91 Works

Tick-borne encephalitis virus NS4A ubiquitination antagonizes type I interferon-stimulated STAT1/2 signalling pathway

Qi Yang, Jia You, Yuan Zhou, Yun Wang, Rongjuan Pei, Xinwen Chen, Min Yang & Jizheng Chen
Tick-borne encephalitis virus (TBEV) accounts for approximately 10,000 annual cases of severe encephalitis in Europe and Asia and causes encephalitis in humans. In this study, we demonstrate TBEV appears to activate the interferon (IFN)-β dependent on RIG-I/MDA5. Both the IFN-β accumulation and the IFN stimulated genes (ISGs) transcription greatly delay. Further studies reveal that TBEV NS4A could block the phosphorylation and dimerization of STAT1/STAT2 to affect type I and II IFN-mediated STAT signalling. Additional data...

The effects of chronic hypoxia and nitric oxide on myocardial contractility in steelhead trout (Onchorhynchus mykiss)

Environmental hypoxia has been intensifying and spreading in recent years due to climate change, and there is accumulating evidence that the cardiac function of hypoxia-intolerant fish is negatively affected by long-term exposure to low oxygen conditions. However, the cause of this reduced heart performance has not been conclusively identified, and it is unknown whether nitric oxide (NO)-mediated effects are involved. This thesis examined how chronic hypoxia (> 8 weeks at ~8 kPa O₂) influenced the...

Narrating Waegook identity: building transitory foreign-teacher community through folklore in the Republic of Korea

With increasing global mobility, itinerant expatriate groups – whether of teachers, retirees, students, or backpackers – constitute transitory folk groups easily overlooked by folklore studies. This thesis is an ethnographic study of a transient folk group of foreign teachers in Suncheon, Republic of Korea, and of how narratives about their experiences inform their sense of identity within that community. My observations of such groups in the Republic of Korea include working as a foreign English...

Drawing the line: advance requests for medical assistance in dying: broad considerations with a special focus on dementia

Julia
This thesis considers the issue of whether to expand Medical Assistance in Dying (MAiD) legislation to include advance requests (ARs) broadly, with particular consideration for the dementia condition. The goal is to provide a deeper understanding of the value tensions involved in a decision of if and how ARs for MAiD should be extended to the Canadian population. To date, much of the discussion of the ethics of advance requests for MAiD focuses on those...

LGBTQ2S tattooing in St. John's, NL.

This thesis offers an ethnographic account of LGBTQ2S tattooing in St. John’s, Newfoundland and Labrador through 19 interviews, four months of participant observation, and a media analysis. Interviews took place with tattooed and non-tattooed LGBTQ2S individuals, and tattoo artists/apprentices, ranging from 20 to 68 years old. Tattoo narratives were collected to understand what it might mean to be LGBTQ2S in St. John’s, in 2018. Research revealed that some LGBTQ2S individuals use tattoos for commemoration, self-expression,...

Lithofacies and alteration of the Hurricane zone, of the Boomerang volcanogenic massive sulphide deposit, Tulks belt, Central Newfoundland, Canada

The Hurricane zone of the Boomerang volcanogenic massive sulphide (VMS) deposit is part of the VMShosting Cambro-Ordovician Tulks volcanic belt. The Hurricane zone is one of three lenses in the deposit and consists of a sub-horizontal (semi-)massive sulphide lens with combined resources of 55,100 tonnes @ 13.4% Zn, 7.0% Pb, 1.20% Cu, 159.0 g/t Ag, and 2.00 g/t Au. Mineralization is hosted in intermediate to felsic volcaniclastic rocks of the ca. 488 Ma Pats Pond...

Spatio-temporal modelling of fish stocks: deriving spatially-explicit MSY references points using a metapopulation model

Many fisheries are successfully managed using reference points (RPs) based on the maximum sustainable yield (MSY), in particular fMSY , the fishing mortality rate that achieves MSY. Typically, fMSY is derived assuming fish are homogeneously distributed in space. However, fishing should be spatially allocated to optimize yields and reduce stock depletion, and fMSY should be derived assuming fish are heterogeneously distributed. In this thesis, we apply a deterministic, age-structured model to derive spatially-explicit MSY RPs....

The dreaming boy and the waking city: alcohol consumption and the construction of a working-class identity in late nineteenth century Stockholm

Sweden’s capital city of Stockholm grew in commercial importance in the second half of the nineteenth century as the country experienced rapid industrialisation. This resulted in high labour mobility as people migrated to the city seeking work. The sanitary and housing conditions of the working class varied according to income and the availability of employment. Stockholm’s administration and middle-class imposed its authority on transitory workers with the passage of the Vagrancy Act of 1885 and...

