111 Works

Nanoparticle-mediated delivery of Tanshinone IIA reduces adverse cardiac remodeling following myocardial infarctions in a mice model: role of NF-κB pathway

Shuai Mao, Lei Wang, Peipei Chen, Yong Lan, Rui Guo & Minzhou Zhang
Our previous works have shown that tanshinone IIA inhibited maladaptive extracellular matrix remodeling in cardiac fibroblasts implicating its potential role in treating of pathologic cardiac remodeling. However, the intrinsically poor solubility and bioavailability of tanshinone IIA hindered its clinical application. Here we develop monomethoxy-poly (ethylene glycol)-poly (lactic acid)-D-α-Tocopheryl polyethylene glycol 1000 succinate (mPEG-PLA-TPGS) nanoparticle incorporating tanshinone IIA (tanshinone IIA-NPs) and study its efficacy in post-infarction left ventricular (LV) remodeling. Male C57BL/6 mice underwent left coronary...

One novel naphthalene derivative and other constituents with anti-complementary activities from the aerial parts of Dracocephalum moldavica

Jia-Ming Wang, Jin-Feng Sun, Long Jin, Meng-Jie Wang, Yan-Yan Huang, Mei Jin, Wei Zhou & Gao Li
One novel naphthalene derivative, 2-octa-2′,4′,6′-atriynenaphthalene (1), together with eighteen known compounds (2–19) were isolated from the aerial parts of Dracocephalum moldavica L. Compounds 2, 8, 10, 13, 15–17 and 19 were obtained from the family Lamiaceae for the first time, and compounds 11 and 18 were firstly identified from the genus of Dracocephalum. All the isolates were evaluated for anti-complementary activities through the classical and alternative pathways, and the targets of the most active compounds...

Efficient Learning of Quadratic Variance Function Directed Acyclic Graphs via Topological Layers

Wei Zhou, Xin He, Wei Zhong & Junhui Wang
Directed acyclic graph (DAG) models are widely used to represent casual relationships among random variables in many application domains. This article studies a special class of non-Gaussian DAG models, where the conditional variance of each node given its parents is a quadratic function of its conditional mean. Such a class of non-Gaussian DAG models are fairly flexible and admit many popular distributions as special cases, including Poisson, Binomial, Geometric, Exponential, and Gamma. To facilitate learning,...

Additional file 2 of STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth

Hongwu Li, Ping Liu, Dapeng Li, Zixi Wang, Zhao Ding, Meng Zhou, Xu Chen, Manli Miao, Junli Ding, Wei Lin, Yehai Liu & Xiaojun Zha
Additional file 2: Supplementary Table 1. Clinical features of 60 HNSCC patients. Supplementary Table 2. Oligonucleotide sequences used in this study. Supplementary Table 3. Antibodies used in this study. Supplementary Table 4. Primer sequences used for qRT-PCR in this study. Supplementary Table 5. Primers used for luciferase reporter in this study. Supplementary Table 6. Primers used for ChIP Assays in this study.

sj-doc-1-chl-10.1177_17475198221126026 – Supplemental material for Homolytic aromatic substitution of acyl radicals: Oxidative coupling of 2-methylquinolines with quinoxalines

Xue Li, Xian Hao Wu, Jia Feng Yu, Yuan Yuan Zhang, Zhong Ke Hou & Yuan Yuan Xie
Supplemental material, sj-doc-1-chl-10.1177_17475198221126026 for Homolytic aromatic substitution of acyl radicals: Oxidative coupling of 2-methylquinolines with quinoxalines by Xue Li, Xian Hao Wu, Jia Feng Yu, Yuan Yuan Zhang, Zhong Ke Hou and Yuan Yuan Xie in Journal of Chemical Research

sj-doc-1-chl-10.1177_17475198221126026 – Supplemental material for Homolytic aromatic substitution of acyl radicals: Oxidative coupling of 2-methylquinolines with quinoxalines

Xue Li, Xian Hao Wu, Jia Feng Yu, Yuan Yuan Zhang, Zhong Ke Hou & Yuan Yuan Xie
Supplemental material, sj-doc-1-chl-10.1177_17475198221126026 for Homolytic aromatic substitution of acyl radicals: Oxidative coupling of 2-methylquinolines with quinoxalines by Xue Li, Xian Hao Wu, Jia Feng Yu, Yuan Yuan Zhang, Zhong Ke Hou and Yuan Yuan Xie in Journal of Chemical Research

Additional file 1 of Association of H3K9me3 with breast cancer prognosis by estrogen receptor status

Meng Zhou, Jin-qi Yan, Qian-xin Chen, Yuan-zhong Yang, Yue-lin Li, Yue-xiang Ren, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang & Ze-fang Ren
Additional file 1. Figure S1. Flowchart of the study cohort. Figure S2. X-tile plot of the selected cut-off value for H3K9me3 in tumor tissues. Table S1. Univariate association between the demographic and clinicopathological characteristics and the outcomes.

