226 Works

EXAMINING ATTITUDES, PERCEPTIONS, AND OBSERVATIONS OF TOBACCO USE AND COMPLIANCE AT A SMALL PRIVATE LIBERAL ARTS COLLEGE IN KENTUCKY WITH A DESIGNATED AREA TOBACCO POLICY

Michael Dalessio
A multitude of higher education institutions have adopted comprehensive smoke- and tobacco-free policies to minimize tobacco use, increase quit attempts, and reduce exposure to secondhand smoke on campus. However, the majority of campuses across the U.S. still have non-comprehensive policies and/or designated tobacco use areas. Given the limited research in this area, the purpose of this dissertation was to assess the attitudes, perceptions, tobacco use behaviors, and actual observational compliance of students, faculty, and staff...

Beyond Telling

Jane Samuel
Despite calls for increased Adoption Communication Openness (ACO) within the adoptive family, research indicates that families still struggle to accomplish the recommended elements and levels of openness. What could be holding families back from this key process? Three focus groups comprised of 17 adoptive parents of early adolescents (aged 10-14) who were age 0-2 at the time of placement were thematically coded. This inductive analysis revealed the complexity rooted in being —sometimes successfully and sometimes...

Investigating the Use of In-Place Lateral Pull Off Tests to Determine the Compressive Strength of Structural Concrete

Charlie Sun
The Kentucky Transportation Cabinet’s current practice for determining the compressive strength of structural concrete consists of two methods. Both methods require that samples be delivered to an off-site facility for testing. Accordingly, affected parties on the project site must wait for the delivery of samples to the off-site facility, the performance of tests and analysis of test data, and the return of test results to the project site. Analysis of existing structural concrete requires core...

Reducing Construction Costs Through Effective Field Communication and Administration

Gabriel B. Dadi, Roy E., Jr. Sturgill, Steven Waddle & Steven Douglas Kreis
Falling Road Fund receipts have placed added strain on the Kentucky Transportation Cabinet’s (KYTC) already-underfunded highway program. Revenue declines have increased the urgency of improving the efficiency and cost-effectiveness of the Cabinet’s operations. One method KYTC can use to realize greater cost savings is improving the administration of construction projects. Effective field communication and administration helps control construction costs, enhances quality, and minimizes delays and claims. One challenge the Cabinet will need to confront to...

HOLOCENE HYDROCLIMATIC AND VEGETATION RECONSTRUCTION IN THE SIERRA NEVADA USING POLLEN AND STABLE ISOTOPES FROM CONVICT LAKE

Morgan Black
The forested environments of the subalpine and upper montane zones of the eastern Sierra Nevada mountains (California) are biodiverse and valuable ecosystems that are sensitive to hydroclimate changes. The history of high-altitude vegetation changes in the eastern Sierra Nevada is underexplored, and this knowledge gap can be addressed using a paleolimnological approach. In this study, we use a long (~9.5 m) sediment core from Convict Lake, a glacial lake situated in the upper montane zone...

Nanoharvesting and Delivery of Bioactive Materials Using Engineered Silica Nanoparticles

M. Arif Khan
Mesoporous silica nanoparticles (MSNPs) possess large surface areas and ample pore space that can be readily modified with specific functional groups for targeted binding of bioactive materials to be transported through cellular barriers. Engineered silica nanoparticles (ESNP) have been used extensively to deliver bio-active materials to target intracellular sites, including as non-viral vectors for nucleic acid (DNA/RNA) delivery such as for siRNA induced interference. The reverse process guided by the same principles is called “nanoharvesting”,...

Deterioration Modelling of Bridges on BrM 5.2.3

Sudhir Palle & Theodore, II Hopwood
The Kentucky Transportation Cabinet (KYTC) initiated the study KYSPR 17-532, “Deterioration Modelling of Bridges on BrM 5.2.3,” so it could receive assistance identifying and employing bridge deterioration and cost forecast modeling for its bridge maintenance program. The Kentucky Transportation Center (KTC) was to help coordinate KYTC in adapting BrM 5.2.3’s deterioration and cost modelling features and update the existing guide material to reflect all changes for BrM 5.2.3. This study included acquiring access and becoming...

Developing Material Specification and Application Criteria for Sealing Concrete Bridge Decks

Danny Wells, Sudhir Palle & Theodore, II Hopwood
The Kentucky Transportation Cabinet (KYTC) has more aggressively pursued preventive maintenance in recent years. Sealing concrete bridge decks is one preventive maintenance activity the Cabinet has actively pursued. KYTC’s Divisions of Maintenance and Structural Design requested assistance from researchers at the Kentucky Transportation Center (KTC) in developing a material specification and application criteria for sealing concrete bridge decks at an appropriate time in their life cycle. To develop a material specification and application criteria for...

