Nucleosides and amino acids, isolated from Cordyceps sinensis, protected against cyclophosphamide-induced myelosuppression in miceYu Zhang, Jie Liu, Yan Wang, Chengpeng Sun, Wenjia Li, Jianjian Qiu, Yanling Qiao, Fan Wu, Xiaokui Huo, Yue An, Baojing Zhang, Shuangcheng Ma, Jian Zheng & Xiaochi Ma
The material basis of Cordyceps sinensis (Berk.) Sacc has not yet been well understood and natural C. sinensis resources are very rare. The present study aimed to clarify the substance basis and compare the protective effect of natural and artificially-cultivated C. sinensis against cyclophosphamide (CTX)-induced myelosuppression. Both natural and artificially-cultivated C. sinensis effectively improved CTX-induced decrease of peripheral blood counts and hemopoietic growth factors, pathological changes, and apoptosis of bone marrow. Importantly, artificially-cultivated C. sinensis...
Proteomic Characterization of Bacillus Subtilis on Bio-degumming of Ramie BastQi Yang, Shengwen Duan, Lifeng Cheng, Xiangyuan Feng, Ke Zheng, Chao Xu & Yuande Peng
Ramie bast is a kind of multipurpose biological material. Selective bio-degradation of ramie bast compounds is an important step to partial utilization of complex polysaccharides. Bacillus subtilis is a kind of dominant species with its ability to degrade ramie bast. In order to understand how polysaccharides were catalyzed and utilized in the metabolism of the bacteria, the proteome of B. subtilis strain 168 was analyzed in the presence of ramie bast as sole carbon source,...
Taberdines L and M, two new alkaloids from Tabernaemontana divaricataLingling Han, Kepu Huang, Chen Chen, Wentao Zhu, Yehan Ma, Xiaojiang Hao, Hongping He & Yu Zhang
Two new alkaloids, taberdines L (1) and M (2), together with six known alkaloids, were isolated from the twigs and leaves of Tabernaemontana divaricata. Taberdine L (1) represents the first optically active natural member of the allo iboga class of alkaloids with the ethyl side chain in a bridgehead position. Their structures including absolute configuration were elucidated by a combination of MS, NMR, and ECD calculation. The in vitro cytotoxic activities of 1 and 2...
Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapyGang Chen, Aftab Ullah, Gang Xu, Zhou Xu, Fei Wang, Tianqing Liu, Yi Su, Tangjie Zhang & Kaikai Wang
Transdermal drug delivery for local or systemic therapy provides a potential anticancer modality with a high patient compliance. However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tumor targeting photosensitizer IR780 (IR780/lipo/gels) for tumor photothermal therapy (PTT). The formulation effectively delivered IR780 to subcutaneous tumor and deep metastatic sites, while the hydrogels were applied...
Accumulation and translocation of selenium in a soil–rice system in Guangxi, ChinaZhen Wang, Fei Pang & Wei Huang
Selenium (Se) is an essential element for the human body. Humans meet their basic Se requirements primarily through food consumption. The largest Se-rich contiguous area in China is located in the southeast of Guangxi. In this study, the Se accumulation and translocation in the Guangxi rice–soil system was assessed. Organically bound Se (O-Se) was found to be the main type of soil Se (72.5%), and had a good linear relationship with soil total Se (TSe)...
Enhanced cytotoxicity of a redox-sensitive hyaluronic acid-based nanomedicine toward different oncocytes via various internalization mechanismsYunai Du, Sheng Wang, Tianhao Zhang, Dongsheng He, Jiasheng Tu & Yan Shen
Receptor-mediated active targeting and tumor microenvironment responsive systems from polymeric micelles have been studied for rapid cellular internalization and triggered drug release. Previously we have constructed redox-responsive polymeric micelles composed of vitamin E succinate conjugated hyaluronic acid (HA-ss-TOS), which are able to actively target CD44 proteins and quickly release loaded drugs upon exposure to high levels of glutathione (GSH) in tumor cells. In the present study, we found that despite different cellular internalization mechanisms, micelles...
Neuronal mitochondria-targeted therapy for Alzheimer’s disease by systemic delivery of resveratrol using dual-modified novel biomimetic nanosystemsYang Han, Xiaoyang Chu, Lin Cui, Shiyao Fu, Chunsheng Gao, Yi Li & Baoshan Sun
Reactive oxygen species (ROS)-induced neuronal mitochondrial dysfunction is a key pathologic factor in sporadic Alzheimer’s disease (AD). Neuronal mitochondria have been proposed to be a promising therapeutic target for AD, especially for the failures of phase III clinical trials on conventional amyloid-β (Aβ) targeted therapy. However, the efficient intravenous delivery of therapeutic agents to neuronal mitochondria in the brain remains a major challenge due to the complicated physiological environment. Recently, biomaterials-based nanomedicine has been widely...
Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathwayQi Yang, Jia You, Yuan Zhou, Yun Wang, Rongjuan Pei, Xinwen Chen, Min Yang & Jizheng Chen
Tick-borne encephalitis virus (TBEV) accounts for approximately 10,000 annual cases of severe encephalitis in Europe and Asia and causes encephalitis in humans. In this study, we demonstrate TBEV appears to activate the interferon (IFN)-β dependent on RIG-I/MDA5. Both the IFN-β accumulation and the IFN stimulated genes (ISGs) transcription greatly delay. Further studies reveal that TBEV NS4A could block the phosphorylation and dimerization of STAT1/STAT2 to affect type I and II IFN-mediated STAT signalling. Additional data...
Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancerZhenyu Song, Zhiyuan Zhuo, Zhe Ma, Chuansheng Hou, Gang Chen & Guoxiong Xu
Our study is to explore the expression profiles and potential functions of circRNAs in prostate cancer (PCa). A total of 95 circRNAs and 830 mRNAs were screened to be significantly differentially expressed in PCa tissues by microarrays. Co-expression and competitive endogenous RNA (ceRNA) network were constructed to reveal the potential regulatory mechanisms of circRNAs. Three circRNAs, hsa_circ_0001206, hsa_circ_0001633, and hsa_circ_0009061 were validated to be down-regulated in PCa by quantitative real-time PCR (qRT-PCR) and hsa_circ_0001206 as...
A polyoxyethylene sorbitan oleate modified hollow gold nanoparticle system to escape macrophage phagocytosis designed for triple combination lung cancer therapy via LDL-R mediated endocytosisYan Shen, Yun Xia, Ershuang Yang, Zixuan Ye, Yuan Ding, Jiasheng Tu, Yong Zhang & Pengcheng Xu
Presently, a combination of chemotherapy, radiotherapy, thermotherapy, and other treatments has become a hot topic of research for the treatment of cancer, especially lung cancer. In this study, novel hollow gold nanoparticles (HGNPs) were used as drug carriers, and in order to improve the targeting ability of HGNPs to a lung tumor site, polyoxyethylene sorbitol oleate (PSO) was chosen here as a target ligand since it can be specifically recognized by the low-density lipoprotein (LDL)...
Down-regulation of microRNA-125b-2-3p is a risk factor for a poor prognosis in hepatocellular carcinomaHe-Qing Huang, Gang Chen, Dan-Dan Xiong, Ze-Feng Lai, Li-Min Liu, Ye-Ying Fang, Jin-Hai Shen, Xiang-Yu Gan, Liu-Feng Liao & Yi-Wu Dang
Hepatocellular carcinoma (HCC) is a leading cause of mortality in cancer patients, but the association between miR-125b-2-3p and the onset and prognosis of HCC has not been reported in previous studies; thus, the clinicopathological implications of miR-125b-2-3p in HCC require elaboration. To examine the expression of miR-125b-2-3p in HCC, both in-house RT-qPCR and public datasets were used to calculate the standard mean difference (SMD) and the summary receiver operating characteristic (sROC). MiR-125b-2-3p was markedly lower...
Help-seeking preferences among Chinese college students exposed to a natural disaster: a person-centered approachWei Shi & Brian J. Hall
Direct exposure to natural disasters is associated with increased mental disorders. Help-seeking behaviour among Chinese adults is low and the barriers and facilitators of help-seeking among Chinese adults exposed to natural disasters is understudied. Using a person-centred approach, this study describes help-seeking preferences and their correlates in a sample of Chinese college students after experiencing Typhoon Hato, the strongest storm to affect Macao, China in the past 50 years. The baseline sample was collected one...
The effects of ground cover management on fruit yield and quality: a meta-analysisLinfa Fang, Xiaojun Shi, Yong Zhang, Yehua Yang, Xueliang Zhang, Xiaozhong Wang & Yuting Zhang
An important management strategy for the development of sustainable agriculture in orchards is the management of ground cover. However, there is a knowledge gap regarding the effects of ground cover on fruit yield and quality. We performed a meta-analysis of 580 observations collected from 116 peer-reviewed field studies, to assess the effects of ground cover on fruit yield and quality indicators. Overall, ground cover significantly increased fruit yield, soluble solid content, sugar content, and vitamin...
