona, Nicole Díaz Contreras, Ángela González Cano, Claudia Mazo Bontá & Aitana Grasso-Cladera
Los hospitales de día ofrecen atención especializada a usuarios/as con patologías psiquiátricas graves. Las actividades grupales habituales del hospital de día han demostrado efectividad en población infanto-juvenil. Existen importantes limitaciones de acceso a estos servicios y una forma de ampliar la cobertura es a través de la atención telemática. Sin embargo, no existen estudios sobre atención telemática de hospital de día en Chile. El presente estudio es parte de la fase preparatoria de un futuro...

Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer

Jing Zhao, Huidan Lu, Danxia Xu, Ruiqi Sun, Chengyu Fang, Qiyu Zhao, Chang He, Yuwei Pan, Feng Xu & Tianan Jiang
Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Poor prognosis and low survival rates have driven the development of novel therapeutic strategies. Nanosecond pulsed electric field has emerged as a novel, minimal invasive and non-thermal treatment for solid tumors. It is of great significance to study the combination therapy of nsPEF and other treatment strategies for pancreatic cancer. We developed neutrophil membrane-wrapped liposomal nanoparticles loaded with gemcitabine (NE/Lip-GEM) and investigated their...

Mediating role for metacognitive processes in the relationship between schizotypy and anxiety and depression symptoms

Lucy Webster, Christine Norman, Gary Jones & Mike Marriott
Introduction: Depression and anxiety symptoms are highly prevalent in schizophrenia-spectrum disorders and are commonly associated with schizotypy in non-clinical samples. However, it remains unclear what factors could be contributing to the relationships between schizotypy and anxiety and depression symptoms. Using path analysis, we explored the complex interplay between schizotypy, metacognitive beliefs, cognitive insight, and symptoms of emotional distress. Methods: Self-report data of schizotypy, metacognitive beliefs, cognitive insight, depression, and anxiety symptoms were collected from 344...

Additional file 1 of Short-term effects of tropical cyclones on the incidence of dengue: a time-series study in Guangzhou, China

Chuanxi Li, Zhe Zhao, Yu Yan, Qiyong Liu, Qi Zhao & Wei Ma
Additional file 1: Table S1. The detail information of tropical cyclones during the study period. Table S2. The lag and cumulative effects of tropical storm and typhoon on dengue incidence among subgroups. Figure. S1. The lag effects of tropical cyclones on dengue incidence when changing the meteorological factors in the model. Figure. S2. The lag effects of tropical cyclones on dengue incidence when changing the df (2–5) for WAT, WCP, WARH, and time. Figure. S3....

Additional file 4 of Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study

Neyme Veli, Christopher A. Martin, Katherine Woolf, Joshua Nazareth, Daniel Pan, Amani Al-Oraibi, Rebecca F. Baggaley, Luke Bryant, Laura B. Nellums, Laura J. Gray, Kamlesh Khunti & Manish Pareek
Additional file 4: Table S3. Comparison of key demographic and occupational parameters of second questionnaire responders and non-responders.

Additional file 1 of Investigating health service availability and readiness for antenatal testing and treatment for HIV and syphilis in Papua New Guinea

Olga PM Saweri, Neha Batura, Justin Pulford, M. Mahmud Khan, Xiaohui Hou, William S Pomat, Andrew J Vallely & Virginia Wiseman
Additional file 1. STROBE Statement—Checklist of items that should be included in reports of cross-sectional studies Title of the study: Investigating health service availability and readiness for antenatal testing and treatment for HIV and syphilis in Papua New Guinea.

The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates.

Claudia Buhigas, Anne Y Warren, Wing-Kit Leung, Hayley C Whitaker, Hayley J Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J Woodcock, Sue Merson, Fiona M Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Iñigo Martincorena, G Steven Bova, Christopher S Foster, Peter Campbell, Norman J Maitland, David E Neal, Charlie E Massie, Andy G Lynch, Rosalind A Eeles, Colin S Cooper … & Daniel S Brewer
BACKGROUND: Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied Whole Genome DNA Sequencing (WGS) to a group of morphologically normal tissue (n = 51), including benign prostatic hyperplasia (BPH) and non-BPH samples, from men with and men without prostate cancer. We assess whether the observed genetic...

Additional file 1 of GATA-type transcriptional factor SpGAT1 interacts with SpMIG1 and promotes lipid accumulation in the oleaginous yeast $$Saitozyma \ podzolica$$ S a i t o z y m a p o d z o l i c a zwy-2-3

Yulu Ran, Hui Xu, Qingzhuoma Yang, Yi Xu, Huahao Yang, Dairong Qiao & Yi Cao
Additional file 1: Table S1. Strains and plasmids. Table S2. Primers for gene amplification and qRT-PCR. Table S3. cDNA sequence of SpGAT1 and SpMIG1.

Additional file 1 of Implementing service transformation for children and adolescents with eating disorders across England: the theory, politics, and pragmatics of large-scale service reform

Ivan Eisler, Mima Simic, Peter Fonagy & Rachel Bryant-Waugh
Additional file 1: Table S1. Outline programme of National Whole Team training.

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