81 Works

Additional file 1 of Glycosylated haemoglobin and prognosis in 10,536 people with cancer and pre-existing diabetes: a meta-analysis with dose-response analysis

Suping Ling, Michael Sweeting, Francesco Zaccardi, David Adlam & Umesh T. Kadam
Additional file 1 Search algorithms on 25th Nov 2021. Supplementary Table 1. Reasons of exclusion of studies following full-text review. Supplementary Table 2. Data conversions and references of included studies. Supplementary Table 3. Newcastle-Ottawa score for included studies. Supplementary Table 4. Trim-and-fill analyses results. Supplementary Fig. 1. Flowchart for data conversion. Supplementary Fig. 2. Funnel plots following trim-and-fill. Supplementary Fig. 3. Meta-analysis within studies of high quality (NOS score ≥ 6). Supplementary Fig. 4a. Subgroup...

Additional file 2 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 2. Delphi survey instruction.

Additional file 2 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 2. Delphi survey instruction.

Additional file 6 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 6. Consensus meeting statements.

Additional file 3 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 3. Full round 1 results.

Thermo-hydraulic performance of a circular microchannel heat sink using swirl flow and nanofluid

Aldo Rona, Abdullah Ali, Hakim Tarteeb Kadhim Kadhim, Matteo Angelino & Shian Gao
Increasing the power and reliability of microelectronic components requires heat sinks with greater heat transport performance. This study investigates the hydraulic and heat transport performance of a silicon heat sink under a constant heat flux of 100 W/cm2 with liquid coolant running through parallel microchannels. The coupled heat transfer through the silicon walls and the coolant, modelled as a single-phase fluid, is examined over the Reynolds number range 100 to 350 for micro-channels of circular...

STIMULATE-ICP-Delphi (symptoms, trajectory, inequalities and management: Understanding long-COVID to address and transform existing integrated care pathways Delphi): Study protocol.

Christina M van der Feltz-Cornelis, Jennifer Sweetman, Gail Allsopp, Emily Attree, Michael G Crooks, Daniel J Cuthbertson, Denise Forshaw, Mark Gabbay, Angela Green, Melissa Heightman, Toby Hillman, Lyth Hishmeh, Kamlesh Khunti, Gregory YH Lip, Paula Lorgelly, Hugh Montgomery, W David Strain, Emma Wall, Caroline Watkins, Nefyn Williams, Dan G Wootton, Amitava Banerjee & STIMULATE-ICP Consortium
INTRODUCTION: As mortality rates from COVID-19 disease fall, the high prevalence of long-term sequelae (Long COVID) is becoming increasingly widespread, challenging healthcare systems globally. Traditional pathways of care for Long Term Conditions (LTCs) have tended to be managed by disease-specific specialties, an approach that has been ineffective in delivering care for patients with multi-morbidity. The multi-system nature of Long COVID and its impact on physical and psychological health demands a more effective model of holistic,...

Additional file 1 of An evaluation of the implementation of interventions to reduce postoperative infections and optimise antibiotic use across the surgical pathway in India: a mixed-methods exploratory study protocol

Shalini Ahuja, Sanjeev Singh, Esmita Charani, Surya Surendran, Vrinda Nampoothiri, Fabia Edathadathil, Anu George, Andrew Leather, Carolyn Tarrant, Alison Holmes, Nick Sevdalis & Gabriel Birgand
Additional file 1: Appendix 1. Implementation science: basic concepts and definitions. Appendix 2. Summary of characteristics of studies meeting final (stage 2) inclusion criteria. Appendix 3. The search strategy for the Medline/EMBASE database. Appendix 4. Eight gold-standard implementation outcomes as defined by the implementation science evidence-base [19] and adopted by the WHO [16]. Appendix 5. Definitions of implementation strategies, ERIC framework [17].

Additional file 1 of An evaluation of the implementation of interventions to reduce postoperative infections and optimise antibiotic use across the surgical pathway in India: a mixed-methods exploratory study protocol

Shalini Ahuja, Sanjeev Singh, Esmita Charani, Surya Surendran, Vrinda Nampoothiri, Fabia Edathadathil, Anu George, Andrew Leather, Carolyn Tarrant, Alison Holmes, Nick Sevdalis & Gabriel Birgand
Additional file 1: Appendix 1. Implementation science: basic concepts and definitions. Appendix 2. Summary of characteristics of studies meeting final (stage 2) inclusion criteria. Appendix 3. The search strategy for the Medline/EMBASE database. Appendix 4. Eight gold-standard implementation outcomes as defined by the implementation science evidence-base [19] and adopted by the WHO [16]. Appendix 5. Definitions of implementation strategies, ERIC framework [17].

