2,256 Works

A metal tolerance protein, MTP10, is required for the calcium and magnesium homeostasis in Arabidopsis

Haiman Ge, Qiaolin Shao, Jinlin Chen, Jiahong Chen, Xueqin Li, Yu Tan, Wenzhi Lan, Lei Yang & Yuan Wang
Nutrient antagonism typically refers to the fact that too high a concentration of one nutrient inhibits the absorption of another nutrient. In plants, Ca2+ (Calcium) and Mg2+ (Magnesium) are the two most abundant divalent cations, which are known to have antagonistic interactions. Hence, maintaining their homeostasis is crucial for plant growth and development. In this study, we showed that MTP10 (Metal Tolerance Protein 10) is an important regulator for maintaining homeostasis of Mg and Ca...

Discovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo

Jing Wu, Ren De Zhu, Guo Min Cao, Jun Cheng Du, Xin Liu, Liang Zhuo Diao, Zhao Yan Zhang, Yang Sheng Hu, Xin Hua Liu & Jing Bo Shi
T-LAK-cell-originated protein kinase (TOPK), a novel member of the mitogen-activated protein kinase family, is considered an effective therapeutic target for skin inflammation. In this study, a series (A − D) of paeonol derivatives was designed and synthesised using a fragment growing approach, and their anti-inflammatory activities against lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells were tested. Among them, compound B12 yielded the best results (IC50 = 2.14 μM) with low toxicity (IC50 > 50...

Controlled synthesis of cube-like ZnSnO3 decorated by nickel-based films and electrochemical applications on lithium-sulfur batteries

Mianjiao Jiang, Jun Wu, Hongmei Guo, Hongfang Zhang, Manli Zhu & Xiaobang Xu
Transition metal oxide was considered as an effective cathode additive to depress ‘shuttle effect’ in lithium-sulfur (Li-S) batteries via forming a strong polar chemical bond with polysulfides. Here, we firstly synthesized unique S@Ni/NiO/ZnSnO3 microcubes as composite cathodes for Li-S batteries, in which Ni/NiO films were deposited onto surface of as-prepared ZnSnO3 microcubes via a hydrothermal reaction and later calcinations process. The S@Ni/NiO/ZnSnO3 composite showed attractive electrochemical performances with a high initial discharge-specific capacity of 1070...

The Effect of the Acidic Gas Pollutant on Wool Keratin Fiber Structure

Zhe Jiang, Rubing Bai, Jinfang Zhang, Ende Li, Yifan Cui, Ning Zhang, Nan Zhang & Qiang Wang
Increase in air pollution caused by acidic gases, such as nitrogen dioxide, call for the need to study potential effects on the structure of textile materials. Wool is a natural protein fiber which is easily damaged due to rich reaction positions and cross-linked bonds in the fiber. This study reports, for the first time, effect of nitrogen dioxide, as a model acid gas pollutant, on the structure of wool. On the macro level, wool fabric...

Has_circ_0008583 modulates hepatocellular carcinoma progression through the miR-1301-3p/METTL3 pathway

Fenfen Wang, Zhengyuan Xie, Nuobei Zhang, Hao Ding, Kai Xiong, Li Guo, Hongyan Huang & Zhili Wen
Has_circ_0008583 is reported to be involved in the progression of hepatocellular carcinoma (HCC), while its biological role in HCC remains unclear. Here, the qRT-PCR was used to detect the expression of has_circ_0008583. The CCK-8 kit was performed to measure cell proliferation. The cell migration and invasion were evaluated by Transwell. A dual-luciferase reporter assay was performed to confirm the target combination between the genes in has_circ_0008583/miR-1301-3p/METTL3 axis. The in vivo role of has_circ_0008583 was verified...

Rapid Qualitative and Quantitative Characterization of Arnebiae Radix by Near-Infrared Spectroscopy (NIRS) with Partial Least Squares—Discriminant Analysis (PLS-DA)

Na Zhao, Zhaoyang Li, Youping Li, Gaixia Liu, Xiling Deng, Qian Ma, Chenglin Hong & Shiguo Sun
Near infrared (NIR) spectroscopy with chemometrics was used for rapid source identification and component quantification of Arnebiae Radix. The modeling parameters were determined using the processing trajectory method. The quantitative model of target components was established using the model fusion method. The root mean square error of calibration (RMSEC), root mean square error of validation (RMSEP), determination coefficient of calibration (Rcal2) and validation (Rpre2), and the ratio of standard error of prediction to standard deviation...

