Additional file 1: Figure S1. Boxplot showing MFIs of all Isotype antibody controls.

Additional file 3: Figure S3. Boxplot showing MFIs of all rat Isotype antibody controls.

Additional file 5: Figure S5. Boxplot showing MFIs of all Mouse antibodies without Mouse IgG3 antibodies.

Additional file 5: Figure S5. Boxplot showing MFIs of all Mouse antibodies without Mouse IgG3 antibodies.

Additional file 6: Figure S6. Boxplot showing MFIs of Mouse IgG3 antibodies only.

Additional file 9: Table S1. Table summarizing the results of the HPA analysis related to the biomarkers identified for renal cancer.

Additional file 4: Fig. S1. Expressed lncRNAs in two crosses.

Additional file 5: Fig. S2. Expression levels of lncRNAs and PCgenes in sunflower endosperm.

Additional file 7: Fig. S4. DNA methylation profiles of protein-coding genes (PCgenes) in sunflower endosperm from SY1.

Additional file 1: Figure S1. Study design. Figure S2. Tumor response of patients in the dose-escalation and dose-expansion phase. Figure S3. Percentage change from baseline in target lesion tumour burden over time in patients with select tumors at the recommended dose (30 mg/kg q3w). Figure S4. Receiver operating characteristic curve analysis of pSmad2 level in tumor cells for ORR per RECIST v1.1. Table S1. Pharmacokinetic parameters following a single infusion. Table S2. Summary of treatment-related...

Verify the applicability of three-level simulation to BDFA through experiments

Supporting information

Additional file 6: Fig. S6. Seroprevalence of tested antigens in the CoLaus|PsyCoLaus. List of the 27 antigens available from the CoLaus|PsyCoLaus study that are shared with the UK Biobank. The percentages indicate the seroprevalence of antibodies against infectious disease antigens tested using Multiplex Serology platform. The grey boxes indicate the pathogen on which the antigen protein is found, and the family to which the pathogen belongs.

Additional file 1: Supplementary Figures S1-S23 and Supplementary Tables S1-S3.

Additional file 2. Peer review history.

Additional file 1. Supplementary material regarding (i) the definition of cancer cases for HCC, GBC, Adv.PrC and Loc.PrC; (ii) the definition and implementation of the data-shared lasso; (iii) the models used to derive point estimates and confidence intervals from the model selected by the data-shared lasso; and (iv) the univariate analysis conducted for comparison.

Additional file 2: Supplementary tables and figures. Figure S1. Pearson correlation between the 117 original metabolites. Figure S2. Sensitivity analyses of mutually adjusted ORs for the overall associations and cancer type-specific deviations. Figure S3. Sensitivity analysis of mutually adjusted ORs for the overall associations and cancer type-specific deviations with or without excluding hormone users. Figure S4. p-values of tests for departure from linearity and effect modification by BMI. Figure S5. ORs for the overall associations...

Additional file 1. Appendix: Figures of Quantile regression and DEA Results.

Verify the applicability of three-level simulation to BDFA through experiments

The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes with chromatin clearance through the release of the DNase I inhibitor actin. Actin-mediated inhibition was compensated by upregulation of DNase I or the actin scavenger gelsolin. Splenocyte death and neutrophil extracellular trap (NET) clearance deficiencies were prevalent in individuals with severe COVID-19...

Supplemental material, sj-pdf-1-smm-10.1177_09622802221139233 for Standard error estimation in meta-analysis of studies reporting medians by Sean McGrath, Stephan Katzenschlager, Alexandra J Zimmer, Alexander Seitel, Russell Steele and Andrea Benedetti in Statistical Methods in Medical Research

The structural instability of inactivated Foot-and-mouth disease virus antigen hinders the development of vaccine industry. The use of an inexpensive, biocompatible formulation to slow down the degradation of antigen would address the problem. Here, phosphate-buffered saline (PBS) was showed to be effective in stabilizing 146S and hence determined as basic solution buffer. Excipients such as trehalose, sucrose, arginine, cysteine, calcium chloride, BSA and ascorbic acid were found to protect 146S from massive structural breakdown. Using...

Additional file 1.

Additional file 2: Table S2. Table showing the complete sLGGs cohort emphasizing the original histology before molecular pathology reevaluation, anatomical location, and molecular-biology data.

Supplementary Material 1