399 Works

BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) promotes lung adenocarcinoma by interacting with Zinc Finger Protein ZNF143 and regulating glycolysis

Xiaolei Zhou, Yanli Yuan, Hongping Kuang, Bingxiang Tang, Hui Zhang & Manlin Zhang
Lung adenocarcinoma (LUAD) is one of the most common causes of cancer death in men. BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) has been reported to contribute to the initiation and development of several cancers. Here, we aimed to explore the potential role of BUB1B in LUAD. We found BUB1B was upregulated in LUAD, suggesting its potential role as a biomarker for LUAD diagnosis. Significantly, LUAD patients with high BUB1B expression had a shorter survival...

Adaptación telemática de las actividades grupales de un hospital de día infanto-juvenil: Experiencias de participantes adolescentes

Stefanella Costa Cordella, Karin Borgeaud Carmona, Nicole Díaz Contreras, Ángela González Cano, Claudia Mazo Bontá & Aitana Grasso-Cladera
Los hospitales de día ofrecen atención especializada a usuarios/as con patologías psiquiátricas graves. Las actividades grupales habituales del hospital de día han demostrado efectividad en población infanto-juvenil. Existen importantes limitaciones de acceso a estos servicios y una forma de ampliar la cobertura es a través de la atención telemática. Sin embargo, no existen estudios sobre atención telemática de hospital de día en Chile. El presente estudio es parte de la fase preparatoria de un futuro...

Pathogenicity factors of Phytophthora melonis revealed by comparative proteomics

Aqeel Ahmad, Waheed Akram, Rui Wang, Iqra Shahzadi, Muhammad Umer, Nasim Ahmad Yasin & Tingquan Wu
Deciphering the transcriptional activities of pathogenicity genes is critical to understand pathogenesis mechanisms of Phytophthora melonis, a devastating pathogen of cucurbits. In this study, we have performed comparative proteomics among P. melonis mutants to evaluate the interacting pathogenicity proteins. Structural characterization of all detected proteins discovered the physicochemical factors behind their pathogenic behavior. Results revealed that gamma radiations have an extreme potential to mutate P. melonis spores, and can be a safe alternative of chemical...

Additional file 1 of Implementing service transformation for children and adolescents with eating disorders across England: the theory, politics, and pragmatics of large-scale service reform

Ivan Eisler, Mima Simic, Peter Fonagy & Rachel Bryant-Waugh
Additional file 1: Table S1. Outline programme of National Whole Team training.

Additional file 1 of Short-term effects of tropical cyclones on the incidence of dengue: a time-series study in Guangzhou, China

Chuanxi Li, Zhe Zhao, Yu Yan, Qiyong Liu, Qi Zhao & Wei Ma
Additional file 1: Table S1. The detail information of tropical cyclones during the study period. Table S2. The lag and cumulative effects of tropical storm and typhoon on dengue incidence among subgroups. Figure. S1. The lag effects of tropical cyclones on dengue incidence when changing the meteorological factors in the model. Figure. S2. The lag effects of tropical cyclones on dengue incidence when changing the df (2–5) for WAT, WCP, WARH, and time. Figure. S3....

Additional file 2 of GATA-type transcriptional factor SpGAT1 interacts with SpMIG1 and promotes lipid accumulation in the oleaginous yeast $$Saitozyma \ podzolica$$ S a i t o z y m a p o d z o l i c a zwy-2-3

Yulu Ran, Hui Xu, Qingzhuoma Yang, Yi Xu, Huahao Yang, Dairong Qiao & Yi Cao
Additional file 2: Fig. S1. Single cell lipid yield and fatty acid profile of S.podzolica zwy-2-3 cultivated in rapamycin treatment and different C/N ratio mediums. a Single cell lipid yield stained by Nile red. b Fatty acid profiles analyzed by GC-MS. Fig. S2. Results of SpGAT1 mutant identification. a Results of amplifying hygromycin gene, homologous arm, and part of SpGAT1 gene (lane 1: marker 5000 bp, lane 2: amplifying hygromycin gene and LB homologous arm...

The Curious Role of COVID-19 in Sentencing: The Relevance and Mitigating Weight of Ill Health and Harsh Prison Conditions

Brendon Murphy, John Anderson & Mirko Bagaric
Australian courts have held that the COVID-19 pandemic should impact on the nature and severity of criminal sanctions. Broadly, it has been argued that prisoners are more likely to be infected with COVID-19, to experience adverse outcomes because of existing compromised health conditions, and to experience more onerous incarceration due to lengthy periods in lockdown. The courts, on balance, have been sympathetic to these and other arguments, and accordingly have been willing to extend a...

