18 Works

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial.

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
BACKGROUND: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and then...

Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial.

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
BACKGROUND: Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and then...

Additional file 1 of Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred

Richter Razafindratsimandresy, Marie-Line Joffret, Soa Fy Andriamandimby, Seta Andriamamonjy, Sendraharimanana Rabemanantsoa, Vincent Richard, Francis Delpeyroux, Jean-Michel Heraud & Maël Bessaud
Additional file 1: Table S1. Accession numbers of the sequences used to draw the tree displayed in Fig. 7.

Additional file 3 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 3. Analyses and findings on anemia and PRO-CCM. Table S5. Prevalence of anemia among all women of reproductive age at baseline and endline, by study arm. Table S6. Unadjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models. Table S7. Adjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models.

Additional file 2 of Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred

Richter Razafindratsimandresy, Marie-Line Joffret, Soa Fy Andriamandimby, Seta Andriamamonjy, Sendraharimanana Rabemanantsoa, Vincent Richard, Francis Delpeyroux, Jean-Michel Heraud & Maël Bessaud
Additional file 2: Figure S1. Detection of NPEVs on RD and HEp-2c cells.

Additional file 1 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 1: Figure S1. Flowchart of the households and individuals included on the survey from the baseline. Figure S2. Comparison of malaria incidence and positivity in the intervention area during March-October 2017 with average values for Mananjary District. Figure S3. Comparison of malaria community case management in the intervention and control arms during pro-CCM implementation and during the two years prior. Figure S4. Map of Mananjary district and the fokontany included in the intervention...

Additional file 2 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 2. Table S1. Distribution of positive RDT results in the 22 fokontany. Table S2. Impact of Pro-CCM and IRS on malaria prevalence, per-protocol analyses. Table S3. Comparison of observed proportion of parasite prevalence by RDT by age group between intervention and control arms. Table S4. Comparison of reported bed net use (LLIN) by age group between baseline and endline surveys.

Additional file 3 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 3. Analyses and findings on anemia and PRO-CCM. Table S5. Prevalence of anemia among all women of reproductive age at baseline and endline, by study arm. Table S6. Unadjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models. Table S7. Adjusted analyses of prevalence of anemia among all women of reproductive age at baseline, using logistic regression models.

Additional file 1 of Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Additional file 1. Modified MARAIS Score (modified from Marais et al. [27]).

Additional file 3 of Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred

Richter Razafindratsimandresy, Marie-Line Joffret, Soa Fy Andriamandimby, Seta Andriamamonjy, Sendraharimanana Rabemanantsoa, Vincent Richard, Francis Delpeyroux, Jean-Michel Heraud & Maël Bessaud
Additional file 3: Figure S2. Phylogenetic trees of Madagascan EV-Cs based on the 5′UTR, the VP1- and the 3D-encoding sequences. The isolates are colour-coded according to their respective type; triangles indicate isolates from this study, circles isolates from previous works.

Genetic diversity and molecular epidemiology of Middle East Respiratory Syndrome Coronavirus in dromedaries in Ethiopia, 2017–2020

Ziqi Zhou, Abraham Ali, Elias Walelign, Getnet F. Demissie, Ihab El Masry, Takele Abayneh, Belayneh Getachew, Pavithra Krishnan, Daisy Y.M. Ng, Emma Gardner, Yilma Makonnen, Eve Miguel, Véronique Chevalier, Daniel K. Chu, Ray T. Y. So, Sophie Von Dobschuetz, Gezahegne Mamo, Leo L. M. Poon & Malik Peiris
Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary camels and causes zoonotic infection and disease in humans. Although over 80% of the global population of infected dromedary camels are found in Africa, zoonotic disease had only been reported in the Arabia Peninsula and travel-associated disease has been reported elsewhere. In this study, genetic diversity and molecular epidemiology of MERS-CoV in dromedary camels in Ethiopia were investigated during 2017–2020. Of 1766 nasal swab samples...

Additional file 1 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 1: Figure S1. Flowchart of the households and individuals included on the survey from the baseline. Figure S2. Comparison of malaria incidence and positivity in the intervention area during March-October 2017 with average values for Mananjary District. Figure S3. Comparison of malaria community case management in the intervention and control arms during pro-CCM implementation and during the two years prior. Figure S4. Map of Mananjary district and the fokontany included in the intervention...

