1,331 Works

Neutrophil membrane-coated nanoparticles for enhanced nanosecond pulsed electric field treatment of pancreatic cancer

Jing Zhao, Huidan Lu, Danxia Xu, Ruiqi Sun, Chengyu Fang, Qiyu Zhao, Chang He, Yuwei Pan, Feng Xu & Tianan Jiang
Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide. Poor prognosis and low survival rates have driven the development of novel therapeutic strategies. Nanosecond pulsed electric field has emerged as a novel, minimal invasive and non-thermal treatment for solid tumors. It is of great significance to study the combination therapy of nsPEF and other treatment strategies for pancreatic cancer. We developed neutrophil membrane-wrapped liposomal nanoparticles loaded with gemcitabine (NE/Lip-GEM) and investigated their...

Supplementary document for Broadband behavior of quadratic metalenses with a wide field of view - 6011078.pdf

Yang Liu, Jianhao Zhang, Xavier Le Roux, Eric Cassan, Delphine Marris-Morini, Laurent Vivien, Carlos Alonso Ramos & Daniele Melati
Supplemental document with additional data, simulation results, and figures.

Supplementary document for Moiré artifacts reduction in Talbot-Lau X-ray phase contrast imaging using three-step iterative approach - 6020061.pdf

Siwei Tao, Yueshu Xu, ling bai, Zonghan Tian, Xiang Hao, Cuifang Kuang & Xu Liu
Supplement 1

A short report of novel RARG-HNRNPM fusion gene in resembling acute promyelocytic leukemia

Yang Song, Jiangxue Hou, Li Wan, Kaiqi Liu, Chunlin Zhou, Shuning Wei, Guangji Zhang, Dong Lin, Yan Li, Qiuyun Fang, Yuntao Liu, Benfa Gong, Xiaoyuan Gong, Ying Wang, Hui Wei, Jianxiang Wang & Yingchang Mi
Resembling acute promyelocytic leukemia (APL) is a unique subtype of APL who sharing clinical, morphological, and immunophenotypic features with typical APL, but lacking evidence of PML-RARA fusion gene and usually insensitive to arsenic trioxide (ATO) and all-trans retinoic acid (ATRA). For years, RARA, RARB and RARG rearrangement were found in resembling APL continually. The confirmed partner genes of RARG rearrangement included CPSF6, NUP98, NPM1, PML, and HNRNPC. These patients were a group of resembling APL...

mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern

Haomeng Wang, Zhao Chen, Zhenghua Wang, Jin Li, Zhihong Yan, Jinbo Yuan, Airu Zhu, Lan Chen, Ye Liu, Chenlong Hu, Ali Zhu, Guowei Li, Yuehu Li, Jie Deng, Liqiao Ma, Xiuwen Sui, Wei Miao, Junqiang Li, Xiuyu Zheng, Jinhua Piao, Yanfeng Yao, Juhong Rao, Chao Shan, Zhiming Yuan, Jincun Zhao … & Tao Zhu
In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against...

Upstream open reading frames mediate autophagy-related protein translation

Ying Yang, Damián Gatica, Xu Liu, Runliu Wu, Rui Kang, Daolin Tang & Daniel J. Klionsky
Macroautophagy/autophagy, a highly conserved catabolic pathway that maintains proper cellular homeostasis is stringently regulated by numerous autophagy-related (Atg) proteins. Many studies have investigated autophagy regulation at the transcriptional level; however, relatively little is known about translational control. Here, we report the upstream open reading frame (uORF)-mediated translational control of multiple Atg proteins in Saccharomyces cerevisiae and in human cells. The translation of several essential autophagy regulators in yeast, including Atg13, is suppressed by canonical uORFs...

Additional file 1 of Ambient air pollution associated with incidence and dynamic progression of type 2 diabetes: a trajectory analysis of a population-based cohort

Yinglin Wu, Shiyu Zhang, Samantha E. Qian, Miao Cai, Haitao Li, Chongjian Wang, Hongtao Zou, Lan Chen, Michael G. Vaughn, Stephen Edward McMillin & Hualiang Lin
Additional file 1: Details of outcomes. Table S1. The UDI, definition and measurements of covariates. Table S2. Characteristics of the participants included or excluded in the study. Table S3. Distributions of the annual average exposures among 398,993 participants. Table S4. Associations between air pollution and risk of cause-specific mortality. Table S5. Results of 2-pollutant models. Table S6. Results of sensitivity analyses in the model including traffic noise (n = 393,515). Table S7. Results of sensitivity...

Additional file 4 of SWI/SNF complex gene variations are associated with a higher tumor mutational burden and a better response to immune checkpoint inhibitor treatment: a pan-cancer analysis of next-generation sequencing data corresponding to 4591 cases

Yue Li, Xinhua Yang, Weijie Zhu, Yuxia Xu, Jiangjun Ma, Caiyun He & Fang Wang
Additional file 4: Table S1. Synthetic lethal interactive pairs and chemical inhibitors involving SWI/SNF members.

