Creating possibility spaces for the development of circular bioeconomy initiativesPer-Anders Langendahl, Cecilia Mark-Herbert & Matthew Cook
To help move society towards more sustainable states, policies have been developed in various countries to create a circular bioeconomy (CBE) in biobased sectors such as forestry and agriculture. In operationalizing CBE, initiatives must be created in which feedback loops between life-cycle stages are established to enable a “stock” of resources to be recirculated in the economy. By creating such feedback loops, CBE aims to decouple economic growth from natural resource depletion and degradation. However,...
Additional file 1 of Pro-thrombotic changes associated with exposure to ambient ultrafine particles in patients with chronic obstructive pulmonary disease: roles of lipid peroxidation and systemic inflammationTeng Wang, Xi Chen, Haonan Li, Wu Chen, Yifan Xu, Yuan Yao, Hanxiyue Zhang, Yiqun Han, Lina Zhang, Chengli Que, Jicheng Gong, Xinghua Qiu & Tong Zhu
Additional file 1: Table S1. Classification of COPD participants based on GOLD scoring. Table S2. Daily concentrations of ambient air particulate matter and meteorological parameters during the study period. Table S3. Sensitivity analyses of the association between the ultrafine particles (UFPs) level and the serum thromboxane B2 concentratio. Table S4. Summary of the lower limit of quantification (LLOQ), goodness of fit (R2), recovery, precision, and detection rate of each biomarker. Table S5. Determinants for the...
Additional file 1 of Bile acid distributions, sex-specificity, and prognosis in colorectal cancerYuping Cai, Xinyi Shen, Lingeng Lu, Hong Yan, Huang Huang, Patricia Gaule, Engjel Muca, Casey M. Theriot, Zahra Rattray, Nicholas J. W. Rattray, Jun Lu, Nita Ahuja, Yawei Zhang, Philip B. Paty, Sajid A. Khan & Caroline H. Johnson
Additional file 1: Table S1. Names of the bile acids measured in tumor tissues. Table S2. Demographics of colon cancer patients from samples used within this study. Table S4. Comparison of bile acid abundance between RCCs and LCCs by sex and age. Table S5. Pearson correlation of glucuronic acid to bile acid abundances in patients with LCC ≥ 55 years old (n=99). Table S6. Correlations between prognosis-linked bile acid and T regulatory cell abundances in...
Supplementary document for Multidimensional quantitative characterization of the tumor microenvironment by multicontrast nonlinear microscopy - 6044388.pdfYanping Li, Binglin Shen, Yuan Lu, Jinhui Shi, Zewei Zhao, Huixian Li, Rui Hu, Junle Qu & Liwei Liu
Additional file 1 of LAG3 blockade coordinates with microwave ablation to promote CD8+ T cell-mediated anti-tumor immunityDong Shao, Yaping Chen, Hao Huang, Yingting Liu, Junjun Chen, Dawei Zhu, Xiao Zheng, Lujun Chen & Jingting Jiang
Additional file 1: Figure S1. Flow cytometry analysis was used to confirm the differences of sub-populations in MWA and MWA combined with the LAG3 blockade groups. A. Gating strategy of tumor infiltrating Foxp3+Tregs. B. The percentage of Tregs was not significantly changed in MWA and MWA combined with the LAG3 blockade groups (n=5 for each group). C. Gating strategy of sub-sets of tumor infiltrating DCs and macrophages. D. There were not significant changes of DCs,...
Supplementary document for Quantum and quasi-classical effects in the strong field ionization and subsequent excitation of nitrogen molecules - 5939627.pdfLiang Xu, Qi Lu, Vladimir Tikhonchuk, Bin Zhou, Runzhe Yang, Qingqing Liang, He Feng, Rostyslav Danylo, Aurelien Houard & Andre Mysyrowicz
Supplementary document for Quantitative tumor depth determination using dual wavelength excitation fluorescence - 5997611.pdfChristine OBrien, Kevin Bishop, Haini Zhang, Xiao Xu, Leonid Shmuylovich, Elizabeth Conley, Karen Nwosu, Katie Duncan, Suman Mondal & Gail Sudlow
Additional file 1 of Adaptations of evidence-based trauma-focused interventions for children and adolescents: a systematic reviewBrittany C. L. Lange, Ashley Nelson, Jason M. Lang & Shannon Wiltsey Stirman
Additional file 1. PRISMA 2020 Checklist.
Additional file 2 of Adaptations of evidence-based trauma-focused interventions for children and adolescents: a systematic reviewBrittany C. L. Lange, Ashley Nelson, Jason M. Lang & Shannon Wiltsey Stirman
Additional file 2. Search Strategy.