ELK1-Induced upregulation of long non-coding TNK2-AS1 promotes the progression of acute myeloid leukemia by EZH2-mediated epigenetic silencing of CELF2

Dongfang Guo, Airong Zhang, Meifang Suo, Ping Wang & Yile Liang
Acute myeloid leukemia (AML) is the second most common hematological malignancy after lymphoma in the world. Long non-coding RNAs (LncRNAs) have been suggested as key regulators of cancer development and progression in AML. As a member of lncRNA family, the biological role and mechanisms of tyrosine kinase non receptor 2 antisense RNA 1 (TNK2-AS1) in AML is still unclear. The expression of TNK2-AS1 was measured with RT-qPCR in AML cell lines. The changes of the...

Wood vinegar alleviates photosynthetic inhibition and oxidative damage caused by Pseudomonas syringae pv. tabaci (Pst) infection in tobacco leaves

Yuan Ye, Sun Hongwei, Wang Yue, Xu Zisong, Han Shixin, He Guoqiang, Yin Kuide & Huihui Zhang
We used chlorophyll fluorescence technology and biochemical methods to analyze the effects of wood vinegar (WV) on the photosynthetic mechanism and reactive oxygen species metabolism of tobacco (Nicotiana tabacum L.) leaves infected by Pseudomonas syringae pv. tabaci (Pst). The results showed that Pst infection reduced the chlorophyll content and the activities of PSII and PSI, which inhibited the normal photosynthesis of tobacco leaves. However, pretreatment with WV alleviated the degradation of chlorophyll. Treatment with WV...

The vehicle routing problem with release dates and flexible time windows

Xinrui Sun, Kunpeng Li & Wenli Li
In the context of the increasing demands for home delivery of fresh food, this article addresses the terminal distribution problem in an urban environment, which is called the vehicle routing problem with flexible time windows and order release dates (VRPFTWRD). This study develops a mathematical model and presents a set of valid inequalities based on the problem characteristics. According to the model and the inequalities, a branch-and-cut algorithm (B&C) is proposed for solving the problem....

Hydrogen sulfide protects retina from blue light-induced photodamage and degeneration via inhibiting ROS-mediated ER stress-CHOP apoptosis signal

Sen Zhu, Xuan Li, Bingrong Dang, Fen Wu, Kexin Gou, Chunming Wang & Changjun Lin
Background: Hydrogen sulfide (H2S) is a small reducing gas molecule with various biological functions such as anti-oxidative, anti-apoptotic and anti-inflammatory activities. In this study, we investigated the therapeutic effects of exogenous H2S in the experimental models of retinal photodamage in vivo and in vitro. Methods: Rats with open eyelids were pretreated with H2S (80~120 μmol/kg) for 10 days and then continuously exposed to blue light (435~445nm, 11.2W/m2) for 8 h to establish in vivo experimental...

Magnetic resonance imaging parameter-based machine learning for prognosis prediction of high-intensity focused ultrasound ablation of uterine fibroids

Jinwei Zhang, Chao Yang, Chunmei Gong, Ye Zhou, Chenghai Li & Faqi Li
Objectives: To develop and apply magnetic resonance imaging (MRI) parameter-based machine learning (ML) models to predict non-perfused volume (NPV) reduction and residual regrowth of uterine fibroids after high-intensity focused ultrasound (HIFU) ablation. Methods: MRI data of 573 uterine fibroids in 410 women who underwent HIFU ablation from the Chongqing Haifu Hospital (training set, N = 405) and the First Affiliated Hospital of Chongqing Medical University (testing set, N = 168) were retrospectively analyzed. Fourteen MRI...

Elevated D-Dimer levels correlate with the development of hepatorenal syndrome and a poor outcome in patients with cirrhosis

Baode Chen, Jing Liu, Yongtao Li, Xuelin He, Cheng Zhou, Yu Chen & Min Zheng
Whether hemostatic status was correlated with the diverse types of acute kidney injury in cirrhotic patients is unclear. The present study aimed to investigate the relationship between hemostatic markers and the diverse types of acute kidney injury (AKI) in liver cirrhosis. Cirrhotic patients with consecutive treatment at the First Affiliated Hospital of Medicine School, Zhejiang University, were pooled in a cohort. Their demographic and clinical data, biochemistry parameters and hemostatic markers were assessed to identify...

Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration

Zhengqian Liu, Xin Zhou, Peng Zheng, Chenheng Bu, Xiao’ou Yan, Haizhou Yu & Yong Xu
The purpose of this research was to explore the diagnostic/prognostic significance and prospective molecular mechanisms of mitogen-activated protein kinase kinase kinases (MAP3Ks) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Diagnostic/prognostic significance of MAP3Ks was screened in the GSE1450 data set and validated in the Guangxi cohort. Various bioinformatics tools were used to explore the biological functions of prognosis-related genes. Subsequently, molecular biology assays were used to verify the biological functions and molecular mechanisms of...

