Association of air pollution exposure during gestational and the first year of life with physical growth in preschoolersMenglan Guo, Chenchang Xiao, Hong Yan, Bin Yu, Mengxi Zhai, Liqing Wei, Xiaohong Yin & Quzhen Gesang
This study explored the association of exposure to air pollutants during gestational and the first year of life with physical growth in preschoolers. The linear and logistic regression models were used to estimate the associations between air pollution and childhood growth. After adjusting for confounders, z-scores of body mass index (zBMI, and 95% confidence intervals, 95%CI) increased by 1.164(1.054,1.285), 1.136(1.050,1.228) and 1.165(1.041,1.303), associated with per interquartile range (IQR) increase in NO2 (nitrogen dioxide), PM2.5 and...
Rare earth elements in the iron-oxide apatite (IOA) deposit: insights from apatiteShengchao Yan & Wei Liu
Kiruna-type or IOA deposits are characterized by magnetite-apatite-actinolite associations and may contain considerable amounts of rare earth elements (REEs) that can be exploited as by-products. REEs in the Kiruna-type deposit, heterogeneously distributed, are mainly hosted in phosphates (e.g. apatite). Published data of apatite, together with other evidence, can be used to decipher the source, enrichment mechanism, and post-ore modification of REEs in the Kiruna-type deposits. Sr isotopes and melt inclusions compositions of apatite, together with...
Identification of differentially expressed genes and pathways in kidney of ANCA-associated vasculitis by integrated bioinformatics analysisXu Deng, Junying Gao & Fei Zhao
The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systematic of relatively rare autoimmune diseases with unknown cause. Kidney involvement is one of the most common clinical manifestations, and the degree of renal damage is closely associated with the development and prognosis of AAV. In this study, we utilized the Robust Rank Aggreg (RRA) method in R to integrate GSE104948, GSE104954, GSE108109, GSE108112, and GSE108113 profile datasets loaded from Gene Expression Omnibus (GEO) database and...
Additional file 1 of Economic evaluation of implementation science outcomes in low- and middle-income countries: a scoping reviewAkash Malhotra, Ryan R. Thompson, Faith Kagoya, Felix Masiye, Peter Mbewe, Mosepele Mosepele, Jane Phiri, Jairos Sambo, Abigail Barker, Drew B. Cameron, Victor G. Davila-Roman, William Effah, Brian Hutchinson, Michael Laxy, Brad Newsome, David Watkins, Hojoon Sohn & David W. Dowdy
Additional file 1. Protocol for scoping review.
Additional file 2 of Creation and evaluation of a participatory child abuse and neglect workshop for medical studentsChristos Giannakas, Aspasia Manta, Maria Effrosyni Livanou, Vasiliki Daniil, Angeliki Paraskeva, Maria-Konstantina Georgiadou, Nefeli Griva, Vassiliki Papaevangelou, Maria Tsolia, John M. Leventhal & Alexandra Soldatou
Additional file 2: Table 3. Self-assessment questions (modified from Lee et al., 2012 ).
Additional file 1 of LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axisTingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang, Bingchao Qi, Gaotong Ren, Chenchen Hu, Feng Zhang, Hyung J. Chun, Liqiang Song, Jianqiang Hu & Yan Li
Additional file 1. The IMP2 protein sequences.
Additional file 4 of LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axisTingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang, Bingchao Qi, Gaotong Ren, Chenchen Hu, Feng Zhang, Hyung J. Chun, Liqiang Song, Jianqiang Hu & Yan Li
Additional file 4. Fig. S3. Airn effected the fibrotic progress independent of TGF-β/smads signaling pathway in HG-treated CFs.
Additional file 1 of RBM10 regulates alternative splicing of lncRNA Neat1 to inhibit the invasion and metastasis of NSCLCShan Cong, Xin Di, Ranwei Li, Yingshu Cao, Xin Jin, Chang Tian, Min Zhao & Ke Wang
Additional file 1: Figure S1. The flow chart of Clip-Seq.
Additional file 1 of Diagnostic delay of myositis: an integrated systematic reviewTergel Namsrai, Anne Parkinson, Anita Chalmers, Christine Lowe, Matthew Cook, Christine Phillips & Jane Desborough
Additional file 1. Supplementary table 1. Search string conducted on Pubmed/Medline. Supplementary table 2. Data extraction tool. Supplementary table 3. Adapted version of Newcastle-Ottawa score. Supplementary table 4. Data extraction summary of selected studies. Supplementary table 5. Meta-aggregation results of initial symptoms by subtypes of IIM. Factors identified in case studies as related to diagnostic delay. Supplementary table 6. Factors identified in case studies as related to diagnostic delay. Supplementary table 7. Factors of diagnostic...