Additional file 5 of Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study

Neyme Veli, Christopher A. Martin, Katherine Woolf, Joshua Nazareth, Daniel Pan, Amani Al-Oraibi, Rebecca F. Baggaley, Luke Bryant, Laura B. Nellums, Laura J. Gray, Kamlesh Khunti & Manish Pareek
Additional file 5: Table S4. Unadjusted and adjusted odds ratios for an outcome of hesitancy for regular SARS-CoV-2 vaccination using complete cases (n=4030).

Additional file 1 of A genome-wide association study of survival in patients with sepsis

Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jose M. Lorenzo-Salazar, Almudena Corrales, Eva Suarez-Pajes, Rui Feng, Luis A. Rubio-Rodríguez, Megan L. Paynton, Raquel Cruz, M. Isabel García-Laorden, Miryam Prieto-González, Aurelio Rodríguez-Pérez, Demetrio Carriedo, Jesús Blanco, Alfonso Ambrós, Elena González-Higueras, Elena Espinosa, Arturo Muriel, Eduardo Tamayo, María M. Martin, Leonardo Lorente, David Domínguez, Abelardo García de Lorenzo, Heather M. Giannini, John P. Reilly … & Carlos Flores
Additional file 1. Supplementary methods, figures, and tables.The supplementary methods include a description of the GEN-SEP and MESSI study populations, genotyping and quality control, more details of the genome-wide association study of 28-day sepsis survival and the index event bias assessment, tools for the annotation of the functional effects of the sentinel variants and the gene expression of related genes, the association of polygenic risks of sepsis with the 28-day sepsis survival, the replication of...

Additional file 1 of Respiratory health among adolescents living in the Highveld Air Pollution Priority Area in South Africa

Danielle A. Millar, Thandi Kapwata, Zamantimande Kunene, Mirriam Mogotsi, Bianca Wernecke, Rebecca M. Garland, Angela Mathee, Linda Theron, Diane T. Levine, Michael Ungar, Chiara Batini, Catherine John & Caradee Y. Wright
Additional file 1.

Additional file 2 of Modelling multiple time-scales with flexible parametric survival models

Nurgul Batyrbekova, Hannah Bower, Paul W. Dickman, Anna Ravn Landtblom, Malin Hultcrantz, Robert Szulkin, Paul C. Lambert & Therese M-L. Andersson
Additional file 2: Supplementary Figure 1.

sj-pdf-1-jrs-10.1177_01410768221131897 - Supplemental material for Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study

Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry Hemingway, Cathie Sudlow & Amitava Banerjee
Supplemental material, sj-pdf-1-jrs-10.1177_01410768221131897 for Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study by Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry...

Age-specific survival trends and life-years lost in women with breast cancer 1990–2016: the NORDCAN survival studies

Frida E. Lundberg, Niels Kroman, Mats Lambe, Therese M.-L. Andersson, Gerda Engholm, Tom Børge Johannesen, Anni Virtanen, David Pettersson, Elínborg J. Ólafsdóttir, Helgi Birgisson, Paul C. Lambert, Lina Steinrud Mørch & Anna L. V. Johansson
A recent overview of cancer survival trends 1990–2016 in the Nordic countries reported continued improvements in age-standardized breast cancer survival among women. The aim was to estimate age-specific survival trends over calendar time, including life-years lost, to evaluate if improvements have benefited patients across all ages in the Nordic countries. Data on breast cancers diagnosed 1990–2016 in Denmark, Finland, Iceland, Norway, and Sweden were obtained from the NORDCAN database. Age-standardized and age-specific relative survival (RS)...

The RERE Deacetylase Complex

Edward A. Brown
Histone Deacetylases (HDACs) are important transcriptional regulators which remove acetyl groups from histone tails. Removal of acetyl groups affects gene expression. HDACs are part of large co-regulatory complexes. One of these complexes is called RERE and the core is comprised of: RERE, ATN1 and HDAC1. The RERE protein is a member of the atrophin family and is associated with developmental defects and neurological diseases. The aim of this project was to use structural and biochemical...

The RERE Deacetylase Complex

Edward A. Brown
Histone Deacetylases (HDACs) are important transcriptional regulators which remove acetyl groups from histone tails. Removal of acetyl groups affects gene expression. HDACs are part of large co-regulatory complexes. One of these complexes is called RERE and the core is comprised of: RERE, ATN1 and HDAC1. The RERE protein is a member of the atrophin family and is associated with developmental defects and neurological diseases. The aim of this project was to use structural and biochemical...

