45 Works

Additional file 1 of A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

Andrea Cappozzo, Cathal McCrory, Oliver Robinson, Anna Freni Sterrantino, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Licia Iacoviello, Fulvio Ricceri, Sabina Sieri, Paolo Chiodini, Gareth J. McKay, Amy Jayne McKnight, Frank Kee, Ian S. Young, Bernadette McGuinness, Eileen M. Crimmins, Thalida Em Arpawong, Rose Anne Kenny, Aisling O’Halloran, Silvia Polidoro, Giuliana Solinas, Paolo Vineis, Francesca Ieva … & Giovanni Fiorito
Additional file 1. Supplementary Results and Supplementary Figures S1, S2, S3, and S4.

Additional file 1 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote … & Vivian Viallon
Additional file 1. Supplementary material regarding (i) the definition of cancer cases for HCC, GBC, Adv.PrC and Loc.PrC; (ii) the definition and implementation of the data-shared lasso; (iii) the models used to derive point estimates and confidence intervals from the model selected by the data-shared lasso; and (iv) the univariate analysis conducted for comparison.

Additional file 2 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Marie Breeur, Pietro Ferrari, Laure Dossus, Mazda Jenab, Mattias Johansson, Sabina Rinaldi, Ruth C. Travis, Mathilde His, Tim J. Key, Julie A. Schmidt, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Joseph A. Rothwell, Nasser Laouali, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Fabian Eichelmann, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote … & Vivian Viallon
Additional file 2: Supplementary tables and figures. Figure S1. Pearson correlation between the 117 original metabolites. Figure S2. Sensitivity analyses of mutually adjusted ORs for the overall associations and cancer type-specific deviations. Figure S3. Sensitivity analysis of mutually adjusted ORs for the overall associations and cancer type-specific deviations with or without excluding hormone users. Figure S4. p-values of tests for departure from linearity and effect modification by BMI. Figure S5. ORs for the overall associations...

Toxicological effects of rare earth elements to photosynthetic organisms

Edith Padilla Suárez, Antonietta Siciliano, Marco Guida, Giovanni Pagano, Marco Trifuoggi, Sara Serafini, Emilia Galdiero, Franca Tommasi, Giusy Lofrano, Isidora Gjata, Antonios Apostolos Brouziotis, Renato Liguori & Giovanni Libralato
Rare earth elements (REEs) have become a key component in many technological applications. Due to the rapid increase in their use, the potential environmental exposure has also expanded. However, the effects on the ecosystem have not been yet thoroughly evaluated, leaving many knowledge gaps. To evaluate the effects of REEs, a set of experiments with acute and chronic exposure were performed on photosynthetic organisms. The effects of acute exposure of four elements (cerium, gadolinium, lanthanum...

Additional file 1 of Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125

Andrea Colarusso, Concetta Lauro, Marzia Calvanese, Ermenegilda Parrilli & Maria Luisa Tutino
Additional file 1: Table S1. Characteristics of BCD constructs for pGFP expression. Table S2. List of primers used in this work. Fig. S1. Average plasmid copy number (PCN) of pP79-107 (B). Fig. S2. Ranking of bicistronic designs (BCDs) with a fluorescent reporter. Fig. S3. flCDKL5 production profiles with pBCD-107 (L) plasmids. Fig. S4. Development of Bicistronic Entry Clones. Fig. S5. Development of Bicistronic Designs. Fig. S6. Development of Tricistronic Designs.

Additional file 2 of A novel microRNA signature for the detection of melanoma by liquid biopsy

Claudia Sabato, Teresa Maria Rosaria Noviello, Alessia Covre, Sandra Coral, Francesca Pia Caruso, Zein Mersini Besharat, Elena Splendiani, Laura Masuelli, Cecilia Battistelli, Alessandra Vacca, Giuseppina Catanzaro, Agnese Po, Andrea Anichini, Michele Maio, Michele Ceccarelli, Anna Maria Di Giacomo & Elisabetta Ferretti
Additional file 2: Table S1. A detailed list of differentially expressed pEV-microRNAs obtained from high-throughput PCR profiles in metastatic melanoma patients.

