Adhesives with properties of low-temperature and water-resistance are important in manufacturing. In this work, dopamine hydrochloride (DA), containing catechol groups, was introduced into the polymer by covalent grafting to obtain water-resistant films. Films with low-temperature and water-resistance properties were obtained through layer-by-layer assembly of branched polyethyleneimine (bPEI) and chemically cross-linked hyaluronate (HA)-DA (denoted HA-D). The film surfaces were wetted with moisture generated from low-temperature pretreatment, and the resulting films, named as bPEI/HA-D multilayer films, could...

Supplemental material, sj-pdf-1-ajs-10.1177_03635465211030259 for Quadriceps Tendon Autograft Versus Bone–Patellar Tendon–Bone and Hamstring Tendon Autografts for Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis by Wenli Dai, Xi Leng, Jian Wang, Jin Cheng, Xiaoqing Hu and Yingfang Ao in The American Journal of Sports Medicine

It was found that bisphenol F (BPF) could be anaerobically transformed to 4,4-dihydroxybenzophenone using nitrate as an electron acceptor by Pseudomonas sp. LS. However, BPF removal was a slow process under anaerobic conditions. In the present study, effects of graphene oxide (GO) and graphene on the anaerobic transformation of BPF were studied in detail. Results showed that GO (2–10 mg/L) and graphene (2–20 mg/L) could increase the anaerobic biotransformation rate of BPF. For GO-mediated system,...

Smart phase transformation systems@hard capsule (SPTS@hard capsule) based on lyotropic liquid crystalline (LLC) were developed for oral sustained release in this study. Doxycycline hydrochloride (DOXY) and meloxicam (MLX) were used as hydrophilic and hydrophobic model drug, respectively. Two systems were added with different additives, that is, gelucire 39/01, PEG 1000 and Tween 80 to adjust their melting point and release profiles. The phase transformation of these systems could be triggered by water as well as...

We conducted a meta-analysis to systematically review the efficacy and safety of pembrolizumab for advanced NSCLC. Databases were searched for randomized controlled trials (RCTs) treated with pembrolizumab till July 2021. Seven RCTs and 3988 patients were included. Our analysis suggests that pembrolizumab was more effective at improving PFS (HR, 0.59; 95% CI: 0.43–0.79; p = 0.0005), OS (HR, 0.65; 95% CI: 0.55–0.76; p ＜ 0.00001) and ORR (RR, 1.85; 95% CI: 1.64–2.09; p ＜ 0.00001)...

Participation of undergraduate students in research helps them nurture critical thinking, develop research skills, enhance self-confidence, and clarify their education or career paths. The curriculum is central to integrating teaching and research, and is a primary source for providing undergraduate research experience. This study designed a MATLAB course for undergraduate students in Cartography and Geographic Information Science. This course integrated various models of research–teaching nexus and combined MATLAB with the profession, aiming to benefit students’...

This paper considers a single-machine scheduling problem with sequence-dependent setup times and energy-generation and storage systems. Each job requires a sequence-dependent setup to be processed on the machine, and both setup and processing of the job require job-dependent amounts of energy. The energy consumed by the machine can be bought from an Electric Power Company (EPC) or generated by own Distributed Energy Resource (DER), such as solar photovoltaic or wind, and the energy can be...

Research was insufficient on the surface urban heat islands (SUHIs) in China during the morning and before midnight. Therefore, we studied the spatio-temporal variations and ten determinants of SUHI intensities (SUHIIs) at ∼10:30 am and ∼10:30 pm of 932 urban region agglomerations in the five ecological regions in China and further simulate these SUHIIs using the machine learning algorithm. The main findings were as follows. (1) The daytime SUHIIs in all regions were largest in...

Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease that is closely related to inflammation and apoptosis. The traditional Chinese medicine compound preparation Huangqin decoction (HQD) has been widely used in the clinical treatment of UC, but the specific mechanism of its function is still inconclusive. To explore the pathogenesis of UC based on the IFN-γ/JAK/ETS signalling pathway, and to clarify the biological mechanism of HQD. Forty 8-week-old male C57BL/6 mice were randomly divided...

A rapid, sensitive and species preservative analytical method for the simultaneous determination of six selenium (Se) species has been developed. Enzymatic probe sonication (EPS) was investigated as a novel and alternative technology for the extraction of Se species from feed matrices and the results were compared with the conventional hot water extraction, enzymatic hydrolysis and sequential extraction. The critical parameters of EPS such as enzyme types, extraction time, temperature, ultrasonic power and sample/enzyme ratio were...

