139 Works

Additional file 1 of Maternal blood pressure associates with placental DNA methylation both directly and through alterations in cell-type composition

Lucile Broséus, Daniel Vaiman, Jörg Tost, Camino Ruano San Martin, Milan Jacobi, Joel D. Schwartz, Rémi Béranger, Rémy Slama, Barbara Heude & Johanna Lepeule
Additional file 1: Supplementary methods and figures S1-S7. S1 - Workflow of DNA methylation data pre-processing; S2 - Overview of blood pressure data; S3 - Reference placental cell-type composition observed in the EDEN cohort; S4 - Pearson correlation between DMR effect sizes; S5.A - Sensitivity analyses for DMRs found in our main analysis; S5.B - Sensitivity analysis excluding preeclampsia cases for the DMRs found in our main analysis; S6.A - Magnitude and 95% confidence intervals...

Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa.

Kesego Tapela, Fatima O Oyawoye, Charles Ochieng' Olwal, Precious C Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C Rayner, Gordon A Awandare, Lily Paemka, Yaw Bediako & Peter Kojo Quashie
BACKGROUND: West Africa has recorded a relatively higher proportion of asymptomatic coronavirus disease 2019 (COVID-19) cases than the rest of the world, and West Africa-specific host factors could play a role in this discrepancy. Here, we assessed the association between COVID-19 severity among Ghanaians with their immune profiles and ABO blood groups. METHODS: Plasma samples were obtained from Ghanaians PCR-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive individuals. The participants were categorized into symptomatic and...

Additional file 4 of Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Kesego Tapela, Fatima O. Oyawoye, Charles Ochieng’ Olwal, Precious C. Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K. Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C. Rayner, Gordon A. Awandare, Lily Paemka, Yaw Bediako & Peter Kojo Quashie
Additional file 4. Cytokine concentration levels in COVID-19 patients. Comparison of cytokine concentration levels between COVID-19 symptomatic, asymptomatic patients, pre-COVID-19 health participants, COVID-19 pandemic health individuals and COVID-19 non-survivors. The cytokine concentration levels were measured from plasma of COVID-19 symptomatic (n = 29) and asymptomatic (n = 29), individuals, pre-COVID-19 health participants (100), COVID-19 pandemic health individuals (33) and COVID-19 non-survivors (2). The median quantity of the cytokines is shown by a horizontal line across...

Additional file 1 of Assessing real-world effectiveness of therapies: what is the impact of incretin-based treatments on hospital use for patients with type 2 diabetes?

Clémence Bussiere, Pauline Chauvin, Jean-Michel Josselin & Christine Sevilla-Dedieu
Supplementary Material 1

Additional file 3 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 3: Additional Table 1. Association between the incidence rate of childhood acute lymphoblastic leukaemia and three potential ecological confounders characterising the municipality of residence at birth: size of urban unit, residential UV radiation exposure, and a socioeconomic deprivation index (RNCE, 1990–2015).

Additional file 4 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 4: Additional Table 2. Distribution of the at-risk population a over 1990-2015 by category of crop density and potential confounding factor stratum (size of urban unit, residential UV radiation exposure, and a French deprivation index), children born in 1990-2015, mainland France.

Additional file 4 of Residential proximity to croplands at birth and childhood leukaemia

Sophie Bamouni, Denis Hémon, Laure Faure, Jacqueline Clavel & Stéphanie Goujon
Additional file 4: Additional Table 2. Distribution of the at-risk population a over 1990-2015 by category of crop density and potential confounding factor stratum (size of urban unit, residential UV radiation exposure, and a French deprivation index), children born in 1990-2015, mainland France.

Additional file 4 of Transcriptomics and miRNomics data integration in lymphoblastoid cells highlights the key role of immune-related functions in lithium treatment response in Bipolar disorder

Nadia Cattane, Cindie Courtin, Elisa Mombelli, Carlo Maj, Cristina Mora, Bruno Etain, Frank Bellivier, Cynthia Marie-Claire & Annamaria Cattaneo
Additional file 4 Supplementary Table 4. List of 21 relevant functional networks identified by performing a network analysis in IPA on 335 differentially expressed mRNAs.

