To date, several different types of synthetic genetic switches, including riboregulators, riboswitches, and toehold switches, have been developed to construct AND, OR, NOT, NAND, NOR, and NOT IMPLICATION (NIMP) gates. The logic gate can integrate multiple input signals following a set of algorithms and generate a response only if strictly defined conditions are met. However, there are still some logic gates that have not been implemented but are necessary to build complex genetic circuits. Here,...

Additional file 1. Included all the supplementary tables for this manuscript.

Additional file 1. Appendix A. Supplementary data.

Supplemental material, sj-docx-1-npx-10.1177_1934578X221127960 for The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy by Qingqing Shan, Yifan Zhang, Xu Zhang, Wei Wang and Zongan Liang in Natural Product Communications

Additional file 1: Flowchart 1. Diagram of the hypothesis of pathogenesis Unknown antigens or environmental factors can trigger the activation of innate immune cells. These activated immune cells can produce a large number of inflammatory factors, such as interleukin (IL)-23 and TNF -α, which can induce the differentiation of primitive T cells into Th17 cells, and the activated Th17 cells then can overproduce IL-17 and IL-22, etc., promoting the proliferation of keratinocytes and recruiting pro-inflammatory...

Supplemental material, sj-doc-2-tct-10.1177_15330338221132669 for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer by Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao and Xin Wang in Technology in Cancer Research & Treatment

Supplemental material, sj-doc-6-tct-10.1177_15330338221132669 for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer by Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao and Xin Wang in Technology in Cancer Research & Treatment

Patients with chronic obstructive pulmonary disease (COPD) suffer from persistent cough and breathlessness, which can be ameliorated by the Chinese herbal medicine glycyrrhiza. Furthermore, the SRC/MAPK pathway is activated in the process of oxidative stress and inflammation, which afflict COPD progression. Thus, this research aimed at dissecting the mechanism of compound glycyrrhiza oral solution (CGOS) relieving oxidative stress and inflammation in COPD via the SRC/MAPK pathway. After a COPD rat model was established using lipopolysaccharide...

Supplemental material, sj-docx-1-jcc-10.1177_00220221221132810 for Unsociability and Psychological and School Adjustment in Chinese Children: The Moderating Effects of Peer Group Cultural Orientations by Siman Zhao, Mengting Liu, Xinyin Chen, Dan Li, Junsheng Liu and Shihong Liu in Journal of Cross-Cultural Psychology

Supplemental material, sj-docx-1-sgo-10.1177_21582440221141299 for Correlation Monitoring Method and model of Science-Technology-Industry in the AI Field: A Case of the Neural Network by Xiaoli Wang, Yun Liu, Lingdi Chen and Yifan Zhang in SAGE Open

Understanding the prevalence of vision conditions in a population is critical for determining the most appropriate strategies for detecting and correcting eye conditions in a community. This is particularly important in very remote regions where access to vision testing services is limited. Although recent studies have provided detailed analyses of the prevalence of vision conditions in Aboriginal and/or Torres Strait Islander children in urban and regional areas of Australia, there is a paucity of research...

Supplemental Document

Antibiotic resistance genes (ARGs) are widespread in aquaculture and pose a huge threat to aquaculture organisms and human health. In this study, occurrences and relative abundances of ARGs were analysed in the guts of products cultured in freshwater ponds in the Yangtze River Delta region in China. A total of 29 ARGs were found in the gut samples, with detection frequencies ranging from 4.8% to 81%, and the relative abundances (ARGs/16S rRNA) ranging from 10−7...

A fixed one-sided significance level of 5% is commonly used to interpret the statistical significance of randomized clinical trial (RCT) outcomes. While it is necessary to reduce the false positive rate, the threshold used could be chosen quantitatively and transparently to specifically reflect patient preferences regarding benefit–risk tradeoffs as well as other considerations. How can patient preferences be explicitly incorporated into RCTs in Parkinson’s disease (PD), and what is the impact on statistical thresholds for...

Supplemental material, sj-docx-1-npx-10.1177_1934578X221127960 for The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy by Qingqing Shan, Yifan Zhang, Xu Zhang, Wei Wang and Zongan Liang in Natural Product Communications

Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as a novel transcriptional activator of cytoprotective autophagy crucial for zinc homeostasis in cancer cells. Gain- and loss-of-function studies showed that E2F4 promoted autophagy in a cell cycle-dependent manner, resulting in facilitated degradation of MT (metallothionein) proteins, elevated distribution of Zn2+ within autophagosomes,...

Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as a novel transcriptional activator of cytoprotective autophagy crucial for zinc homeostasis in cancer cells. Gain- and loss-of-function studies showed that E2F4 promoted autophagy in a cell cycle-dependent manner, resulting in facilitated degradation of MT (metallothionein) proteins, elevated distribution of Zn2+ within autophagosomes,...

Supplemental material, sj-docx-2-npx-10.1177_1934578X221127960 for The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy by Qingqing Shan, Yifan Zhang, Xu Zhang, Wei Wang and Zongan Liang in Natural Product Communications

Supplemental material, sj-docx-2-npx-10.1177_1934578X221127960 for The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy by Qingqing Shan, Yifan Zhang, Xu Zhang, Wei Wang and Zongan Liang in Natural Product Communications

Understanding the prevalence of vision conditions in a population is critical for determining the most appropriate strategies for detecting and correcting eye conditions in a community. This is particularly important in very remote regions where access to vision testing services is limited. Although recent studies have provided detailed analyses of the prevalence of vision conditions in Aboriginal and/or Torres Strait Islander children in urban and regional areas of Australia, there is a paucity of research...

Supplemental material, sj-docx-1-heb-10.1177_10901981221148965 for Framing Effects in Youth E-Cigarette Use Prevention: Individual Text Messages Versus Simulated Text Exchanges by Xiaoquan Zhao, Xiaomei Cai and Andrea Malterud in Health Education & Behavior

Additional file 1. Included all the supplementary tables for this manuscript.

Additional file 1. Appendix A. Supplementary data.

Antibiotic resistance genes (ARGs) are widespread in aquaculture and pose a huge threat to aquaculture organisms and human health. In this study, occurrences and relative abundances of ARGs were analysed in the guts of products cultured in freshwater ponds in the Yangtze River Delta region in China. A total of 29 ARGs were found in the gut samples, with detection frequencies ranging from 4.8% to 81%, and the relative abundances (ARGs/16S rRNA) ranging from 10−7...