1,339 Works

Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway

Qi Yang, Jia You, Yuan Zhou, Yun Wang, Rongjuan Pei, Xinwen Chen, Min Yang & Jizheng Chen
Tick-borne encephalitis virus (TBEV) accounts for approximately 10,000 annual cases of severe encephalitis in Europe and Asia and causes encephalitis in humans. In this study, we demonstrate TBEV appears to activate the interferon (IFN)-β dependent on RIG-I/MDA5. Both the IFN-β accumulation and the IFN stimulated genes (ISGs) transcription greatly delay. Further studies reveal that TBEV NS4A could block the phosphorylation and dimerization of STAT1/STAT2 to affect type I and II IFN-mediated STAT signalling. Additional data...

Acylation of the antimicrobial peptide CAMEL for cancer gene therapy

Jingjing Song, Panpan Ma, Sujie Huang, Juanli Wang, Huan Xie, Bo Jia & Wei Zhang
Obtaining ideal gene delivery vectors is still a major goal in cancer gene therapy. CAMEL, a short hybrid antimicrobial peptide, can kill cancer cells by membrane lysis. In this study, we constructed a series of non-viral vectors by attaching fatty acids with different chain lengths to the N-terminus of CAMEL. Our results showed that the cellular uptake and transfection efficiency of acyl-CAMEL started to significantly increase from a chain length of 12 carbons. C18-CAMEL was...

Combined photodynamic-chemotherapy investigation of cancer cells using carbon quantum dot-based drug carrier system

Xin Li, Kandasamy Vinothini, Thiyagarajan Ramesh, Mariappan Rajan & Andy Ramu
The combined chemotherapy and photodynamic therapy have significant advantages for cancer treatments, which have higher therapeutic effects compared with other medicines. Herein, we focused on the synthesis of carbon quantum dot (CQD) based nanocarrier system. CQD and 5-aminolevulinic acid (5-ALA) were conjugated with mono-(5-BOC-protected-glutamine-6-deoxy) β-cyclodextrin (CQD-Glu-β-CD) moiety, and finally, the anticancer chemotherapy doxorubicin (DOX) drug was loaded in the 5-ALA-CQD-Glu-β-CD system. The stepwise physicochemical changes for the preparation of the DOX loaded 5-ALA-CQD-Glu-β-CD system were...

Additional file 1 of Early coagulopathy after pediatric out-of-hospital cardiac arrest: secondary analysis of a randomized clinical trial

Dawei Zhou, Tong Li, Yi Lv, Dijia Wang, Rongli Zhang, Qing Lin, Chao Wang, Dong Zhao, Shuyang Fei & Wei He
Additional file 1: Supplemental Table 1. Comparison of baseline characteristics between survivors and non-survivors. Supplemental Figure 1. Kaplan-Meier plots for cumulative 1-year survival according to early coagulopathy. The difference was statistically significant according to the log-rank test (P <0.001).

Healthy outcomes of patients with COVID-19 two years after the infection: a prospective cohort study

Dapeng Li, Xuejiao Liao, Zhi Liu, Zhenghua Ma, Jingke Dong, Guoqin Zheng, Mei Zi, Fang Wang, Qing He, Guobao Li, Zheng Zhang & Lei Liu
The long-term effect of coronavirus disease 2019 (COVID-19) has been rarely known. This study aimed to investigate healthy outcomes of COVID-19 survivors up to 2 years after the infection. A total of 155 COVID-19 patients, who were discharged from Shenzhen Third People's Hospital from February 2020 to April 2020, were enrolled and followed up until March 4, 2022. COVID-19 survivors received questionnaires of long COVID symptoms and psychological symptoms, pulmonary function tests, chest computed tomography...

Additional file 3 of CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72

Zhenguang Ying, Kaifang Wang, Junfeng Wu, Mingyu Wang, Jing Yang, Xia Wang, Guowei Zhou, Haibin Chen, Hongwu Xu, Stephen Cho Wing Sze, Feng Gao, Chunman Li & Ou Sha
Additional file 3: Fig. S3. Apoptosis or cycle changes in astrin-KO cells and identification of astrin-KO cell line. (A) Parental, astrin-KO and HCR-KO HeLa cells were analyzed with astrin, HCR, cyclin B1 and Cleaved PARP antibodies. HeLa cells treated with DMSO, Paclitaxel, Bafilomycin and MG132 were analyzed with Cleaved PARP and HCR antibodies. (B) Parental and astrin-KO HeLa cells were immunoblotted with an astrin antibody.

Additional file 1 of Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

Yan Li & Zhenbin Xu
Additional file 1. Search strategy and results.

Additional file 2 of Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

Yan Li & Zhenbin Xu
Additional file 2. Methodological Quality of case–control and cross-sectional studies included in the meta-analysis.

Additional file 2 of Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Additional file 2: Table S2. Comparison of clinical outcomes between single first-line and repeated first-line treatment subgroups in rituximab cohort

Additional file 3 of Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Additional file 3: Table S3. Comparison of clinical outcomes between early and delayed initiation of rituximab subgroups in rituximab cohort

Additional file 5 of Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

Yan Li & Zhenbin Xu
Additional file 5. Summary of the subgroup analyses of the correlation between circulating irisin levels and BMI.

Additional file 6 of Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

Yan Li & Zhenbin Xu
Additional file 6. Funnel plots of included studies.