Educational interventions to integrate surgical staff within medical units during the COVID-19 pandemic: EDUCOVID survey

Raffaele Brustia, Giuliana Amaddeo, Rami Rhaiem, Eric Levesque, Antoine Monsel, Vanessa Baaroun, Mylène Dimmock, Marc-Antoine Rousseau, Oriane Wagner-Ballon, Francoise Botterel, Pascal Andujar & Daniele Sommacale
The SARS-CoV-2 (COVID-19) pandemic required a rapid surge of healthcare capacity to face a growing number of critically ill patients. For this reason, a support reserve of physicians, including surgeons, were required to be reassigned to offer support. To realize a survey on the educational programs deployed (face-to-face or e-learning focusing on infective area, basic gestures, COVID clinical management and intensive care medicine), and their impact on behavior change (Kirkpatrick 3) of the target population...

Additional file 1 of A universal predictive and mechanistic urinary peptide signature in acute kidney injury

Alexis Piedrafita, Justyna Siwy, Julie Klein, Amal Akkari, Ana Amaya-garrido, Alexandre Mebazaa, Anna Belen Sanz, Benjamin Breuil, Laura Montero Herrero, Bertrand Marcheix, François Depret, Lucie Fernandez, Elsa Tardif, Vincent Minville, Melinda Alves, Jochen Metzger, Julia Grossac, Harald Mischak, Alberto Ortiz, Stéphane Gazut, Joost P. Schanstra, Stanislas Faguer, Nicolas Mayeur, Audrey Casemayou & François Labaste
Additional file 1: Supplementary Figure S1: S100A9 expression after epithelial injury. A. Urinary calprotectin (S100A8/A9) abundance 4 hours after cardiac bypass-surgery. B–F. Blood urea nitrogen (B), mRNA S100a9 (C), S100A9 immunostaining (D-E) and mRNA Kim1 (F) in sham mice and after bilateral renal ischemia/reperfusion (hours 6, 24 and 48). G–J. mRNA expression of S100a9 and Kim1 in MCT cells submitted to interleukin-1b (IL1β, 10 ng/mL) or tumor necrosis factor-1a (TNFa, 10 ng/mL) (G-H) or hypoxia...

Additional file 4 of Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study

Glória Matambisso, Nanna Brokhattingen, Sónia Maculuve, Pau Cisteró, Henriques Mbeve, Anna Escoda, Judice Miguel, Elena Buetas, Ianthe de Jong, Boaventura Cuna, Cardoso Melembe, Nelo Ndimande, Gemma Porras, Haily Chen, Kevin K. A. Tetteh, Chris Drakeley, Benoit Gamain, Chetan Chitnis, Virander Chauhan, Llorenç Quintó, Beatriz Galatas, Eusébio Macete & Alfredo Mayor
Additional file 4. Supplementary results (P. falciparum parasite densities).

Additional file 6 of A proteomic screen of Ty1 integrase partners identifies the protein kinase CK2 as a regulator of Ty1 retrotransposition

Anastasia Barkova, Indranil Adhya, Christine Conesa, Amna Asif-Laidin, Amandine Bonnet, Elise Rabut, Carine Chagneau, Pascale Lesage & Joël Acker
Additional file 6: Table S5-S7. Yeast Strains, plasmids and primers used in this study.

Supplemental Material from Interhemispheric communication during haptic self-perception

Gaiqing Kong, Antonio Cataldo, Miruna Nitu, Lucile Dupin, Hiroaki Gomi & Patrick Haggard
During the haptic exploration of a planar surface, slight resistances against to the hand's movement are illusorily perceived as asperities (bumps) in the surface. If the surface being touched is one's own skin, an actual bump would also produce increased tactile pressure from the moving finger onto the skin. We investigated how kinaesthetic and tactile signals combine to produce haptic perceptions during self-touch. Participants performed two successive movements with the right hand. A haptic force-control...

Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise

Julie J. Burtt, Julie Leblanc, Kristi Randhawa, Addie Ivanova, Murray A. Rudd, Ruth Wilkins, Edouard I. Azzam, Markus Hecker, Nele Horemans, Hildegarde Vandenhove, Christelle Adam-Guillermin, Olivier Armant, Dmitry Klokov, Karine Audouze, Jan Christian Kaiser, Simone Moertl, Katalin Lumniczky, Ignacia B. Tanaka, Yutaka Yamada, Nobuyuki Hamada, Isaf Al-Nabulsi, R. Julian Preston, Simon Bouffler, Kimberly Applegate, Donald Cool … & Vinita Chauhan
The Adverse Outcome Pathway (AOP) framework, a systematic tool that can link available mechanistic data with phenotypic outcomes of relevance to regulatory decision-making, is being explored in areas related to radiation risk assessment. To examine the challenges including the use of AOPs to support the radiation protection community, an international horizon-style exercise was initiated through the Organisation for Economic Co-operation and Development Nuclear Energy Agency High-Level Group on Low Dose Research Radiation/Chemical AOP Joint Topical...

Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning

Thomas Jaylet, Roel Quintens, Mohamed Abderrafi Benotmane, Jukka Luukkonen, Ignacia Braga Tanaka, Chrystelle Ibanez, Christelle Durand, Magdalini Sachana, Omid Azimzadeh, Christelle Adam-Guillermin, Knut Erik Tollefsen, Olivier Laurent, Karine Audouze & Olivier Armant
Brain development during embryogenesis and in early postnatal life is particularly complex and involves the interplay of many cellular processes and molecular mechanisms, making it extremely vulnerable to exogenous insults, including ionizing radiation (IR). Microcephaly is one of the most frequent neurodevelopmental abnormalities that is characterized by small brain size, and is often associated with intellectual deficiency. Decades of research span from epidemiological data on in utero exposure of the A-bomb survivors, to studies on...

Massive tramadol ingestion resulting in fatal brain injury – a pharmacokinetic study with discussion on the involved mechanisms of toxicity

Alicja Puszkiel, Isabelle Malissin, Salvatore Cisternino, Nicolas Pallet, Xavier Declèves & Bruno Mégarbane
Tramadol-attributed toxicity may involve opioid-like, serotoninergic, and noradrenergic mechanisms. We investigated the mechanisms of toxicity in a massive tramadol ingestion case by examining serial clinical, imaging, electroencephalography, pharmacokinetics, and genotyping data. A 32-year-old female who presumably ingested 9000 mg sustained-release tramadol was found comatose without hypoglycemia, bradypnea, hypotension, marked hypoxemia or seizures. She developed eyelid myoclonus and non-reactive mydriasis. Electroencephalogram showed non-reactive encephalopathy. MRI showed extensive brain injury. Despite supportive care and ventricular derivation, brain...

Additional file 1 of Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Kesego Tapela, Fatima O. Oyawoye, Charles Ochieng’ Olwal, Precious C. Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K. Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C. Rayner, Gordon A. Awandare, Lily Paemka, Yaw Bediako & Peter Kojo Quashie
Additional file 1. Cytokine concentration levels in COVID-19 patients. A: Comparison of cytokine concentration levels between COVID-19 symptomatic and asymptomatic patients. The median quantity of the cytokines is shown by a horizontal line across the violin plots while the lower and upper dotted lines represent the 25th and 75th percentiles, respectively. B: Change on cytokine concentration levels over time in COVID-19 positive individuals. The cytokine concentration levels were measured from plasma of COVID-19 symptomatic (n...

Additional file 2 of Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Kesego Tapela, Fatima O. Oyawoye, Charles Ochieng’ Olwal, Precious C. Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K. Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C. Rayner, Gordon A. Awandare, Lily Paemka, Yaw Bediako & Peter Kojo Quashie
Additional file 2. Change on cytokine concentration levels over time in COVID-19 positive individuals. The cytokine concentration levels analysed from plasma of COVID-19 asymptomatic (n = 3), monthly for four months. The quantity of the cytokines for each sampling month is shown by the line graph.

Additional file 7 of Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Kesego Tapela, Fatima O. Oyawoye, Charles Ochieng’ Olwal, Precious C. Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K. Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C. Rayner, Gordon A. Awandare, Lily Paemka, Yaw Bediako & Peter Kojo Quashie
Additional file 7. The Pearson correlation coefficient (r) between concentration levels of cytokines with significant difference between symptomatic and asymptomatic cases (14 cytokines), and baseline viral loads (Ct value) of the patients at p value<0.05.

Additional file 1 of Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Kesego Tapela, Fatima O. Oyawoye, Charles Ochieng’ Olwal, Precious C. Opurum, Jones Amo Amponsah, Kekeli Aku Lumor Segbedzi, Becky Tetteh, Frederick Kumi-Ansah, Joe K. Mutungi, Evangeline Obodai, Emmanuella Amoako, Seth Agyemang, Nicaise Tuikue Ndam, William Kwabena Ampofo, Julian C. Rayner, Gordon A. Awandare, Lily Paemka, Yaw Bediako & Peter Kojo Quashie
Additional file 1. Cytokine concentration levels in COVID-19 patients. A: Comparison of cytokine concentration levels between COVID-19 symptomatic and asymptomatic patients. The median quantity of the cytokines is shown by a horizontal line across the violin plots while the lower and upper dotted lines represent the 25th and 75th percentiles, respectively. B: Change on cytokine concentration levels over time in COVID-19 positive individuals. The cytokine concentration levels were measured from plasma of COVID-19 symptomatic (n...

