45 Works

Additional file 1 of Understanding how and under what circumstances decision coaching works for people making healthcare decisions: a realist review

Junqiang Zhao, Janet Jull, Jeanette Finderup, Maureen Smith, Simone Maria Kienlin, Anne Christin Rahn, Sandra Dunn, Yumi Aoki, Leanne Brown, Gillian Harvey & Dawn Stacey
Additional file 1: Appendix A: Demographic of executive and stakeholder group members. Appendix B: Initial program theory. Appendix C: Relevance rating checklist. Appendix D: Data extraction form.

Additional file 1 of Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study

Hai Deng, Peng Hu, Huoxing Li, Huanning Zhou, Xiuyi Wu, Maohua Yuan, Xueru Duan, Miaochao Lao, Chuchu Wu, Murui Zheng, Xiang Qian Lao, Wenjing Zhao & Xudong Liu
Additional file 1: Figure S1. Flow chart of selection of hypertensive patients. Table S1. Association between lipid indicators and the risk of T2DM. Table S2. Stratified analyses on the association between triglyceridemic-waist phenotypes and the risk of T2DM. Table S3. Stratified analyses on the association between triglyceride glucose index and the risk of T2DM. Table S4. Stratified analyses on the association between lipid accumulation product and the risk of T2DM. Table S5. Stratified analyses on...

Emerging pharmacologic interventions for pre-eclampsia treatment

Xiao Zhang, Yue Chen, Dongli Sun, Xiaojun Zhu, Xia Ying, Yao Yao, Weidong Fei & Caihong Zheng
Pre-eclampsia is a serious pregnancy complication and a major global concern for the mortality of both mother and fetus. Existing symptomatic treatments do not delay disease progression; thus, timely delivery of the baby is the most effective measure. However, the risk of various maternal and fetal injuries remains. In this review, we summarize potential strategies for pharmacologic interventions in pre-eclamptic therapy. Specifically, we discuss the pathophysiological process of various effective candidate therapeutics that act on...

AMEE Guide to ethical teaching in online medical education: AMEE Guide No. 146

Ken Masters, David Taylor, Teresa Loda & Anne Herrmann-Werner
The Covid-19 pandemic necessitated Emergency Remote Teaching (ERT): the sudden move of educational materials online. While ERT served its purpose, medical teachers are now faced with the long-term and complex demands of formal online teaching. One of these demands is ethical online teaching. Although ethical teaching is practiced in face-to-face situations, online teaching has new ethical issues that must be accommodated, and medical teachers who wish to teach online must be aware of these and...

sj-docx-1-jpc-10.1177_21501319221131684 – Supplemental material for Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review

Diana Sarakbi, Dianne Groll, Joan Tranmer & Kim Sears
Supplemental material, sj-docx-1-jpc-10.1177_21501319221131684 for Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review by Diana Sarakbi, Dianne Groll, Joan Tranmer and Kim Sears in Journal of Primary Care & Community Health

sj-docx-2-jpc-10.1177_21501319221131684 – Supplemental material for Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review

Diana Sarakbi, Dianne Groll, Joan Tranmer & Kim Sears
Supplemental material, sj-docx-2-jpc-10.1177_21501319221131684 for Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review by Diana Sarakbi, Dianne Groll, Joan Tranmer and Kim Sears in Journal of Primary Care & Community Health

sj-docx-3-jpc-10.1177_21501319221131684 – Supplemental material for Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review

Diana Sarakbi, Dianne Groll, Joan Tranmer & Kim Sears
Supplemental material, sj-docx-3-jpc-10.1177_21501319221131684 for Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review by Diana Sarakbi, Dianne Groll, Joan Tranmer and Kim Sears in Journal of Primary Care & Community Health

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.

King L Hung, Jens Luebeck, Siavash R Dehkordi, Caterina I Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H Lomeli, Natasha E Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E Houlahan, Wenting Yang, Rocío Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G Henssen, Julie A Law, William J Greenleaf, Roger S Lo, Paul S Mischel, Vineet Bafna … & Howard Y Chang
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment and pulsed field gel electrophoresis of agarose-entrapped genomic DNA, previously developed for bacterial chromosome segments, to isolate megabase-sized human ecDNAs. We demonstrate strong enrichment of ecDNA molecules containing EGFR, FGFR2 and MYC from human cancer cells and NRAS ecDNA from human metastatic melanoma with acquired therapeutic resistance. Targeted enrichment of ecDNA versus...

