115 Works

Study on influencing factors of Pickering emulsion stabilized by modified montmorillonite and fatty alcohol polyoxyethylene ether

Qian Chen, Zeyu Yang, Xiumei Tai, Yanyun Bai & Guoyong Wang
Pickering emulsion is widely used in food, drug administration, and cosmetics. In practical applications, surfactants are often co-present with particles, so it is particularly critical to study particle-surfactant interactions. Pickering emulsions were prepared using stearyltrimethylammoniumchloride organic montmorillonite (STAC/MMT) and fatty alcohol polyoxyethylene ether (AEO-3) as stabilizers. Effects of AEO-3 content, STAC/MMT content, oil-water ratio, emulsification temperature, emulsification time on emulsion stability were systematically revealed by studying the particle size distribution and phase volume of the...

Angiopoietin-like protein 8, molecular cloning and regulating lipid accumulation in goat intramuscular preadipocytes

Wei Huang, Yaqiu Lin, Hua Xiang, Jiangjiang Zhu & Yong Wang
This study aimed to clone the full-length open reading frame (ORF) of goat ANGPTL8 gene sequence, reveal its molecular and expression characteristics, and explore its effect on the differentiation of goat intramuscular preadipocytes. The full-length ORF sequence of goat ANGPTL8 gene was cloned by RT-PCR technology, and bioinformatics analysis was performed by related biological software. RT-qPCR was used to detect the expression of ANGPTL8 mRNA in goat tissues. Further use of RNA interference to study...

Supplemental Material, sj-pdf-1-teu-10.1177_13548166211021175 - Effects of tourism development on economic growth: An empirical study of China based on both static and dynamic spatial Durbin models

Honghong Liu, Ye Xiao, Bin Wang & Dianting Wu
Supplemental Material, sj-pdf-1-teu-10.1177_13548166211021175 for Effects of tourism development on economic growth: An empirical study of China based on both static and dynamic spatial Durbin models by Honghong Liu, Ye Xiao, Bin Wang and Dianting Wu in Tourism Economics

Sex Difference in Lipid Levels in First-Diagnosed Drug-Naïve Depression Patients: A Case-Control and 12-Weeks Follow-up Study

Rui Yang, Lu Wang, Song Cao, Ming Chen, Chu-Jun Wu, Floyd Silva, Man-Jun Shen, Jin-Dong Chen, Mi-Mi Tang & Bi-Lian Liu
Patients with depression have a high prevalence of developing dyslipidemia. In this study, we aim to investigate the difference of serum lipids, including total cholesterol (TCH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), between the depressed patients and healthy controls. Sex differences in lipids and their psychological correlations were also included. The study included 56 healthy controls (males/females =26/30) and 110 first-diagnosed drug-naïve outpatients (males/females =35/75). A total of 42 patients...

Supplemental Material, sj-pdf-1-teu-10.1177_13548166211021175 - Effects of tourism development on economic growth: An empirical study of China based on both static and dynamic spatial Durbin models

Honghong Liu, Ye Xiao, Bin Wang & Dianting Wu
Supplemental Material, sj-pdf-1-teu-10.1177_13548166211021175 for Effects of tourism development on economic growth: An empirical study of China based on both static and dynamic spatial Durbin models by Honghong Liu, Ye Xiao, Bin Wang and Dianting Wu in Tourism Economics

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation

Youhua Liu, Yuanling Zhao, Ruifan Wu, Yushi Chen, Wei Chen, Yuxi Liu, Yaojun Luo, Chaoqun Huang, Botao Zeng, Xing Liao, Guanqun Guo, Yizhen Wang & Xinxia Wang
5-Methylcytosine (m5C) is a type of RNA modification that exists in tRNAs and rRNAs and was recently found in mRNA. Although mRNA m5C modification has been reported to regulate diverse biological process, its function in adipogenesis remains unknown. Here, we demonstrated that knockdown of NOL1/NOP2/Sun domain family member 2 (NSUN2), a m5C methyltransferase, increased lipid accumulation of 3T3-L1 preadipocytes through accelerating cell cycle progression during mitotic clonal expansion (MCE) at the early stage of adipogenesis....

