Additional file 3. Effect of PHLPP 1 or PHLPP2 over-expression on AS160 in insulin signaling and insulin resistant condition in neuronal cells (SHSY-5Y).

Additional file 5. Flowchart of PHLPP isoform specific regulation of Akt isoforms, AS160 and glucose uptake in insulin signaling and -resistance in neuronal cells.

For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an essential enzyme that catalyses the replication from RNA template and therefore remains an attractive therapeutic target for anti-COVID drug discovery. In the present study, we performed a comprehensive in silico screening for 16,776 potential molecules from recently established drug libraries based on two important pharmacophores (3-amino-4-phenylbutan-2-ol and piperazine). Based on initial assessment, 4042 molecules were obtained suitable as drug candidates, which were following Lipinski’s rule. Molecular docking...

For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an essential enzyme that catalyses the replication from RNA template and therefore remains an attractive therapeutic target for anti-COVID drug discovery. In the present study, we performed a comprehensive in silico screening for 16,776 potential molecules from recently established drug libraries based on two important pharmacophores (3-amino-4-phenylbutan-2-ol and piperazine). Based on initial assessment, 4042 molecules were obtained suitable as drug candidates, which were following Lipinski’s rule. Molecular docking...

Additional file 6. Effect of PHLPP1 or PHLPP2 silencing or over-expression on Akt isoforms, AS160 and neuronal glucose uptake under insulin resistant condition in neuronal cells (N2A/SHSY-5Y).

Additional file 4. Effect of Scribble silencing on N2A cells.

Additional file 4. Effect of Scribble silencing on N2A cells.

This work attempts to identify the latent factors controlling the hydrogeochemistry and assess the groundwater quality and associated health risks in the intermontane valley of Nalagarh in the sub-Himalayan zone in northern India. Analytical results of 64 groundwater samples, 32 each collected during pre monsoon and post monsoon seasons show contrasting results for their major chemical constituents. During pre monsoon period, only 3% of the samples exceed their permissible limits for pH, EC, TH and...

Human cytomegalovirus (HCMV) is a widespread virus that can cause serious and irreversible neurological damage in newborns and even death in children who do not have the access to much-needed medications. While some vaccines and drugs are found to be effective against HCMV, their extended use has given rise to dose-limiting toxicities and the development of drug-resistant mutants among patients. Despite half a century’s worth of research, the lack of a licensed HCMV vaccine heightens...

Human cytomegalovirus (HCMV) is a widespread virus that can cause serious and irreversible neurological damage in newborns and even death in children who do not have the access to much-needed medications. While some vaccines and drugs are found to be effective against HCMV, their extended use has given rise to dose-limiting toxicities and the development of drug-resistant mutants among patients. Despite half a century’s worth of research, the lack of a licensed HCMV vaccine heightens...

Additional file 1:

Additional file 1. Effect of PHLPP1 silencing on N2A cells.

Additional file 2. Effect of PHLPP2 silencing on N2A cells.

Additional file 5. Flowchart of PHLPP isoform specific regulation of Akt isoforms, AS160 and glucose uptake in insulin signaling and -resistance in neuronal cells.

This work attempts to identify the latent factors controlling the hydrogeochemistry and assess the groundwater quality and associated health risks in the intermontane valley of Nalagarh in the sub-Himalayan zone in northern India. Analytical results of 64 groundwater samples, 32 each collected during pre monsoon and post monsoon seasons show contrasting results for their major chemical constituents. During pre monsoon period, only 3% of the samples exceed their permissible limits for pH, EC, TH and...

The optimized molecular geometry, vibrational assessments, natural bond orbital (NBO) analyses for 3-Methylpyridine were performed by B3LYP/6–311++G (d,p) functional. Computational vibrational frequencies and NMR spectra were compared with the recorded experimental data. The charge distribution, reactive areas, and electrostatic potential were well defined with the help of Molecular Electrostatic Potential surface (MEP) and Fukui functions. The energy difference between HOMO and LUMO revealed chemical activity of the titled molecule. Natural bond order analysis (NBO) was...

Additional file 1. Effect of PHLPP1 silencing on N2A cells.

Additional file 2. Effect of PHLPP2 silencing on N2A cells.

Additional file 1:

Human cytomegalovirus (HCMV) is a widespread virus that can cause serious and irreversible neurological damage in newborns and even death in children who do not have the access to much-needed medications. While some vaccines and drugs are found to be effective against HCMV, their extended use has given rise to dose-limiting toxicities and the development of drug-resistant mutants among patients. Despite half a century’s worth of research, the lack of a licensed HCMV vaccine heightens...

A 3D finite element model has been developed for studying the ballistic behaviour of bi-layer ceramic-metal target plates under the impact loads induced by the projectiles of different diameter to length ratios. The bi-layer target constituted of alumina 95, as front layer, backed by aluminium alloy 2024-T3 layer, has been impacted by steel 4340 blunt and ogival nosed projectiles of diameter to length ratios, 0.5 and 1.1. The constitutive behaviour of ceramic was modelled using...

The ballistic behaviour of a bi-layer ceramic-metal target against steel projectile with varying layer thicknesses has been investigated using a three-dimensional finite element model. The bi-layer target was made of alumina 99.5 % ceramic front layer and aluminium 2024-T3 metallic back layer with an areal dimension of 100×100 mm and the thickness of both layers were varied, with the total thickness of the composite being kept as 10 mm and 20 mm. A steel 4340...

The optimized molecular geometry, vibrational assessments, natural bond orbital (NBO) analyses for 3-Methylpyridine were performed by B3LYP/6–311++G (d,p) functional. Computational vibrational frequencies and NMR spectra were compared with the recorded experimental data. The charge distribution, reactive areas, and electrostatic potential were well defined with the help of Molecular Electrostatic Potential surface (MEP) and Fukui functions. The energy difference between HOMO and LUMO revealed chemical activity of the titled molecule. Natural bond order analysis (NBO) was...