Additional file 1 of Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway

Yuhua Gao, Ningning Mi, Ying Zhang, Xiangchen Li, Weijun Guan & Chunyu Bai
Additional file 1: Figure S1.The analysis of biological characteristics in human ADSCs.The ADSCs had successfully differentiated into chondrocytes(A), adipocytes(B), and osteoblasts(C). CD29, CD90, and CD105 were positive in human ADSCs(D). Figure S2.The ADSC-secreted EVs were incubated with M1 phenotype macrophages. Fluorescence images were used to evaluate localization of FITC-labeled NF-κB1 (p50) and Cy5-labeled NF-κB(p65). FQ,fluorescence quantitation; a.u., arbitrary unit. FigureS3. Internalizationof normal EVs and F4/80-EVs into M1 phenotype macrophages. Microscopic visualizationof internalization(left), and analysisof EVs...

Additional file 1 of Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

Andrea Anichini, Alessandra Molla, Gabriella Nicolini, Valentina Eleonora Perotti, Francesco Sgambelluri, Alessia Covre, Carolina Fazio, Maria Fortunata Lofiego, Anna Maria Di Giacomo, Sandra Coral, Antonella Manca, Maria Cristina Sini, Marina Pisano, Teresa Noviello, Francesca Caruso, Silvia Brich, Giancarlo Pruneri, Andrea Maurichi, Mario Santinami, Michele Ceccarelli, Giuseppe Palmieri, Michele Maio & Roberta Mortarini
Additional file 1. Supplementary Methods.

Additional file 1 of Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

Andrea Anichini, Alessandra Molla, Gabriella Nicolini, Valentina Eleonora Perotti, Francesco Sgambelluri, Alessia Covre, Carolina Fazio, Maria Fortunata Lofiego, Anna Maria Di Giacomo, Sandra Coral, Antonella Manca, Maria Cristina Sini, Marina Pisano, Teresa Noviello, Francesca Caruso, Silvia Brich, Giancarlo Pruneri, Andrea Maurichi, Mario Santinami, Michele Ceccarelli, Giuseppe Palmieri, Michele Maio & Roberta Mortarini
Additional file 1. Supplementary Methods.

Stability of Ceylon spinach (Basella alba L.) seed protein extract and its effect on the microbiological, chemical and sensory quality of sturgeon fillets stored at 4 °C

Ying Zhang, Qing Zhang, Liang Gao, Kang Zhou, Shang Wu, Jiawei Han & Meng Gui
The antimicrobial activity and preservative effect of Ceylon spinach (Basella alba L.) seed protein extract on sturgeon fillets stored at 4°C were investigated in this study. The results showed that Ceylon spinach seed protein extract (CSSPE) had inhibitory effect on 33 microorganisms, including 1 fungus and 32 bacteria (25 gram-negative bacteria and 7 gram-positive bacteria). In addition, CSSPE inhibited bacterial growth (total viable counts, Pseudomonas, Aeromonas and psychrotrophs), suppressed ATP degradation and retained good-quality characteristic...

Additional file 8 of Floral organ transcriptome in Camellia sasanqua provided insight into stamen petaloid

Menglong Fan, Xinlei Li, Ying Zhang, Si Wu, Zhixin Song, Hengfu Yin, Weixin Liu, Zhengqi Fan & Jiyuan Li
Additional file 8: Figure S1. The correlation analysis of RNA-seq data.

sj-pdf-1-smm-10.1177_09622802221129861 - Supplemental material for A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials

Ying Zhang, John S Preisser, Elizabeth L Turner, Paul J Rathouz, Mark Toles & Fan Li
Supplemental material, sj-pdf-1-smm-10.1177_09622802221129861 for A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials by Ying Zhang, John S Preisser, Elizabeth L Turner, Paul J Rathouz, Mark Toles and Fan Li in Statistical Methods in Medical Research

“Better late than never but never late is better”, especially in young women. A multicenter Italian study on diagnostic delay for symptomatic endometriosis

Ida Pino, Gaia Maria Belloni, Valeria Barbera, Eugenio Solima, Davide Radice, Stefano Angioni, Saverio Arena, Valentino Bergamini, Massimo Candiani, Antonio Maiorana, Alberto Mattei, Ludovico Muzii, Luca Pagliardini, Maria Grazia Porpora, Valentino Remorgida, Renato Seracchioli, Paolo Vercellini, Fulvio Zullo, Errico Zupi & Michele Vignali
The aim of the study was to assess the length of diagnostic delay of symptomatic endometriosis in Italy and analyse the presence of correlations between the socio-demographic status of patients and the clinical characteristics/type of diagnosis. This multicenter cross-sectional questionnaire-based study was conducted in 10 tertiary Italian referral centres for diagnosis and treatment endometriosis. A total of 689 respondents with histologically proven endometriosis and onset of the disease with pain symptoms completed an on-line self-reported...

