296,690 Works

Association of Organophosphate Pesticide Exposure and a Marker of Asthma Morbidity in an Agricultural Community

Wande Benka-Coker, Christine Loftus, Catherine Karr & Sheryl Magzamen
Objectives: We explored the short-term impact of pesticide exposure on asthma exacerbation among children with asthma in an agricultural community. Methods: We obtained repeated urine samples from a subset of 16 school-age children with asthma (n = 139 samples) as part of the Aggravating Factors of Asthma in a Rural Environment (AFARE) study cohort. Biomarkers of organophosphate (OP) pesticide exposure (dialkylphosphates (DAPs)), and asthma exacerbation (leukotriene E4 (uLTE4)) were assessed in urine samples. We used...

Association of Organophosphate Pesticide Exposure and a Marker of Asthma Morbidity in an Agricultural Community

Wande Benka-Coker, Christine Loftus, Catherine Karr & Sheryl Magzamen
Objectives: We explored the short-term impact of pesticide exposure on asthma exacerbation among children with asthma in an agricultural community. Methods: We obtained repeated urine samples from a subset of 16 school-age children with asthma (n = 139 samples) as part of the Aggravating Factors of Asthma in a Rural Environment (AFARE) study cohort. Biomarkers of organophosphate (OP) pesticide exposure (dialkylphosphates (DAPs)), and asthma exacerbation (leukotriene E4 (uLTE4)) were assessed in urine samples. We used...

The side chain effects on TPD-based copolymers: the linear chain leads to a higher jsc

Qiang Tao, Yafen Fu, Qian Liu, E. Zhou, Dong Yan, Zhengjun Fang, Yunfeng Liao, Xianwei Huang, Jiyong Deng & Donghong Yu
Alkyl substituents appended to polymers play the determining role on self-assembly and film-forming properties, and on device performance. In this work, we highlight the effects of the linear and branched flexible chains appended to the acceptor moiety (A) in D-A type copolymers. Two thieno[3,4-c]-pyrrole-4,6-dione (TPD) based copolymers PT1 and PT2 with different alkyl chains, were designed and synthesized. By comparison their UV-vis absorptions, HOMO/LUMO energy levels, as well as the characters in polymer solar cells,...

The side chain effects on TPD-based copolymers: the linear chain leads to a higher jsc

Qiang Tao, Yafen Fu, Qian Liu, E. Zhou, Dong Yan, Zhengjun Fang, Yunfeng Liao, Xianwei Huang, Jiyong Deng & Donghong Yu
Alkyl substituents appended to polymers play the determining role on self-assembly and film-forming properties, and on device performance. In this work, we highlight the effects of the linear and branched flexible chains appended to the acceptor moiety (A) in D-A type copolymers. Two thieno[3,4-c]-pyrrole-4,6-dione (TPD) based copolymers PT1 and PT2 with different alkyl chains, were designed and synthesized. By comparison their UV-vis absorptions, HOMO/LUMO energy levels, as well as the characters in polymer solar cells,...

Malaria tropica infection overrules immunity by hybrid phenotype formation.

Peter Arend
Although the process of pathogen transmission across species barriers has not yet been completely elucidated, species barriers are most likely overcome in malaria tropica infection. The abundant serine syntheses of the protozoan parasite Plasmodium falciparum, which lacks the ability to perform O-GalNAc glycosylation and does not survive outside its metazoan host, hypothetically obtain access to the metazoan host’s evolutionarily first protein glycosylation (or serologically A-like, O-GalNAcα1-Ser/Thr-R, “T nouvelle” (Tn) antigen formation). In humans, this genetically...

Malaria tropica infection overrules immunity by hybrid phenotype formation.

Peter Arend
Although the process of pathogen transmission across species barriers has not yet been completely elucidated, species barriers are most likely overcome in malaria tropica infection. The abundant serine syntheses of the protozoan parasite Plasmodium falciparum, which lacks the ability to perform O-GalNAc glycosylation and does not survive outside its metazoan host, hypothetically obtain access to the metazoan host’s evolutionarily first protein glycosylation (or serologically A-like, O-GalNAcα1-Ser/Thr-R, “T nouvelle” (Tn) antigen formation). In humans, this genetically...

Malaria tropica disease and ABO(H) blood group phenotype-determined innate immunity

Peter Arend
Although the process of pathogen transmission across species barriers has not yet been completely elucidated, species barriers are most likely overcome in malaria tropica infection. The abundant serine syntheses of the protozoan parasite Plasmodium falciparum, which lacks the ability to perform O-GalNAc glycosylation and does not survive outside its metazoan host, hypothetically obtain access to the metazoan host’s evolutionarily first protein glycosylation (or serologically A-like, O-GalNAcα1-Ser/Thr-R, “T nouvelle” (Tn) antigen formation). In humans, this genetically...