Linking Laser-Ablation ICP-MS analysis and sulfide textures in identifying gold remobilization and enrichment processes in modern seafloor massive sulfides, Kolumbo arc volcano, Greece

Stephanos P. Kilias , Evangelia Zygouri , Nikolaos Zegkinoglou , Manuel Keith , Thomas Zack , Daniel J. Smith , Paraskevi Nomikou & Paraskevi Polymenakou
Target settings to secure sustainable access to raw materials include seafloor massive sulphide (SMS) resources. Gold-rich SMS deposits, are often the result of complex interplay of multiple Au enrichment events. Recent studies have shown that high-grade Au ores result from Au remobilization from preexisting mineralization, driven by fluid-induced coupled dissolution-reprecipitation (CDR) reactions; however investigations into this process in modern Au-rich SMS, are lacking. To tackle this issue, Au-rich [AuBULK≤32ppm; Au/(Cu+Zn+Pb)=1.9], polymetallic (Sb, Tl, Hg, Ag,...

STIMULATE-ICP-Delphi (symptoms, trajectory, inequalities and management: Understanding long-COVID to address and transform existing integrated care pathways Delphi): Study protocol.

Christina M van der Feltz-Cornelis, Jennifer Sweetman, Gail Allsopp, Emily Attree, Michael G Crooks, Daniel J Cuthbertson, Denise Forshaw, Mark Gabbay, Angela Green, Melissa Heightman, Toby Hillman, Lyth Hishmeh, Kamlesh Khunti, Gregory YH Lip, Paula Lorgelly, Hugh Montgomery, W David Strain, Emma Wall, Caroline Watkins, Nefyn Williams, Dan G Wootton, Amitava Banerjee & STIMULATE-ICP Consortium
INTRODUCTION: As mortality rates from COVID-19 disease fall, the high prevalence of long-term sequelae (Long COVID) is becoming increasingly widespread, challenging healthcare systems globally. Traditional pathways of care for Long Term Conditions (LTCs) have tended to be managed by disease-specific specialties, an approach that has been ineffective in delivering care for patients with multi-morbidity. The multi-system nature of Long COVID and its impact on physical and psychological health demands a more effective model of holistic,...

Additional file 1 of A comparison between the clinical frailty scale and the hospital frailty risk score to risk stratify older people with emergency care needs

Abdullah Alshibani, Tim Coats, Laia Maynou, Fiona Lecky, Jay Banerjee & Simon Conroy
Additional file 1: Supplementary table 1. Information about important study basline covariates. Supplementary table 2. Two way cross-tabulation of CFS and HFRS categories — original categories. Supplementary table 3. Two way cross-tabulation of CFS and HFRS categories — frail versus non-frail categories. Supplementary table 4. Hospital-related outcomes by CFS, HFRS categories – mean (SD) and frequencies (%). Supplementary table 5. Adjusted logistic regression for study covariates in the CFS and HFRS multivariate logistic regression models....

Additional file 5 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 5. Full round 2 results.

Additional file 8 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 8. Round 1 free-text comments.

Additional file 9 of Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Martina Svobodova, Nina Jacob, Kerry Hood, Katie Gillies, Rachel Hale, Jennifer Bostock, Peter Bower, Adrian Edwards, Penelope Farthing, Sarah Rawlinson, Shaun Treweek & Jeremy Howick
Additional file 9. Round 2 free-text comments.

Additional file 3 of Hesitancy for receiving regular SARS-CoV-2 vaccination in UK healthcare workers: a cross-sectional analysis from the UK-REACH study

Neyme Veli, Christopher A. Martin, Katherine Woolf, Joshua Nazareth, Daniel Pan, Amani Al-Oraibi, Rebecca F. Baggaley, Luke Bryant, Laura B. Nellums, Laura J. Gray, Kamlesh Khunti & Manish Pareek
Additional file 3: Table S2. Derivation of variables used in the analysis from questionnaire data.

Additional file 1 of Respiratory health among adolescents living in the Highveld Air Pollution Priority Area in South Africa

Danielle A. Millar, Thandi Kapwata, Zamantimande Kunene, Mirriam Mogotsi, Bianca Wernecke, Rebecca M. Garland, Angela Mathee, Linda Theron, Diane T. Levine, Michael Ungar, Chiara Batini, Catherine John & Caradee Y. Wright
Additional file 1.

Registration Year

  • 2023
    6
  • 2022
    72
  • 2021
    3

Resource Types

  • Text
    81

Affiliations

  • University of Leicester
    81
  • Cardiff University
    26
  • University of Aberdeen
    22
  • University of Manchester
    22
  • University Hospitals of Leicester NHS Trust
    20
  • Leicester General Hospital
    18
  • National Institute for Health Research
    16
  • University College London
    16
  • University of Nottingham
    11
  • Loughborough University
    8