The structures of protonated and alkali metal cationized nucleobase self-assemblies and base pairs by infrared multiphoton dissociation spectroscopy and computational methods

Nucleobases are the bricks of nucleic acids such as deoxyribonucleic acid (DNA)/ribonucleic acid (RNA) molecules. In the current research, ionic nucleobase self-assemblies and base pairs were studied using gas-phase ion techniques in either a Fourier transform ion cyclotron resonance (FTICR) or ‘paul-type’ quadrupole ion-trap (QIT) mass spectrometers. Sustained off-resonance irradiation collision-induced dissociation (SORI-CID) and infrared multiphoton dissociation (IRMPD) were used to fragment the target ions. IRMPD spectroscopy was employed to collect spectra by using tunable...

An exploration of the relationships between students’ listening skills, self-rated academic listening, and their metacognitive awareness

This empirical study investigated international students’ challenges in listening to academic lectures, and their use of metacognitive listening strategies to overcome their problems. The participants were 46 international students at Memorial University of Newfoundland who were enrolled in various levels of different academic programs. The data were collected using the following instruments: an IELTS listening test, demographic questions, the self-rated academic listening questionnaire (ALSA), the metacognitive awareness listening questionnaire (MALQ), and two open-ended questions. The...

Effect of an inverted seated position with upper arm blood flow restriction on neuromuscular fatigue

Change in body position, in addition to disturbances to the homeostasis of our body, can exacerbate neuromuscular fatigue. Experiencing a voluntary or involuntary inverted position is a stressful condition and can alter sympathetic nervous system activity, which has been suggested as a primary mechanism that may inhibit neuromuscular and cardiovascular function. Moreover, there is a possibility of complete or partial blood flow due to limb compression during life-threatening conditions such as overturned vehicles. Blood flow...

Can we stop learning safety by accident?

The question has been asked in many forums, why are major accidents still occurring? Awareness is an important basic learning factor to properly manage the lessons to be learned from major accidents. Over time, the recommendations made following an accident may be forgotten, procedures allowed to lapse, changes are made to equipment and the accident is just waiting to happen again. The memory within an organization that should help to prevent process safety accidents decays...

Fabrication of doxorubicin-gated mesoporous polydopamine nanoplatforms for multimode imaging-guided synergistic chemophotothermal therapy of tumors

Min Yang, Ningnan Zhang, Tao Zhang, Xian Yin & Jie Shen
A versatile theranostic agent that integrated with therapeutic and diagnostic functions is extremely essential for cancer theranostic. Herein, a multifunctional theranostic nanoplatform (PFP@MPDA-DOX) based on perfluoropentane (PFP) encapsulated mesoporous polydopamine (MPDA) is elaborately designed, followed by gating of drug doxorubicin (DOX) for preventing cargo leaking. The MPDA with pH-responsive biodegradation behavior was served as nanocarrier, which also endows the nanoplatform with a large cavity for PFP filling. The nanoparticles were then gated with DOX molecule...

Iron-catalyzed cross-coupling of arylboronic acids with unactivated N-heterocycles and quinones under microwave heating

Traditional C-C cross-coupling reactions generally rely on the use of expensive and sometimes toxic metal catalysts, such as palladium or ruthenium. These methods generally require two functionalized reagents, which can increase reaction cost. In the interests of sustainability and reduced costs there has been considerable interest in catalysis using earth-abundant metals, such as iron, as well as in C-H activation reactions. One example of a C-H activation reaction is the Minisci reaction, which is a...

Micellar- and polymer-enhanced ultrafiltration for heavy metal and sulfate removal from aqueous solutions

Micellar-enhanced ultrafiltration (MEUF) and polymer-enhanced ultrafiltration (PEUF) show potential as promising techniques to remove dissolved ions from wastewater, but they remain inadequately understood. In this thesis, the MEUF removal of copper, nickel, and cobalt ions from aqueous solutions was investigated. The effect of surfactant-to-metal (S/M) ratio and pH on MEUF performance (i.e., metal rejection rate and permeate flux) were examined to obtain the preferred operational conditions. A resampling-based artificial neural network (ANN) modeling was proposed...

Plantwide simulation and monitoring of offshore oil and gas production facility

Monitoring is one of the major concerns in offshore oil and gas production platform since the access to the offshore facilities is difficult. Also, it is quite challenging to extract oil and gas safely in such a harsh environment, and any abnormalities may lead to a catastrophic event. The process data, including all possible faulty scenarios, is required to build an appropriate monitoring system. Since the plant wide process data is not available in the...

Opening up containment: making space in Newfoundland salmonid aquaculture

Studies in geography and STS looking at containment-in-practice have shown that thinking about containment as a hermetic closing off of a definite space is not suitable for this world, which is characterized by leakages, overflows, excesses, movements, and borders being crossed, contested and drawn again. However, renderings of containment still play an important role in the practices that make and break our worlds. This thesis attempts to open up containment by thinking through how containment...

