In this study, a series of naringenin-O-alkylamine derivatives were designed and obtained by introducing an alkylamine fragment into the naringenin skeleton. The in vitro biological activity results revealed that compounds 5f and 7k showed good antioxidant activity with ORAC values of 2.3eq and 1.2eq, respectively. Compounds 5f and 7k were reversible and excellent huAChE inhibitors with IC50 values of 0.91 μM and 0.57 μM, respectively. Moreover, compounds 5f and 7k could inhibit self-induced Aβ1–42 aggregation...

Supplemental material, sj-docx-1-pus-10.1177_09636625221138357 for Intention of health experts to counter health misinformation in social media: Effects of perceived threat to online users, correction efficacy, and self-affirmation by Liang Chen and Hongjie Tang in Public Understanding of Science

In this work, the authors present a detailed train-track interaction model of a long freight train operation to predict long-term rail surface damage. In addition to vehicles and track, intermediate maintenance actions in the form of cyclic grinding passes have also been modelled according to European standards to realistically represent the evolving wheel-rail interface. The influence of longitudinal train dynamics in the form of inter-vehicle interactions, traction, braking, gradients, etc is also included in this...

Ferrous iron (Fe(II)) reacts with peroxymonosulphate (PMS) to form active oxidants that can degrade refractory organic pollutants. However, the conversion rate of Fe(III) to Fe(II) is slow, which limits its actual application. In the study, the effect of fulvic acid (FA) on the degradation of dimethyl phthalate (DMP) by Fe(II)/PMS was investigated. Moreover, the degradation process of DMP was predicted by the preliminary identification of active free radicals and intermediates. As expected, FA gave rise...

Resistance to BCR-ABL tyrosine kinase inhibitor (TKI) is the cause of treatment failure in blast phase chronic myeloid leukaemia (BP-CML). Agents that act synergistically with BCR-ABL TKI are required to improve response. This work investigated the effects of stachydrine in CML. CML cells were treated with control or stachydrine at 20, 40 and 80 µM. Proliferation and apoptosis were examined after 72 h treatment. Combination studies were performed in four groups: control, TKI, stachydrine and...

Gold nanoparticles (AuNPs) were successfully fabricated by Pholiota adiposa polysaccharide (PAP-1a) without employing any other chemicals. The physical and chemical properties of PAP-AuNPs were determined using transmission electron microscopy (TEM), dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDXR), Fourier-transform infrared spectroscopy (FT-IR), and atomic force microscopy (AFM). In an attempt to analyze the immune regulation, antitumor effect, and biological safety, the production of NO and TNF-α, IL-12p70, and IL-1β from RAW264.7 as well as the...

Satellite-based aerosol optical depth (AOD) retrieval products are essential in air pollution and climate change research. Unfortunately, cloud contaminations and unfavorable surface conditions result in a considerable proportion of missing AOD data. Numerous studies have been conducted to reconstruct large-scale AOD data gaps by utilizing adjacent spatiotemporal information or modeling AOD data via various external geographical data. However, the erratic variation of AOD and the inconvenience of external data weaken the accuracy and efficiency of...

One new 6a,11a-dehydropterocarpan derivative, 6-O-methyl-anhydrotuberosin (1), one new 6a-hydroxypterocarpan, (6aR,11aR,11bR)-hydroxytuberosone (7), and seven known compounds including two 6a,11a-dehydropterocarpans (2 and 4), two coumestans (3 and 5), one isoflavonoid (6) and two other phenolic compounds (8 and 9) were isolated from the roots of Pueraria lobata. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1 D and 2DNMR, HRESIMS). Compounds 1, 2, 4–5 showed potent LSD1 inhibitory activities with IC50 values...

T-LAK-cell-originated protein kinase (TOPK), a novel member of the mitogen-activated protein kinase family, is considered an effective therapeutic target for skin inflammation. In this study, a series (A − D) of paeonol derivatives was designed and synthesised using a fragment growing approach, and their anti-inflammatory activities against lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells were tested. Among them, compound B12 yielded the best results (IC50 = 2.14 μM) with low toxicity (IC50 > 50...

This study aimed to investigate the protective effects and mechanisms of myricetin on acute liver failure in mice induced by lipopolysaccharide (LPS)/D-galactosamine (D-Gal). Our results showed myricetin (25, 50 and 100 mg/kg) pretreatment significantly improved the pathological changes of liver tissues, decreased serum ALT and AST (p < 0.001) induced by LPS/D-GalN. Moreover, MDA and MPO levels were reduced (p < 0.001), CAT and SOD activities were increased (p < 0.001) with myricetin (50 and...

Currently, human papillomavirus (HPV) vaccines are in short supply, so the development of HPV vaccines has a broad market prospect. The 3-, 9-, and 15-valent HPV vaccines developed by ourselves all contain HPV58-derived antigen components. It is important to detect HPV 58 during vaccine production. Here, we introduced a development process of HPV58 type-specific antibodies and a detection kit. Briefly, HPV58 L1-Virus Like Particles (VLPs) were used as antigens to immunize mice, followed by extraction...

Osteoarthritis (OA) is a progressive disease characterized by degeneration of cartilage and echinacoside (Ech) has anti-inflammatory and antioxidant effects in various human diseases. This study aimed to reveal the effect and potential mechanism of Ech on OA. The in vitro OA model was established by rat chondrocytes treated with IL-1β, and the in vivo OA model was established by anterior cruciate ligament transaction. The effect of Ech on the viability, inflammatory response, extracellular matrix (ECM)...

