Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular matrix remodeling in cardiac fibroblasts implicating its potential role in treating of pathologic cardiac remodeling. However, the intrinsically poor solubility and bioavailability of tanshinone IIA hindered its clinical application. Here we develop monomethoxy-poly (ethylene glycol)-poly (lactic acid)-D-α-Tocopheryl polyethylene glycol 1000 succinate (mPEG-PLA-TPGS) nanoparticle incorporating tanshinone IIA (tanshinone IIA-NPs) and study its efficacy in post-infarction left ventricular (LV) remodeling. Male C57BL/6 mice underwent left coronary...

To analyze the feasibility of and pain-related tolerance to a maximal cardiopulmonary exercise test (CPET), and the relationship between the aerobic capacity and central sensitization (CS) in patients with chronic low back pain (CLBP). An observational study, combining a cross-sectional and a prospective 24-hour follow-up was performed. Participants underwent a maximal CPET on a cycle ergometer and were assessed with three measures of CS (CS Inventory, quantitative sensory testing and heart rate variability). Before the...

Additional file 1: Supplemental Material 1. Online questionnaire on PPC structures in Europe used for the study purpose.

Additional file 2. National Health Commission of China for Guiding Principle of Clinical Use of Antibiotics.

Additional file 1. Catalogue for Clinical Application of Antibacterial Drugs.

In this work, an efficient synthesis of 3-hydroxy chromones was accomplished through oxidative cyclization mediated by lipase. This enzymatic process has salient features of environmental friendliness, mild reaction condition, satisfactory yield, green reusable biocatalyst, and short reaction time. The proposed method expands the application of lipase in organic synthesis.

Additional file 1: Fig. S1. Plot of population-averaged input function. The y-axis is in logarithmic scale. Fig. S2. Bland–Altman plot of lesion Ki differences obtained with the IDIF minus the PIF scaled to the scan time interval at 30–60 min p.i. (PIF_30) (A), and the PIF scaled to the IDIF at shorter scan time intervals p.i. (PIF_40 and PIF_50) (B and C). For readability, the scales have been adjusted per subfigure.

Additional file 1: Fig. S1. Plot of population-averaged input function. The y-axis is in logarithmic scale. Fig. S2. Bland–Altman plot of lesion Ki differences obtained with the IDIF minus the PIF scaled to the scan time interval at 30–60 min p.i. (PIF_30) (A), and the PIF scaled to the IDIF at shorter scan time intervals p.i. (PIF_40 and PIF_50) (B and C). For readability, the scales have been adjusted per subfigure.

Additional file 1.

Additional file 1.

Additional file 2.

Additional file 1: Supplementary Fig. 1 Morphology of ‘HFBZ’ and ‘LFBZ’ fruit at harvest. a ‘HFBZ’ fruit (Left) and ‘LFBZ’ (Right) fruit. b Transverse and longitudinal diameter, and weight of ‘HFBZ’ and ‘LFBZ’ fruit. c Anthocyanin content of ‘HFBZ’ and ‘LFBZ’ fruit. The scale bar is 1 cm in a. Supplementary Fig. 2 Liquid chromatography profiles of sucrose, glucose, and fructose standards. Supplementary Fig. 3 Chromatograms of free amino acid standard (a) and free amino...

Revised Supporting information

To systematically review literature on nutritional intake, nutritional status and nutritional interventions, and to study their association with short- and long-term clinical outcomes in people with a major dysvascular lower limb amputation. PubMed, Ovid, CINAHL, and The Cochrane Library were searched. Studies were included if nutritional intake, nutritional status, or nutritional interventions in people with a major dysvascular lower limb amputation were analyzed. Of the 3038 unique papers identified, 30 studies were included. Methodological quality...

Supplemental Material for Bortezomib induces cellular senescence in A549 lung cancer cells by stimulating telomere shortening by Lei Wang, Hang Yin, Shiren Huang, Sini Huang, Congcong Huang, Zhao Zhang, amd Hui Liu in Human & Experimental Toxicology

Additional file 1: Supplementary Fig. 1 Morphology of ‘HFBZ’ and ‘LFBZ’ fruit at harvest. a ‘HFBZ’ fruit (Left) and ‘LFBZ’ (Right) fruit. b Transverse and longitudinal diameter, and weight of ‘HFBZ’ and ‘LFBZ’ fruit. c Anthocyanin content of ‘HFBZ’ and ‘LFBZ’ fruit. The scale bar is 1 cm in a. Supplementary Fig. 2 Liquid chromatography profiles of sucrose, glucose, and fructose standards. Supplementary Fig. 3 Chromatograms of free amino acid standard (a) and free amino...

Supplemental material, sj-docx-1-smo-10.1177_20503121221133935 for Food taboos among pregnant women and associated factors in eastern Ethiopia: A community-based cross-sectional study by Wbalem Amare, Abera Kenay Tura, Agumasie Semahegn and Kedir Teji Roba in SAGE Open Medicine

Additional file 2. Informed consent form.

Revised Supporting information

Supplemental material, sj-pdf-1-eso-10.1177_23969873221143210 for Timing and causes of death after endovascular thrombectomy in patients with acute ischemic stroke by Wouter M Sluis, Wouter H Hinsenveld, Robert-Jan B Goldhoorn, Lianne H Potters, Agnetha AE Bruggeman, Anouk van der Hoorn, Joseph CJ Bot, Robert J van Oostenbrugge, Hester F Lingsma, Jeannette Hofmeijer, Wim H van Zwam, Charles BLM Majoie and H Bart van der Worp in European Stroke Journal

Supplemental Material for Clinical outcomes of mild versus moderate hypothermic circulatory arrest with antegrade cerebral perfusion in adult aortic arch surgery: A systematic review and meta-analysis by Lei Wang, Guodong Zhong, Xiaochai Lv, Yi Dong, Yanting Hou and Liangwan Chen in Perfusion

Supplemental Material for Clinical outcomes of mild versus moderate hypothermic circulatory arrest with antegrade cerebral perfusion in adult aortic arch surgery: A systematic review and meta-analysis by Lei Wang, Guodong Zhong, Xiaochai Lv, Yi Dong, Yanting Hou and Liangwan Chen in Perfusion

Supplemental material, sj-docx-1-inc-10.1177_17511437221139547 for The prevalence of mental frailty in ICU survivors and informal caregiver strain: A 1-year retrospective study of the Frisian aftercare cohort by Lise F E Beumeler, Carina Bethlehem, Thialda T Hoogstins-Vlagsma, Tim van Zutphen, Hanneke Buter, Gerjan J Navis and E Christiaan Boerma in Journal of the Intensive Care Society

Supplemental material, sj-docx-1-taj-10.1177_20406223231153097 for The efficacy of telemedicine for pain management in patients with cancer: a systematic review and meta-analysis by Wenyu Chen, Jie Huang, Zhifang Cui, Lei Wang, Liang Dong, Weifeng Ying and Ye Zhang in Therapeutic Advances in Chronic Disease

Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is highly expressed in smokers, but little is known about the molecular mechanism of UCHL1 in airway epithelium and its possible role in affecting extracellular matrix (ECM) remodelling in the underlying submucosa. Since cigarette smoking is a major cause of lung diseases, we studied its effect on UCHL1 expression and DNA methylation patterns in human bronchial epithelial cells, obtained after laser capture micro-dissection (LCM) or isolated from residual tracheal/main stem...