198 Works

\"To Claim That Greatness for Themselves”

Emily Libecap
The Kentucky Horse Park describes itself as the world’s only equine theme park. However, the park is not entirely without historical precedent; instead, world’s fairs, amusement parks, and theme parks all form a century-long pedigree chart through which the park can trace its ancestors. The Kentucky Horse Park’s links to these predecessors deepen our understanding of how the park is a reflection of the world around it and the motivations for how and why it...

Markov Decision Processes with Embedded Agents

Luke Harold Miles
We present Markov Decision Processes with Embedded Agents (MDPEAs), an extension of multi-agent POMDPs that allow for the modeling of environments that can change the actuators, sensors, and learning function of the agent, e.g., a household robot which could gain and lose hardware from its frame, or a sovereign software agent which could encounter viruses on computers that modify its code. We show several toy problems for which standard reinforcement-learning methods fail to converge, and...

Wilderness of Freedom

Hannah Gautsch
As a modiste well-versed in the social expectations of the domestic world, Elizabeth Keckley crafted an autobiography that would appeal to this wide variety of audiences. Throughout the 1850s, women across the nation negotiated the terms of True Womanhood and identified activism as a space where women could engage with national concerns. At the same time, literary production in the US was increasing exponentially, creating room for literature to be used as a means of...

Building Public Health in a Rural State

Abigail Stephens
During the period from 1883-1914, the Kentucky State Board of Health developed strategies for preventing disease in the state by enforcing hard power measures of vaccination, quarantine, and isolation of disease suspects, and through the soft power measures of written and spoken communication. Throughout this period their efforts to prevent and contain disease were limited by inadequate funding as well as opposition from the public, local authorities, and the state legislature, demonstrating that while hard...

Helping the Have-Nots

Myles Englis
Anterior cruciate ligament injuries are among the most common and traumatic sport-related injuries, and often negatively impact one’s quality of life during and post-rehabilitation. For many NCAA Division I and professional female athletes, rehabilitation is streamlined with a multidisciplinary team, including sport psychology. For others (e.g., NAIA, NCAA Division II, III athletes) this may not always be the case, as many of these athletic programs may not have the resources to meet the various needs...

Sexual Expression and Self-Confidence in Long-Distance Relationships

Morgann Kidwell
Little is known about the impact of distance on sexual expression and self-confidence in long-distance relationships, especially as mediated by technology. The purpose of the present study is to investigate how sexual expression and self-confidence vary in romantic relationships between those in long- versus short-distance relationships. Data from 327 participants—156 in long-distance relationships and 171 in short-distance relationships—were collected via Amazon MTurk. Results indicate that forms of technology-mediated sexual expression are widely used in long-distance...

Gentrification and the Black Church

Jordan McCray
Black churches have been playing an important, stabilizing and supportive role for their members, their neighborhoods, and their communities more broadly. However, these churches’ memberships, community functions, and abilities to support their members have been threatened by the accelerating displacement of African Americans due to the ongoing effects of gentrification, defined by massive economic investment in low-income areas leading to the displacement of low-income residents. At the same time, COVID-19 has also changed the ways...

Uncovering Frontier Mythologies

Corrin Turkowitch
This thesis analyzes the relationship between settler colonialism and public memory in B.F. Nelson Park, a downtown park in Minneapolis. My focus is the Pioneer statue, a large granite memorial depicting a frontier family in the middle of the park, which I examine through the lenses of race, gender, power, and violence. Using archival and landscape analysis I examine the historical and present built environment of the park and how it relates to white supremacy....

Pharmacist Provision of Contraception Services in Kentucky

Dustin Miracle
Unintended pregnancy continues to be a prevalent issue across the United States, impacting millions of women annually. While several states have enacted policies expanding pharmacist services to allow for provision of hormonal contraception, Kentucky has yet to do so. Likewise, although provision of nonprescription hormonal contraception could be authorized under Kentucky regulation, prior to this study, this had yet to be done. The objectives of this study were to 1) understand the opinions of Kentucky...

ANALYZING SLAB HOLES IN SUBDUCTION ZONES AND THEIR IMPACTS THROUGH NUMERICAL SIMULATIONS

Taylor Arrowood
Subduction zones form as higher density oceanic lithosphere is forced beneath an over-riding, lower density, continental or oceanic plate; a process driven by contrasts in buoyancy throughout this system. We seek to explore subduction zones in which the subducting lithosphere is discontinuous after passing through the trench, forming a slab gap. The main research objective is to determine the effect of slab gaps on surface topography in a subduction-related orogen and asthenospheric flow into the...

