198 Works

SPONTANEOUS POSTPARTUM HYPERTENSION IN THE AFRICAN GREEN MONKEY

Patrick Rivera
Postpartum hypertension (PPHT) is a hypertensive disorder of the puerperium that occurs in women at a rate between 0.8-28% although the exact incidence is unknown due primarily to its transient presentation during a time of reduced medical supervision. The etiology of PPHT is currently unknown with no present experimental animal model. We present the African green monkey (Chlorocebus aethiops sabaeus; AGM) as a potentially translational NHP model of PPHT in humans. AGMs were identified as...

Evaluation of Radiative Conductivity inside a Porous Media with the Effect of Participating Medium Based on Microscale Imaging

Mingping Zheng
Space vehicles will experience high loads of heat while entering the planetary atmosphere. At such high temperature, radiation becomes the dominant mode of heat transfer. Since the atmospheric entry environment is nearly impossible to duplicate in a laboratory environment, a numerical model to evaluate thermal performance of the thermal protection system was established. The model simulates the radiative heat transfer process in highly porous media, and the process also takes into account the influence of...

Combining Approximate Computing And Adiabatic Logic For Low-Power And Energy-Efficient Iot Edge Computing

Wu Yang
The growing data-intensive applications that run on IoT edge devices require the circuit to be low-power consumption and energy-efficient for limited resources. As conventional Complementary Metal-Oxide-Semiconductor (CMOS) scales down to the nanometer technology node, it reaches its limits, such as leakage and power consumption. Adiabatic logic and approximate computing are emerging techniques for the low-power circuit. Adiabatic logic can recycle energy which is a promising solution for building energy-efficient circuits. However, the power clock scheme...

STRUCTURAL ADAPTATION OF EQUINE PROXIMAL SESAMOID BONES TO HIGH-SPEED EXERCISE

Kathryn Mary Babiarz
Proximal sesamoid bone (PSB) fractures are one of the most commonly reported catastrophic musculoskeletal injuries (CMI) in Thoroughbred racing. Despite the seriousness of these injuries, an understanding of the structural changes that occur normally within PSBs in response to the biomechanical forces of high-speed exercise and how they relate to pathological events leading to fracture remain limited. To address this critical knowledge gap, PSBs from Thoroughbred horses were analyzed with both computed tomography (CT) and...

Evaluation of Orange Pavement Striping for Use in Work Zones

Erin Lammers, William Staats & Ken Agent
Interstate widening projects are commonplace in Kentucky, and safety is of primary concern within the project work zone. Past experience with long work zones revealed two critical safety issues: driver confusion due to unclear pavement markings and a lack of continuous work zone signage for motorists indicating they are still within a work zone. This concern is heightened in transition and taper areas. Highly visible markings in an alternative color other than standard yellow or...

Cloning and Functional Characterizations of Circular RNAs from the Human MAPT Locus

Justin Welden
Under pathophysiological conditions, the microtubule protein tau (MAPT) forms neurofibrillary tangles that are the hallmark of sporadic Alzheimer’s disease as well as familial frontotemporal dementias linked to chromosome 17 (FTDP-17). In this work, I report that MAPT forms circular RNAs through backsplicing of exon 12 to either exon 10 or exon 7 (12→10; 12→7), and that these circular RNAs are translated into proteins. Using stable cell lines overexpressing the circular tau RNAs 12→7 and 12→10,...

THE TUMOR SUPPRESSOR PAR-4 REGULATES HYPERTROPHIC OBESITY

Nathalia Araujo
Prostate Apoptosis Response-4 (Par-4) is a tumor suppressor ubiquitously expressed in all tissues and able to selectively induce apoptosis in cancer cells. Although well established in the context of cancer, relatively little is known about the function of Par-4 in the healthy and non-tumorigenic context. Observations from our lab showed that Par-4 knockout mouse lines were obese and displayed adipocyte hypertrophy under a normal chow diet when compared to Par-4 wild-type mice. These Par-4 knockout...

Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes

Lan-Qing Li, Jing Li, Hong-Ping Long, Ji-Kai Liu & Xian Wang
Four new resorcinol derivatives, namely (−)/(+)-xylarinig A (1), as well as xylarinigs B (2) and C (3), were isolated from the ethyl acetate extracts of the solid fermentation of Xylaria nigripes. Their structures were established by comprehensive spectroscopic analysis combined with electronic circular dichroism (ECD) calculations. Compound 1 is an optical mixture, and was resoluted into optical pure enatiomers (+)-1 and (−)-1 by chiral HPLC. The neuroprotective effects of 1–3 against the damage of PC12...