Additional file 1 of FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer

Yufei Long, Tuotuo Chong, Xiaoming Lyu, Lujia Chen, Xiaomin Luo, Oluwasijibomi Damola Faleti, Simin Deng, Fei Wang, Mingliang He, Zhipeng Qian, Hongli Zhao, Wenyan Zhou, Xia Guo, Ceshi Chen & Xin Li
Additional file 1: Supplementary Fig. 1. (A) RT-qPCR analyses of FOXD1 mRNA in the indicated breast tumor cell lines and MCF-10A. Error bars, SEM. n = 3. (B) Western blotting analyses of FOXD1 expression in the indicated breast tumor cell lines and MCF-10A. (C)RT-qPCR analysis of FOXD1 expression in control and sh-FOXD1 cells (MDA231 and MDA468), or control and FOXD1 overexpression cells (MCF-7). Error bars, SEM. n = 3. **p < 0.01, ***p<0.001 by Student’s...

Appendix Tables and Figures of RSPB-2022-1850 from Tree-ring evidence of ecological stress memory

Yumei Mu, Lixin Lyu, Yan Li & Ouya Fang
Appendix Tables and Figures supporting our foudings.

sj-docx-1-jbf-10.1177_22808000221124418 – Supplemental material for Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system

Li Gao, Liu Yang, Lixiao Guo, Haibin Wang, Yinghu Zhao, Jun Xie & Nan Shi
Supplemental material, sj-docx-1-jbf-10.1177_22808000221124418 for Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system by Li Gao, Liu Yang, Lixiao Guo, Haibin Wang, Yinghu Zhao, Jun Xie and Nan Shi in Journal of Applied Biomaterials & Functional Materials

sj-docx-1-jbf-10.1177_22808000221124418 – Supplemental material for Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system

Li Gao, Liu Yang, Lixiao Guo, Haibin Wang, Yinghu Zhao, Jun Xie & Nan Shi
Supplemental material, sj-docx-1-jbf-10.1177_22808000221124418 for Improving the solubility of melanin nanoparticles from apricot kernels is a potent drug delivery system by Li Gao, Liu Yang, Lixiao Guo, Haibin Wang, Yinghu Zhao, Jun Xie and Nan Shi in Journal of Applied Biomaterials & Functional Materials

New polyacetylenes from Bidens procera

Jinli Tian, Shaohua Yu, Lu Wang, Denggang Kong, Wei Zhao, Zhenhua Tian & Honglei Zhou
A phytochemical investigation of Bidens procera L.C.Xu ex X.W.Zheng afforded two novel polyacetylenes, tridecane-2E-monoene-4,6,8-triyntylen-1,13-diol-12-O-β-glucoside (1) and tetradecane-2E,8E-diene-4,6-diyne-1,14-diol-13-O-β-glucoside (2), together with ten known compounds (3 − 12). Their chemical structures were elucidated by NMR and MS spectrums as well as the comparison of the published data. Furthermore, the chemotaxonomy of the yielded compounds was also discussed.

Additional file 6 of The global, regional, and national early-onset colorectal cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

Hongfeng Pan, Zeyi Zhao, Yu Deng, Zhifang Zheng, Ying Huang, Shenghui Huang & Pan Chi
Additional file 6: Table S1. Incidence of early-onset colorectal cancer in 1990 and 2019 with AAPC from 2009 and 2019 at countries/territories level, both sexes.

Additional file 7 of The global, regional, and national early-onset colorectal cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

Hongfeng Pan, Zeyi Zhao, Yu Deng, Zhifang Zheng, Ying Huang, Shenghui Huang & Pan Chi
Additional file 7: Table S2. Prevalence of early-onset colorectal cancer in 1990 and 2019 with AAPC from 2009 and 2019 at countries/territories level, both sexes.

Additional file 8 of The global, regional, and national early-onset colorectal cancer burden and trends from 1990 to 2019: results from the Global Burden of Disease Study 2019

Hongfeng Pan, Zeyi Zhao, Yu Deng, Zhifang Zheng, Ying Huang, Shenghui Huang & Pan Chi
Additional file 8: Table S3. Mortality of early-onset colorectal cancer in 1990 and 2019 with AAPC from 2009 and 2019 at countries/territories level, both sexes.

Additional file 12 of Circulating tumor DNA integrating tissue clonality detects minimal residual disease in resectable non-small-cell lung cancer

Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu … & Rong Yin
Additional file 12. Supplementary discussion.

Additional file 1 of Mining on Alzheimer’s diseases related knowledge graph to identity potential AD-related semantic triples for drug repurposing

Yi Nian, Xinyue Hu, Rui Zhang, Jingna Feng, Jingcheng Du, Fang Li, Larry Bu, Yuji Zhang, Yong Chen & Cui Tao
Additional file 1. AD-related UMLS concepts used in the study.

Supplementary document for Mid-infrared Nb₄N₃-based superconducting nanowire single photon detectors for wavelengths up to 10 μm - 5989819.pdf

Yiming Pan, Hui Zhou, XINGYU ZHANG, Huiqin Yu, Lu Zhang, Mengting Si, Hao Li, Lixing YOU & Zhen Wang
detailed description of some measurements

Additional file 1 of Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Additional file 1. Selection of clinical questions.

Additional file 1 of Evidence-based expert consensus on the management of primary central nervous system lymphoma in China

Tong Chen, Yuanbo Liu, Yang Wang, Qing Chang, Jinsong Wu, Zhiliang Wang, Daoying Geng, Jin-Tai Yu, Yuan Li, Xiao-Qiu Li, Hong Chen, Dongxiao Zhuang, Jianyong Li, Bin Wang, Tao Jiang, Lanting Lyu, Yuqin Song, Xiaoguang Qiu, Wenbin Li, Song Lin, Xinghu Zhang, Dehong Lu, Junqiang Lei, Yaolong Chen & Ying Mao
Additional file 1. Selection of clinical questions.

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