sj-pdf-1-vmj-10.1177_1358863X221130378 – Supplemental material for Consistent smoking and development of arterial stiffening in adult men: Results of the Olivetti Heart Study

Lanfranco D’Elia, Maria Masulli, Roberto Iacone, Ornella Russo, Pasquale Strazzullo & Ferruccio Galletti
Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221130378 for Consistent smoking and development of arterial stiffening in adult men: Results of the Olivetti Heart Study by Lanfranco D’Elia, Maria Masulli, Roberto Iacone, Ornella Russo, Pasquale Strazzullo and Ferruccio Galletti in Vascular Medicine

sj-pdf-1-vmj-10.1177_1358863X221130378 – Supplemental material for Consistent smoking and development of arterial stiffening in adult men: Results of the Olivetti Heart Study

Lanfranco D’Elia, Maria Masulli, Roberto Iacone, Ornella Russo, Pasquale Strazzullo & Ferruccio Galletti
Supplemental material, sj-pdf-1-vmj-10.1177_1358863X221130378 for Consistent smoking and development of arterial stiffening in adult men: Results of the Olivetti Heart Study by Lanfranco D’Elia, Maria Masulli, Roberto Iacone, Ornella Russo, Pasquale Strazzullo and Ferruccio Galletti in Vascular Medicine

Matching-adjusted indirect comparison of efficacy outcomes in trials of calcipotriol plus betamethasone dipropionate foam and cream formulations for the treatment of plaque psoriasis

Kim A. Papp, Henrik Thoning, Sascha Gerdes, Matteo Megna, Henrik Brandi, Marie Y. Jablonski Bernasconi & Oriol Yélamos
Once-daily, fixed-combination calcipotriol 50 μg/g (Cal) plus betamethasone dipropionate 0.5 mg/g (BD) is available in aerosol foam and cream formulations. As no head-to-head data are available, we use a matching-adjusted indirect comparison (MAIC) approach to compare Cal/BD foam and cream. Anchored and unanchored MAIC analyses were conducted using individual patient data (IPD) from five Cal/BD foam trials and two trials of Cal/BD cream. Outcomes of interest were the proportion of patients with Physician's Global Assessment...

Matching-adjusted indirect comparison of efficacy outcomes in trials of calcipotriol plus betamethasone dipropionate foam and cream formulations for the treatment of plaque psoriasis

Kim A. Papp, Henrik Thoning, Sascha Gerdes, Matteo Megna, Henrik Brandi, Marie Y. Jablonski Bernasconi & Oriol Yélamos
Once-daily, fixed-combination calcipotriol 50 μg/g (Cal) plus betamethasone dipropionate 0.5 mg/g (BD) is available in aerosol foam and cream formulations. As no head-to-head data are available, we use a matching-adjusted indirect comparison (MAIC) approach to compare Cal/BD foam and cream. Anchored and unanchored MAIC analyses were conducted using individual patient data (IPD) from five Cal/BD foam trials and two trials of Cal/BD cream. Outcomes of interest were the proportion of patients with Physician's Global Assessment...

Additional file 1 of An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier & Carmela Matrone
Additional file 1: Table S1. Key Resource Table. Table S2. Dendritic branching analysis of Figure 1E. Data are the mean ± SEM of three independent experiments in triplicate. Two-way ANOVA followed by Tukey’s test for multiple comparisons. *P < 0.05; **P < 0,01; ****P < 0,0001 vs Ctrl and #P<0.05 vs Sema 3A + siNpn 1.

Additional file 2 of Landscape of immune-related signatures induced by targeting of different epigenetic regulators in melanoma: implications for immunotherapy

Andrea Anichini, Alessandra Molla, Gabriella Nicolini, Valentina Eleonora Perotti, Francesco Sgambelluri, Alessia Covre, Carolina Fazio, Maria Fortunata Lofiego, Anna Maria Di Giacomo, Sandra Coral, Antonella Manca, Maria Cristina Sini, Marina Pisano, Teresa Noviello, Francesca Caruso, Silvia Brich, Giancarlo Pruneri, Andrea Maurichi, Mario Santinami, Michele Ceccarelli, Giuseppe Palmieri, Michele Maio & Roberta Mortarini
Additional file 2: Supplementary Figs. S1 to S21. Supplementary Fig. S1. Expression in ten melanoma cell lines of genes and gene families targeted by epigenetic drugs. Supplementary Fig. S2. Differentiation profile of melanoma cell lines. Supplementary Fig. S3. Susceptibility of ten melanoma cell lines to the anti-proliferative effects of epigenetic drugs. Supplementary Fig. S4. Methylation status of LINE-1, MAGE-A1 and NY-ESO-1 in 9 melanoma cell lines treated with guadecitabine. Supplementary Fig. S5. Volcano plot of...