Additional file 1 of Genome-centric insight into metabolically active microbial population in shallow-sea hydrothermal ventsXiaofeng Chen, Kai Tang, Mu Zhang, Shujing Liu, Mingming Chen, Peiwen Zhan, Wei Fan, Chen-Tung Arthur Chen & Yao Zhang
Additional file 1: Fig. S1. Fragment recruitment analysis. Fig. S2. The relative abundance of transporter proteins in metaproteome. Fig. S3. Profiles of transporter genes in the assembled MAGs within Epsilonbacteraeota and Gammaproteobacteria.
Additional file 3 of Accuracy of next-generation sequencing for molecular profiling of small specimen of lung cancer: a prospective pilot study of side-by-side comparisonXiaosong Ben, Dan Tian, Weitao Zhuang, Rixin Chen, Sichao Wang, Zihao Zhou, Cheng Deng, Ruiqing Shi, Songlin Liu, Dongkun Zhang, Jiming Tang, Liang Xie, Haiyu Zhou, Zhou Zhang, Min Li, Xuanye Zhang & Guibin Qiao
Additional file 3: Figure S3. The difference (A) and correlation (B) between resection specimen-based TMB and CNB-based TMB. RS: resection specimen; CNB: core needle biopsy; TMB: tumor mutation burden.
24-Epicastasterone and KH2PO4 protect grain production of wheat crops from terminal heat impacts by modulating leaf physiologyMin Li, Qianfei Wei, Yulei Zhu, Jincai Li, Najeeb Ullah & Youhong Song
Heat stress during the grain filling is one of most critical factors impacting grain yield in winter wheat. In a two-year field experiment, we studied the effects of 24-Epicastasterone and KH2PO4 on heat-stressed wheat applied during different times. A completely randomized block design was used with three reagents, that is, 24-Epicastasterone, KH2PO4 and H2O and three spraying times, that is, pre-heat, under-heat and post-heat. Two cultivars, that is, Huaimai 33 and Annong 0711 were subjected...
Additional file 1 of LncRNA PCED1B-AS1 knockdown inhibits osteosarcoma via methylation-mediated miR-10a downregulationBing Wang, Li Yao, Yuefu Dong, Jian Liu & Jian Wu
Additional file 1. Supplemental Table 1: clinicopathologic characteristics of patient samples in OS. Supplemental Table 2: Correlation between PCEDB1-AS1 expression and clinicopathologic features in OS patients.
Additional file 1 of High-frequency electrical stimulation attenuates neuronal release of inflammatory mediators and ameliorates neuropathic painHuan Yang, Timir Datta-Chaudhuri, Sam J. George, Bilal Haider, Jason Wong, Tyler D. Hepler, Ulf Andersson, Michael Brines, Kevin J. Tracey & Sangeeta S. Chavan
Additional file 1: Supplementary Figure 1. Light activated sensory neurons release inflammatory mediators. DRG sensory neurons harvested from Vglut2-Cre/ChR2-eYFP mice were cultured for 48–72 h and then stimulated with blue light (470 nm) at 20 Hz, 10% duty cycle for 15 min. Supernatant was harvested at indicated time points, and levels of HMGB1 (A), substance P (B) and CGRP (C) were quantified. N = 4-5 per group. *P < 0.05, **P < 0.01, ***P <...
Additional file 2 of Novel trends of genome evolution in highly complex tropical sponge microbiomesJoseph B. Kelly, David E. Carlson, Jun Siong Low & Robert W. Thacker
Additional file 2: Fig. S2. Plots depicting prevalence of MAGs associated with Caribbean Ircinia by source and region, inferred using the relative abundance matrix produced by CoverM. A. Bar chart depicting the percent of MAGs that are found across multiple host species. B. Bar chart depicting the regional specificity of MAGs. C. PCA of taxonomic community compositions of each host species’ microbiome.
Additional file 1 of Childhood diabetes mellitus and early-onset kidney diseases later in life: a nationwide population-based matched cohort studyJiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu & Jiong Li
Additional file 1: Supplementary results. Fig. S1. Flow chartof inclusion/exclusion of participants in this study. Fig. S2. Cumulative incidence of overall early-onset kidneydiseases later in life among children by age of diagnosis of type 1 diabetesmellitus (0-5, 6-12, and 13-17 years). Fig. S3. Cumulative incidence of overall early-onset kidney diseases later inlife among children by age of diagnosis of type 2 diabetes mellitus (0-5, 6-12,and 13-17 years). Table S1. International Classification of Diseases codes for...