Selenium-associated differentially expressed microRNAs and their targeted mRNAs across the placental genome in two U.S. birth cohorts

Fu-Ying Tian, Elizabeth M. Kennedy, Karen Hermetz, Amber Burt, Todd M. Everson, Tracy Punshon, Brian P. Jackson, Ke Hao, Jia Chen, Margaret R. Karagas, Devin C. Koestler & Carmen Marsit
Selenium is an important micronutrient for foetal development. MicroRNAs play an important role in the function of the placenta, in communication between the placenta and maternal systems, and their expression can be altered through environmental and nutritional cues. To investigate the associations between placental selenium concentration and microRNA expression in the placenta, our observational study included 393 mother-child pairs from the New Hampshire Birth Cohort Study (NHBCS) and the Rhode Island Child Health Study (RICHS)....

Comprehensive Analysis of Monocarboxylate Transporter 4 (MCT4) expression in breast cancer prognosis and immune infiltration via integrated bioinformatics analysis

Chen Yuan, Jie Zhang, Jianjuan Lou, Siqi Wang, Yanni Jiang, Feiyun Wu & Shouju Wang
Lactate blunts the anticancer immune response in breast cancer (BC). However, little is known about the exact effect of lactate transporters such as monocarboxylate transporter 4 (MCT4) on immunotherapy. In this study, we investigated the expression status and prognostic value of MCT4 in BC through large-scale transcriptome data. Our results showed that MCT4 was overexpressed in BC, particularly in the basal-like molecular subtype. Overexpression of MCT4 was significantly correlated with high BC lesion grade and...

Tumor-targeted Gd-doped mesoporous Fe3O4 nanoparticles for T1/T2 MR imaging guided synergistic cancer therapy

Shaohui Zheng, Shang Jin, Min Jiao, Wenjun Wang, Xiaoyu Zhou, Jie Xu, Yong Wang, Peipei Dou, Zhen Jin, Changyu Wu, Jingjing Li, Xinting Ge & Kai Xu
In this study, a novel intelligent nanoplatform to integrate multiple imaging and therapeutic functions for targeted cancer theranostics. The nanoplatform, DOX@Gd-MFe3O4 NPs, was constructed Gd-doped mesoporous Fe3O4 nanoparticles following with the doxorubicin (DOX) loading in the mesopores of the NPs. The DOX@Gd-MFe3O4 NPs exhibited good properties in colloidal dispersity, photothermal conversion, NIR triggered drug release, and high T1/T2 relaxicity rate (r1=9.64 mM−1s−1, r2= 177.71 mM−1s−1). Benefiting from the high MR contrast, DOX@Gd-MFe3O4 NPs enabled simultaneous...

Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment

Yu Wang, Qianmei Wang, Wei Feng, Qian Yuan, Xiaowei Qi, Sheng Chen, Pu Yao, Qing Dai, Peiyuan Xia, Dinglin Zhang & Fengjun Sun
Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-responsive nanoplatforms to improve the bioactivity of Lut. Folic acid (FA) was employed to decorate the nanoparticles (NPs) to enhance its targeting ability. The size of Lut-loaded ROS-responsive nanoparticles (Lut/Oxi-αCD NPs) and FA-modified Lut/Oxi-αCD NPs...

Silmitasertib-induced macropinocytosis promoting DDP intracellular uptake to enhance cell apoptosis in oral squamous cell carcinoma

Shaojuan Song, Xin Xia, Jiajia Qi, Xiaopei Hu, Qian Chen, Jiang Liu, Ning Ji & Hang Zhao
Cisplatin (DDP) is a first-line chemotherapeutic drug applied for the treatment of oral squamous cell carcinoma (OSCC). The anticancer activity of DDP is tightly linked to its intracellular uptake. It is unwise to increase the DDP intake by increasing the dose or shortening the dosing interval because of the severe systemic toxicity (nephrotoxicity, ototoxicity and neurotoxicity) in DDP application. The main uptake pathways of DDP include passive diffusion and active transporter transport. Therefore, finding additional...

Taberdines L and M, two new alkaloids from Tabernaemontana divaricata

Lingling Han, Kepu Huang, Chen Chen, Wentao Zhu, Yehan Ma, Xiaojiang Hao, Hongping He & Yu Zhang
Two new alkaloids, taberdines L (1) and M (2), together with six known alkaloids, were isolated from the twigs and leaves of Tabernaemontana divaricata. Taberdine L (1) represents the first optically active natural member of the allo iboga class of alkaloids with the ethyl side chain in a bridgehead position. Their structures including absolute configuration were elucidated by a combination of MS, NMR, and ECD calculation. The in vitro cytotoxic activities of 1 and 2...

