We present phase diagrams of variously enriched and depleted mantle rocks down to 800 kilometers depth and explore density as the parameter governing convection and compositional stratification. Some results are surprising and not all are included in present concepts and models: (1) Primitive and enriched mantle compositions are buoyant in the uppermost lower mantle compared to depleted mantle, especially, when they are warmer, but also at identical temperatures. Hence, if the upper mantle is depleted...

SCFD1 (sec1 family domain containing 1) was recently shown to function in autophagosome-lysosome fusion, and multiple studies have demonstrated the regulatory impacts of acetylation (a post-translational modification) on macroautophagy/autophagy. Here, we demonstrate that both acetylation- and phosphorylation-dependent mechanisms control SCFD1ʹs function in autophagosome-lysosome fusion. After detecting a decrease in the extent of SCFD1 acetylation under autophagy-stimulated conditions, we found that KAT2B/PCAF catalyzes the acetylation of residues K126 and K515 of SCFD1; we also showed that...

Additional file 2: Figure S1. Original blot and images. Figure S2. HMGB2 expression is not correlated with survival of patients with LUSC.

Additional file 3. Appendix 3.

Additional file 4. Appendix 4.

The interview guide including survey questions.

Additional file 1: Supplementary Table 1. Summaries of the standardized patient cases, with main goal and suggested use of communication tools.

Additional file 1. Appendix 1.

The dynamic and complex peculiarities of the oral environment present several challenges for controlling the aroma release during food consumption. They also pose higher requirements for designing food with better sensory quality. This requires a comprehensive understanding of the basic rules of aroma transmission and aroma perception during food oral processing and its behind mechanism. This review summarized the latest developments in aroma release from food to retronasal cavity, aroma release and delivery influencing factors,...

Supplemental material, sj-docx-1-taj-10.1177_20406223221127237 for Risk factors of aortic regurgitation progression in Chinese patients with Takayasu’s arteritis: a prospective cohort study by Yujiao Wang, Lili Ma, Ying Sun, Wensu Yu, Sifan Wu, Huiyong Chen, Xiaomin Dai, Lingying Ma and Lindi Jiang in Therapeutic Advances in Chronic Disease

Supplemental Material for UUrine Galectin-3 binding protein reflects nephritis activity in systemic lupus erythematosus by Francesca Faustini, Helena Idborg, Enrico Fuzzi, Anders Larsson, Wen-Rong Lie, Sven Pötzsch, Shinji L Okitsu, Elisabet Svenungsson and Iva Gunnarsson in Lupus

Two new nor-triterpenoids ganodrenol A (1), B (2), and a new natural product ganodrenol C (3), along with three known nor-triterpenoids (4–6) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (1–6) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of...

COVID-19 has affected more or less every nation across the world and affected the economy very badly. Infection of this virus in human took the life of millions. We have already faced the first and the second waves of COVID-19 and recently, the nations or humanity is afraid of new strain, that is, OMICRON. Considered to highly infectious than the previous strains. Therefore, the researchers are working to find a promising molecule with no or...

Supplemental material, sj-pdf-1-cpj-10.1177_00099228221134441 for Electrocardiographic QTc as a Surrogate Measure of Cardiac Risk in Children, Adolescents, and Young Adults With Eating Disorders by Perry B. Dinardo, Ellen S. Rome, Ira B. Taub, Wei Liu, Kenneth Zahka and Peter F. Aziz in Clinical Pediatrics

To describe how managers of employees on sick-leave, due to chronic pain conditions, experience participating in a three-party meeting using the Demand and Ability Protocol (DAP) in the return-to-work process. This study is based on individual semi-structured interviews with 17 managers of employees with chronic pain. Interviews were conducted after participating in a three-party meeting including the employee, manager, and a representative from the rehabilitation team. The data were analyzed using thematic analysis with an...

Additional file 1. The tables of the filtering parameters setting using Prinseq-lite software, primers and probes used to detect co-infection respiratory viruses, type analysis of common virus-related sequence viral in MP positive and MP negative (TTV has been removed). Table S1: The filtering parameters setting using Prinseq-lite software. Table S2: Primers and probes used to detect co-infection respiratory viruses. Table S3: Type analysis of common virus-related sequence viral in MP positive and MP negative (TTV...

Additional file 1.

Chikungunya virus (CHIKV) causes Chikungunya fever (CHIKF) and till date no effective medicine for its cure is available in market. Different research groups find various possible interactions between small molecules and non-structural proteins, viz. nsP3, one of the most important viral elements in CHIKV. In this work, authors have studied the interactions of nsP3 of CHIKV with pyranooxazoles. Initially, a one-pot three-component reaction was designed using oxazolidine-2,4-dione, benzaldehyde and cyanoethylacetate to get a proposed biological...

Additional file 2. Table S2: The different parameters used for the optimisation of the SVM based classifier.

supplement 1

Additional file 9.

We studied associations between fractional exhaled nitric oxide (FeNO), health and household exposure among school children (N = 348) in Penang, Malaysia. Multiple logistic regression and linear mixed models were applied. Overall, 46.0% had elevated FeNO (>20 ppb) and 10.6% diagnosed asthma. Male gender (p = 0.002), parental asthma or allergy (p = 0.047), cat allergy (p = 0.009) and seafood allergy (p < 0.001), diagnosed asthma (p = 0.001), wheeze (p = 0.001), ocular...

Additional file 1. Estimating genotype probabilities in pooled blocks with marginal likelihoods, self-consistency and heterozygotes degeneracy.

Additional file 3. Outline of the ACT intervention adapted for plwMND.

We report a long campaign to track the 1.8 hr photometric wave in the recurrent nova T Pyxidis, using the global telescope network of the Center for Backyard Astrophysics. During 1996-2011, that wave was highly stable in amplitude and waveform, resembling the orbital wave commonly seen in supersoft binaries. The period, however, was found to increase on a timescale P/P-dot=3x10^5 yr. This suggests a mass transfer rate of ~10^-7 M_sol/yr in quiescence. The orbital signal...