Critical Path for Project Development

Steven Douglas Kreis, Bryan Gibson, Jeff Jasper, Christopher W. Van Dyke, Candice Y. Wallace, Rachel Catchings & Sarah M. McCormack
Overseeing the delivery of highway projects at the Kentucky Transportation Cabinet (KYTC) requires the successful coordination of activities and inputs from multiple external agencies and members of the agency’s Project Development team, who have varied disciplinary backgrounds. Despite the complexity of project delivery, the Cabinet presently does not estimate hours and project milestone dates until after it has selected a design consultant. Moving forward KYTC should explore requiring consultants to develop a critical path method...

SUPERINTENDENTS AND THE MICROPOLITICS OF INNOVATION IN RURAL SCHOOL DISTRICTS

Catherine Nunn Lawless
Research shows that public school districts that follow traditional means of instruction and assessment are insufficiently preparing students for success in the today’s global world. As a result, students are entering into higher education institutions and the workforce without the necessary skills to succeed in these 21st century environments. Extant literature suggest that there is a broad consensus on this perspective in public and private sectors nationally and globally. Evidence shows that some school district...

Development of Mithramycin Analogues with Improved Efficacy and Reduced Toxicity for Treatment of ETS-Dependent Tumors in Ewing Sarcoma and Prostate Cancer

Joseph Michael Eckenrode
Introduction: Genetic rearrangements in Ewing sarcoma, prostate, and leukemia cells result in activation of oncogenic ETS transcription factor fusions. Mithramycin (MTM) has been identified as an inhibitor of EWS-FLI1 transcription factor, a gene fusion product responsible for oncogenesis in Ewing sarcoma. Despite preclinical success, a phase I/II clinical trial testing MTM therapy in refractory Ewing sarcoma was terminated. Liver and blood toxicities resulted in dose de-escalation and sub-therapeutic exposures. However, the promise of selectively targeting...

Design and Process of 3D-Printed Parts Using Composite Theory

Jordan Garcia
3D printing is a revolutionary manufacturing method that allows the productions of engineering parts almost directly from modeling software on a computer. With 3D printing technology, future manufacturing could become vastly efficient. However, it is observed that the procedures used in 3D printing differ substantially among the printers and from those used in conventional manufacturing. In this thesis, the mechanical properties of engineering products fabricated by 3D printing were comprehensively evaluated and then compared with...

Evaluation of Guardrail Needs and Update of Guardrail Rating Program

Brian K. Howell, William Nicholas Staats & Nancy Albright
The Kentucky Transportation Cabinet (KYTC) seeks to reduce the frequency of roadway departure crashes, which often prove fatal. Roadside barriers such as guardrail have proven effective at mitigating these crashes, however, the demand for installations is high throughout the state. KYTC must prioritize prospective guardrail locations to match available funds with the most critical, or unsafe, sites. The current guardrail rating program (GRP) was established in 1989 to identify and prioritize guardrail needs. Despite periodic...

Design Process for the Containment and Manipulation of Liquids in Microgravity

Chris Meek
In order to enhance accessibility to microgravity research, the design process for experiments on the ISS must be streamlined and accessible to all scientific disciplines, not just aerospace engineers. Thus, a general design and analysis toolbox with accompanying best practices manual for microgravity liquid containment is proposed. The work presented in this thesis improves the design process by introducing a modular liquid tank design which can be filled, drained, or act as a passive liquid-gas...

Toward and Enzyme-Coupled, Bioorthogonal Platform for Methyltransferases

Tyler D. Huber
Methyl group transfer from S-adenosyl-l-methionine (AdoMet) to various substrates including DNA, proteins, and natural products (NPs), is accomplished by methyltransferases (MTs). Analogs of AdoMet, bearing an alternative S-alkyl group can be exploited, in the context of an array of wild-type MT-catalyzed reactions, to differentially alkylate DNA, proteins, and NPs. This technology provides a means to elucidate MT targets by the MT-mediated installation of chemoselective handles from AdoMet analogs to biologically relevant molecules and affords researchers...

BIOINFORMATIC AND EXPERIMENTAL ANALYSES OF AXOLOTL REGENERATION

Nour Al Haj Baddar
Salamanders have an extraordinary ability to regenerate appendages after loss or amputation, irrespective of age. My dissertation research explored the possibility that regenerative ability is associated with the evolution of novel, salamander-specific genes. I utilized transcriptional and genomic databases for the axolotl to discover previously unidentified genes, to the exclusion of other vertebrate taxa. Among the genes identified were multiple mmps (Matrix metalloproteases) and a jnk1/mapk8 (c-jun-N-terminal kinase) paralog. MMPs function in extracellular matrix remodeling...

PRINCIPAL BEHAVIORS THAT FOSTER COLLECTIVE EFFICACY AMONG TEACHERS IN RURAL SECONDARY SCHOOLS IN KENTUCKY

Tanya Jo Jury
The purpose of this study was to examine principal behaviors, identified by teachers and principals, which foster collective efficacy among teachers. As instructional leaders of a school, principals are expected to lead their schools. Behaviors exhibited by the principal can either help or hinder the success of the school and teachers and students in that school. This study will assist principals, aspiring principals, and instructors of principal preparation programs in knowing what behaviors are necessary...