Additional file 1 of Deep progressive learning achieves whole-body low-dose 18F-FDG PET imaging

Taisong Wang, Wenli Qiao, Ying Wang, Jingyi Wang, Yang Lv, Yun Dong, Zheng Qian, Yan Xing & Jinhua Zhao
Additional file 1. The details of algorithm design, network training and testing.

Additional file 1 of Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetuses

Fang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Additional file 1. Analysis and interpretation process of fetal ES data.

Additional file 1 of Fecal microbiota dynamics and its relationship to diarrhea and health in dairy calves

Hongwei Chen, Yalu Liu, Kailang Huang, Bin Yang, Yuanyuan Zhang, Zhongtang Yu & Jiakun Wang
Additional file 1: Fig. S1. A schematic showing the experimental design, milk feeding, and fecal sample collection of the two trials.

Additional file 2 of Fecal microbiota dynamics and its relationship to diarrhea and health in dairy calves

Hongwei Chen, Yalu Liu, Kailang Huang, Bin Yang, Yuanyuan Zhang, Zhongtang Yu & Jiakun Wang
Additional file 2: Fig. S2. Heatmap of the ASVs associated with diarrheic status in stage 4 of trial 1. The ASVs were identified based on fold change and analysis using LEfSe or DESeq2.

Additional file 5 of Fecal microbiota dynamics and its relationship to diarrhea and health in dairy calves

Hongwei Chen, Yalu Liu, Kailang Huang, Bin Yang, Yuanyuan Zhang, Zhongtang Yu & Jiakun Wang
Additional file 5: Fig. S4. Heatmap of the ASVs that identified to be diarrheic status transition-associated in trial 2. The ASVs were identified based on fold change and analysis using LEfSe or DESeq2.

Additional file 1 of The effectiveness of case management for cancer patients: an umbrella review

Nina Wang, Jia Chen, Wenjun Chen, Zhengkun Shi, Huaping Yang, Peng Liu, Xiao Wei, Xiangling Dong, Chen Wang, Ling Mao & Xianhong Li
Additional file 1.

Additional file 2 of The effectiveness of case management for cancer patients: an umbrella review

Nina Wang, Jia Chen, Wenjun Chen, Zhengkun Shi, Huaping Yang, Peng Liu, Xiao Wei, Xiangling Dong, Chen Wang, Ling Mao & Xianhong Li
Additional file 2. Searching strategies.

Additional file 1 of AGuIX nanoparticles enhance ionizing radiation-induced ferroptosis on tumor cells by targeting the NRF2-GPX4 signaling pathway

Hao Sun, Hui Cai, Chang Xu, Hezheng Zhai, François Lux, Yi Xie, Li Feng, Liqing Du, Yang Liu, Xiaohui Sun, Qin Wang, Huijuan Song, Ningning He, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Géraldine Leduc, Tristan Doussineau, Yan Wang, Qiang Liu & Olivier Tillement
Additional file 1: Figure S1. (A) Representative images of dissected tumors across the different treatment groups. (B-C) PCNA protein expression levels were selected as indices of tumor tissue proliferation for immunohistochemical detection and analysis. (D-E) TUNEL experiment of tumor tissues in different treatment groups. Figure S2. Hematoxylin and eosin staining tests (Figure S2A) and serum biochemical indices, including albumin, alanine aminotransferase, creatinine, and urea levels,(Figure S2B-E) showed that there was no significant histological evidence of...

Additional file 1 of Comprehensive virome analysis of the viral spectrum in paediatric patients diagnosed with Mycoplasma pneumoniae pneumonia

Qiong Guo, Lili Li, Chao Wang, Yiman Huang, Fenlian Ma, Shanshan Cong, Jingjing Tan, Lihong Yao, Aijun Chen & Lishu Zheng
Additional file 1. The tables of the filtering parameters setting using Prinseq-lite software, primers and probes used to detect co-infection respiratory viruses, type analysis of common virus-related sequence viral in MP positive and MP negative (TTV has been removed). Table S1: The filtering parameters setting using Prinseq-lite software. Table S2: Primers and probes used to detect co-infection respiratory viruses. Table S3: Type analysis of common virus-related sequence viral in MP positive and MP negative (TTV...