Additional file 1 of Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization

Anna C. F. Lewis, Emma F. Perez, Anya E. R. Prince, Hana R. Flaxman, Lizbeth Gomez, Deanna G. Brockman, Paulette D. Chandler, Benjamin J. Kerman, Matthew S. Lebo, Jordan W. Smoller, Scott T. Weiss, Carrie L. Blout Zawatksy, James B. Meigs, Robert C. Green, Jason L. Vassy & Elizabeth W. Karlson
Additional file 1: Tables S1 and S2. Further information on patient survey items; Patient interview guide, with mock report designs; Primary Care Physician interview guide, with mock report designs.

Additional file 3 of The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals

Guillaume Butler-Laporte, Edgar Gonzalez-Kozlova, Chen-Yang Su, Sirui Zhou, Tomoko Nakanishi, Elsa Brunet-Ratnasingham, David Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye … & J Brent Richards
Additional file 3: Protein correlation heatmaps.

Effectiveness of BNT162b2 and CoronaVac vaccinations against mortality and severe complications after SARS-CoV-2 Omicron BA.2 infection: a case–control study

Vincent Ka Chun Yan, Eric Yuk Fai Wan, Xuxiao Ye, Anna Hoi Ying Mok, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Philip Hei Li, Tiantian Ma, Simon Qin, Vincent Kai Chung Wong, Tat Chi Tsang, Sik Hon Tsui, William Chun Ming Chui, Benjamin John Cowling, Gabriel Matthew Leung, Chak Sing Lau, Ian Chi Kei Wong & Esther Wai Yin Chan
Data regarding protection against mortality and severe complications after Omicron BA.2 infection with CoronaVac and BNT162b2 vaccines remains limited. We conducted a case–control study to evaluate the risk of severe complications and mortality following 1–3 doses of CoronaVac and BNT162b2 using electronic health records database. Cases were adults with their first COVID-19-related mortality or severe complications between 1 January and 31 March 2022, matched with up-to 10 controls by age, sex, index date, and Charlson...

Research Data for A case series of constrictive pericarditis and suggested echocardiographic diagnostic criteria

Junfang Li, Rong Li, Guangting Cheng, Changhong Lu, Weigang Liu, Dongmei Sun, Xue Li & Zhibin Wang
Research Data for A case series of constrictive pericarditis and suggested echocardiographic diagnostic criteria by Junfang Li, Rong Li, Guangting Cheng, Changhong Lu, Weigang Liu, Dongmei Sun, Xue Li and Zhibin Wang in Journal of International Medical Research

Integrative pathway enrichment analysis of multivariate omics data

Marta Paczkowska, Jonathan Barenboim, Nardnisa Sintupisut, Natalie S Fox, Helen Zhu, Diala Abd-Rabbo, Miles W Mee, Paul C Boutros, Federico Abascal, Samirkumar B Amin, Gary D Bader, Rameen Beroukhim, Johanna Bertl, Keith A Boroevich, Søren Brunak, Peter J Campbell, Joana Carlevaro-Fita, Dimple Chakravarty, Calvin Wing Yiu Chan, Ken Chen, Jung Kyoon Choi, Jordi Deu-Pons, Priyanka Dhingra, Klev Diamanti, Lars Feuerbach … & L van’t Veer
Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated...

Additional file 1 of A mitochondria-targeted molecular phototheranostic platform for NIR-II imaging-guided synergistic photothermal/photodynamic/immune therapy

Sha Yang, Gui-long Wu, Na Li, Minghui Wang, Peixian Wu, Yuxuan He, Wei Zhou, Hao Xiao, Xiaofeng Tan, Li Tang & Qinglai Yang
Additional file 1: Fig. S1. Synthetic routes of FEPT and FEP. Fig. S2. 1H NMR of compound 2. Fig. S3. 13C NMR of compound 2. Fig. S4. 1H NMR of compound 5. Fig. S5. 13C NMR of compound 5. Fig. S6. 1H NMR of compound IR-FE. Fig. S7. 13C NMR of compound IR-FE. Fig. S8. 1H NMR of compound 8. Fig. S9. 13C NMR of compound 8. Fig. S10. 1H NMR of compound FEPT. Fig....