Additional file 2 of Proactive community case management decreased malaria prevalence in rural Madagascar: results from a cluster randomized trial

Rila Ratovoson, Andres Garchitorena, Daouda Kassie, Jemima A. Ravelonarivo, Voahangy Andrianaranjaka, Seheno Razanatsiorimalala, Avotra Razafimandimby, Fanjasoa Rakotomanana, Laurie Ohlstein, Reziky Mangahasimbola, Sandro A. N. Randrianirisoa, Jocelyn Razafindrakoto, Catherine M. Dentinger, John Williamson, Laurent Kapesa, Patrice Piola, Milijaona Randrianarivelojosia, Julie Thwing, Laura C. Steinhardt & Laurence Baril
Additional file 2. Table S1. Distribution of positive RDT results in the 22 fokontany. Table S2. Impact of Pro-CCM and IRS on malaria prevalence, per-protocol analyses. Table S3. Comparison of observed proportion of parasite prevalence by RDT by age group between intervention and control arms. Table S4. Comparison of reported bed net use (LLIN) by age group between baseline and endline surveys.

Additional file 1 of Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial

Thomas Maitre, Maryline Bonnet, Alexandra Calmy, Mihaja Raberahona, Rivonirina Andry Rakotoarivelo, Niaina Rakotosamimanana, Juan Ambrosioni, José M. Miró, Pierre Debeaudrap, Conrad Muzoora, Angharad Davis, Graeme Meintjes, Sean Wasserman, Robert Wilkinson, Serge Eholié, Frédéric Ello Nogbou, Maria-Camilla Calvo-Cortes, Corine Chazallon, Vanessa Machault, Xavier Anglaret & Fabrice Bonnet
Additional file 1. Modified MARAIS Score (modified from Marais et al. [27]).

Additional file 2 of Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred

Richter Razafindratsimandresy, Marie-Line Joffret, Soa Fy Andriamandimby, Seta Andriamamonjy, Sendraharimanana Rabemanantsoa, Vincent Richard, Francis Delpeyroux, Jean-Michel Heraud & Maël Bessaud
Additional file 2: Figure S1. Detection of NPEVs on RD and HEp-2c cells.

Additional file 3 of Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred

Richter Razafindratsimandresy, Marie-Line Joffret, Soa Fy Andriamandimby, Seta Andriamamonjy, Sendraharimanana Rabemanantsoa, Vincent Richard, Francis Delpeyroux, Jean-Michel Heraud & Maël Bessaud
Additional file 3: Figure S2. Phylogenetic trees of Madagascan EV-Cs based on the 5′UTR, the VP1- and the 3D-encoding sequences. The isolates are colour-coded according to their respective type; triangles indicate isolates from this study, circles isolates from previous works.

Genetic diversity and molecular epidemiology of Middle East Respiratory Syndrome Coronavirus in dromedaries in Ethiopia, 2017–2020

Ziqi Zhou, Abraham Ali, Elias Walelign, Getnet F. Demissie, Ihab El Masry, Takele Abayneh, Belayneh Getachew, Pavithra Krishnan, Daisy Y.M. Ng, Emma Gardner, Yilma Makonnen, Eve Miguel, Véronique Chevalier, Daniel K. Chu, Ray T. Y. So, Sophie Von Dobschuetz, Gezahegne Mamo, Leo L. M. Poon & Malik Peiris
Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary camels and causes zoonotic infection and disease in humans. Although over 80% of the global population of infected dromedary camels are found in Africa, zoonotic disease had only been reported in the Arabia Peninsula and travel-associated disease has been reported elsewhere. In this study, genetic diversity and molecular epidemiology of MERS-CoV in dromedary camels in Ethiopia were investigated during 2017–2020. Of 1766 nasal swab samples...

Additional file 1 of Enterovirus detection in different regions of Madagascar reveals a higher abundance of enteroviruses of species C in areas where several outbreaks of vaccine-derived polioviruses occurred

Richter Razafindratsimandresy, Marie-Line Joffret, Soa Fy Andriamandimby, Seta Andriamamonjy, Sendraharimanana Rabemanantsoa, Vincent Richard, Francis Delpeyroux, Jean-Michel Heraud & Maël Bessaud
Additional file 1: Table S1. Accession numbers of the sequences used to draw the tree displayed in Fig. 7.

Registration Year

  • 2023
    2
  • 2022
    16

Resource Types

  • Text
    18

Affiliations

  • Institut Pasteur de Madagascar
    18
  • University of Antananarivo
    10
  • Institut Pasteur du Cambodge
    8
  • Centre de Coopération Internationale en Recherche Agronomique pour le Développement
    8
  • Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
    6
  • Center for Global Health
    6
  • University of Toliara
    6
  • Centers for Disease Control and Prevention
    6
  • Institut Pasteur
    6
  • University of Montpellier
    6