Abietane diterpenoids with neuroprotective activities from Phlegmariurus carinatus

Yang Liu, Qiang Wang, Dong-Kun Zheng, De Zhang, Zhen Xie, Jia-Wei Hu, Xin-Hua Xie, Jing Li & Shu-Ping Jiang
Two new abietane diterpenoids, phlecarinatone A (1) and phlecarinatone B (2), along with two known analogues (3 and 4), were isolated from Phlegmariurus carinatus. The structures of 1 − 4 were unambiguously elucidated by comprehensive spectroscopic analyses. Abietane diterpenoids were isolated from the plant for the first time. All isolates were tested for their neuroprotective activities against H2O2-induced SH-SY5Y cells injury, and compound 2 showed moderate effect at the concentrations ranging from 5 ∼ 20...

Help or punishment: acute stress moderates basal testosterone's association with prosocial behavior

Huagen Wang, Zhen Zhen, Ruida Zhu, Bohai Yu, Shaozheng Qin & Chao Liu
The gonadal hormone testosterone is well-recognized to facilitate various behaviors for obtaining social status. A good reputation (i.e. competitive, generous, and trustworthy) is of crucial importance for acquiring high social status. It is unclear which type of reputation is preferred by individuals under the influence of testosterone. Given that the recent dual-hormone hypothesis emphasizes the modulating effect of stress (cortisol) on the influence of testosterone, it would be intriguing to test the role of stress-induced...

Prevention of ulcerative colitis by Huangqin decoction: reducing the intestinal epithelial cell apoptosis rate through the IFN-γ/JAK/ETS signalling pathway

Xiaowei Mo, Kairui Tang, Lijing Deng, Xingyi Zhou, Xiaojuan Li, Yupei Zhang & Jing Wang
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease that is closely related to inflammation and apoptosis. The traditional Chinese medicine compound preparation Huangqin decoction (HQD) has been widely used in the clinical treatment of UC, but the specific mechanism of its function is still inconclusive. To explore the pathogenesis of UC based on the IFN-γ/JAK/ETS signalling pathway, and to clarify the biological mechanism of HQD. Forty 8-week-old male C57BL/6 mice were randomly divided...

Research strategy for constructing a green infrastructure network based on spatial prioritization

Dongmeng Wang, Chang Liu, Yue Guo, Puxia Tang, Jie Jiao, Weihan Kong, Ling Zhang, Yiping Liu & Dezheng Kong
The destruction of the ecological system caused by urban expansion has led to the environmental deterioration, cities have become increasingly vulnerable. In this study, six districts and counties along the Yellow River in Zhengzhou were selected as the study area. First, green infrastructure elements were extracted by morphological spatial pattern analysis. Then, outside the urban areas, we used connectivity analysis to evaluate the importance of core areas, adopted minimum cumulative resistance model to extract potential...

Supplemental material - Nanoarchitectured Graphene Organic Framework for Drug Delivery and Chemo-photothermal Synergistic Therapy

Chengfeng Xu, Shuting Yao, Peng Jiang, Cui Wang, Jinhua Hu, Junmin Wan, Zhiwen Hu & Bing Wang
Supplementary material for Nanoarchitectured Graphene Organic Framework for Drug Delivery and Chemo-photothermal Synergistic Therapy by Chengfeng Xu, Shuting Yao, Peng Jiang, Cui Wang, Jinhua Hu, Junmin Wan, Zhiwen Hu, and Bing Wang in Journal of Biomaterials Applications

Supplemental material - Nanoarchitectured Graphene Organic Framework for Drug Delivery and Chemo-photothermal Synergistic Therapy

Chengfeng Xu, Shuting Yao, Peng Jiang, Cui Wang, Jinhua Hu, Junmin Wan, Zhiwen Hu & Bing Wang
Supplementary material for Nanoarchitectured Graphene Organic Framework for Drug Delivery and Chemo-photothermal Synergistic Therapy by Chengfeng Xu, Shuting Yao, Peng Jiang, Cui Wang, Jinhua Hu, Junmin Wan, Zhiwen Hu, and Bing Wang in Journal of Biomaterials Applications

Racism by Design?

Hao Ding & Anastasia Loukaitou-Sideris
We examined land use and design controls in three municipalities in Los Angeles County (CA)—Alhambra, Arcadia, and San Gabriel—that have experienced a recent influx of Asian residents. We drew from archival research of newspaper articles, planning documents, city council and planning commission meeting minutes, and interviews with 14 local planners, architects, planning and design review commissioners, and resident groups. We found that the three cities developed stringent development controls, encouraged Anglo or Spanish heritage architectural...

