Two unexpected tetranuclear supramolecular boxes, [Zn4(L')4(CH3OH)2]·2CH3OH (1) and [Co4(L)2(L')2(CH3OH)2]·acetone (2), with M4(μ3-O)2(μ2-O)4 core were obtained through reacting coumarin Schiff base H2L (H2L = 4-hydroxy-3-((2-hydroxyphenyl-imino)-methyl)-2hchrome-2-one) with Zn(OAc)2·4H2O and Co(OAc)2·4H2O, respectively. Interestingly, the original ligand (H2L) has changed into a new structure (H2L') in the process of forming single crystals. The structures of 1 and 2 were characterized by X-ray single crystal diffraction. 1 and 2 are tetranuclear structures including four metal centers (Zn(II) or Co(II)), four...

Amestolkins A (1) and B (2), two previously undescribed phthalides sharing the same planar structure of (1, 5-dihydroxyhexyl)-7-hydroxyisobenzofuran-1(3H)-one were isolated from Talaromyces amestolkiae. Their absolute configurations were elucidated by comprehensive analyses of spectroscopic evidences in high-resolution electrospray mass spectra (HRESIMS) and nuclear magnetic resonance (NMR) combined with electronic circular dichroism (ECD) and NMR calculations. 1 and 2 showed anti-neuroinflammatory activity by inhibiting the gene expressions of proinflammatory factors including C-C motif chemokine ligand 2 (CCL-2),...

Chemical investigation of the edible mushroom Sarcomyxa edulis led to the isolation of one new highly degraded sterol (1), and one new β-carboline alkaloid (2), along with nine known compounds (3-11) for the first time from this mushroom. The structures of new compounds were elucidated using HR-ESI-MS data and NMR spectroscopy. In addition, anti-inflammatory activity of new compounds was evaluated against lipopolysaccharide-induced NO production in RAW 264.7 macrophages. Compound 2 exhibited a good anti-inflammatory activity...

Supplemental material, sj-docx-1-tct-10.1177_15330338221139167 for Comprehensive Analysis of Circular RNA Expression Profiles in Gefitinib-Resistant Lung Adenocarcinoma Patients by Junyong Zou, MD, Huiyin Lan, MD, Wei Li, MD, Shuanshuan Xie, MD, Zhongkai Tong, MD, Xiaolian Song, MD, and Changhui Wang, MD in Technology in Cancer Research & Treatment

Supplemental document with additional data, simulation results, and figures.

Supplemental material, sj-docx-1-acr-10.1177_02841851211065142 for MRI-based radiomics analysis to evaluate the clinicopathological characteristics of cervical carcinoma: a multicenter study by Yi Liu, Ting Song, Tian-Fa Dong, Wei Zhang and Ge Wen in Acta Radiologica

The non-receptor protein tyrosine phosphatase (PTP) SHP2 encoded by the PTPN11 gene is a critical regulator in a number of cellular signalling processes and pathways, including the MAPK and the immune-inhibitory programmed cell death PD-L1/PD-1 pathway. Hyperactivation and inactivation of SHP2 is of great therapeutic interest for its association with multiple developmental disorders and cancer-related diseases. In this work, we characterised a potent SHP2 allosteric inhibitor 2-((3 R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (PB17-026-01) by using structure-based design. To study...

The non-receptor protein tyrosine phosphatase (PTP) SHP2 encoded by the PTPN11 gene is a critical regulator in a number of cellular signalling processes and pathways, including the MAPK and the immune-inhibitory programmed cell death PD-L1/PD-1 pathway. Hyperactivation and inactivation of SHP2 is of great therapeutic interest for its association with multiple developmental disorders and cancer-related diseases. In this work, we characterised a potent SHP2 allosteric inhibitor 2-((3 R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (PB17-026-01) by using structure-based design. To study...

Additional file 2.

Supplemental material, sj-docx-1-tct-10.1177_15330338221142400 for Combined Radiomics–Clinical Model to Predict Radiotherapy Response in Inoperable Stage III and IV Non-Small-Cell Lung Cancer by Wenrui Chen, Li Wang, Yu Hou, Lan Li, Li Chang, Yunfen Li, Kun Xie, Linbo Qiu, Dan Mao, Wenhui Li and Yaoxiong Xia in Technology in Cancer Research & Treatment

Supplemental material, sj-docx-3-tct-10.1177_15330338221142400 for Combined Radiomics–Clinical Model to Predict Radiotherapy Response in Inoperable Stage III and IV Non-Small-Cell Lung Cancer by Wenrui Chen, Li Wang, Yu Hou, Lan Li, Li Chang, Yunfen Li, Kun Xie, Linbo Qiu, Dan Mao, Wenhui Li and Yaoxiong Xia in Technology in Cancer Research & Treatment