COMPUTATIONAL INSIGHTS ON MEDICINAL CHEMISTRY TARGETING CYP450s

Alexander Fenton
Modern-day medicinal chemistry has provided researchers with a wide variety of tools to not only gather greater insight from their data, but also to generate data in new ways. One such tool is the construction of computational protein models from crystallographic datasets, and their subsequent use to understand the structure-activity relationships of protein-ligand complexes. These models can be utilized for their predictive power to inform the synthesis of, and improvement of, lead compounds. It is...

COMPARATIVE EFFECTS OF WORDS PLUS PICTURES AND WORDS ALONE ON THE READING COMPREHENSION OF YOUTH WITH DISABILITIES

Lindsay Caudill
This study compared the effectiveness and efficiency of two instructional conditions on the reading comprehension of fifth and sixth grade students with moderate and severe disabilities. A words plus pictures and words alone condition were examined through the use of an adapted alternating treatment design replicated across 3 participants. Results indicated that the effect was minimal, with words plus pictures being slightly more effective.

RESIDUAL SPATIAL AUTOCORRELATION IN MACROECOLOGICAL AND BIOGEOGRAPHICAL MODELING

Guetchine Gaspard
Macroecological and biogeographical modelers have predicted the distribution of species across space relying on the relationship between biotic processes and environmental variables. Such a method employs data associated, for instance, with species abundance or presence/absence, climate, geomorphology, and soils. Statistical analyses found in previous studies have highlighted the importance of accounting for the effects of spatial autocorrelation (SAC), which indicates a level of dependence between pairs of nearby observations. A consensus has existed that residual...

REMOTE SUPPORTED COMMUNICATION FOR ADULTS WITH CHRONIC APHASIA

Allie Hopper
Supported communication is defined as anything that improves access to or participation in communication events or activities (King, Simmons-Mackie, & Beukelman, 2012). This thesis describes the results of a study that took place when a training program to provide graduate students in Communication Sciences and Disorders (CSD) with “hands on” experience in providing supported communication to persons with chronic aphasia (PWA) was interrupted by the outbreak of Coronavirus-19 and switched to a remote delivery format...

A QUALITATIVE EXAMINATION OF THE AGENCY OF WOMEN IN THEIR 30S AND 40S WHO USE DATING APPLICATIONS

Tera Buerkle
The use of dating applications (apps) to find romantic and sexual partners is widespread across age groups, however, there is a paucity of research on dating apps with those in middle adulthood. Sexual script theory suggests that women’s agency (i.e. the ability to act in one’s own best interest) may be impacted by expectations from an inherently sexualized context, such as dating apps. Feminist theory contends that women’s agency is complicated by gender socialization due...

The Effects of Systematic Manipulation of Reinforcement Within a Classroom Management System

Amanda Gayle Chavez
Research suggests that best practice is for teachers to incorporate evidence-based classroom management strategies into their daily routines to improve student behavior. One aspect crucial to evidence-based practices is the rate at which teachers deliver reinforcement. Though research recommends reinforcement be provided frequently within classroom management systems (Robacker et al., 2016), no objective recommendation exists that assists teachers in delivering it systematically. In this study, a single case withdrawal design was used to analyze the...

Stress, Burnout, and Well-Being in New Veterinary Graduates

Addie Reinhard
Suicide, stress, and burnout are occurring at high rates among veterinary professionals, and the transition from student to practicing veterinarian has been shown to be a particularly stressful time. The aim of this study was to evaluate an online professional development program for new veterinary graduates incorporating peer social support and training in professional skills important for success in the transition to practice. In this mixed methods study, the program was evaluated qualitatively with focus...

Synthesis of Dual Small Molecule Hybrids to Probe the Synergy between DNA Repair Enzymes and IDO1

Nathaniel George
Indoleamine 2 3-dioxygenase (IDO) has recently been highlighted as a promising target for small molecule based immunotherapy. IDO is often coopted by various cancer cells to promote an immune-suppressive environment around tumors. DNA damage repair (DDR) enzymes have recently been targeted for inhibition to promote genetic instability and bolster immune recognition. DDR enzymes such as PARP and POLγ are common inhibition targets due to their direct effects on cellular function. In the process of designing...

