Additional file 1: Supplementary table 1. Frequencies of the congenital anomalies registered in SINASC according to ICD-10 categories. Mato Grosso do Sul, Brazil. 2015-2018.

Additional file 2: Supplementary table 2. Frequencies and incidences of congenital anomalies per 10,000 births according to the ICD-10 and the year of occurrence. Mato Grosso do Sul, Brazil. 2015-2018.

Additional file 3: Supplementary table 3. Frequencies of maternal, gestational, and birth data according to the ICD-10 categories of congenital anomalies. Mato Grosso do Sul, Brazil. 2015-2018.

Atopic dermatitis (AD) is a chronic inflammatory skin disease and colonization by Staphylococcus aureus may affect up to 100% of these patients. Virulent and resistant isolates can worsen AD patient clinical condition and jeopardize the treatment. We aimed to detect virulence genes and to evaluate the biofilm production of S. aureus isolates from infected skin lesions of children with AD. Methicillin resistance was detected by phenotypic and molecular tests and the virulence genes were detected...

Additional file 2. Table S2. Socio-demographic according to group the indigenous people from Amazon State and individuals from Northeast region. FIOCRUZ Biological Samples Panel, 2020.

Gestational trophoblastic neoplasia (GTN) is a rare tumor that arises from trophoblastic tissues with high remission rates after chemotherapy treatment. GTN can develop from any gestational events, such as miscarriage, ectopic pregnancy, and preterm/term pregnancy, but is more frequent after hydatidiform mole. The sensitivity of this tumor to chemotherapy and the presence of an exceptional tumor marker allow high remission rates, especially when patients are treated in referral centers. Observational, retrospective, prospective, systematic reviews, and...

Atopic dermatitis (AD) is a chronic inflammatory skin disease and colonization by Staphylococcus aureus may affect up to 100% of these patients. Virulent and resistant isolates can worsen AD patient clinical condition and jeopardize the treatment. We aimed to detect virulence genes and to evaluate the biofilm production of S. aureus isolates from infected skin lesions of children with AD. Methicillin resistance was detected by phenotypic and molecular tests and the virulence genes were detected...

Additional file 3. Appendix.

Additional file 1: Table S1. Plants from central Argentina screened for Mdr1 and Cdr1 inhibitory effect. Fig. S1 Flow cytometric determinations of the effect of Acalypha communis extract on Nile Red accumulation in: (A) Candida albicans 1114; (B) Saccharomyces cerevisiae AD/CaMDR1; (C) Saccharomyces cerevisiae AD/CaCDR1; and (D) Candida glabrata 109. Fig. S2 Flow cytometric determinations of the effect of Solanum atriplicifolium extract on Nile Red accumulation in: (A) Candida albicans 1114; (B) Saccharomyces cerevisiae AD/CaMDR1;...

Atopic dermatitis (AD) is a chronic inflammatory skin disease and colonization by Staphylococcus aureus may affect up to 100% of these patients. Virulent and resistant isolates can worsen AD patient clinical condition and jeopardize the treatment. We aimed to detect virulence genes and to evaluate the biofilm production of S. aureus isolates from infected skin lesions of children with AD. Methicillin resistance was detected by phenotypic and molecular tests and the virulence genes were detected...

Additional file 3. Appendix.

Supplementary Material 1

Supplementary Material 1

Supplementary Material 2

Additional file 2: Supplementary table 2. Frequencies and incidences of congenital anomalies per 10,000 births according to the ICD-10 and the year of occurrence. Mato Grosso do Sul, Brazil. 2015-2018.

Ureases catalyze the hydrolysis of urea into carbamate and ammonia. Well-conserved proteins, most plant ureases are hexamers of a single chain subunit, like the most abundant isoform of the jack bean (Canavalia ensiformis) urease (JBU). Canatoxin (CNTX) was originally isolated from these seeds as a neurotoxic protein, and later characterized as an isoform of JBU with lower molecular mass and enzyme activity. Inactive CNTX oligomers form upon storage and stabilization of CNTX was achieved by...

We synthesised and screened 18 aromatic derivatives of guanylhydrazones and oximes aromatic for their capacity to bind to dengue virus capsid protein (DENVC). The intended therapeutic target was the hydrophobic cleft of DENVC, which is a region responsible for its anchoring in lipid droplets in the infected cells. The inhibition of this process completely suppresses virus infectivity. Using NMR, we describe five compounds able to bind to the α1-α2 interface in the hydrophobic cleft. Saturation...

Additional file 1: Table S1. Plants from central Argentina screened for Mdr1 and Cdr1 inhibitory effect. Fig. S1 Flow cytometric determinations of the effect of Acalypha communis extract on Nile Red accumulation in: (A) Candida albicans 1114; (B) Saccharomyces cerevisiae AD/CaMDR1; (C) Saccharomyces cerevisiae AD/CaCDR1; and (D) Candida glabrata 109. Fig. S2 Flow cytometric determinations of the effect of Solanum atriplicifolium extract on Nile Red accumulation in: (A) Candida albicans 1114; (B) Saccharomyces cerevisiae AD/CaMDR1;...

Additional file 1: Supplementary table 1. Frequencies of the congenital anomalies registered in SINASC according to ICD-10 categories. Mato Grosso do Sul, Brazil. 2015-2018.

Ureases catalyze the hydrolysis of urea into carbamate and ammonia. Well-conserved proteins, most plant ureases are hexamers of a single chain subunit, like the most abundant isoform of the jack bean (Canavalia ensiformis) urease (JBU). Canatoxin (CNTX) was originally isolated from these seeds as a neurotoxic protein, and later characterized as an isoform of JBU with lower molecular mass and enzyme activity. Inactive CNTX oligomers form upon storage and stabilization of CNTX was achieved by...

Supplementary Material 2

Additional file 1. Table S1. Risk behaviors for HCV infection according to each group in the study FIOCRUZ Viral Hepatitis Laboratory, Biological Samples Panel, 2020.

Gestational trophoblastic neoplasia (GTN) is a rare tumor that arises from trophoblastic tissues with high remission rates after chemotherapy treatment. GTN can develop from any gestational events, such as miscarriage, ectopic pregnancy, and preterm/term pregnancy, but is more frequent after hydatidiform mole. The sensitivity of this tumor to chemotherapy and the presence of an exceptional tumor marker allow high remission rates, especially when patients are treated in referral centers. Observational, retrospective, prospective, systematic reviews, and...