To help move society towards more sustainable states, policies have been developed in various countries to create a circular bioeconomy (CBE) in biobased sectors such as forestry and agriculture. In operationalizing CBE, initiatives must be created in which feedback loops between life-cycle stages are established to enable a “stock” of resources to be recirculated in the economy. By creating such feedback loops, CBE aims to decouple economic growth from natural resource depletion and degradation. However,...

Additional file 1: Table S1. Classification of COPD participants based on GOLD scoring. Table S2. Daily concentrations of ambient air particulate matter and meteorological parameters during the study period. Table S3. Sensitivity analyses of the association between the ultrafine particles (UFPs) level and the serum thromboxane B2 concentratio. Table S4. Summary of the lower limit of quantification (LLOQ), goodness of fit (R2), recovery, precision, and detection rate of each biomarker. Table S5. Determinants for the...

Additional file 1: Table S1. Names of the bile acids measured in tumor tissues. Table S2. Demographics of colon cancer patients from samples used within this study. Table S4. Comparison of bile acid abundance between RCCs and LCCs by sex and age. Table S5. Pearson correlation of glucuronic acid to bile acid abundances in patients with LCC ≥ 55 years old (n=99). Table S6. Correlations between prognosis-linked bile acid and T regulatory cell abundances in...

Supplementary Materials

Additional file 1: Figure S1. Flow cytometry analysis was used to confirm the differences of sub-populations in MWA and MWA combined with the LAG3 blockade groups. A. Gating strategy of tumor infiltrating Foxp3+Tregs. B. The percentage of Tregs was not significantly changed in MWA and MWA combined with the LAG3 blockade groups (n=5 for each group). C. Gating strategy of sub-sets of tumor infiltrating DCs and macrophages. D. There were not significant changes of DCs,...

Supplemental Document

Supplemental figures

Additional file 1. PRISMA 2020 Checklist.

Additional file 2. Search Strategy.

Additional file 1: Fig. S1. Fragment recruitment analysis. Fig. S2. The relative abundance of transporter proteins in metaproteome. Fig. S3. Profiles of transporter genes in the assembled MAGs within Epsilonbacteraeota and Gammaproteobacteria.

Additional file 3: Figure S3. The difference (A) and correlation (B) between resection specimen-based TMB and CNB-based TMB. RS: resection specimen; CNB: core needle biopsy; TMB: tumor mutation burden.

Heat stress during the grain filling is one of most critical factors impacting grain yield in winter wheat. In a two-year field experiment, we studied the effects of 24-Epicastasterone and KH2PO4 on heat-stressed wheat applied during different times. A completely randomized block design was used with three reagents, that is, 24-Epicastasterone, KH2PO4 and H2O and three spraying times, that is, pre-heat, under-heat and post-heat. Two cultivars, that is, Huaimai 33 and Annong 0711 were subjected...

Additional file 1. Supplemental Table 1: clinicopathologic characteristics of patient samples in OS. Supplemental Table 2: Correlation between PCEDB1-AS1 expression and clinicopathologic features in OS patients.

Additional file 1: Supplementary Figure 1. Light activated sensory neurons release inflammatory mediators. DRG sensory neurons harvested from Vglut2-Cre/ChR2-eYFP mice were cultured for 48–72 h and then stimulated with blue light (470 nm) at 20 Hz, 10% duty cycle for 15 min. Supernatant was harvested at indicated time points, and levels of HMGB1 (A), substance P (B) and CGRP (C) were quantified. N = 4-5 per group. *P < 0.05, **P < 0.01, ***P <...

Additional file 2: Fig. S2. Plots depicting prevalence of MAGs associated with Caribbean Ircinia by source and region, inferred using the relative abundance matrix produced by CoverM. A. Bar chart depicting the percent of MAGs that are found across multiple host species. B. Bar chart depicting the regional specificity of MAGs. C. PCA of taxonomic community compositions of each host species’ microbiome.

Additional file 1: Supplementary results. Fig. S1. Flow chartof inclusion/exclusion of participants in this study. Fig. S2. Cumulative incidence of overall early-onset kidneydiseases later in life among children by age of diagnosis of type 1 diabetesmellitus (0-5, 6-12, and 13-17 years). Fig. S3. Cumulative incidence of overall early-onset kidney diseases later inlife among children by age of diagnosis of type 2 diabetes mellitus (0-5, 6-12,and 13-17 years). Table S1. International Classification of Diseases codes for...

Additional file 1. Analysis and interpretation process of fetal ES data.

Supplemental material, sj-docx-1-tah-10.1177_20406207221134409 for Association between haploidentical hematopoietic stem cell transplantation combined with an umbilical cord blood unit and graft-versus-host disease in pediatric patients with acquired severe aplastic anemia by Di Yao, Yuanyuan Tian, Jie Li, Bohan Li, Jun Lu, Jing Ling, Defei Zheng, Yanhua Yao, Peifang Xiao, Lijun Meng and Shaoyan Hu in Therapeutic Advances in Hematology

Additional file 1. Figure S1 Representative flow cytometry dot plots showing the gating strategy for B lymphocyte subsets. Figure S2 Representative flow cytometry dot plots showing the gating strategy for T lymphocyte subsets. Figure S3 Representative flow cytometry dot plots showing the gating strategy for basic cell subsets. Figure S4 Representative flow cytometry dot plots showing the gating strategy for Treg lymphocyte subsets.

Additional file 1. COREQ (COnsolidated criteria for REporting Qualitative research) Checklist.

Fungal meroterpenoids are important bioactive natural products. Their biosynthetic machineries are highly diverse, and reconstitutions lead to the production of unnatural meroterpenoids. In this study, heterologous gene expression in Aspergillus oryzae and in vitro assays elucidated the biosynthetic pathway of the orthoester-containing fungal meroterpenoid austalide F. Remarkably, the α-ketoglutarate-dependent oxygenase AstB produces the hemiacetal intermediate, and the methyltransferase AstL transfers a methyl group on it to construct the orthoester functionality. This study presents the extraordinary...

Supplemental material, sj-pdf-1-pmj-10.1177_02692163221136160 for Palliative care for adolescents and young adults with advanced illness: A scoping review by Mohamed Abdelaal, Jonathan Avery, Ronald Chow, Nasreen Saleem, Rouhi Fazelzad, Pamela Mosher, Breffni Hannon, Camilla Zimmermann and Ahmed al-Awamer in Palliative Medicine

Additional file 1: Figure S1. Design the articles based on Haddon model and beliefs the parents needed.

Additional file 2: Figure S2. Articles uploaded to the WeChat officialaccount.

Additional file 3: Figure S3. Screenshots of parents and doctorscommunicating with each other in the WeChat group.