In order to devise more effective penetration enhancers, 4-O-acylterpineol derivatives which were expected to be hydrolyzed into nontoxic metabolites by esterase in the living epidermis, were synthesized from 4-terpineol (4-TER) enantiomers and straight chain fatty acids. Their promoting activities on the SR-flurbiprofen and its enantiomers were tested across full-thickness rabbit skin, as well as to correlate under in vitro and in vivo conditions. The permeation studies indicated that both d-4-O-acylterpineol and l-4-O-acylterpineol had significant enhancing...

Supplemental material, sj-docx-1-tan-10.1177_17562864221138148 for Vigabatrin-associated brain abnormalities on MRI in tuberous sclerosis complex patients with infantile spasms: are they preventable? by Lin Wan, Wen He, Yang-Yang Wang, Yong Xu, Qian Lu, Meng-Na Zhang, Qiu-Hong Wang, Shuo Dun, Li-Ying Liu, Xiu-Yu Shi, Jing Wang, Lin-Yan Hu, Bo Zhang, Guang Yang and Li-Ping Zou in Therapeutic Advances in Neurological Disorders

Supplemental Material for The impact of comprehensive blood conservation program on major complications after total aortic arch replacement by Weidong Yan, Qiaoni Zhang, Sizhe Gao, Gang Liu, Yuan Teng, Jing Wang, Jian Wang, Boyi Zhou, Shujie Yan, and Bingyang Ji in Perfusion

Supplemental Material for The impact of comprehensive blood conservation program on major complications after total aortic arch replacement by Weidong Yan, Qiaoni Zhang, Sizhe Gao, Gang Liu, Yuan Teng, Jing Wang, Jian Wang, Boyi Zhou, Shujie Yan, and Bingyang Ji in Perfusion

Supplemental material, sj-docx-1-hol-10.1177_09596836221138336 for Synchronous change in the intensified millet cultivation and ecological environment from the early to middle Holocene on the Inner Mongolia Plateau, northern China by Keliang Zhao, Huiping Wei, Zhanhu Zhao, Yaping Zhang, Wenqing Liu, Jian Wang, Guanhan Chen, Hui Shen, Hua Du, Peng Cheng, Shan Chen, Peter Weiming Jia, Xinying Zhou and Xiaoqiang Li in The Holocene

Supplemental material, sj-docx-1-hol-10.1177_09596836221138336 for Synchronous change in the intensified millet cultivation and ecological environment from the early to middle Holocene on the Inner Mongolia Plateau, northern China by Keliang Zhao, Huiping Wei, Zhanhu Zhao, Yaping Zhang, Wenqing Liu, Jian Wang, Guanhan Chen, Hui Shen, Hua Du, Peng Cheng, Shan Chen, Peter Weiming Jia, Xinying Zhou and Xiaoqiang Li in The Holocene

Additional file 1: Figure S1. Pan-cancer analysis of ACE2 expression in tumor and para-tumor tissues in the TCGA database. Significance was calculated with Student’s t-test. ns-P>0.05, *P<0.05, **P<0.01, ***P<0.001, ****P < 0.0001. Figure S2. Pan-cancer analysis of the correlations between ACE2 and immunological features. (A) Correlations between ACE2 and 122 immunomodulators (chemokines, receptors, MHC and immunostimulators). The color reveals the correlation coefficient. The asterisks reveal statistical differences assessed by Pearson analysis. (B) Correlations between ACE2...

Additional file 1: Demographic, breast cancer epidemiological and screening factors of the female populations in China.

Additional file 3: Age-specific incidence, mortality and survival rates of breast cancer.

Additional file 4: Age-specific number of females and standardized life expectancy

Supplementary Material 1

Supplementary Material 5: Table S3: The risk of bias for case-control/cross-sectional studies by the Newcastle-Ottawa scale (NOS)

Supplementary Material 5: Table S3: The risk of bias for case-control/cross-sectional studies by the Newcastle-Ottawa scale (NOS)

Supplementary Material 6: PRISMA 2020 Checklist

Cadmium (Cd) causes serious damage to plants. Although calcium (Ca) signal has been found to respond to certain stress, the localization of Ca and molecular mechanisms underlying Ca signal in plants during Cd stress are largely unknown. In this study, Ca2+-sensing fluorescent reporter (GCaMP3) transgenic duckweed showed the Ca2+ signal response in Lemna turionifera 5511 (duckweed) during Cd stress. Subsequently, the subcellular localization of Ca2+ has been studied during Cd stress by transmission electron microscopy,...