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.

King L Hung, Jens Luebeck, Siavash R Dehkordi, Caterina I Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H Lomeli, Natasha E Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E Houlahan, Wenting Yang, Rocío Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G Henssen, Julie A Law, William J Greenleaf, Roger S Lo, Paul S Mischel, Vineet Bafna … & Howard Y Chang
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment and pulsed field gel electrophoresis of agarose-entrapped genomic DNA, previously developed for bacterial chromosome segments, to isolate megabase-sized human ecDNAs. We demonstrate strong enrichment of ecDNA molecules containing EGFR, FGFR2 and MYC from human cancer cells and NRAS ecDNA from human metastatic melanoma with acquired therapeutic resistance. Targeted enrichment of ecDNA versus...

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

Alexandra Pokhilko, Gaia Brezzo, Lahiru Handunnetthi, Raphael Heilig, Rachel Lennon, Colin Smith, Stuart M Allan, Alessandra Granata, Sanjay Sinha, Tao Wang, Hugh S Markus, Alexandra Naba, Roman Fischer, Tom Van Agtmael, Karen Horsburgh & M Zameel Cader
The extracellular matrix (ECM) is a key interface between the cerebrovasculature and adjacent brain tissues. Deregulation of the ECM contributes to a broad range of neurological disorders. However, despite this importance, our understanding of the ECM composition remains very limited mainly due to difficulties in its isolation. To address this, we developed an approach to extract the cerebrovascular ECM from mouse and human post-mortem normal brain tissues. We then used mass spectrometry with off-line high-pH...

Additional file 1 of A high-throughput neutralizing assay for antibodies and sera evaluation against Epstein-Barr virus

Ling Zhong, Claude Krummenacher, Wanlin Zhang, Junping Hong, Qisheng Feng, Qinjian Zhao, Yixin Chen, Mu-Sheng Zeng, Yi-Xin Zeng, Miao Xu & Xiao Zhang
Additional file 1. Figure S1. CNE2-EBV-GFP infection of Akata cells was determined by FCM and HCIS. Figure S2. Neutralizing titers of 12 rhesus macaque sera against CNE2-EBV-GFP virus infection of B cells determined by FCM and HCIS. Figure S3. Anti-gp350 IgG titer in rhesus macaque monkey sera and its correlation with B cell neutralizing titer. Figure S4. Akata-EBV-GFP infection of HNE1 cells was determined by FCM and HCIS. Figure S5. Neutralizing activity of CL59 determined...

A General Framework for Identifying Hierarchical Interactions and Its Application to Genomics Data

Xiao Zhang, Xingjie Shi, Yiming Liu, Xu Liu & Shuangge Ma
The analysis of hierarchical interactions has long been a challenging problem due to the large number of candidate main effects and interaction effects, and the need for accommodating the “main effects, interactions” hierarchy. The two-stage analysis methods enjoy simplicity and low computational cost, but contradict the fact that the outcome of interest is attributable to the joint effects of multiple main factors and their interactions. The existing joint analysis methods can accurately describe the underlying...

Multi-Modality Breast MRI Segmentation Using nn-UNet for Preoperative Planning of Robotic Surgery Navigation

Motaz Alqaoud, John Plemmons, Eric Feliberti, Kaipa, Siqin Dong, Gabor Fichtinger, Yimming Xiao & Michel Audette
Segmentation of the chest region and breast tissues is essential for surgery planning and navigation. This paper proposes the foundation for preoperative segmentation based on two cascaded architectures of deep neural networks (DNN) based on the state-of-the-art nnU-Net. Additionally, this study introduces a polyvinyl alcohol cryogel (PVA-C) breast phantom based on the segmentation of the DNN automated approach, enabling the experiments of navigation system for robotic breast surgery. Multi-modality breast MRI datasets of T2W and...