The feasibility of one-stage flexible ureteroscopy lithotripsy in solitary kidney patients with 1–3 cm renal stones and risk factors of renal function changesYang Pan, Han Chen, Hualin Chen, Xiaoxiang Jin, Yunxiao Zhu & Gang Chen
To compare perioperative outcomes and long-term renal function changes between prior stenting (PS) and not prior stenting (NPS) before flexible ureteroscopy lithotripsy (f-URS) for solitary kidney patients. Solitary kidney patients with 10–30 mm renal stones were enrolled in this historical control study. Perioperative parameters and complications were compared. Stone-free was defined as the absence of any residual stones on a CT scan. Renal function changes were evaluated by estimated glomerular filtration rate (eGFR) and adjusted...
Bidirectional regulation of structural damage on autophagy in the C. elegans epidermisRong Fu, Xiaowan Jiang, Yuyan Yang, Chunxia Wang, Yun Zhang, Yi Zhu & Huimin Zhang
A variety of disturbances such as starvation, organelle damage, heat stress, hypoxia and pathogen infection can influence the autophagic process. However, how the macroautophagy/autophagy machinery is regulated intrinsically by structural damage of the cell remains largely unknown. In this work, we utilized the C. elegans epidermis as the model to address this question. Our results showed that structural damage by mechanical wounding exerted proximal inhibitory effect and distant promotional effect on autophagy within the same...
Synthesis, herbicidal activity study, and molecular docking of novel acylthiourea derivativesBinbin Jiang, Yunlong Chai, Xu He, Yan Wang, Bo Chen, Yang Li & Ranhong Li
A series of new acylthiourea derivatives were synthesized and characterized. The results of preliminary herbicidal activity tests showed that most compounds had good herbicidal activity against Digitaria adscendens and Amaranthus retroflexus, especially for compounds 4b (N-(2-chloro-4-methylsulfonylbenzoyl)-N’-(2-chlorophenyl) thiourea) and 4f (N-(2-chloro-4-methylsulfonylbenzoyl)-N’-(2,3-dichlorophenyl) thiourea). In vivo acetylhydroxylate synthase (AHAS) enzyme activity inhibition tests showed that all compounds had inhibitory activities against the enzyme at a concentration of 100 mg·L−1, with the highest inhibition rate up to 37.05% (compound...
Radiomics analysis of ultrasound to predict recurrence of hepatocellular carcinoma after microwave ablationJia-peng Wu, Wen-zhen Ding, Yu-ling Wang, Sisi Liu, Xiao-qian Zhang, Qi Yang, Wen-jia Cai, Xiao-ling Yu, Fang-yi Liu, Dexing Kong, Hui Zhong, Jie Yu & Ping Liang
To develop and validate an ultrasonic radiomics model for predicting the recurrence and differentiation of hepatocellular carcinoma (HCC). Convolutional neural network (CNN) ResNet 18 and Pyradiomics were used to analyze gray-scale-ultrasonic images to predict the prognosis and degree of differentiation of HCC. This retrospective study enrolled 513 patients with HCC who underwent preoperative grayscale-ultrasonic imaging, and their clinical characteristics were observed. Patients were randomly divided into training (n = 413) and validation (n = 100)...
