Additional file 1: Figure S1. Associations between L-carnitine and the risk of gestational diabetes mellitus (GDM) in Chinese women.

Supplemental material, sj-pdf-1-imr-10.1177_03000605221148905 for Prevalence and management of hypertension in Central China: a cross-sectional survey by Wenlu Xing, Shan Wang, Xinyun Liu, Jicheng Jiang, Qiuping Zhao, Yuming Wang, You Zhang and Chuanyu Gao in Journal of International Medical Research

Supplemental material, sj-docx-1-cat-10.1177_10760296221151164 for Derivation and External Validation of a Risk Assessment Model of Venous Thromboembolism in Hospitalized Chinese Patients by Xiaolan Chen, Jiali Huang, Jinxuan Liu, Jiaqi Chang, Lei Pan, Yong Wang, Yuan Gao and Yuanhua Yang in Clinical and Applied Thrombosis/Hemostasis

Supplemental material, sj-docx-1-cat-10.1177_10760296221151164 for Derivation and External Validation of a Risk Assessment Model of Venous Thromboembolism in Hospitalized Chinese Patients by Xiaolan Chen, Jiali Huang, Jinxuan Liu, Jiaqi Chang, Lei Pan, Yong Wang, Yuan Gao and Yuanhua Yang in Clinical and Applied Thrombosis/Hemostasis

Sixteen alkaloid compounds were isolated from the dried rhizomes of P. zanlanscianense, including a pair of new enantiomers (R/S)-7'-ethoxy-trans-p-couma-royltyramine (1a/1b) and 14 known compounds (2-14) isolated from this plant for the first time. The structures of new compounds were identified by IR, NMR and MS spectroscopic analysis, and their absolute configurations were determined by comparison of the experimental and calculated ECD data.

Diagnosis of cancer at early stages can significantly increase a patient’s survival rate and improve their quality of life. Tissue biopsy, considered as the clinically validated gold standard approach, has been applied to diagnose diseases and cancers. However, tissue biopsy faces a series of issues for wide practical utilizations, such as its invasive nature with associated risk and the difficulty of repeated sampling. Recently, liquid biopsy as an alternative candidate for clinical applications (e.g., early...

Supplementary material

Supplemental Document

Interleukin-17 (IL-17) family cytokines play critical roles in inflammation and pathogen resistance. Inflammation in the central nervous system, denoted as neuroinflammation, promotes the onset and progression of Alzheimer’s disease (AD). Previous studies showed that IL-17A neutralizing antibody treatment alleviated Amyloid β (Aβ) burden in rodent models of AD, while overexpression of IL-17A in mouse lateral ventricles rescued part of the AD pathology. However, the involvement of IL-17 in AD and its mechanism of action remain...

Glucose fluctuation is more harmful than sustained hyperglycemia, but the effect on cardiomyocyte apoptosis have not yet been clarified. In this study, we aim to identify the effect of glucose fluctuation on cardiomyocyte apoptosis and explore the underlying mechanism. Sprague-Dawley rats were intraperitoneally injected with streptozotocin (STZ) and divided into three groups: controlled diabetic group (C-STZ); uncontrolled diabetic group (U-STZ) and glucose fluctuated diabetic group (GF-STZ). After twelve weeks, echocardiography, Hematoxylin-eosin (HE) staining, and Masson...

Supplementaryexperimental details

In current clinical trial development, historical information is receiving more attention as it provides utility beyond sample size calculation. Meta-analytic-predictive (MAP) priors and robust MAP priors have been proposed for prospectively borrowing historical data on a single endpoint. To simultaneously synthesize control information from multiple endpoints in confirmatory clinical trials, we propose to approximate posterior probabilities from a Bayesian hierarchical model and estimate critical values by deep learning to construct pre-specified strategies for hypothesis testing....

Herein, we prepare two types of MgAl-LDHs coatings single-doped by imidazolium ionic liquid 1-decyl-3-methylimidazolium bromide ([Demim]Br) or sodium dodecylbenzenesulphonate (SDBS) and double-doped by [Demim]Br and SDBS on AZ31B Mg alloy by using an in-situ hydrothermal treatment. Their surface morphology and corrosion resistance immersed in 3.5 wt-% NaCl solution are explored. Our results suggest that the double doping of [Demim]Br and SDBS will change the surface morphology of the coating and a uniform and dense film...

Insulin resistance (IR) is a complex pathological condition resulting from the dysregulation of cellular response to insulin hormone in insulin-dependent cells and is recognized as a pathogenic hallmark and strong risk factor for metabolic syndrome. The present study aims to elucidate the molecular mechanism of the pathogenesis of IR. Here, we used human umbilical vein endothelial cells (HUVECs) to establish the IR cell model induced by 1 × 10−6 mmol/L insulin. After 48 h, reactive...