A. caviae infection triggers IL-1β secretion through activating NLRP3 inflammasome mediated by NF-κB signaling pathway partly in a TLR2 dependent manner

Qiankun Yang, Jianguo Zhang, Feixue Liu, Huizhen Chen, Wei Zhang, Haitao Yang, Nana He, Jingquan Dong & Panpan Zhao
Aeromonas caviae, an important food-borne pathogen, induces serious invasive infections and inflammation. The pro-inflammatory IL-1β functions against pathogenic infections and is elevated in various Aeromonas infection cases. However, the molecular mechanism of A. caviae-mediated IL-1β secretion remains unknown. In this study, mouse macrophages (PMs) were used to establish A. caviae infection model and multiple strategies were utilized to explore the mechanism of IL-1β secretion. IL-1β was elevated in A. caviae infected murine serum, PMs lysates...

Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain

Shixin Tang, Hongyang Zhang, Yinyin Xia, Shiyue Luo, Yijun Liu, Xinhao Duan, Zhen Zou, Chengzhi Chen, Lixiao Zhou & Jingfu Qiu
Di (2-ethylhexyl) phthalate (DEHP) is one of the most prevalent xenoestrogen endocrine disruptor in daily life. A growing number of studies showed that DEHP could exhibit long-term adverse health effects on the human body, particularly in the liver, kidneys, heart and reproductive systems. However, the impact of oral intake of DEHP on the nervous system is extremely limited. In the present study, the adult C57BL/6J male mice were intragastrically administered with two dosages of DEHP...

Two 2D Zn(II) coordination polymers assembled from thiophene dicarboxylate and flexible N-(4-pyridylmethyl)imidazole derivatives: syntheses, crystal structures, and photoluminescent properties

Li-Ping Xue & Qing Wang
Two 2D Zn(II) coordination polymers, formulated as [Zn(μ2-tdc)(μ-pmid)] (1), {[Zn(μ2-tdc)(μ-pmmid)2·4H2O]}n (2) (H2tdc = 2,5-thiophenedicarboxylic acid, pmid = 1-(4-pyridylmethyl)imidazole; pmmid = 1-(4-pyridylmethyl)-2-methylimidazole) have been synthesized by reactions of Zn(OAc)2·2H2O and H2tdc with flexibleN-(4-pyridylmethyl)imidazole derivatives under the mild reaction conditions and characterized by single-crystal X-ray diffraction and other physicochemical methods. Structure determination demonstrates compound 1 displays a 2-fold 2D → 2D parallel interpenetrating structure, while compound 2 shows a 2D non-interpenetrating network. These results reveal that the...

LINC00313 alleviates osteoarthritis progression in mice through promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK signaling pathway

Hongyan Li, Qingpeng Wang & Dapeng Gong
This study aimed to explore the underlying role and mechanism of LINC00313 in osteoarthritis (OA) progression. CHON-001 chondrocytes were treated with interleukin (IL)-1β to induce OA in vitro, and then transfected with LINC00313 overexpression plasmids (pcDNA-LINC00313) or small interfering RNA against tumor necrosis factor (TNF) receptor-associated factor 1 (si-TRAF1). Cell viability, apoptosis, levels of inflammatory cytokines tumor necrosis factor-α (TNF-α), IL-6 and IL-8, and expression of extracellular matrix (ECM) degradation related proteins in CHON-001 cells...

Fe3S2 cluster complexes containing aminodiphosphine ligand: synthesis, characterization, crystal structures and electrochemical properties

Jun Yang, Wen-Jing Tian, Shuang Lü, Jiao He, Kui Hu, Peng Yan, Hang Xu, Mao-Xin Zeng, Yu-Long Li & Qian-Li Li
In this article, six new Fe3S2 cluster complexes Fe3(µ3S)2(CO)7[(Ph2P)2NR] (1-6) (R = (CH2)2CH3, CH(CH3)2, (CH2)3CH3, CH2CH(CH3)2, p-C6H4CCH and m-C6H4CCH) were successfully synthesized by reactions of Fe3S2(CO)9 and the corresponding aminodiphosphines under refluxing toluene. Meanwhile, treatment of Fe3S2(CO)9 and (Ph2P)2NCH(CH3)Ph afforded two new Fe3S2 cluster complexes Fe3(µ3-S)2(CO)7[(Ph2P)2NCH(CH3)Ph] (7) and Fe3(µ3-S)2(CO)7[(κ2-Ph2P)2NCH(CH3)(Ph)] (8). Complexes 1–8 were characterized by elemental analysis, FT-IR, NMR spectroscopy, and especially X-ray crystallography. The elctrochemical properties were investigated by cyclic voltammetry, showing that they...

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  • Chinese Academy of Sciences
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  • Chinese Academy of Medical Sciences & Peking Union Medical College
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