Additional file 1 of Health effects of milk consumption: phenome-wide Mendelian randomization study

Shuai Yuan, Jing Sun, Ying Lu, Fengzhe Xu, Doudou Li, Fangyuan Jiang, Zhongxiao Wan, Xue Li, Li-Qiang Qin & Susanna C. Larsson
Additional file 1: Supplementary Methods. Table S1. Mappings of ICD-10 and ICD-9 codes to the phenotypes identified by MR-PheWAS at the nominal significance level (p<0.05). Table S2. Information on the FinnGen study and international consortia. Table S3. Search strategy in the PubMed database. TableS4. Characteristics of participants in the UK Biobank (N=339,197). Table S5. Outcomes included in the analyses and outcomes excluded due to power (N<200 cases). Table S6. Phenotypes associated with genetically predicted milk...

Supplementary document for Custom terahertz waveforms using complementary organic nonlinear optical crystals - 6099948.pdf

Claire Rader, Megan Nielson, Brittany Knighton, Zachary Zaccardi, David Michaelis & Jeremy Johnson
Extra description of EO-sampling, phase matching, spectral modeling, and circular polarization.

Additional file 4 of Rapid and simultaneous detection of multiple pathogens in the lower reproductive tract during pregnancy based on loop-mediated isothermal amplification-microfluidic chip

Xiaofang Xu, Yiguo Jia, Ruolin Li, Yuting Wen, Yuchen Liang, Guangjie Lao, Xiaojuan Liu, Wei Zhou, Huawei Liu, Jiang Xie, Xiaoxia Wang, Wenming Xu & Qun Sun
Additional file 4. PCR primers of target genes.

sj-docx-1-dhj-10.1177_20552076221140763 - Supplemental material for Access, charge and quality of tele-dermatology e-consults in China: A standardized patients study

Rui Guo, Mengchi Hou, Yangyang Han & Xing Lin Feng
Supplemental material, sj-docx-1-dhj-10.1177_20552076221140763 for Access, charge and quality of tele-dermatology e-consults in China: A standardized patients study by Rui Guo, Mengchi Hou, Yangyang Han and Xing Lin Feng in Digital Health

Ferulic acid produces neuroprotection against radiation-induced neuroinflammation by affecting NLRP3 inflammasome activation

Guifang Liu, Yao Nie, Congshu Huang, Guihua Zhu, Xuemei Zhang, Changkun Hu, Zhihui Li, Yue Gao & Zengchun Ma
After radiation therapy of brain tumors, radiation-induced cognitive impairment is a common and severe complication. Neuroinflammation mediated by microglia is a critical event that accelerates cognitive or functional decline. Ferulic acid (FA), a phenolic plant component, possesses multiple pharmacological effects, such as anti-inflammatory and anti-radiation. The current research attempts to ascertain the protection of FA on radiation-induced neuroinflammation and the mechanism of this effect. C57BL/6 mice were irradiated with 60Co γ-ray to establish a brain...

Co-encapsulation of magnetic Fe3O4 nanoparticles and doxorubicin into biocompatible PLGA-PEG nanocarriers for early detection and treatment of tumours

Chenghua Liang, Nan Li, Zikai Cai, Rongpu Liang, Xiaoming Zheng, Li Deng, Longbao Feng, Rui Guo & Bo Wei
At present, cancer is the first cause of death for humans, but early detection and treatment can help improve prognoses and reduce mortality. However, further development of carrier-assistant drug delivery systems (DDSs) is retarded by the aspects such as the low drug-carrying capacity, carrier-induced toxicity and immunogenicity, complex synthesis manipulation. The development of nanoscale drug delivery systems (NDDS) have been rapidly developed to address these issues. In this article, we used PLGA-PEG with good biocompatibility...