Additional file 2 of Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies

Ying Du, Chao Zhao, Juntong Liu, Chuan Li, Qi Yan, Lin Li, Yunfeng Hao, Dan Yao, Huaxing Si, Yingjun Zhao & Wei Zhang
Additional file 2: Table S2. Comparison of clinical outcomes between single first-line and repeated first-line treatment subgroups in rituximab cohort

Omicron infections profile and vaccination status among 1881 liver transplant recipients: a multi-centre retrospective cohort

Ensi Ma, Jingwen Ai, Yi Zhang, Jianming Zheng, Xiaogang Gao, Junming Xu, Hao Yin, Zhiren Fu, Hao Xing, Li Li, Liying Sun, Heyu Huang, Quanbao Zhang, Linlin Xu, Yanting Jin, Rui Chen, Guoyue Lv, Zhijun Zhu, Wenhong Zhang & Zhengxin Wang
A wave of Omicron infections rapidly emerged in China in 2022, but large-scale data concerning the safety profile of vaccines and Coronavirus disease 2019 (COVID-19) infection features in liver transplant (LT) recipients have not been collected. Therefore, the aim of this study was to assess the protectiveness and safety profile of the inactivated vaccines in LT patients against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infections. A multi-centre retrospective study was conducted in...

In vitro anti-PRV activity of dihydromyricetin from Ampelopsis grossedentata

Wei Sun, Shanshan Liu, Anfa Lu, Fan Yang & Junhong Duan
Pseudorabies (PR) is an acute infectious disease caused by pseudorabies virus (PRV). There are no available drugs due to the emergence of variant of PRV. Dihydromyricetin (DMY) is a flavonoid extracted from Ampelopsis grossedentata (A. grossedentata), which has a variety of pharmacological activities. In this study, we aim to investigate the in vitro anti-PRV activity of DMY extracted from A. grossedentata. MTT assay was used to detect the cytotoxicity and antiviral activity of DMY. The...

Additional file 2 of AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial

Zhiyao Chen, Xiaonan Yang, Jia Guo, Tao Jin, Ziqi Lin, Ping Zhu, Jing Li, Ling Li, Xin Sun, Dan Du, Kun Jiang, Yanqiu He, Fei Cai, Lan Li, Cheng Hu, Qingyuan Tan, Wei Huang, Lihui Deng & Qing Xia
Additional file 2. PRECIS-2 scores of chaiqin chengqi decoction for predicted moderately severe and severe acute pancreatitis (CAP trial) domains.

Additional file 1 of CD19+CD24hiCD38hi regulatory B cells deficiency revealed severity and poor prognosis in patients with sepsis

Chunmei Wang, Huihui Xu, Rui Gao, Fengying Leng, Fangjie Huo, Yinzhen Li, Siting Liu, Mingzheng Xu & Jianwen Bai
Additional file 1. Table S1. Clinical and laboratory data in septic patients and healthy donors.

Rapid and Highly Efficient Solid-Phase Microextraction Based on in Situ Derivation of Robust Carbonaceous Nanostrips on Anodized Titanium Fiber for Sensitive Determination of Polycyclic Aromatic Hydrocarbons in Environmental Water

Lei Zhang, Pei Liu, Hua Zhou, Junliang Du, Xuemei Wang & Xinzhen Du
With titanium wire as a titanium source and a fiber substrate, titania nanostrips (TiO2NSs) were in situ grown on the fiber surface by electrochemical anodization and used as supporting templates for subsequent uniform deposition of polar glucose via hydrothermal reaction. After annealing, controllable in situ derivation of TiO2NSs-templated carbonaceous coating (TiO2@CNSs) was achieved on the Ti fiber substrate. Coupled to high-performance liquid chromatography with UV detection, the extraction performance was investigated using representative aromatic compounds...

Effects of nano-titanium dioxide on calcium homeostasis in vivo and in vitro: a systematic review and meta-analysis

Yaqian Yang, Yiman Zhao, Qianqian Wang, Mi Liu, Hongmei Chang, Li Li, Xiaojia Meng, Yaxin Deng, Chunmei Ling, Kui Wang, Guanling Song & Xin Sui
With the extensive application of titanium dioxide nanoparticles (TiO2 NPs), their impacts on calcium homeostasis have aroused extensive attention from scholars. However, there are still some controversies in relevant reports. Therefore, a systematic review was performed followed by a meta-analysis to explore whether TiO2 NPs could induce the imbalance in calcium homeostasis in vivo and in vitro through Revman5.4 and Stata15.0 in this research. Fourteen studies were included through detailed database retrieval and literature screening....

Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH

Dawei Li, Yueqi Leng, Zhengzheng Liao, Jinfang Hu, Yan Sun, Sa Deng, Chao Wang, Xiangge Tian, Jian Zhou & Ruoyu Wang
Two new nor-triterpenoids ganodrenol A (1), B (2), and a new natural product ganodrenol C (3), along with three known nor-triterpenoids (4–6) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (1–6) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of...

Registration Year

  • 2022

Resource Types

  • Text


  • Second Military Medical University
  • Shanghai Jiao Tong University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Sun Yat-sen University
  • Fudan University
  • Zhejiang University
  • Capital Medical University
  • Chinese Academy of Sciences
  • Sichuan University
  • Peking University