Additional file 1: Cost estimates for the rest of the first year or in post-CVD phase. Table S1. Lifetime cost-effectiveness results for each subgroup. Table S2. Baseline characteristics of the study participants. Table S3. Unit prices of drugs. Table S4. Costs of each treatment procedure. Table S5. Hazard ratios and parameters for scale and shape of the subgroup analysis.

Additional file 1: Supplemental file 1. Visualization of the Evolution of CIDO.

Additional file 1: Supplemental file 1. Visualization of the Evolution of CIDO.

Additional file 3: Supplemental Table 2. CIDO statistics including terms imported from major reference ontologies.

Additional file 3: Supplemental Table 2. CIDO statistics including terms imported from major reference ontologies.

Additional file 2: Table S1. The sequences of UGT genes in S. chusanum. Table S2. Accession numbers of amino acid sequences used for glycosyltransferases phylogenetic reconstruction. Table S3. The conversion rate generated by the phloretin or naringenin to produce the corresponding C-glycosides at the 100 μM substrate concentration. Table S4. The kinetic parameters of recombinant ScCGT1 and other CGTs using phloretin (1) or 2-hydroxynaringenin (2) as substrate and UDP-glucose as the sugar donor. Table S5....

Additional file 2: Table S1. The sequences of UGT genes in S. chusanum. Table S2. Accession numbers of amino acid sequences used for glycosyltransferases phylogenetic reconstruction. Table S3. The conversion rate generated by the phloretin or naringenin to produce the corresponding C-glycosides at the 100 μM substrate concentration. Table S4. The kinetic parameters of recombinant ScCGT1 and other CGTs using phloretin (1) or 2-hydroxynaringenin (2) as substrate and UDP-glucose as the sugar donor. Table S5....

Additional file 1: Table S1. The edge count of the compound-target-pathway network for the absorbed compounds of Zishen Yutai pills by orally administered in a POF mouse model. Table S2. The tabular form of PPI result. Table S3. The target degree for PPI network results. Table S4. KEGG Pathway analysis of proteins regulated by the absorbed compounds from Zishen Yutai pills in the POF treatment.

No current RNA-targeted interference tools have been reported to simultaneously up and down-regulate different gene expressions. Here we characterized an RNA-targeted genetic regulatory strategy composed of a flap endonuclease 1 (FEN1) and specific mis-hairpin DNA probes (mis-hpDNA), to realize the orthogonal genetic regulation. By targeting mRNA, the strategy hindered the translation and silenced genes in human cells with efficiencies of ~60%. By targeting miRNA, the strategy prevented the combination of miRNA to its specific mRNA...

Vector autoregressive (VAR) models are widely used in practical studies, e.g., forecasting, modelling policy transmission mechanism, and measuring connection of economic agents. To better capture the dynamics, this paper introduces a new class of time-varying VAR models in which the coefficients and covariance matrix of the error innovations are allowed to change smoothly over time. Accordingly, we establish a set of theories, including the impulse responses analyses subject to both of the short-run timing and...

Supplementary Material 1

Supplementary Material 4

Supplementary Material 6

This study decomposes the bilateral trade flows using a three-dimensional panel data model. Under the scenario that all three dimensions diverge to infinity, we propose an estimation approach to identify the number of global shocks and countryspecific shocks sequentially, and establish the asymptotic theories accordingly. From the practical point of view, being able to separate the pervasive and nonpervasive shocks in a multi-dimensional panel data is crucial for a range of applications, such as, international...

Additional file 1: Table 1S. Distribution of population characteristics in included individuals and the total population of UK Biobank. Table 2S. Single-nucleotide polymorphisms used to build the genetic risk score for type 2 diabetes. Table 3S. The coding of the variables under assessment of the covariates in the UK Biobank study. Table 4S. Pearson correlation coefficients among the five air pollutants. Table 5S. Risk of incident type 2 diabetes according to air pollution within each...

Additional file 3. Additional methods.

The rhizome of Rohdea chinensis (Baker) N.Tanaka (RRc) is a famous folk medicine for the treatment of carbuncles and pharyngitis. Steroidal saponins (SSs) were considered to be the most abundant active constituents in RRc. However, to date, the in-depth study of SSs is still lacking. This study was aimed to investigate the SSs profiles of RRc extract by HPLC-ESI-QTOF-MS/MS. Analysis was performed on an Agilent poroshell 120 EC-C18 column (2.1 mm × 100 mm, i.d.,...

Additional file 10: Table S5. Changes in DALYs number according to population-level determinants and causes from 1990 to 2019.

Additional file 3: Supplementary Figure 3. Physical examination of the child in Case two at final follow-up

Additional file 1: Table S1. Detailed information on the 96 tick libraries examined here. Figure S1. Gene arrangements in tick mitochondrial genomes across eight genera. There are 23 linear maps in 19 species of Haemaphysalis, nine in Amblyomma species, two in Bothriocroton species, three in two Hyalomma species, 13 in 10 Rhipicephalus species, 18 in 16 Ixodes species, one of Nuttalliellidae species and 26 linear maps of Argasid ticks. Each mitochondrial genome has 13 protein-coding...

Additional file 11. Methods.

Additional file 12. Supplementary discussion.

Additional file 13. Supplementary results.

Additional file 9. Figure S6: ctDNA testing, LDCT scans, and disease-related events of patients during follow-up periods. . Swimmer plot illustrating the first positive ctDNA testing, the last negative LDCT scans, and pathological events of patients that experienced recurrence or deceased. B). The original and adjusted time intervals between the first positive ctDNA testing and final LDCT scans that detected disease recurrence. Abbreviations: LDCT – low-dose computed tomography, LUAD – lung adenocarcinoma, LUSC - lung...

Additional file 9. Figure S6: ctDNA testing, LDCT scans, and disease-related events of patients during follow-up periods. . Swimmer plot illustrating the first positive ctDNA testing, the last negative LDCT scans, and pathological events of patients that experienced recurrence or deceased. B). The original and adjusted time intervals between the first positive ctDNA testing and final LDCT scans that detected disease recurrence. Abbreviations: LDCT – low-dose computed tomography, LUAD – lung adenocarcinoma, LUSC - lung...