The effective electrocatalysts for hydrogen evolution reaction (HER) in alkaline aqueous is critical point to reduce energy losses for water electrolysis. Here, a highly active and stable electrochemical catalyst of platinum (Pt) nanoparticles loaded on three-dimensional Ti3C2Tx-reduced graphite oxide (rGO) hybrid support (Pt/Ti3C2Tx-rGO3D) has been developed for hydrogen evolution reaction (HER). The large surface of 3 D support provides an adequate site for deposition of Pt nanoparticles, leading to superior HER activity with low overpotential...

Spinal cord injury (SCI) refers to the interruption of the tracts inside the spinal cord caused by various factors. The repair of damaged axons has always been a difficult point in clinical treatment and neuroscience research. The treatment of SCI with Buyang huanwu decoction (BYHWD), a well-known recipe for invigorating Qi (a vital force forming part of any living entity in traditional Chinese culture) and promoting blood circulation, shows a good effect. The rubrospinal tract...

The objective of this analysis was to compare the Asthma Control Test (ACT) and the Asthma APGAR asthma control assessment tools in African-Ancestry/Black (AA/B) and Hispanic/Latinx (H/L) adults with moderate to severe asthma. This pre-planned sub-study of the PREPARE clinical trial compares the baseline ACT and Asthma APGAR scores for the PREPARE populations using correlation coefficients, generalized linear modeling and receiver operating curve (ROC) analyses. Correlations were also assessed for both control tests and the...

Swirl vane uniflow cyclones have advantages of a compact structure and low pressure drop but the problem of low particle collection efficiency. In the present study, we demonstrated that the performance of a swirl vane uniflow cyclone can be significantly improved by installing a reverse vortex finder (RVF) behind the swirl vane additionally. It was found that the RVF can act as a vortex stabilizer, which can lower the turbulent kinetic energy and eliminate the...

Atherosclerosis (AS) is a chronic inflammatory disease which gives rise to life-threatening complications like ischemic stroke. Rupture of carotid atherosclerotic plaque is the main cause of ischemic stroke. Emerging evidence has demonstrated that disturbed circadian rhythms could accelerate the progression of atherosclerosis by regulating endothelial function. Moreover, our previous study implicated the circadian gene circadian locomotor output cycles kaput (CLOCK) in the pathogenesis of unstable plaques. In this study, we explored the underlying mechanism that...

Quantitative real time PCR (RT-PCR) is widely used as the gold standard for clinical detection of SARS-CoV-2. However, due to the low viral load specimens and the limitations of RT-PCR, significant numbers of false negative reports are inevitable, which results in failure to timely diagnose, cut off transmission, and assess discharge criteria. To improve this situation, an optimized droplet digital PCR (ddPCR) was used for detection of SARS-CoV-2, which showed that the limit of detection...

The RNA interference (RNAi) pathway directs an important antiviral immunity mechanism in plants and invertebrates. Recently, we and others have demonstrated that the antiviral RNAi response is also conserved in mammals, at least to five distinct RNA viruses, including Zika virus (ZIKV). ZIKV may preferentially infect neuronal progenitor cells (NPCs) in the developing foetal brain. Ex vivo ZIKV infection induces RNAi-mediated antiviral response in human NPCs, but not in the more differentiated NPCs or somatic...

The RNA interference (RNAi) pathway directs an important antiviral immunity mechanism in plants and invertebrates. Recently, we and others have demonstrated that the antiviral RNAi response is also conserved in mammals, at least to five distinct RNA viruses, including Zika virus (ZIKV). ZIKV may preferentially infect neuronal progenitor cells (NPCs) in the developing foetal brain. Ex vivo ZIKV infection induces RNAi-mediated antiviral response in human NPCs, but not in the more differentiated NPCs or somatic...

Heavy metal ion pollution has become a serious problem. In this paper, a new type of adsorbent, reduced graphene oxide grafted by 4-sulfophenylazo groups (RGOS), was synthesized to adsorb heavy metal ions in an aqueous solution via two kinds of adsorption modes, ion exchange and coordination. The maximum adsorption capacities of the RGOS for Pb(II), Cu(II), Ni(II), Cd(II) and Cr(III) were 689, 59, 66, 267 and 191 mg/g, respectively. Adsorption equilibrium time of RGOS for...

Background: COVID-19 has rapidly become a major health emergency worldwide. The characteristic, outcome, and risk factor of COVID-19 in patients with decompensated cirrhosis remain unclear. Methods: Medical records were collected from 23 Chinese hospitals. Patients with decompensated cirrhosis and age- and sex-matched non-liver disease patients were enrolled with 1:4 ratio using stratified sampling. Results: There were more comorbidities with higher Chalson Complication Index (p < 0.001), higher proportion of patients having gastrointestinal bleeding, jaundice, ascites,...

Background: COVID-19 has rapidly become a major health emergency worldwide. The characteristic, outcome, and risk factor of COVID-19 in patients with decompensated cirrhosis remain unclear. Methods: Medical records were collected from 23 Chinese hospitals. Patients with decompensated cirrhosis and age- and sex-matched non-liver disease patients were enrolled with 1:4 ratio using stratified sampling. Results: There were more comorbidities with higher Chalson Complication Index (p < 0.001), higher proportion of patients having gastrointestinal bleeding, jaundice, ascites,...