Supplemental Material, sj-pdf-2-ptd-10.1177_08968608221080586 - ISPD peritonitis guideline recommendations: 2022 update on prevention and treatmentPhilip Kam-Tao Li, Kai Ming Chow, Yeoungjee Cho, Stanley Fan, Ana E Figueiredo, Tess Harris, Talerngsak Kanjanabuch, Yong-Lim Kim, Magdalena Madero, Jolanta Malyszko, Rajnish Mehrotra, Ikechi G Okpechi, Jeff Perl, Beth Piraino, Naomi Runnegar, Isaac Teitelbaum, Jennifer Ka-Wah Wong, Xueqing Yu & David W Johnson
Supplemental Material, sj-pdf-2-ptd-10.1177_08968608221080586 for ISPD peritonitis guideline recommendations: 2022 update on prevention and treatment by Philip Kam-Tao Li, Kai Ming Chow, Yeoungjee Cho, Stanley Fan, Ana E Figueiredo, Tess Harris, Talerngsak Kanjanabuch, Yong-Lim Kim, Magdalena Madero, Jolanta Malyszko, Rajnish Mehrotra, Ikechi G Okpechi, Jeff Perl, Beth Piraino, Naomi Runnegar, Isaac Teitelbaum, Jennifer Ka-Wah Wong, Xueqing Yu and David W Johnson in Peritoneal Dialysis International
Additional file 3 of Development of gold Immunochromatographic assay strip based on specific polyclonal antibodies against capsid protein for rapid detection of porcine circovirus 2 in Zhejiang province, ChinaHaojie Ding, Yu Shen, Yafan Gao, Songrui Wu, ChengZuo Xie, Hao Sun, Hongli Zhang, Hongchao Sun, Ying Shan, Jianzu Ding, Bin Zheng, Shaohong Lu & Xunhui Zhuo
Additional file 3: Supplement Fig. 3. Western blot analysis between recombinant antigen and purified polyclonal antibody. The blot membrane was cut prior to hybridization with polyclonal antibody A: the blot membrane was in the Brightfield; B: the blot membrane was imaged by the Bio-Rad ChemiDoc XRS+.
sj-doc-1-sgo-10.1177_21582440221128177 – Supplemental material for Depressive Symptoms of Chinese Rural-to-Urban Migrant Children: A Systematic Review and Meta-AnalysisLixia Yan, Siyuan Wang, Yang Yuan, Yu Zhang & Junhua Zhang
Supplemental material, sj-doc-1-sgo-10.1177_21582440221128177 for Depressive Symptoms of Chinese Rural-to-Urban Migrant Children: A Systematic Review and Meta-Analysis by Lixia Yan, Siyuan Wang, Yang Yuan, Yu Zhang and Junhua Zhang in SAGE Open
Supplementary document for High brightness and broad modulation bandwidth InGaN-based red micro-LEDs integrated with plasmonic gratings - 6087766.pdfGuogang Zhang, Lijun Zhang, Fang-Fang REN, Yi Li & yongjin wang
Diagnostic test accuracy of waist-to-height ratio as a screening tool for cardiovascular risk in children and adolescents: a meta-analysisFusheng Zhang, Yanbai Han, Hongli Wang, Yong Li & Zhiwei Yan
Waist-to-height ratio (WHtR) is a controversial evaluation index of cardiovascular risk factors (CVRFs) in children and adolescents. To assess the accuracy of WHtR as a measure to screen for clusters of at least one CVRF (CVRF1), two CVRFs (CVRF2), and three CVRFs (CVRF3) in different ages, sexes, regions and cut-offs. The PubMed, Web of Science, EBSCOhost, Springer, Taylor & Francis Online, Wiley Online Library, Wanfang, and CNKI databases were searched for eligible publications up to...
Supplementary document for Light as quantum back-action nullifying meter - 5830299.pdfSankar Davuluri & Yong Li
Additional file 2 of Downregulation of zinc finger protein 71 in laryngeal squamous cell carcinoma tissues and its potential molecular mechanism and clinical significance: a study based on immunohistochemistry staining and data miningFang-Cheng Jiang, Jia-Yuan Luo, Yi-Wu Dang, Hui-Ping Lu, Dong-Ming Li, Zhi-Guang Huang, Yu-Lu Tang, Ye-Ying Fang, Yu-Xing Tang, Ya-Si Su, Wen-Bin Dai, Shang-Ling Pan, Zhen-Bo Feng, Gang Chen & Juan He
Additional file 2: Table S2. Specific information of included datasets collected from public resources.
Additional file 6 of Downregulation of zinc finger protein 71 in laryngeal squamous cell carcinoma tissues and its potential molecular mechanism and clinical significance: a study based on immunohistochemistry staining and data miningFang-Cheng Jiang, Jia-Yuan Luo, Yi-Wu Dang, Hui-Ping Lu, Dong-Ming Li, Zhi-Guang Huang, Yu-Lu Tang, Ye-Ying Fang, Yu-Xing Tang, Ya-Si Su, Wen-Bin Dai, Shang-Ling Pan, Zhen-Bo Feng, Gang Chen & Juan He
Additional file 6: Figure S1. Subcellular location of ZNF71 protein (downloaded from HPA website).
Guangdong Academy of Medical Sciences846
Chinese Academy of Medical Sciences & Peking Union Medical College587
Shanghai Jiao Tong University574
Nanjing Medical University528
Chinese Academy of Sciences524
Huazhong University of Science and Technology490
West China Hospital of Sichuan University483