Two new iridoid glycosides from Odontites vulgaris

Meng-Jie Wang, De Yang, Sheng-Bao Diao, Zheng-Yu Hu, Hui-Ming Hua, Yu-Qing Zhao, Wei Zhou & Gao Li
Two new iridoid glycosides, named 3′-O-benzoyl-dolichocymboside D (1) and dolichocymboside E (2), along with ten known glycosides (3–12), were isolated from the ethanol extract of the whole plants of Odontites vulgaris Moench. The structures of the isolated compounds were elucidated by 1D and 2D NMR and HR-ESI-MS spectra and by comparison with those reported in the literature. This is the first report on compounds 11 and 12 isolated from the family Scrophulariaceae, and compounds 8–10...

Two new iridoid glycosides from Odontites vulgaris

Meng-Jie Wang, De Yang, Sheng-Bao Diao, Zheng-Yu Hu, Hui-Ming Hua, Yu-Qing Zhao, Wei Zhou & Gao Li
Two new iridoid glycosides, named 3′-O-benzoyl-dolichocymboside D (1) and dolichocymboside E (2), along with ten known glycosides (3–12), were isolated from the ethanol extract of the whole plants of Odontites vulgaris Moench. The structures of the isolated compounds were elucidated by 1D and 2D NMR and HR-ESI-MS spectra and by comparison with those reported in the literature. This is the first report on compounds 11 and 12 isolated from the family Scrophulariaceae, and compounds 8–10...

sj-docx-1-tag-10.1177_17562848231155023 – Supplemental material for An explainable artificial intelligence system for diagnosing Helicobacter Pylori infection under endoscopy: a case–control study

Mengjiao Zhang, Jie Pan, Jiejun Lin, Ming Xu, Lihui Zhang, Renduo Shang, Liwen Yao, Yanxia Li, Wei Zhou, Yunchao Deng, Zehua Dong, Yijie Zhu, Xiao Tao, Lianlian Wu & Honggang Yu
Supplemental material, sj-docx-1-tag-10.1177_17562848231155023 for An explainable artificial intelligence system for diagnosing Helicobacter Pylori infection under endoscopy: a case–control study by Mengjiao Zhang, Jie Pan, Jiejun Lin, Ming Xu, Lihui Zhang, Renduo Shang, Liwen Yao, Yanxia Li, Wei Zhou, Yunchao Deng, Zehua Dong, Yijie Zhu, Xiao Tao, Lianlian Wu and Honggang Yu in Therapeutic Advances in Gastroenterology

Effectiveness of BNT162b2 and CoronaVac vaccines in preventing SARS-CoV-2 Omicron infections, hospitalizations, and severe complications in the pediatric population in Hong Kong: a case-control study

Vincent Ka Chun Yan, Franco Wing Tak Cheng, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Carlos King Ho Wong, Xue Li, Eric Yuk Fai Wan, Joshua Sung Chih Wong, Esther Wai Yin Chan, Ian Chi Kei Wong, Mike Yat Wah Kwan & Patrick Ip
Severe COVID-19 appears to be disproportionately more common in children and adolescents since the emergence of Omicron. More evidence regarding vaccine effectiveness (VE) is urgently needed to assist policymakers in making decisions and minimize vaccine hesitancy among the public. This was a case-control study in the pediatric population using data extracted from the electronic health records database in Hong Kong. Individuals aged 3–17 with COVID-19 confirmed by polymerase chain reaction were included in the study....

Investigation of Pb (II) and Cd (II) removal from aqueous solution by organic-modified xonotlite

Wei Zhou, Junliang Xin & Wenqing Tang
In this work, a novel xonotlite nanocomposite was synthesised with abandoned eggshell by hydrothermal method, and organic-modified with toluene diisocyanate (TDI) for the removal of Pb(II) and Cd(II) from wastewater. The xonotlite and organic-modified xonotlite were characterised by X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunner-Emmet-Teller (BET) and Fourier transform infrared spectroscopy (FTIR) methods. The effect of solution pH, contact time, adsorbent dose, and initial concentrations were also investigated. The organic-modified xonotlite was found to...

sj-docx-1-tah-10.1177_20406207221127532 – Supplemental material for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation

Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu & Yue Han
Supplemental material, sj-docx-1-tah-10.1177_20406207221127532 for Avatrombopag for the treatment of thrombocytopenia post hematopoietic stem-cell transplantation by Meng Zhou, Jiaqian Qi, Chengyuan Gu, Hong Wang, Ziyan Zhang, Depei Wu and Yue Han in Therapeutic Advances in Hematology

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