Supplementary document for Spatial mode and wavelength switchable erbium-doped fiber laser based on a fiber beam shaper - 6163868.pdfKai Chen, WENTAN FANG, Xiaohui Ma, Zhou Yong, Zhang Wei, Xiaolin Chen, Song Huang, Meisong Liao, Yasutake Ohishi & Weiqing Gao
Nonparametric Two-Sample Tests of High Dimensional Mean Vectors via Random IntegrationYunlu Jiang, Xueqin Wang, Canhong Wen, Yukang Jiang & Heping Zhang
Testing the equality of the means in two samples is a fundamental statistical inferential problem. Most of the existing methods are based on the sum-of-squares or supremum statistics. They are possibly powerful in some situations, but not in others, and they do not work in a unified way. Using random integration of the difference, we develop a framework that includes and extends many existing methods, especially in high-dimensional settings, without restricting the same covariance matrices...
A General Framework for Identifying Hierarchical Interactions and Its Application to Genomics DataXiao Zhang, Xingjie Shi, Yiming Liu, Xu Liu & Shuangge Ma
The analysis of hierarchical interactions has long been a challenging problem due to the large number of candidate main effects and interaction effects, and the need for accommodating the “main effects, interactions” hierarchy. The two-stage analysis methods enjoy simplicity and low computational cost, but contradict the fact that the outcome of interest is attributable to the joint effects of multiple main factors and their interactions. The existing joint analysis methods can accurately describe the underlying...
Three dimensional Ti3C2Tx and rGO hybrid supported Pt catalyst for the high performance hydrogen evolution reactionZhou Chang, Chenxi Xu, Ranran Wang, Wei Liu, Zuolei Zhu, Zhongwei Fang & Jigui Cheng
The effective electrocatalysts for hydrogen evolution reaction (HER) in alkaline aqueous is critical point to reduce energy losses for water electrolysis. Here, a highly active and stable electrochemical catalyst of platinum (Pt) nanoparticles loaded on three-dimensional Ti3C2Tx-reduced graphite oxide (rGO) hybrid support (Pt/Ti3C2Tx-rGO3D) has been developed for hydrogen evolution reaction (HER). The large surface of 3 D support provides an adequate site for deposition of Pt nanoparticles, leading to superior HER activity with low overpotential...
Supplementary document for Multidimensional quantitative characterization of the tumor microenvironment by multicontrast nonlinear microscopy - 6044388.pdfYanping Li, Binglin Shen, Yuan Lu, Jinhui Shi, Zewei Zhao, Huixian Li, Rui Hu, Junle Qu & Liwei Liu
Additional file 1 of Novel trends of genome evolution in highly complex tropical sponge microbiomesJoseph B. Kelly, David E. Carlson, Jun Siong Low & Robert W. Thacker
Additional file 1: Fig. S1. Phylogenetic depiction of MAG distributions across Caribbean Ircinia species and redundancy in primary metabolic modes. The heatmap immediately to the right of the tree indicates the ln-transformed relative abundances of each MAG by host specimen. Species abbreviations accompanying specimen labels at the bottom of the heatmap are as follows: ICam (I. campana), IcfR (I. cf. reteplana), IRad (I. radix), ILae (I. laeviconulosa), IBoc (I. bocatorensis B), ILow (I. lowi), IVan...
Additional file 2 of Novel trends of genome evolution in highly complex tropical sponge microbiomesJoseph B. Kelly, David E. Carlson, Jun Siong Low & Robert W. Thacker
Additional file 2: Fig. S2. Plots depicting prevalence of MAGs associated with Caribbean Ircinia by source and region, inferred using the relative abundance matrix produced by CoverM. A. Bar chart depicting the percent of MAGs that are found across multiple host species. B. Bar chart depicting the regional specificity of MAGs. C. PCA of taxonomic community compositions of each host species’ microbiome.
A forest type-specific threshold method for improving forest disturbance and agent attribution mappingYating Li, Xiao Xu, Zhenzi Wu, Hui Fan, Xiaojia Tong & Jiang Liu
Detecting forest disturbances and attributing their contributing agents with Landsat time series (LTS) images has advanced substantially in recent years; however, whether different forest types require individual disturbance indices or specific disturbance thresholds to accurately map forest disturbances and their causes over a vast region remains limited known. This study investigated the effectiveness of six spectral indices (SIs) and two threshold methods (a forest-specific threshold and a common threshold) for detecting forest disturbances among four...