Update on novel antipsychotics and pharmacological strategies for treatment-resistant schizophrenia

Andrea de Bartolomeis, Mariateresa Ciccarelli, Licia Vellucci, Michele Fornaro, Felice Iasevoli & Annarita Barone
Treatment resistant schizophrenia (TRS), the lack of response to at least two antipsychotics administered at adequate dose and duration, epitomizes in psychiatry one of the most difficult-to-treat pathologies, epidemiologically relevant (affecting one-third of schizophrenia patients) and with severe consequences for the patients in terms of overall functioning. After 50 years, only one drug is approved for TRS: clozapine. Furthermore, a few patients do not respond even to clozapine and are indicated as clozapine-resistant patients. In...

Additional file 1 of An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier & Carmela Matrone
Additional file 1: Table S1. Key Resource Table. Table S2. Dendritic branching analysis of Figure 1E. Data are the mean ± SEM of three independent experiments in triplicate. Two-way ANOVA followed by Tukey’s test for multiple comparisons. *P < 0.05; **P < 0,01; ****P < 0,0001 vs Ctrl and #P<0.05 vs Sema 3A + siNpn 1.

Additional file 2 of An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier & Carmela Matrone
Additional file 2: Fig.S1. Characterization of Ctrl, Sema 3A-GFP, siSema 3A, siNpn 1 and Sema 3A+siNpn 1 neurons 48 h after transfection. (A) IF analysis with Sema 3A (green) and Npn 1 (red) of neurons transfected (Sema 3A) or not (Ctrl) with Sema 3A-GFP. Scale bar: 20μm. Figures were acquired by 40x objective and cropped in order to visualize single neuron and highlight the preferential Sema 3A localization on the apical dendrites in Sema 3A...

Additional file 2 of An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Gabriella Ferretti, Alessia Romano, Rossana Sirabella, Sara Serafini, Thorsten Jürgen Maier & Carmela Matrone
Additional file 2: Fig.S1. Characterization of Ctrl, Sema 3A-GFP, siSema 3A, siNpn 1 and Sema 3A+siNpn 1 neurons 48 h after transfection. (A) IF analysis with Sema 3A (green) and Npn 1 (red) of neurons transfected (Sema 3A) or not (Ctrl) with Sema 3A-GFP. Scale bar: 20μm. Figures were acquired by 40x objective and cropped in order to visualize single neuron and highlight the preferential Sema 3A localization on the apical dendrites in Sema 3A...

Una prima datazione lichenometrica per la determinazione dell’epoca di riesposizione del paleostrato impresso

Adolfo Panarello, Giuseppe Pandolfo & Paolo Mietto
A first determination of the value of the annual growth factor (0.766 mm/yr) of Aspicilia cinerea has been done through the application of a lichenometric system calibrated in the surroundings of the “Devil’s Trails” palaeontological site (Roccamonfina volcano). The application of this parameter to some samples within this site allowed researchers to know that the re-exposure of the surface preserving fossil human and animal footprints did not start before the early 1800s. This seems perfectly...

Osservazioni sui meccanismi di locomozione dell’autore della Pista A delle “Ciampate del diavolo”

Alessandro Mondanaro, Adolfo Panarello, Maria Modafferi, Marina Melchionna, Carmela Serio, Francesco Carotenuto, Stefano Tavani, Paolo Mietto & Pasquale Raia
The world-famous Roccamonfina site represents one among the very few opportunities to investigate about the evolution of bipedal locomotion of Middle Pleistocene humans. The site includes at least 80, finely preserved human footprints in anatomical position, divided into four trackways. We applied a biomechanical model to verify if the Roccamonfina’s individuals minimized energy expenditure during locomotion, moving downhill along an oblique route cutting the slope in order to avoid the steepest gradient. In keeping with...

Registration Year

  • 2022
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Affiliations

  • University of Naples Federico II
    45
  • National University of Singapore
    14
  • Henan University
    10
  • North West Agriculture and Forestry University
    10
  • West China Hospital of Sichuan University
    10
  • Cancer Hospital of Shantou University Medical College
    10
  • Central South University
    10
  • Georgetown University Medical Center
    10
  • Fudan University Shanghai Cancer Center
    10
  • Wenzhou Medical University
    10