MICROALGAE AND ZINC SOURCE SUPPLEMENTATION OF BROILER BREEDER DIETS AFFECTS BROILER BREEDER SKELETAL DEVELOPMENT AND REPRODUCTION WITH TRANSGENERATIONAL IMPACTS ON OFFSPRING PERFORMANCE AND SKELETAL CHARACTERISTICS

Marquisha A. Paul
Leg problems and disorders are of major concern for the poultry industry and animal welfare. Previous studies suggest that it may be possible to improve skeletal characteristics through nutrition. Omega-3 fatty acids, including Docosahexaenoic acid (DHA), are essential nutrients and are known to play an important role in bone tissue development. FORPLUS™ (Alltech, Inc.) is an unextracted, whole-cell microalgae (Aurantiochytrium limacinum CCAP 4087/2) that contains 64% fat and 16% DHA. Zinc (Zn) is a trace...

Mobile Technology and Classroom Relationships

Joe Martin
This dissertation examines the relational implications of the presence of mobile technology within the basic communication course. To guide the research and interpret the results Mottet, Frymier, and Beebe’s (2006) rhetorical and relational goals theory is utilized. To investigate this phenomenon a survey design was employed, and participants were asked to respond to open-ended, closed-ended, and descriptive questions. Results of this study shed light upon how and when university students use technology, as well as...

DEVELOPMENTAL CHANGES IN THE PIG FROM BIRTH TO 42 DAYS POST-WEANING (1.5 – 25 KILOGRAMS BODYWEIGHT)

Sarah Elefson
This study evaluated the changes in body composition, glycogen tissue reserves, visceral organ growth, and small intestine morphology in the young pig. A total of 96 crossbred pigs were euthanized at birth (pre-suckle), days 1, 2, 3, 5, 7, 14 postpartum, weaning at day 21, and days 1, 2, 3, 5, 7, 14, 28, and 42 post-weaning. Body composition of the pig had increasing dry matter and fat, decreasing ash, calcium and phosphorus, and relatively...

EFFECTS OF CURCUMIN AND FENUGREEK SOLUBLE FIBER SUPPLEMENTS ON SUBMAXIMAL AND MAXIMAL AEROBIC PERFORMANCE INDICES IN UNTRAINED COLLEGE-AGED SUBJECTS

Jensen Goh
Submaximal exercise performance is, in part, limited by the accumulation of metabolic byproducts and energy system capacities. Curcumin and the combination of curcumin and fenugreek soluble fiber (CurQfen®) have been shown to increase endogenous antioxidants and metabolic byproduct clearance as well as reduce inflammation and lipid peroxidation, and therefore, may enhance submaximal aerobic thresholds. In addition, there is evidence that the galactomannan component of fenugreek, used to enhance bioavailability of curcumin, may also have potential...

THE INTERACTIVE EFFECT OF A TEXT MESSAGE INTERVENTION AND CONNECTIVITY AMONG RURAL ADOLESCENTS

Kara Coldiron
Social cohesion among peers profoundly influences decision making during adolescence. Despite this, the current research is very limited concerning the association of social cohesion and intimacy among rural adolescent peers with dietary intake and weight outcomes. This is problematic because social cohesion could be an unknown contributing factor in obesity among rural adolescents. The purpose of this study was to investigate how social cohesion and intimacy among rural adolescents in Kentucky and North Carolina affects...

2016 Maintenance Customer Survey

R. Clark Graves & David L. Allen
The Kentucky Transportation Center, with the assistance of the University of Kentucky’s Survey Research Center, administered a telephone survey to 1,221 licensed drivers throughout the state to gauge their opinion of the Kentucky Transportation Cabinet’s (KYTC) maintenance activities. Survey respondents were distributed throughout KYTC’s 12 highway districts. The survey focused on five areas of highway maintenance: roadside features, pavement surfaces, shoulders, drainage and signs/markings. Respondents indicated they were most satisfied with the current maintenance of...

The Role of CD8 T Cell Immunodominance and Regulatory T Cells in Neonatal Immunity to Influenza Virus

Luke Heil
Neonates are more susceptible to influenza virus infection than adults, resulting in increased morbidity and mortality as well as delayed clearance of the virus. Efforts to improve influenza infection outcomes in neonates typically center on prevention, although current vaccines fall short of complete protection and can only be administered in humans after 6 months of life. We propose that as the neonatal immune system responds differently than the adult immune system, interventions that are efficacious...

Uncertain Inheritance

Anna Bedsole
Thus, Uncertain Inheritance traces the heiress in Anglo-Irish Big House novels situated at key times of change for the Irish Ascendancy. The Gothic triad of orphaned heiress, dead mother, and sinister uncle does not belong exclusively to the realm of Irish Gothic authors, but rather this triad is used for different discursive purposes than in its English counterparts. Sheridan Le Fanu’s Uncle Silas (1864), Sommerville and Ross’s An Irish Cousin (1903), and Elizabeth Bowen’s The...

Registration Year

  • 2019
    226

Resource Types

  • Text
    226

Affiliations

  • University of Kentucky
    226
  • Iowa State University
    1