Additional file 1 of GATA-type transcriptional factor SpGAT1 interacts with SpMIG1 and promotes lipid accumulation in the oleaginous yeast $$Saitozyma \ podzolica$$ S a i t o z y m a p o d z o l i c a zwy-2-3

Yulu Ran, Hui Xu, Qingzhuoma Yang, Yi Xu, Huahao Yang, Dairong Qiao & Yi Cao
Additional file 1: Table S1. Strains and plasmids. Table S2. Primers for gene amplification and qRT-PCR. Table S3. cDNA sequence of SpGAT1 and SpMIG1.

Additional file 1 of Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer

Xueli Tian, Rui Wang, Tingxuan Gu, Fayang Ma, Kyle Vaughn Laster, Xiang Li, Kangdong Liu, Mee-Hyun Lee & Zigang Dong
Supplementary Material 1

sj-docx-1-tag-10.1177_17562848221127474 – Supplemental material for Associations between inflammatory bowel disease, social isolation, and mortality: evidence from a longitudinal cohort study

Jie Chen, Jiawei Geng, Jiayi Wang, Zhenhua Wu, Tian Fu, Yuhao Sun, Xuejie Chen, Xiaoyan Wang & Therese Hesketh
Supplemental material, sj-docx-1-tag-10.1177_17562848221127474 for Associations between inflammatory bowel disease, social isolation, and mortality: evidence from a longitudinal cohort study by Jie Chen, Jiawei Geng, Jiayi Wang, Zhenhua Wu, Tian Fu, Yuhao Sun, Xuejie Chen, Xiaoyan Wang and Therese Hesketh in Therapeutic Advances in Gastroenterology

Efficient cell navigation methods and applications of an aperture 4 hexagonal discrete global grid system

Jianbin Zhou, Jin Ben, Xinhai Huang, Rui Wang, Xiaoyu Liang, Junjie Ding & Qishuang Liang
Hexagonal discrete global grid systems are multi-resolution frameworks for earth data and have attracted much attention in research towards the next generation of geographic information system. Each resolution of the framework divides the earth into a hexagonal grid of cells and cell codes are used instead of Cartesian coordinates to organize and query data. Aperture (the ratio of cells between resolutions) 4 systems have structural advantages compared with aperture 3 and 7, but haven’t been...

Mediating role for metacognitive processes in the relationship between schizotypy and anxiety and depression symptoms

Lucy Webster, Christine Norman, Gary Jones & Mike Marriott
Introduction: Depression and anxiety symptoms are highly prevalent in schizophrenia-spectrum disorders and are commonly associated with schizotypy in non-clinical samples. However, it remains unclear what factors could be contributing to the relationships between schizotypy and anxiety and depression symptoms. Using path analysis, we explored the complex interplay between schizotypy, metacognitive beliefs, cognitive insight, and symptoms of emotional distress. Methods: Self-report data of schizotypy, metacognitive beliefs, cognitive insight, depression, and anxiety symptoms were collected from 344...

Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer

Jing Zhao, Huidan Lu, Danxia Xu, Ruiqi Sun, Chengyu Fang, Qiyu Zhao, Chang He, Yuwei Pan, Feng Xu & Tianan Jiang
Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Poor prognosis and low survival rates have driven the development of novel therapeutic strategies. Nanosecond pulsed electric field has emerged as a novel, minimal invasive and non-thermal treatment for solid tumors. It is of great significance to study the combination therapy of nsPEF and other treatment strategies for pancreatic cancer. We developed neutrophil membrane-wrapped liposomal nanoparticles loaded with gemcitabine (NE/Lip-GEM) and investigated their...

Changes over time in the Chronic Liver Disease risk score predict liver-related outcomes: longitudinal analysis of the Whitehall II study

Fredrik Åberg, Annie Britton & Panu K. Luukkonen
The Chronic Liver Disease (CLivD) risk score was recently shown to predict future advanced liver disease in the general population. We here investigated the impact of individual CLivD-score changes over time. Participants of both phase 3 (baseline, 1991–1994) and phase 5 (follow-up, 1997–1999) examinations of the Whitehall II study were followed for liver-related outcomes (hospitalization, cancer, death) until December 2019 through linkage with electronic healthcare registers. The CLivD score, its modifiable components (alcohol use, waist–hip...

Additional file 4 of Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study

Neyme Veli, Christopher A. Martin, Katherine Woolf, Joshua Nazareth, Daniel Pan, Amani Al-Oraibi, Rebecca F. Baggaley, Luke Bryant, Laura B. Nellums, Laura J. Gray, Kamlesh Khunti & Manish Pareek
Additional file 4: Table S3. Comparison of key demographic and occupational parameters of second questionnaire responders and non-responders.

The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates.

