Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary...

Additional file 1: S1. Checklist CONSORT extension to randomized pilot and feasibility trials.

This article aims to describe the time trend in number of dual diagnosis patients treated in the psychiatric system in Denmark from 2000 to 2017. We calculated the share of patients with dual diagnosis, number of dual diagnosis contacts, number of unique individuals with dual diagnosis as well as number of new patients with dual diagnosis among patients in psychiatric treatment, i.e. among inpatients, outpatients and patients in emergency departments. In order to calculate this,...

Additional file 1. Sequencing results of the five candidate circRNAs.

Additional file 3. Supplemental methods and results.

Additional file 2. Search strategy for all electronic databases.

Additional file 2: S2. CERT (Consensus on Exercise Reporting Template).

Additional file 6: S6. Usual care exercise after cartilage or meniscus repair in the knee joint - week 7 postoperatively.

Additional file 7: S7. Supplementary results. S7 Table 1. Patient characteristics at 16 and 26-week assessment. S7 Table 2. Clinical application (adherence), training characteristics and pain at rest and during BFR-LLST added to usual care exercise. S7 Table 3. Change per week in thigh circumference, knee joint and quadriceps pain, perceived exertion and training load during the, on average, 11 weeks of BFR-LLST added to usual care exercise intervention period (15 sessions). S7 Table 4....

Additional file 1. Supplementary material A 1: Self-complete questionnaire for surgical patients

Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated...

Background: Psychological traumatic experiences can lead to posttraumatic stress disorder (PTSD). Secondary psychotic symptoms are not common but may occur. Objectives: Since psychotic symptoms of schizophrenia have been related to aberrant reward processing in the striatum, using the same paradigm we investigate whether the same finding extends to psychotic and anhedonic symptoms in PTSD. Methods: A total of 70 male refugees: 18 PTSD patients with no secondary psychotic symptoms (PTSD-NSP), 21 PTSD patients with secondary...

In this study, we evaluated the performance of the flow cytometer-based Sysmex UF-5000 automated urine analyzer as a screening tool for ruling out urinary tract infections in elderly patients presenting at the emergency department. A total of 1119 unselected patient samples (including 544 samples from elderly patients) submitted for urine culture were included in this study. Samples were measured on UF-5000 and dipsticks and the results were compared with interpretation of culture results, which is...

Additional file 6: S6. Usual care exercise after cartilage or meniscus repair in the knee joint - week 7 postoperatively.

Mediastinal radiation is associated with increased risk of myocardial infarction (MI) among non-Hodgkin lymphoma (NHL) survivors. To evaluate how preexisting cardiovascular risk factors (CVRFs) modify the association of mediastinal radiation and MI among a national population of NHL survivors with a range of CVRFs. Using Danish registries, we identified adults diagnosed with lymphoma 2000–2010. We assessed MI from one year after diagnosis through 2016. We ascertained CVRFs (hypertension, dyslipidemia, and diabetes), vascular disease, and intrinsic...

Additional file 1: Additional statistical analysis of subgroups population and association with outcome.

Additional file 1. Sequencing results of the five candidate circRNAs.

Additional file 3. Supplemental methods and results.

Additional file 1. Supplementary methods also including the following tables and figures Table S2. List of BCAC studies (including ABCS source) with the corresponding country and geographic area. Table S4: Clinical utility of the 5-year contralateral breast cancer risk prediction models (PredictCBC-1A with PredictCBC-2.0A and PredictCBC-1B with PredictCBC-2.0B). Figure S1. Visual assessment of calibration through calibration plots in the internal–external cross-validation at 5 years for the PredictCBC-2.0A model. Figure S2. Visual assessment of calibration through...

To understand the potential impact of new treatment options for urinary tract cancer, recent population trends in incidence, mortality and survival should be elucidated. This study estimated changes in the incidence, mortality and relative survival of urinary tract cancer in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) between 1990 and 2019. Annual counts of incident cases and deaths due to urinary tract cancer (International Classification of Diseases, Tenth Revision, Clinical Modification codes C65–C68,...

Supplemental material, sj-docx-1-aor-10.1177_00034894221139362 for Clinical Presentation and Outcome of Sinonasal Extraosseous Plasmacytoma in Denmark: A Nationwide Cohort From 1980 to 2017 by Patrick René Gerhard Eriksen, Elham Khakbaz, Erik Clasen-Linde, Peter de Nully Brown, Laura Haunstrup, Mette Christoffersen, Peter Asdahl, Troels Møller Thomsen, Jonas Gerner-Rasmussen, Steffen Heegaard and Christian von Buchwald in Annals of Otology, Rhinology & Laryngology

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning...

Supplemental material, sj-pdf-2-cep-10.1177_03331024221147482 for DNA-methylation and immunological response in medication overuse headache by Louise Ninett Carlsen, Christine Søholm Hansen, Lisette J. A. Kogelman, Thomas Mears Werge, Henrik Ullum, Jonas Bybjerg-Grauholm, Thomas Folkmann Hansen and Rigmor Højland Jensen in Cephalalgia

Additional file1. Table S1: Characteristics and prevalence of pre- and postmenopausal breast cancer among women included in the analyses of birthweight and women who could potentially have been included in these analyses. Table S2: Characteristics and prevalence of pre- and postmenopausal breast cancer among women included in the analyses of puberty markers and women who could potentially have been included in these analyses. Table S3: Characteristics of women with and without information on ER status...

Immune checkpoint inhibitors have revolutionized the treatment of metastatic renal cell carcinoma and malignant melanoma but are also associated with a risk of severe side effects. Nephrotoxicity is an immune checkpoint inhibitor-related adverse effect, but acute kidney injury (AKI) can also be caused by other more common conditions. This study aimed to describe the incidence and causes of AKI in patients treated with combination therapy of immune checkpoint inhibitors. This retrospective cohort study included 200...