7-Hydroxy questin, a new anthraquinone from a wetland fungus Aspergillus flavipes PJ03-11

Chong Yu, Shuang Lin, Xiaorui Ma, Jie Zhang, Caixia Wu, Ben Ma, Haifeng Wang & Yuehu Pei
One new anthraquinone, questinlin (1), four known anthraquinones (2–5), together with three known benzophenone derivatives (6–8) were isolated from a wetland fungus Aspergillus flavipes PJ03-11. Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D, 2D NMR (HMQC, HMBC), mass spectrometry, and optical rotation and IR spectra. In addition, the cytotoxic activities against three human cancer cell lines (HepG2, Caco-2 and A549) were evaluated. In this article, Aspergillus flavipes PJ03-11, a wetland...

Alkaloids from endophytic fungus Aspergillus fumigatus HQD24 isolated from the Chinese mangrove plant Rhizophora mucronata

Renjian Zou, Chengwen Wei, Xuexia Zhang, Dongdong Zhou & Jing Xu
Chemical investigation of endophytic fungus Aspergillus fumigatus HQD24, isolated from the flower of Rhizophora mucronata led to the isolation of eight alkaloids, including pyripyropene A (1), 1,11-dideacetyl-pyripyropene A (2), pyripyropene E (3), chaetominine (4), tryptoquivaline J (5), fumitremorgin C (6), 1-acetyl-β-carboline (7), and nicotinic acid (8). Their structures were unambiguously elucidated on the basis of extensive spectroscopic data and comparison with the data of literature. Compound 2 was known as a synthetic product and isolated...

Antibacterial activities of the chemical constituents of Schizophyllum commune MST7-3 collected from coal area

Guang-Gui Chen, Qin-Feng Zhu, Xing-Mei Long, Qian Lu, Kai-Yu Li, Qian Chen, Meng Zhou, Shang-Gao Liao & Guo-Bo Xu
Two fusidane-type active compounds (6 and 7) and five new ones (1–5), along with other nine known compounds (8–16) were isolated from the metabolites of Schizophyllum commune MST7-3. Their structures were elucidated on the basis of spectroscopic analysis. The absolute configurations of compounds 2 and 3 were established by Mosher’s method and optical rotation. Compounds 6 and 7 showed significant antibacterial activities against Stenotrophomonas maltophilia with MIC values of 4 μg/mL and 16 μg/mL, respectively.

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells

Xia Qin, Jun Zhang, Bin Wang, Ge Xu, Xi Yang, Zhen Zou & Chao Yu
Zinc oxide nanoparticles (ZnONPs) hold great promise for biomedical applications. Previous studies have revealed that ZnONPs exposure can induce toxicity in endothelial cells, but the underlying mechanisms have not been fully elucidated. In this study, we report that ZnONPs can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner. In addition, both the lipid reactive oxygen...

A new cyclopentenone derivative from Trichoderma atroviride HH-01

Li Zhu, Jia-Peng Wang, Feng Hao, Dong Gan, Xiao-Ran Zhang, Chen-Zhe Li, Cheng-Yao Wang, Liang Zhang & Le Cai
A new cyclopentenone derivative, atrovinol (1), together with ten known compounds (2-11) were isolated from Trichoderma atroviride HH-01, an endophytic fungus from Illigera rhodantha (Hernandiaceae). Their structures were identified by HRESIMS, 1 D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound 1 exhibited moderate inhibitory activity against Staphylococcus aureus and Bacillus subtilis with MIC values of 8.0 µg/mL and 16.0 µg/mL, respectively.

Folate-functionalized SMMC-7721 liver cancer cell membrane-cloaked paclitaxel nanocrystals for targeted chemotherapy of hepatoma

Wenwen Shen, Shuke Ge, Xiaoyao Liu, Qi Yu, Xue Jiang, Qian Wu, YuChen Tian, Yu Gao, Ying Liu & Chao Wu
In this study, we prepared a folic acid-functionalized SMMC-7721 liver cancer cell membrane (CM)-encapsulated paclitaxel nanocrystals system (FCPN) for hepatoma treatment. Transmission electron microscopy (TEM) characterization showed that FCPN was irregular spherical shapes with a particle size larger than 200 nm and a coated thickness of approximately 20 nm. In an in vitro release experiment, FCPN indicated a slowly release effect of paclitaxel (PTX). Cell experiments demonstrated that FCPN was taken up by SMMC-7721 cells...