Additional file 1 of Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetusesFang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Additional file 1. Analysis and interpretation process of fetal ES data.
sj-docx-1-tah-10.1177_20406207221134409 – Supplemental material for Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-versus-host disease in pediatric patients with acquired severe aplastic anemiaDi Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng & Shaoyan Hu
Supplemental material, sj-docx-1-tah-10.1177_20406207221134409 for Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-versus-host disease in pediatric patients with acquired severe aplastic anemia by Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng and Shaoyan Hu in Therapeutic Advances in Hematology
Additional file 1 of Characteristics of lymphocyte subset alterations in COVID-19 patients with different levels of disease severityWei Dai, Aifang Zhong, Qinghua Qiao, Jian Wu, Weiwei Li, Qiuyue Wu, Hongjian Zhou, Shijie Qin, Weijun Jiang, Jing Zhang & Xinyi Xia
Additional file 1. Figure S1 Representative flow cytometry dot plots showing the gating strategy for B lymphocyte subsets. Figure S2 Representative flow cytometry dot plots showing the gating strategy for T lymphocyte subsets. Figure S3 Representative flow cytometry dot plots showing the gating strategy for basic cell subsets. Figure S4 Representative flow cytometry dot plots showing the gating strategy for Treg lymphocyte subsets.
Additional file 1 of Multimodal co-therapy for unaccompanied minors: a qualitative studySélim Benjamin Guessoum, Sevan Minassian, Pauline de Staël, Fatima Touhami, Madeline DiGiovanni, Rahmeth Radjack, Marie Rose Moro & Laelia Benoit
Additional file 1. COREQ (COnsolidated criteria for REporting Qualitative research) Checklist.
Supplementary material for 'Orthoester Formation in Fungal Meroterpenoid Austalide F Biosynthesis' from Orthoester formation in fungal meroterpenoid austalide F biosynthesisTakayoshi Awakawa, Wei Liu, Tongxuan Bai, Tomo Taniguchi & Ikuro Abe
Fungal meroterpenoids are important bioactive natural products. Their biosynthetic machineries are highly diverse, and reconstitutions lead to the production of unnatural meroterpenoids. In this study, heterologous gene expression in Aspergillus oryzae and in vitro assays elucidated the biosynthetic pathway of the orthoester-containing fungal meroterpenoid austalide F. Remarkably, the α-ketoglutarate-dependent oxygenase AstB produces the hemiacetal intermediate, and the methyltransferase AstL transfers a methyl group on it to construct the orthoester functionality. This study presents the extraordinary...
sj-pdf-1-pmj-10.1177_02692163221136160 – Supplemental material for Palliative care for adolescents and young adults with advanced illness: A scoping reviewMohamed Abdelaal, Jonathan Avery, Ronald Chow, Nasreen Saleem, Rouhi Fazelzad, Pamela Mosher, Breffni Hannon, Camilla Zimmermann & Ahmed al-Awamer
Supplemental material, sj-pdf-1-pmj-10.1177_02692163221136160 for Palliative care for adolescents and young adults with advanced illness: A scoping review by Mohamed Abdelaal, Jonathan Avery, Ronald Chow, Nasreen Saleem, Rouhi Fazelzad, Pamela Mosher, Breffni Hannon, Camilla Zimmermann and Ahmed al-Awamer in Palliative Medicine
Additional file 1 of Effectiveness of WeChat-group-based parental health education in preventing unintentional injuries among children aged 0–3: randomized controlled trial in ShanghaiYuheng Feng, Xueqi Ma, Qi Zhang, Ruo Jiang, Jun Lu, Kaiyue Chen, Huiping Wang, Qinghua Xia, Jicui Zheng, Jingwei Xia & Xiaohong Li
Additional file 1: Figure S1. Design the articles based on Haddon model and beliefs the parents needed.
Additional file 2 of Effectiveness of WeChat-group-based parental health education in preventing unintentional injuries among children aged 0–3: randomized controlled trial in ShanghaiYuheng Feng, Xueqi Ma, Qi Zhang, Ruo Jiang, Jun Lu, Kaiyue Chen, Huiping Wang, Qinghua Xia, Jicui Zheng, Jingwei Xia & Xiaohong Li
Additional file 2: Figure S2. Articles uploaded to the WeChat officialaccount.
Additional file 3 of Effectiveness of WeChat-group-based parental health education in preventing unintentional injuries among children aged 0–3: randomized controlled trial in ShanghaiYuheng Feng, Xueqi Ma, Qi Zhang, Ruo Jiang, Jun Lu, Kaiyue Chen, Huiping Wang, Qinghua Xia, Jicui Zheng, Jingwei Xia & Xiaohong Li
Additional file 3: Figure S3. Screenshots of parents and doctorscommunicating with each other in the WeChat group.
Chinese Academy of Medical Sciences & Peking Union Medical College166
Sun Yat-sen University137
Shanghai Jiao Tong University126
Chinese Academy of Sciences123
Capital Medical University110
University of Chinese Academy of Sciences109