Additional file 1 of Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults

Juliette Patrier, Khanh Villageois-Tran, Piotr Szychowiak, Stéphane Ruckly, Rémi Gschwind, Paul-Henri Wicky, Signara Gueye, Laurence Armand-Lefevre, Mehdi Marzouk, Romain Sonneville, Lila Bouadma, Marie Petitjean, Fariza Lamara, Etienne de Montmollin, Jean-Francois Timsit & Etienne Ruppé
Additional file 1: Table S1. Result of the initial 16S rDNA sequencing in rectal samples. Table S2. Per pathogen rectal and oropharyngeal culture positivity, time to first positivity and abundance at first positivity. Table S3. Adjusted impact of abundance of Enterococcus spp., S. aureus and Candida spp. in oropharynx and rectum on day 90 mortality. (one adjusted model for each). Table S4. Univariate analysis of day 90 mortality* comparing survivors versus descedents. Fig S1. Quantitative...

Additional file 2 of Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors

Alice Blet, Joel B. McNeil, Julie Josse, Bernard Cholley, Raphaël Cinotti, Gad Cotter, Agnès Dauvergne, Beth Davison, Kévin Duarte, Jacques Duranteau, Marie-Céline Fournier, Etienne Gayat, Samir Jaber, Sigismond Lasocki, Thomas Merkling, Katell Peoc’h, Imke Mayer, Malha Sadoune, Pierre-François Laterre, Romain Sonneville, Lorraine Ware, Alexandre Mebazaa & Antoine Kimmoun
Additional file 2: Supplemental Text.

Additional file 1 of Accuracy of clinicians’ ability to predict the need for renal replacement therapy: a prospective multicenter study

Alexandre Sitbon, Michael Darmon, Guillaume Geri, Paul Jaubert, Pauline Lamouche-Wilquin, Clément Monet, Lucie Le Fèvre, Marie Baron, Marie-Line Harlay, Côme Bureau, Olivier Joannes-Boyau, Claire Dupuis, Damien Contou, Virginie Lemiale, Marie Simon, Christophe Vinsonneau, Clarisse Blayau, Frederic Jacobs & Lara Zafrani
Additional file 1: Figure S1. Physician prediction: Visual Likert Scale. Figure S2. PresagEER study timeline. Table S1. Delays between ICU admission, AKI diagnosis and RRT initiation. Table S2. RRT characteristics. Table S3. Characteristics and outcomes of AKI patients (n (%) or median (IQR)). Table S4. Multivariate analysis including variables associated with the risk of requiring RRT (without physician prediction).

Telomere length and mitochondrial DNA copy number in bipolar disorder: A sibling study

Luana Spano, Bruno Etain, Jean-Louis Laplanche, Marion Leboyer, Sébastien Gard, Frank Bellivier & Cynthia Marie-Claire
An accelerated cellular ageing has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature ageing in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored factors that may explain proband-sibling differences. Sixty individuals with BD and seventy-four siblings (34 affected with BD or mood disorders...

Additional file 1 of Atypical working hours are associated with tobacco, cannabis and alcohol use: longitudinal analyses from the CONSTANCES cohort

Nadine Hamieh, Guillaume Airagnes, Alexis Descatha, Marcel Goldberg, Frédéric Limosin, Yves Roquelaure, Cédric Lemogne, Marie Zins & Joane Matta
Additional file 1: Supplementary Table S1. The distribution of employees by periods of follow-up.

Registration Year

  • 2022
    139

Resource Types

  • Text
    139

Affiliations

  • University of Paris
    138
  • Inserm
    58
  • Assistance Publique - Hôpitaux de Paris
    32
  • University of Paris-Saclay
    28
  • Centre Hospitalier Universitaire d'Angers
    22
  • The Francis Crick Institute
    20
  • Noguchi Memorial Institute for Medical Research
    18
  • University of Cambridge
    18
  • University of Angers
    18
  • Hôpital Européen Georges-Pompidou
    16