Early Cretaceous rapid exhumation processes in the southern Great Xing’an Range, NE China: implications for extensional geodynamics

Wen Chen, Wen Zhang, Shuangfeng Zhao, Jingbo Sun, Ze Shen, Qiuyi Du & Zhi Li
The Mesozoic-Cenozoic geological evolution of the southern Great Xing’an Range (GXR) has long been controversial since it is located in the superposed region of different tectonic regimes and involves complex interactions. Here, we present low-temperature thermochronological data from granitoids emplaced in multiple magmatic stages to delineate the tectono-thermal history and further understand the geodynamic process. Most zircon and apatite (U-Th)/He ages, within error, indicate Early Cretaceous: the zircon average (U-Th)/He ages range from 146.7 ±...

Additional file 1 of Effectiveness of electroacupuncture for thin endometrium in infertile women: study protocol for a single-blind, randomized controlled trial

Fangyuan Li, Hua Lu, Xinxin Wang, Qi Zhang, Qianchen Liu & Tong Wang
Additional file 1.

Generalized Poisson integer-valued autoregressive processes with structural changes

Chenhui Zhang, Dehui Wang, Kai Yang, Han Li & Xiaohong Wang
In this paper, we introduce a new first-order generalized Poisson integer-valued autoregressive process, for modeling integer-valued time series exhibiting a piecewise structure and overdispersion. Basic probabilistic and statistical properties of this model are discussed. Conditional least squares and conditional maximum likelihood estimators are derived. The asymptotic properties of the estimators are established. Moreover, two special cases of the process are discussed. Finally, some numerical results of the estimates and a real data example are presented.

Additional file 1 of Transcutaneous electrical acupoint stimulation for high-normal blood pressure: study protocol for a randomized controlled pilot trial

Yu Wang, Guang-Xia Shi, Zhong-Xue Tian, Jun-Hong Liu, You-Sheng Qi, Jian-Feng Tu, Jing-Wen Yang, Li-Qiong Wang & Cun-Zhi Liu
Additional file 1. Completed Standard Protocol Items: Recommendation for Interventional Trials (SPIRIT) 2013 Checklist: items addressed in this clinical trial protocol.

Cross-cultural adaptation, reliability, and validity of the Chinese version of the Acceptance and Action Questionnaire-Adult Hearing Loss

Ying Yang, Yulu Liu, Yanan Xiao, Lianchi Zhang, Yan Li, Hong Zhu & Jin Bian
Few mental health assessment tools are available for people with hearing loss (HL) in China. The Acceptance and Action Questionnaire-Adult Hearing Loss (AAQ-AHL) has been specifically designed to assess psychological inflexibility in adults with HL and may help assess mental health status promptly for targeted psychological interventions. The study aimed to investigate the cross-cultural validity and reliability of the Chinese version of the AAQ-AHL to assess its applicability to teenagers and adults with HL in...

A novel genetic variant potentially altering the expression of MANBA in the cerebellum associated with attention deficit hyperactivity disorder in Han Chinese children

Xinzhen Chen, Ting Yao, Jinliang Cai1, Qi Zhang, Shanyawen Li, Huiru Li, Xihang Fu & Jing Wu
To get additional insight into the genetic factors of attention deficit hyperactivity disorder (ADHD). First, we performed a transcriptome-wide association study (TWAS) integrating human cerebellum-specific variant-expression/splicing correlations to identify ADHD susceptibility genes. Then, the associations between expression/splicing quantitative trait loci (eQTLs/sQTLs) of the transcriptome-wide significant genes and ADHD were observed in a case-control study of Han Chinese children. Furthermore, dual luciferase reporter gene assays were performed to validate the regulatory function of ADHD risk variants....

sj-pdf-1-jfi-10.1177_0192513X211041992 – Supplemental Material for Loneliness Among Chinese Older Adults: The Role of Grandparenthood and Grandparental Childcare by Gender

Jing Zhang, Tineke Fokkema & Bruno Arpino
Supplemental Material, sj-pdf-1-jfi-10.1177_0192513X211041992 for Loneliness Among Chinese Older Adults: The Role of Grandparenthood and Grandparental Childcare by Gender by Jing Zhang, Tineke Fokkema and Bruno Arpino in Journal of Family Issues

Registration Year

  • 2021

Resource Types

  • Text


  • Soochow University
  • Shanghai Jiao Tong University
  • Zhejiang University
  • Chinese Academy of Medical Sciences & Peking Union Medical College
  • Sun Yat-sen University
  • Fudan University
  • Chinese Academy of Sciences
  • Huazhong University of Science and Technology
  • Capital Medical University
  • Sichuan University