The destruction of the ecological system caused by urban expansion has led to the environmental deterioration, cities have become increasingly vulnerable. In this study, six districts and counties along the Yellow River in Zhengzhou were selected as the study area. First, green infrastructure elements were extracted by morphological spatial pattern analysis. Then, outside the urban areas, we used connectivity analysis to evaluate the importance of core areas, adopted minimum cumulative resistance model to extract potential...

Two 2D Zn(II) coordination polymers, formulated as [Zn(μ2-tdc)(μ-pmid)] (1), {[Zn(μ2-tdc)(μ-pmmid)2·4H2O]}n (2) (H2tdc = 2,5-thiophenedicarboxylic acid, pmid = 1-(4-pyridylmethyl)imidazole; pmmid = 1-(4-pyridylmethyl)-2-methylimidazole) have been synthesized by reactions of Zn(OAc)2·2H2O and H2tdc with flexibleN-(4-pyridylmethyl)imidazole derivatives under the mild reaction conditions and characterized by single-crystal X-ray diffraction and other physicochemical methods. Structure determination demonstrates compound 1 displays a 2-fold 2D → 2D parallel interpenetrating structure, while compound 2 shows a 2D non-interpenetrating network. These results reveal that the...

The gonadal hormone testosterone is well-recognized to facilitate various behaviors for obtaining social status. A good reputation (i.e. competitive, generous, and trustworthy) is of crucial importance for acquiring high social status. It is unclear which type of reputation is preferred by individuals under the influence of testosterone. Given that the recent dual-hormone hypothesis emphasizes the modulating effect of stress (cortisol) on the influence of testosterone, it would be intriguing to test the role of stress-induced...

This study aimed to investigate the preventive effect of isostrictiniin (ISO) from Nymphaea candida against CCl4-induced hepatic fibrosis (HF) in mice. HF in mice was induced by intraperitoneally injecting 10% CCl4 olive oil solution twice a week. After intragastric administration for 8 weeks. ISO (25, 50, or 100 mg/kg) could significantly reduce the serum AST, ALT, ALP, HA, LN, PC-III, C-IV, IL-1β, and TNF-α levels in HF mice, and the collagen fiber deposition in ISO...

We fabricated an ultrasound activated ‘nanobomb’ as a noninvasive and targeted physical therapeutic strategy for sonodynamic therapy and priming cancer immunotherapy. This ‘nanobomb’ was rationally designed via the encapsulation of indocyanine green (ICG) and perfluoropentane (PFP) into cRGD peptide-functionalized nano-liposome. The resulting Lip-ICG-PFP-cRGD nanoparticle linked with cRGD peptide could actively targeted ID8 and TC-1 cells and elicits ROS-mediated apoptosis after triggered by low-intensity focused ultrasound (LIFU). Moreover, the phase change of PFP (from droplets to...

Although diversifying the criminal justice apparatus may yield more equitable outcomes, empirical tests of how prosecutors’ race affects their decisions are limited. Informed by Internalized Racism Theory (IRT), we hypothesized that Black prosecutors would be most punitive toward Black defendants, followed by Latino/a defendants, and least toward White and Asian defendants. Employing hierarchical logistic modelling, we analyzed data from a large prosecutorial office to examine the extent to which prosecutors’ race is associated with racial...

Additional file 1: Table S1. Unadjusted Cox regression analysis investigating predictors of MACCE. Figure S1. Calculation of Gensini score of representative case.

The strain variations in Elm earlywood and latewood during drying were studied with digital image correlation method. Also, the moisture contents of different water states were quantified based on time-domain nuclear magnetic resonance technique to reveal the strain-water relationships. Although the shrinkage strains gradually increased with increasing drying time, there was a significant difference in the strain distribution of the earlywood and latewood. Owing to latewood large stress, the earlywood was pulled by it to...

Additional file 1: Figure S1. Schematic illustration of displaying a homing peptide/FLAG on the surface of exosomes. The coding sequence of HHP/FLAG (red bar) was fused in-frame to the LAMP2b cDNA between the signal peptide (SP) and the N-terminus, which was then cloned into pLVX-IRES-ZsGreen1 expression plasmid. Forced expression of the plasmid in CDCs would display the HHP/FLAG (red oval) on the surface of exosomes. Figure S2. Schematic illustration of mice treatment schedule. The TAC...

Macrophages are one of the most important immunoinflammatory cell populations in the tumor microenvironment (TME). In this study, we preliminarily investigated the upstream pathway of M2 macrophage polarization affecting lung cancer progression. Bioinformatics analysis was used to evaluate genes closely associated with lung adenocarcinoma and their relationship with immune cells. THP-1 monocytes were induced into M2 macrophages. The expression of markers in M2 macrophages was detected by quantitative reverse transcription-PCR (qRT-PCR), enzyme linked immunosorbent assay...

Supplemental Document

Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates...

Supplemental material, sj-doc-3-tct-10.1177_15330338221132669 for A Nomogram for Predicting Liver Metastasis of Lymph-Node Positive Luminal B HER2 Negative Subtype Breast Cancer by Analyzing the Clinicopathological Characteristics of Patients with Breast Cancer by Yuhan Yue, Junqing Liang, Yuruo Wu, Weibing Tong, Dan Li, Xuchen Cao and Xin Wang in Technology in Cancer Research & Treatment