Additional file 3. Mean ELISA ODs by antigen. Notes: OD=optical density; red dot=mean of original data; blue dot=mean of each 1,000 bootstrap random samples; light red dashed line=upper and lower 95% confidence interval (CI) of original data; dark red dashed line=upper and lower 99% confidence interval (CI) of original data

Additional file 3. Mean ELISA ODs by antigen. Notes: OD=optical density; red dot=mean of original data; blue dot=mean of each 1,000 bootstrap random samples; light red dashed line=upper and lower 95% confidence interval (CI) of original data; dark red dashed line=upper and lower 99% confidence interval (CI) of original data

Additional file 1. Modified MARAIS Score (modified from Marais et al. [27]).

Additional file 1: Figure S1. Flowchart of the households and individuals included on the survey from the baseline. Figure S2. Comparison of malaria incidence and positivity in the intervention area during March-October 2017 with average values for Mananjary District. Figure S3. Comparison of malaria community case management in the intervention and control arms during pro-CCM implementation and during the two years prior. Figure S4. Map of Mananjary district and the fokontany included in the intervention...

Additional file 2. Table S1. Distribution of positive RDT results in the 22 fokontany. Table S2. Impact of Pro-CCM and IRS on malaria prevalence, per-protocol analyses. Table S3. Comparison of observed proportion of parasite prevalence by RDT by age group between intervention and control arms. Table S4. Comparison of reported bed net use (LLIN) by age group between baseline and endline surveys.

Additional file 3. Analyses and findings on anemia and PRO-CCM. Table S5. Prevalence of anemia among all women of reproductive age at baseline and endline, by study arm. Table S6. Unadjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models. Table S7. Adjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models.

Additional file 2. Distribution of ELISA OD values by antigen.

Additional file 1: ASAQ dosage.

Additional file 3. Analyses and findings on anemia and PRO-CCM. Table S5. Prevalence of anemia among all women of reproductive age at baseline and endline, by study arm. Table S6. Unadjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models. Table S7. Adjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models.

Additional file 2: AL dosage.

Additional file 1. Location of sites in Ethiopia [1A], Ghana [1B] and Madagascar [1C]. Notes: The location of each site is indicated as a black dot and the site’s name in red font; Ethiopia (Figure 1A): nine regional states (black italic, capital letters) and two chartered cities (black italic, lower letters) are shown;SNNPR=Southern Nations, Nationalities and People’s Region; Ghana (Figure 1B): ten regions (black italic, capital letters) are shown; Madagascar (Figure 1C): six provinces (black...

Additional file 1: Figure S1. Flowchart of the households and individuals included on the survey from the baseline. Figure S2. Comparison of malaria incidence and positivity in the intervention area during March-October 2017 with average values for Mananjary District. Figure S3. Comparison of malaria community case management in the intervention and control arms during pro-CCM implementation and during the two years prior. Figure S4. Map of Mananjary district and the fokontany included in the intervention...

Additional file 2. Table S1. Distribution of positive RDT results in the 22 fokontany. Table S2. Impact of Pro-CCM and IRS on malaria prevalence, per-protocol analyses. Table S3. Comparison of observed proportion of parasite prevalence by RDT by age group between intervention and control arms. Table S4. Comparison of reported bed net use (LLIN) by age group between baseline and endline surveys.

Additional file 2. Distribution of ELISA OD values by antigen.

Additional file 1. Location of sites in Ethiopia [1A], Ghana [1B] and Madagascar [1C]. Notes: The location of each site is indicated as a black dot and the site’s name in red font; Ethiopia (Figure 1A): nine regional states (black italic, capital letters) and two chartered cities (black italic, lower letters) are shown;SNNPR=Southern Nations, Nationalities and People’s Region; Ghana (Figure 1B): ten regions (black italic, capital letters) are shown; Madagascar (Figure 1C): six provinces (black...

Additional file 1. Modified MARAIS Score (modified from Marais et al. [27]).

Additional file 1: ASAQ dosage.

Additional file 2: AL dosage.

BACKGROUND: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and then...

BACKGROUND: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and then...