"L'Auto" was the leading French sports daily of the first half of the 20th century. Launched in October 1900, it quickly gained a dominant position in the sports news market, which it held until its demise in August 1944. Its print run made it one of the leading national newspapers. It is renowned for the quality of the information it delivers to its readers day after day, information for which it often has the first...

Intensive care units (ICU) are among the healthcare services most affected by the COVID-19 crisis. Stressors related to insecurity, unpredictability, patient death and family distress are significant, and put healthcare workers (HCWs) at high risk of post-traumatic stress disorder (PTSD). The aims of this study were to measure the prevalence of post-traumatic stress disorder in HCWs and to identify risk factors and protective factors during the epidemic in France. During the first peak of the...

Additional file 1: Table S1. Hemodynamic and echocardiographic measurements according to congestive response to diuretic treatment (Appropriate fluid depletion vs Control). $p < 0.05 comparison between two groups of patient. *p < 0.05 comparison with baseline.

Additional file 1: Figure S1. Expression of HTC in L. lactis after 4 hours post-induction by nisin. Total membrane proteins (5 µg for panel A, 5 and 10 µg for panel B) were separated in a 12% SDS–PAGE and analyzed by Western blot performed using either an antibody specific to caveolin-1 (A; 1/7500) or an HRP-conjugate specific to the His-tag affinity tag (B; 1/5000). A positive control protein containing caveolin-1β (C+) and the band of...

While de novo mutations (DNMs) are key to genetic diversity, they are also responsible for a high number of rare disorders. To date, no study has systematically examined the rate and distribution of DNMs in multiplex families in highly consanguineous populations. Leveraging WGS profiles of 645 individuals in 146 families, we implemented a combinatorial approach using 3 complementary tools for DNM discovery in 353 unique trio combinations. We found a total of 27,168 DNMs (median:...

Additional file 1: Figure S1. Expression of HTC in L. lactis after 4 hours post-induction by nisin. Total membrane proteins (5 µg for panel A, 5 and 10 µg for panel B) were separated in a 12% SDS–PAGE and analyzed by Western blot performed using either an antibody specific to caveolin-1 (A; 1/7500) or an HRP-conjugate specific to the His-tag affinity tag (B; 1/5000). A positive control protein containing caveolin-1β (C+) and the band of...

While de novo mutations (DNMs) are key to genetic diversity, they are also responsible for a high number of rare disorders. To date, no study has systematically examined the rate and distribution of DNMs in multiplex families in highly consanguineous populations. Leveraging WGS profiles of 645 individuals in 146 families, we implemented a combinatorial approach using 3 complementary tools for DNM discovery in 353 unique trio combinations. We found a total of 27,168 DNMs (median:...

Intensive care units (ICU) are among the healthcare services most affected by the COVID-19 crisis. Stressors related to insecurity, unpredictability, patient death and family distress are significant, and put healthcare workers (HCWs) at high risk of post-traumatic stress disorder (PTSD). The aims of this study were to measure the prevalence of post-traumatic stress disorder in HCWs and to identify risk factors and protective factors during the epidemic in France. During the first peak of the...

Additional file 1: Table S1. Hemodynamic and echocardiographic measurements according to congestive response to diuretic treatment (Appropriate fluid depletion vs Control). $p < 0.05 comparison between two groups of patient. *p < 0.05 comparison with baseline.

Additional file 1. Contains Tables S1-S4 and Figures S1-S6, providing further information on data sources, model structures and results of sensitivity analyses.

Additional file 1. Contains Tables S1-S4 and Figures S1-S6, providing further information on data sources, model structures and results of sensitivity analyses.

Additional file 1: Fig. S1. Study flowchart. Table S1. Baseline characteristics and mortality in the groups with vs. without mild-to-moderate postresuscitation shock (PRS) at intensive-care-unit (ICU) admission. Table S2. Multivariate logistic regression modelling to identify admission variables associated with a favourable outcome on day 90 in the overall population (n = 532).

Additional file 1: Fig. S1. Study flowchart. Table S1. Baseline characteristics and mortality in the groups with vs. without mild-to-moderate postresuscitation shock (PRS) at intensive-care-unit (ICU) admission. Table S2. Multivariate logistic regression modelling to identify admission variables associated with a favourable outcome on day 90 in the overall population (n = 532).