Supplemental material, sj-docx-4-tct-10.1177_15330338221142400 for Combined Radiomics–Clinical Model to Predict Radiotherapy Response in Inoperable Stage III and IV Non-Small-Cell Lung Cancer by Wenrui Chen, Li Wang, Yu Hou, Lan Li, Li Chang, Yunfen Li, Kun Xie, Linbo Qiu, Dan Mao, Wenhui Li and Yaoxiong Xia in Technology in Cancer Research & Treatment

We, the Editors, Authors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article: Qini Zhao, Haiming Xu, Lirong Zhang, Long Liu & Libo Wang (2019) GLP-1 receptor agonist lixisenatide protects against high free fatty acids-induced oxidative stress and inflammatory response. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 2325–2332, DOI: 10.1080/21691401.2019.1620248 Since publication, the authors continued their study and found that the original experimental results were unverifiable. The authors checked their...

Our study aimed to compare the predictive value of the COPD Assessment Test (CAT) score at baseline and short-term change in CAT for future exacerbations in chronic obstructive pulmonary disease (COPD) patients. This was a multicentre prospective study. Patients with COPD were recruited into the study and followed up for one year. CAT score and exacerbation in the previous year were collected at baseline. Change in CAT was defined as CAT score changing between baseline...

Multiple myeloma (MM) is an incurable plasma cell malignancy associated with poor survival. Novel therapeutic drugs are urgently needed to improve MM therapy and patient outcomes. This study aimed to investigate the effect of formosanin C (FC), a Chinese medicine monomer, on MM in vitro and disclose the underlying molecular mechanism. The effect of FC on the viability, proliferation, apoptosis, and autophagy of MM cell lines (NCI-H929 and ARP1) was studied through CCK-8, colony formation,...

Proper termination of cell-death-induced neural inflammation is the premise of tissue repair in acute ischemic stroke (AIS). Macrophages scavenge cell corpses/debris and produce inflammatory mediators that orchestrate immune responses. Here, we report that FOXP3, the key immune-repressive transcription factor of Tregs, is conditionally expressed in macrophages in stroke lesion. FOXP3 ablation in macrophages results in detrimental stroke outcomes, emphasizing the beneficial role of FOXP3+ macrophages. FOXP3+ macrophages are distinct from the M1 or M2 subsets...

figures of the result of the rest animals and humans

As per the National Medical Products Administration (NMPA) requirements, the quality and efficacy of generic drugs must be consistent with those of the innovator drug. We aimed to evaluate the bioequivalence and safety of generic metformin hydrochloride sustained-release (MH-SR) tablets (Boke®) developed by Beijing Wanhui Double-crane Pharmaceutical Co. Ltd., China and the innovator product metformin hydrochloride extended-release tablets (Glucophage®-XR) manufactured by Bristol-Myers Squibb Company, New York, NY, in healthy Chinese volunteers. We performed a bioequivalence...

Additional file 1. Tables S1 and S2 and Appendix S1 and S2.

A series of novel hybrid molecules based on disulfides and 1,2,4-triazole were synthesized, and the structures of the resulting compounds (7a–7g, 8a–8g and 9a–9g) were confirmed by their IR, 1H NMR, 13C NMR and HR-ESI-MS spectroscopic data. The in vitro antiproliferative activity of the tested compounds on human cancer cells A549, Hela, SMMC-7721, and normal cells L929 was determined by CCK-8 assay. The obtained data revealed that most of the tested compounds showed some degrees...

more details about the experiment

Additional file 1: Table S1. Sequences of oligonucleotide fragment. Table S2 Sequences of primers required for the experiment. Table S3 Relative expression of several miRNAs screened from the GSE114329 dataset.

The mechanisms by which retinoic acid-inducible gene I (RIG-I), a critical RNA virus sensor, is regulated in many biological and pathological processes remain to be determined. Here, we demonstrate that T cell immunoglobulin and mucin protein-3 (Tim-3), an immune checkpoint inhibitor, mediates infection tolerance by suppressing RIG-I-type I interferon pathway. Overexpression or blockade of Tim-3 affects type I interferon expression, virus replication, and tissue damage in mice following H1N1 infection. Tim-3 signaling decreases RIG-I transcription...

Vascular calcification is prominent in patients with chronic kidney disease (CKD) and is a strong predictor of cardiovascular mortality in the CKD population. However, the mechanism underlying CKD-associated vascular calcification remains unclear. To identify potential therapeutic targets, a 5/6 nephrectomy rat model was established by feeding of a high-phosphorous diet as the CKD group and compared with sham group rats at 4 and 16 weeks. Sequencing analyses of the rat aorta revealed 643 upregulated and...

Supplemental Material for Driving mechanism analysis of wind and sand fixation in semiarid and arid areas: A case of Inner Mongolia, China by Lihan Cui, Zhen Shen, Yuexin Liu, Chaoyue Yu, Qingling Lu, Zhonghao Zhang and Yang Gao in Progress in Physical Geography: Earth and Environment