Bioequivalence and safety evaluation of two preparations of metformin hydrochloride sustained-release tablets (Boke® and Glucophage®-XR) in healthy Chinese volunteers: a randomized phase I clinical trialMing-Li Sun, Chen Liu, Hai-Hong Bai, Ya-Li Wei, Wei Zhang, Hui-Juan Liu, Yin-Juan Li, Long Liu, Yu Wang, Yuan-Xv Tong, Qian Gao, Qian-Ying Liu & Xinghe Wang
As per the National Medical Products Administration (NMPA) requirements, the quality and efficacy of generic drugs must be consistent with those of the innovator drug. We aimed to evaluate the bioequivalence and safety of generic metformin hydrochloride sustained-release (MH-SR) tablets (Boke®) developed by Beijing Wanhui Double-crane Pharmaceutical Co. Ltd., China and the innovator product metformin hydrochloride extended-release tablets (Glucophage®-XR) manufactured by Bristol-Myers Squibb Company, New York, NY, in healthy Chinese volunteers. We performed a bioequivalence...
Additional file 7 of Metabolic engineering of Escherichia coli BW25113 for the production of 5-Aminolevulinic Acid based on CRISPR/Cas9 mediated gene knockout and metabolic pathway modificationChangchuan Ye, Yuting Yang, Xi Chen, Lijie Yang, Xia Hua, Mengjie Yang, Xiangfang Zeng & Shiyan Qiao
Additional file 7: Table S1. Growth rate of strain expressing various related genes in different medium.
Additional file 1 of Childhood diabetes mellitus and early-onset kidney diseases later in life: a nationwide population-based matched cohort studyJiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu & Jiong Li
Additional file 1: Supplementary results. Fig. S1. Flow chartof inclusion/exclusion of participants in this study. Fig. S2. Cumulative incidence of overall early-onset kidneydiseases later in life among children by age of diagnosis of type 1 diabetesmellitus (0-5, 6-12, and 13-17 years). Fig. S3. Cumulative incidence of overall early-onset kidney diseases later inlife among children by age of diagnosis of type 2 diabetes mellitus (0-5, 6-12,and 13-17 years). Table S1. International Classification of Diseases codes for...
Additional file 1 of Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2AMika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, Ralph Paul Maguire, Joël Mercier, Nabeel B. Nabulsi, Sophie Kervyn, Shannan Henry, Jean-Marie Nicolas, Yiyun Huang, Ming-Kai Chen, Jonas Hannestad, Henrik Klitgaard, Armel Stockis & Richard E. Carson
Additional file 1: Fig. S1. 11C-UCB-J activity curves in putamen (closed circles) with model fits (solid curves). a and b Displacement (LEV, 1500 mg at 60 min) and post-dose scans, c and d displacement (BRV, 200 mg at 60 min) and post-dose scans. CND(t) and CS(t) was displayed in the dotted curves and break curves, respectively. Fig. S2. 11C-UCB-J activity curves in cerebellum (closed circles) with model fits (solid curves). a and b displacement (LEV,...
Additional file 2 of Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetusesFang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Additional file 2: Table S1. Clinical characteristics of the fetal cases. Table S2. Fetuses with diagnostic or VUS results obtained additional new phenotypes during prenatal and/or postnatal period. Table S3. Fetuses with positive diagnostic results detected by ES. Table S4. Diagnostic rates in different malformation subgroups. Table S5. Diagnostic rates in relation to NT measurement range. Table S6. Number of variants analyzed in step 1 and 2- case by case. Table S7. Number of variants...
Supplemental Material - Conductive, self-healing, and antibacterial Ag/MXene-PVA hydrogel as wearable skin-like sensorsLumin Li, Xiaofeng Ji & Kai Chen
Supplemental Material for Conductive, self-healing, and antibacterial Ag/MXene-PVA hydrogel as wearable skin-like sensors by Lumin Li, Xiaofeng Ji and Kai Chen in Journal of Biomaterials Applications
Additional file 6 of Effectiveness of WeChat-group-based parental health education in preventing unintentional injuries among children aged 0–3: randomized controlled trial in ShanghaiYuheng Feng, Xueqi Ma, Qi Zhang, Ruo Jiang, Jun Lu, Kaiyue Chen, Huiping Wang, Qinghua Xia, Jicui Zheng, Jingwei Xia & Xiaohong Li
Additional file 6: Table S3. Acceptance of WeChat among intervention group and control group.
Additional file 7 of Effectiveness of WeChat-group-based parental health education in preventing unintentional injuries among children aged 0–3: randomized controlled trial in ShanghaiYuheng Feng, Xueqi Ma, Qi Zhang, Ruo Jiang, Jun Lu, Kaiyue Chen, Huiping Wang, Qinghua Xia, Jicui Zheng, Jingwei Xia & Xiaohong Li
Additional file 7: Table S4. Theeffectiveness of primary and secondary outcome within each group.
Chinese Academy of Medical Sciences & Peking Union Medical College168
Sun Yat-sen University137
Shanghai Jiao Tong University128
Chinese Academy of Sciences125
Capital Medical University110