Additional file 1 of Item response theory and differential test functioning analysis of the HBSC-Symptom-Checklist across 46 countries

Andreas Heinz, Philipp E. Sischka, Carolina Catunda, Alina Cosma, Irene García-Moya, Nelli Lyyra, Anne Kaman, Ulrike Ravens-Sieberer & William Pickett
Additional file 1: Table A1. Sample size,percent females, mean, and standard deviation of age. Table A2. Distribution of the HBSC-SCL items (1-4). Table A3. Distribution of the HBSC-SCLitems (5-8). Table A4. Goodness offit statistics for the bifactor GRM. Table A5. Bifactor statistical indices. Table A6. Multigroup Model Fit. Table A7.Monte Carlo simulation results: Mean parameter stability. Figure A1. HBSC-SCL bar charts. Figure A2. HBSC-SCL polychoric correlations. Figure A3. Test for local dependency of the unidimensional...

Additional file 1 of Item response theory and differential test functioning analysis of the HBSC-Symptom-Checklist across 46 countries

Andreas Heinz, Philipp E. Sischka, Carolina Catunda, Alina Cosma, Irene García-Moya, Nelli Lyyra, Anne Kaman, Ulrike Ravens-Sieberer & William Pickett
Additional file 1: Table A1. Sample size,percent females, mean, and standard deviation of age. Table A2. Distribution of the HBSC-SCL items (1-4). Table A3. Distribution of the HBSC-SCLitems (5-8). Table A4. Goodness offit statistics for the bifactor GRM. Table A5. Bifactor statistical indices. Table A6. Multigroup Model Fit. Table A7.Monte Carlo simulation results: Mean parameter stability. Figure A1. HBSC-SCL bar charts. Figure A2. HBSC-SCL polychoric correlations. Figure A3. Test for local dependency of the unidimensional...

MOF-derived multi-interface carbon-based composites with enhanced polarization loss and efficient microwave absorption

Hongjiao Qu, Peng Zheng, Tao Wang, Xingyu Yu, Junjie Pan, Xiaoli Fan, Tengfei Zhang, Xin Sun & Jianping He
Metal-organic framework materials (MOFs) have been widely studied because of their adjustable composition and controllable structure in the field of microwave absorption (MA). Therein, Prussian blue analogs (PBA) have attracted the attention of researchers with ultra-high metal content. However, the attenuation ability of microwave for PBA-based composites is still unsatisfactory up to now. Therefore, the NiFe/CoFe@C composites were prepared by carbonizing polymetallic PBA (NiCoFe PBA) materials in this work, and the influence of different metal...

sj-docx-3-jpc-10.1177_21501319221131684 – Supplemental material for Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review

Diana Sarakbi, Dianne Groll, Joan Tranmer & Kim Sears
Supplemental material, sj-docx-3-jpc-10.1177_21501319221131684 for Achieving Quality Integrated Care for Adolescent Depression: A Scoping Review by Diana Sarakbi, Dianne Groll, Joan Tranmer and Kim Sears in Journal of Primary Care & Community Health

Additional file 1 of A nomogram for predicting cancer-specific survival for elderly patients with gallbladder cancer

Chong Wen, Jie Tang, Tao Wang & Hao Luo
Additional file 1: Figure S1. Histological type of gallbladder carcinoma in all patients. The vast majority of patients were adenocarcinoma, followed by squamous cell carcinoma, endocrine carcinoma, and some unknown epithelial tumors.

Additional file 1 of PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment

Yao Yao, Xiaoyu Cai, Meng Zhang, Xiao Zhang, Fujia Ren, Yan Zheng, Weidong Fei, Mengdan Zhao & Caihong Zheng
Additional file 1: Table 1. Clinical information of the participants (mean ± SD). Supplementary Figure 1. (A) RF levels in RA patients. (B) ASO levels in RA patients. (C) Scatter plot (left) and histogram (right) of CD11b+CD86+ cells in peripheral blood. (D) Scatter plot (left) and histogram (right) of CD11b+CD86+ cells in synovial tissue. (E) Correlation analysis of the level of PSTPIP2 in CD11b+ monocytes with CD11b+CD86+ cells in peripheral blood. (F) Correlation analysis of...