Evaluation of Orange Pavement Striping for Use in Work Zones

Erin Lammers, William Staats & Ken Agent
Interstate widening projects are commonplace in Kentucky, and safety is of primary concern within the project work zone. Past experience with long work zones revealed two critical safety issues: driver confusion due to unclear pavement markings and a lack of continuous work zone signage for motorists indicating they are still within a work zone. This concern is heightened in transition and taper areas. Highly visible markings in an alternative color other than standard yellow or...

The Kentucky Re-Entry Universal Payload System (KRUPS)

James Nichols
Due to the uniqueness of atmospheric entry environments, ground facilities cannot accurately replicate re-entry conditions. Consequently, scientists primarily rely on numerical models to predict these conditions and inform Thermal Protection System (TPS) designs. These models often lack flight validation, which is necessary for increasing their fidelity. Thus, there is a substantial need to obtain such data to advance modeling capabilities. The Kentucky Re-entry Universal Payload System (KRUPS) is an adaptable test-bed for scientific experimentation with...

The Economic Impact of Diabetes in Kentucky

Michael W. Clark, Jenny A. Minier, Charles J. Courtemanche, Bethany L. Paris & Michael T. Childress
Excerpt from the Executive Summary: The Kentucky Department of Public Health is responsible for improving the health and safety of Kentucky’s residents by preventing disease and injuries and encouraging healthy lifestyles. The department administers nearly 150 programs that address critical health issues affecting Kentuckians. These programs screen newborns for health problems, prevent the spread of infectious diseases, promote oral health, and provide numerous other services. Diabetes represents a growing health concern for the nation and...

A Description of COVID-19 Lifestyle Restrictions Among a Sample of Rural Appalachian Women

Michele Staton, Martha Tillson & J. Matthew Webster
Background: COVID-19 has led to swift federal and state response to control virus transmission, which has resulted in unprecedented lifestyle changes for U.S. citizens including social distancing and isolation. Understanding the impact of COVID-19 lifestyle restrictions and related behavioral risks is important, particularly among individuals who may be more vulnerable (such as rural women with a history of substance use living in Appalachia). Purpose: The overall purpose of this study was to better understand the...

Cancer Curriculum for Appalachian Kentucky Middle and High Schools

Lauren Hudson, Katherine Sharp, Chris Prichard, Melinda J. Ickes, Sahar Alameh & Nathan L. Vanderford
Background: Appalachian Kentucky faces the highest cancer incidence and mortality rates in the country due to poor health behaviors and lifestyle choices. These poor health behaviors are facilitated by a lack of cancer education. Youth represent a vulnerable population that could be greatly impacted by increased cancer education. Teachers have the power to facilitate this learning. Purpose: This study examined the need for cancer education curriculum in Appalachian Kentucky middle and high schools from the...

Post-translational knockdown and post-secretional modification of EsxA determine contribution of EsxA membrane permeabilizing activity for mycobacterial intracellular survival

Yanqing Bao, Lin Wang & Jianjun Sun
Current genetic studies (e.g. gene knockout) have suggested that EsxA and EsxB function as secreted virulence factors that are essential for Mycobaterium tuberculosis (Mtb) intracellular survival, specifically in mediating phagosome rupture and translocation of Mtb to the cytosol of host cells, which further facilitates Mtb intracellular replicating and cell-to-cell spreading. The EsxA-mediated intracellular survival is presumably achieved by its pH-dependent membrane-permeabilizing activity (MPA). However, the data from other studies have generated a discrepancy regarding the...

Cloning and Functional Characterizations of Circular RNAs from the Human MAPT Locus

Justin Welden
Under pathophysiological conditions, the microtubule protein tau (MAPT) forms neurofibrillary tangles that are the hallmark of sporadic Alzheimer’s disease as well as familial frontotemporal dementias linked to chromosome 17 (FTDP-17). In this work, I report that MAPT forms circular RNAs through backsplicing of exon 12 to either exon 10 or exon 7 (12→10; 12→7), and that these circular RNAs are translated into proteins. Using stable cell lines overexpressing the circular tau RNAs 12→7 and 12→10,...