Studies on marginally trapped tubes with positive Cosmological Constant Λ

In general relativity, the cosmological constantΛ is a special term in the Einstein field equations. Many observational clues suggest that Λ is positive. In this thesis, we investigate the behavior of quasilocal horizons of black holes under the condition of positive Λ. We modify the Λ = 0 condition in [10] and recalculate the evolution of marginally trapped tube in Tolman-Bondi spacetime with non-vanishing Λ. Then, we apply the obtained results to some examples of...

Phylogeographic analysis of an Arctic rabies host species, the red (Vulpes vulpes) and arctic (Vulpes lagopus) fox, in the Eastern Subarctic region of Canada

Rabies is a fatal disease that raises public health concerns in the Canadian Eastern Subarctic region, however, the origins and the spread of epizootics of this lethal zoonotic disease are little understood. Coloured or red (Vulpes vulpes) and arctic (Vulpes lagopus) foxes across northern Canada are considered to be the principal maintenance or reservoir hosts of rabies virus. Therefore, I studied the phylogeography of one host, the red fox, to better understand the movement of...

Surviving to thriving: post-secondary education for refugee youth in smaller centres in Canada

The research investigates refugee youth’s aspirations for and access to post-secondary education in St. John’s, Newfoundland and Labrador, Canada. The theoretical framework that underpins this study consists of segmented assimilation theory and the bioecological model of human development. A basic qualitative research approach was employed. Twenty refugee youths and three staff members from educational service providers participated in this study. Data were collected through one-on-one semi-structured interviews. Findings revealed that new life in Canada instilled...

The use of mobile health in the management of Chronic Obstructive Pulmonary Disease

The prevalence and mortality rates of chronic obstructive pulmonary disease (COPD) are increasing worldwide. Therefore, COPD remains a major public health problem. Using an mobile health (mHealth) intervention has the potential to enhance COPD treatment outcomes while mitigating healthcare costs. However, the complexity of the process of developing an mHealth intervention for COPD management is poorly understood, and in-depth assessment of the development process of mHealth interventions for COPD management is currently lacking. This thesis...

A study of dendrochirotid sea cucumbers with a focus on Cucumaria frondosa and its potential use in integrated multi-trophic aquaculture

Sea cucumbers play fundamental roles in marine ecosystems, and they have long been commercially harvested for seafood. In light of stock declines worldwide, research on cold-water suspension-feeding species is expanding. This thesis explores two species from the North Atlantic. The first chapter validates an aging technique in Psolus fabricii, based on the growth rings found in its large calcareous dermal plates. Imaging of plates obtained from juveniles of known age confirmed the annual addition of...

On relations of anisotropy and linear inhomogeneity using Backus average, 1-D tomography and two-parameter velocity inversion

We divide this thesis into three major parts. In the first part, we study three velocity models and corresponding traveltimes to obtain the inhomogeneity and anisotropy of a medium by comparing them to the field data. We derive an analytical relation that relates the linear inhomogeneity of a layered medium to the anisotropy parameter in an equivalent medium. For the analytic ease, we consider the P and S wave velocity gradients to be equal. We...

Investigating the mechanical properties of aluminum and epoxy polymer using molecular dynamics simulations

Molecular Dynamics simulations were used to recreate mechanical testing procedures and to predict the mechanical properties of aluminum and epoxy polymers. In the first study, a procedure for performing nanoindentation on single crystal FCC aluminum was designed and used to test which available force field and parameter sets were best suited for accurately predicting the elastic modulus. The modulus was calculated from the generated force-displacement curve using Oliver & Pharr as well as Hertz indentation...

Attitudes towards online and face-to-face counselling among university students in Newfoundland

This study investigated student attitudes towards online and face-to-face counselling at a university in Newfoundland. In addition, the variables ‘self-stigma’, ‘perceived stigma from others’ and ‘practical barriers to treatment’ were examined for their relationship with attitudes towards counselling. There were 166 students that participated in the study that included an online survey. While participants’ attitudes towards online counselling were favourable (M=39.34), students still significantly preferred face-to-face counselling (M=44.18). Students did not associate discomfort with either...

Registration Year

  • 2020
    91

Resource Types

  • Text
    91

Affiliations

  • Memorial University of Newfoundland
    91
  • Sichuan University
    6
  • Fudan University
    6
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    6
  • First Affiliated Hospital of Xi'an Jiaotong University
    6
  • Peking University
    5
  • Zhejiang University
    4
  • Hong Kong Baptist University
    4
  • Chengdu Medical College
    3
  • Zhongnan Hospital of Wuhan University
    3