MOF-derived multi-interface carbon-based composites with enhanced polarization loss and efficient microwave absorption

Hongjiao Qu, Peng Zheng, Tao Wang, Xingyu Yu, Junjie Pan, Xiaoli Fan, Tengfei Zhang, Xin Sun & Jianping He
Metal-organic framework materials (MOFs) have been widely studied because of their adjustable composition and controllable structure in the field of microwave absorption (MA). Therein, Prussian blue analogs (PBA) have attracted the attention of researchers with ultra-high metal content. However, the attenuation ability of microwave for PBA-based composites is still unsatisfactory up to now. Therefore, the NiFe/CoFe@C composites were prepared by carbonizing polymetallic PBA (NiCoFe PBA) materials in this work, and the influence of different metal...

Additional file 1 of Understanding how and under what circumstances decision coaching works for people making healthcare decisions: a realist review

Junqiang Zhao, Janet Jull, Jeanette Finderup, Maureen Smith, Simone Maria Kienlin, Anne Christin Rahn, Sandra Dunn, Yumi Aoki, Leanne Brown, Gillian Harvey & Dawn Stacey
Additional file 1: Appendix A: Demographic of executive and stakeholder group members. Appendix B: Initial program theory. Appendix C: Relevance rating checklist. Appendix D: Data extraction form.

Cyber Security and Ransomware in Financial Markets

Toni Ahnert, Michael Brolley, David Cimon & Ryan Riordan
Financial markets face the constant threat of cyber attacks. We develop a principal-agent model of cyber-attacking with fee-paying clients who delegate security decisions to financial platforms. We derive testable implications about clients’ vulnerability to cyber attacks and about the fees charged. We characterize which cyber attacks actors choose. We find that ransomware attacks are more successful than traditional attacks and that platforms underinvest in security when security is unobservable. Regulating security investment (e.g., minimum security...

AMEE Guide to ethical teaching in online medical education: AMEE Guide No. 146

Ken Masters, David Taylor, Teresa Loda & Anne Herrmann-Werner
The Covid-19 pandemic necessitated Emergency Remote Teaching (ERT): the sudden move of educational materials online. While ERT served its purpose, medical teachers are now faced with the long-term and complex demands of formal online teaching. One of these demands is ethical online teaching. Although ethical teaching is practiced in face-to-face situations, online teaching has new ethical issues that must be accommodated, and medical teachers who wish to teach online must be aware of these and...

Emerging pharmacologic interventions for pre-eclampsia treatment

Xiao Zhang, Yue Chen, Dongli Sun, Xiaojun Zhu, Xia Ying, Yao Yao, Weidong Fei & Caihong Zheng
Pre-eclampsia is a serious pregnancy complication and a major global concern for the mortality of both mother and fetus. Existing symptomatic treatments do not delay disease progression; thus, timely delivery of the baby is the most effective measure. However, the risk of various maternal and fetal injuries remains. In this review, we summarize potential strategies for pharmacologic interventions in pre-eclamptic therapy. Specifically, we discuss the pathophysiological process of various effective candidate therapeutics that act on...

Microbiological risks associated with hot-drinks vending

Andrew Hall
The UK vending industry has received little microbiological attention. Although reported cases of gastroenteritis related to hot-drinks vending are rare,there is evidence of microbial contamination and one reported outbreak of gastroenteritis concerning consumption of hot chocolate. This thesis examines the microbiologyof hot-drinks vending operations, the effect of commonly used cleaning protocols on the microbial load of vending components and vended hot drinks and assesses the microbiological risks associated with hot-drinks vending machines. A survey of...

Registration Year

  • 2022
    45

Resource Types

  • Text
    45

Affiliations

  • Queen's University
    45
  • Shanghai Jiao Tong University
    17
  • Peking University
    17
  • Ministry of Education of the People's Republic of China
    16
  • Huazhong University of Science and Technology
    14
  • Zhejiang University
    11
  • Capital Medical University
    11
  • Southern University of Science and Technology
    10
  • West China Hospital of Sichuan University
    9
  • Tianjin Medical University Cancer Institute and Hospital
    8