Claudia Buhigas, Anne Y Warren, Wing-Kit Leung, Hayley C Whitaker, Hayley J Luxton, Steve Hawkins, Jonathan Kay, Adam Butler, Yaobo Xu, Dan J Woodcock, Sue Merson, Fiona M Frame, Atef Sahli, Federico Abascal, CRUK-ICGC Prostate Cancer Group, Iñigo Martincorena, G Steven Bova, Christopher S Foster, Peter Campbell, Norman J Maitland, David E Neal, Charlie E Massie, Andy G Lynch, Rosalind A Eeles, Colin S Cooper … & Daniel S Brewer
BACKGROUND: Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field effect present in the normal prostate predisposing to cancer development. In the present study we applied Whole Genome DNA Sequencing (WGS) to a group of morphologically normal tissue (n = 51), including benign prostatic hyperplasia (BPH) and non-BPH samples, from men with and men without prostate cancer. We assess whether the observed genetic...

sj-pdf-15-msj-10.1177_13524585221134213 – Supplemental material for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg & Florian Deisenhammer
Supplemental material, sj-pdf-15-msj-10.1177_13524585221134213 for Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis by Harald Hegen, Janette Walde, Klaus Berek, Georgina Arrambide, Sharmilee Gnanapavan, Batia Kaplan, Michael Khalil, Ruba Saadeh, Charlotte Teunissen, Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer in Multiple Sclerosis Journal

sj-pdf-1-jcb-10.1177_0271678X221141139 - Supplemental material for Gray matter hypoperfusion is a late pathological event in the course of Alzheimer’s disease

Khazar Ahmadi, Joana B Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk JMM Mutsaerts & Oskar Hansson
Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221141139 for Gray matter hypoperfusion is a late pathological event in the course of Alzheimer’s disease by Khazar Ahmadi, Joana B Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk JMM Mutsaerts and Oskar Hansson in Journal of Cerebral Blood Flow & Metabolism

sj-pdf-2-jcb-10.1177_0271678X221141139 - Supplemental material for Gray matter hypoperfusion is a late pathological event in the course of Alzheimer’s disease

Khazar Ahmadi, Joana B Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk JMM Mutsaerts & Oskar Hansson
Supplemental material, sj-pdf-2-jcb-10.1177_0271678X221141139 for Gray matter hypoperfusion is a late pathological event in the course of Alzheimer’s disease by Khazar Ahmadi, Joana B Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk JMM Mutsaerts and Oskar Hansson in Journal of Cerebral Blood Flow & Metabolism

Additional file 2 of Changes in prevalence and the cascade of care for type 2 diabetes over ten years (2005-2015): results of two nationally representative surveys in Mozambique

Tavares Madede, Albertino Damasceno, Nuno Lunet, Orvalho Augusto, Carla Silva-Matos, David Beran & Naomi Levitt
Additional file 2.

sj-docx-1-whe-10.1177_17455057221133635 – Supplemental material for Mental health and neurodevelopment in children and adolescents with Turner syndrome

Jeanne Wolstencroft, William Mandy & David Skuse
Supplemental material, sj-docx-1-whe-10.1177_17455057221133635 for Mental health and neurodevelopment in children and adolescents with Turner syndrome by Jeanne Wolstencroft, William Mandy and David Skuse in Women’s Health

sj-docx-1-asm-10.1177_10731911221137540 – Supplemental material for Self-Compassion in Chinese Young Adults: Its Measurement and Measurement Construct

Mengya Zhao, Tamsin Ford, Janet Smithson, Peng Wang & Anke Karl
Supplemental material, sj-docx-1-asm-10.1177_10731911221137540 for Self-Compassion in Chinese Young Adults: Its Measurement and Measurement Construct by Mengya Zhao, Tamsin Ford, Janet Smithson, Peng Wang and Anke Karl in Assessment

sj-pdf-1-jrs-10.1177_01410768221090672 - Supplemental material for Socioeconomic inequality, waiting time initiatives and austerity in Scotland: an interrupted time series analysis of elective hip and knee replacements and arthroscopies

Graham Kirkwood & Allyson M Pollock
Supplemental material, sj-pdf-1-jrs-10.1177_01410768221090672 for Socioeconomic inequality, waiting time initiatives and austerity in Scotland: an interrupted time series analysis of elective hip and knee replacements and arthroscopies by Graham Kirkwood and Allyson M Pollock in Journal of the Royal Society of Medicine

Adaptación telemática de las actividades grupales de un hospital de día infanto-juvenil: Experiencias de participantes adolescentes

Stefanella Costa Cordella, Karin Borgeaud Carmona, Nicole Díaz Contreras, Ángela González Cano, Claudia Mazo Bontá & Aitana Grasso-Cladera
Los hospitales de día ofrecen atención especializada a usuarios/as con patologías psiquiátricas graves. Las actividades grupales habituales del hospital de día han demostrado efectividad en población infanto-juvenil. Existen importantes limitaciones de acceso a estos servicios y una forma de ampliar la cobertura es a través de la atención telemática. Sin embargo, no existen estudios sobre atención telemática de hospital de día en Chile. El presente estudio es parte de la fase preparatoria de un futuro...

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