THE TUMOR SUPPRESSOR PAR-4 REGULATES HYPERTROPHIC OBESITY

Nathalia Araujo
Prostate Apoptosis Response-4 (Par-4) is a tumor suppressor ubiquitously expressed in all tissues and able to selectively induce apoptosis in cancer cells. Although well established in the context of cancer, relatively little is known about the function of Par-4 in the healthy and non-tumorigenic context. Observations from our lab showed that Par-4 knockout mouse lines were obese and displayed adipocyte hypertrophy under a normal chow diet when compared to Par-4 wild-type mice. These Par-4 knockout...

Measurements of Wind Turbine Wake Evolution and Trajectory During Morning Boundary Layer Transition and Under Wake Steering Conditions via Unmanned Aerial Vehicles

Stewart Nelson
In July of 2019, a flight campaign was conducted using semi-autonomous Unmanned Aerial Vehicles (UAVs) at the Port Alma Kruger Energy wind farm in Ontario, Canada, to study various aspects of wind turbine wake evolution. Horizontal transects across the wakes were measured using modified fixed-wing aircraft fitted with a five-hole probe to measure the wind velocity vector. Reference boundary layer conditions were measured by an octocopter with an assortment of mounted sensors flying vertical profiles...

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes

Lan-Qing Li, Jing Li, Hong-Ping Long, Ji-Kai Liu & Xian Wang
Four new resorcinol derivatives, namely (−)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (−)-1 by chiral HPLC. The neuroprotective effects of 1–3 against the damage of PC12...

The G7 Suite

Joseph Dunn
The G7 Suite is a multi-movement chamber work that combines elements of European Art Music, Indigenous Music from Latin America, and various representations of American music. The melodic material is derived from the national anthems of the Great Seven nations: Canada, France, Germany, Italy, Japan, the United Kingdom, and the United States. Each melody is re-set to new music genres and aligns itself to the rules and expectations within each idiom. This compilation is more...

CROUCHING TIGER CELLO CONCERTO

Xiaohang Yu
Tan Dun’s Crouching Tiger Concerto for Amplified Cello and Orchestra is not only one of the most frequently performed cello concerto of the recent past; it also demonstrates Tan’s masterful synthesis of artistic forms from the Chinese and the Western art music traditions with visual media that extends beyond the concert-hall. The music for this concerto was initially composed as part of the score for Ang Lee’s film Crouching Tiger, Hidden Dragon, itself a landmark...

EVALUATION OF CORN AGRONOMIC MANAGEMENT PRACTICES FOLLOWING A RYE COVER CROP

Daniel Quinn
Fall implementation of a rye (Secale cereale L.) cover crop (RCC) prior to spring corn (Zea mays L.) planting is a management practice used to improve soil conservation, water quality, and limit herbicide dependence. However, corn growth and yield following a RCC is often reduced due to early-season nitrogen (N) stress and decreased plant emergence, which can limit RCC adoption. The objective(s) of this research were to evaluate corn agronomic management practices (e.g., N and...

What Happened in Harris Neck?

Anna Sharpe
This project traces the history and legacy of the seizure of Harris Neck, approximately 2,600 acres on the Georgia coast, once largely composed of rice and cotton plantations. After the Civil War, freedmen and women transformed the area into a thriving Black community. The community of approximately a hundred families, a school, a church, a post office, and many small farms and businesses flourished from the late 1800’s until 1942, when the federal government seized...

LEADING IN THE DIGITAL AGE

Ryan Schubart
This study explored how school leaders make sense of and address digital citizenship as defined by Ribble (2011), and investigated what successes and challenges school leaders experienced while implementing digital citizenship programs in large Southeastern technology-rich schools. This bounded cross-case study, undergirded by Weick’s (1995) Theory of Sensemaking, is also designed to explore how school leaders implement digital citizenship programs at technology-rich schools in a large. 1:1, Southeastern public-school district, and how they view their...

Registration Year

  • 2021
    198

Resource Types

  • Text
    198

Affiliations

  • University of Kentucky
    198
  • Zhejiang University
    10
  • Sun Yat-sen University
    8
  • Xiamen University
    8
  • Sichuan University
    7
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    7
  • State Administration of Traditional Chinese Medicine of the People's Republic of China
    6
  • Chinese Academy of Tropical Agricultural Sciences
    6
  • Hebei Normal University
    6
  • North West Agriculture and Forestry University
    6