MICROMENDING THE METABOLIC RIFT

Casey Byrd
The metabolic rift theory explores materials and social exchanges between rural and city communities and human-nature relations. Metabolic rifts can exist both environmentally and socially and are often geographically or culturally unique. Ultimately the metabolic rift is earmarked by increasing disconnection between humans and their environment. This thesis draws upon life cycle analysis studies, social-economic studies, and environmental and sustainability studies to argue that large-scale contemporary urban composting efforts, although well intended, are insufficient to...

The Influence of Socioindexical Information on the Speech Perception-Production Link

Kyler Laycock
The body of work on speech perception demonstrates the ability of listeners to utilize both visual and acoustic information in their processing of a given speech signal. More recent studies have established that listeners are sensitive to cues in both these modalities which inform their perception of a speaker's identity in parallel with the linguistic message, but the relationship between social information in perception and production together is unclear. This study reports the results of...

\"Playing the Game\"

Graciela Barajas
Latinx members of the FFA Organization are disproportionately underrepresented in leadership positions. When they do get elected to leadership offices, they oftentimes have to accept behaviors that erase their cultural identity. This study aims to find what aspects of their identity they feel they have to give up in order to be seen as a potential state or national FFA candidate. Findings include the participation of the state-officer game, joining cliques that fit the white...

Re-designing Main Memory Subsystems with Emerging Monolithic 3D (M3D) Integration and Phase Change Memory Technologies

Chao-Hsuan Huang
Over the past two decades, Dynamic Random-Access Memory (DRAM) has emerged as the dominant technology for implementing the main memory subsystems of all types of computing systems. However, inferring from several recent trends, computer architects in both the industry and academia have widely accepted that the density (memory capacity per chip area) and latency of DRAM based main memory subsystems cannot sufficiently scale in the future to meet the requirements of future data-centric workloads related...

QUANTIFICATION OF IN-PLAY COMPETITION DEMANDS OF COLLEGIATE AMERICAN FOOTBALL PLAYERS USING GLOBAL POSITIONING SYSTEMS

Alex Brownell
There is limited information describing the competition demands of American football. A greater understanding of competition demands will allow strength and conditioning practitioners to create appropriate training programs to enhance athlete readiness and performance. Therefore, the purpose of this study was to analyze the competition demands of collegiate American football players using global positioning systems (GPS), specifically comparing the in-play GPS versus out-of-play GPS outcomes. Twenty-two American football athletes (Age: 20.8 ± 0.9 yr, Height:...

Discovery of novel serum metabolic biomarkers in patients with polycystic ovarian syndrome and premature ovarian failure

Jiying Chen, Qinger Zhou, Yonggang Zhang, Wenqing Tan, Hanchao Gao, Liying Zhou, Shuixiu Xiao, Jinhua Gao, Jing Li & Zhiying Zhu
Several widely recognized metabolites play a role in regulating the pathophysiological processes of various disorders. Nonetheless, the lack of effective biomarkers for the early diagnosis of polycystic ovarian syndrome (PCOS) and premature ovarian failure (POF) has led to the discovery of serum-based metabolic biomarkers for these disorders. We aimed to identify various differentially expressed metabolites (DEMs) through serum-based metabolic profiling in patients with PCOS and POF and in healthy individuals by using liquid chromatography–mass spectrometry...

A COMPARATIVE STUDY OF STRESS, TRAUMA, WELL-BEING, AND FUTURE ORIENTATION AMONG COMMUNITY COLLEGE STUDENTS

Melinda LeMaster
This study measured perceived stress, past trauma, well-being, and future orientation in a sample of community college students located in the Southeast United States. The sample included 412 participants (78%) female; 59% of student participants reported living in a rural community and 41% in a non-rural community. The mean age was 22 for 70% of participants, while 30% were over age 30. Framed by Family Stress Theory and Human Ecological Systems Theory, the study tested...

Registration Year

  • 2021
    198

Resource Types

  • Text
    198

Affiliations

  • University of Kentucky
    198
  • Zhejiang University
    10
  • Sun Yat-sen University
    8
  • Xiamen University
    8
  • Sichuan University
    7
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    7
  • State Administration of Traditional Chinese Medicine of the People's Republic of China
    6
  • Chinese Academy of Tropical Agricultural Sciences
    6
  • Hebei Normal University
    6
  • North West Agriculture and Forestry University
    6