Additional file 4: of Clocks do not tick in unison: isolation of Clock and vrille shed new light on the clockwork model of the sand fly Lutzomyia longipalpis

JoĂŁo Gesto, Gustavo Rivas, Marcio Pavan, Antonio Meireles-Filho, Paulo Amoretty, Nataly Souza, Rafaela Bruno & Alexandre Peixoto
Additional file 2. Multiple sequence alignment of VRI orthologues in L. longipalpis [GenBank: KR706372], Ae. aegypti [GenBank:XP_001661622], An. gambiae [GenBank:XP_317705], D. melanogaster [GenBank:NP_477191], M. domestica [GenBank:XP_005180212], R. prolixus [VectorBase:RPRC000393], D. plexippus [GenBank:AAT86041], A. pernyi [GenBank:AAS92609] and T. castaneum [GenBank:EFA11543]. The Highlighted region (blue) corresponds to bZIP functional domain. Text colors correlate to conservation thresholds for a position. In red font, highly conserved residues (threshold=90 %). In blue font, weakly conserved residues (threshold=50 %). (PDF 171...

Two new 12-membered macrolides from the endophytic fungal strain Cladosprium colocasiae A801 of Callistemon viminalis

Hong-Xin Liu, Hai-Bo Tan, Sai-Ni Li, Yu-Chan Chen, Hao-Hua Li, Sheng-Xiang Qiu & Wei-Min Zhang
Two new polyketide metabolites, the 12-membered macrolides 4-hydroxy-12-methyloxacyclododecane-2,5,6-trione (1) and 12-methyloxacyclododecane-2,5,6-trione (2), were isolated from the endophytic fungal strain Cladosprium colocasiae A801 of the plant Callistemon viminalis, together with five known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. The antibacterial, cytotoxic, and α-glucosidase inhibitory activities of the new compounds 1 and 2 were evaluated.

Potent leishmanicidal and antibacterial metabolites from Olea ferruginea

Salman Zafar, Faiz -Ur-Rehman, Zafar Ali Shah, Abdur Rauf, Aziz Khan, Muhammad Humayun Khan, Khaliq Ur Rahman, Serab Khan, Abid Ullah & Farzana Shaheen
Inspired from the leishmanicidal and antibacterial potential of the fractions obtained from the crude extract of Olea ferruginea stem, the anti-leishmanial ethyl acetate fraction was subjected to chromatographic separation, leading to the isolation of a new compound ferruginan (1) and a known compound (+)- cycloolivil (2). The structures of 1 and 2 were determined by various spectroscopic techniques and were assayed for their in vitro antibacterial and leishmanicidal potential. Compound 1 showed 75% inhibition after...

Sesquiterpenoids from the roots of Croton crassifolius

Jin-Long Tian, Chen-Xi Li, Xin-Yue Shang, Xue-Wen Hou, Yan Zhang, Ling-Zhi Li, Xiao-Xiao Huang & Shao-Jiang Song
Phytochemical investigation of Croton crassifolius roots afforded five sesquiterpenes (1–5), including two new sesquiterpenes 6S-hydroxy-cyperenoic acid (1) and crassifterpenoid A (5), together with three known compounds (2–4). The structures of the new compounds were determined by comprehensive spectroscopic methods, and their absolute configurations were determined by quantum chemical ECD calculation. Crassifterpenoid A (5) is the first germacrane-type sesquiterpene isolated from C. crassifolius, which enriched the diversity of chemical constituents in Croton crassifolius. In addition, the...

Potent leishmanicidal and antibacterial metabolites from Olea ferruginea

Salman Zafar, Faiz -Ur-Rehman, Zafar Ali Shah, Abdur Rauf, Aziz Khan, Muhammad Humayun Khan, Khaliq Ur Rahman, Serab Khan, Abid Ullah & Farzana Shaheen
Inspired from the leishmanicidal and antibacterial potential of the fractions obtained from the crude extract of Olea ferruginea stem, the anti-leishmanial ethyl acetate fraction was subjected to chromatographic separation, leading to the isolation of a new compound ferruginan (1) and a known compound (+)- cycloolivil (2). The structures of 1 and 2 were determined by various spectroscopic techniques and were assayed for their in vitro antibacterial and leishmanicidal potential. Compound 1 showed 75% inhibition after...

Two new 12-membered macrolides from the endophytic fungal strain Cladosprium colocasiae A801 of Callistemon viminalis

Hong-Xin Liu, Hai-Bo Tan, Sai-Ni Li, Yu-Chan Chen, Hao-Hua Li, Sheng-Xiang Qiu & Wei-Min Zhang
Two new polyketide metabolites, the 12-membered macrolides 4-hydroxy-12-methyloxacyclododecane-2,5,6-trione (1) and 12-methyloxacyclododecane-2,5,6-trione (2), were isolated from the endophytic fungal strain Cladosprium colocasiae A801 of the plant Callistemon viminalis, together with five known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. The antibacterial, cytotoxic, and α-glucosidase inhibitory activities of the new compounds 1 and 2 were evaluated.

Four new C20-diterpenoid alkaloids from Aconitum rotundifolium

Ji-Fa Zhang, Yu Li, Feng Gao, Lian-Hai Shan & Xian-Li Zhou
Four new C20-diterpenoid alkaloids, rotundifosines D-G (1–4), along with eight known ones (5–12) were isolated from the whole plant of Aconitum rotundifolium Kar. & Kir. The structures of the compounds were elucidated on the basis of spectroscopic analyses, including HR-ESI-MS and 1D, 2D NMR. Rotundifosine F (3) is a rare C20-diterpenoid alkaloid with quaternary ammonium salt. Alkaloids 1–4, 5, 6, 9, and 12 were evaluated for cytotoxicity against MCF-7, HCT-116 and HepG2 human cancer cell...

A new ionone derivative from the leaves of Picrasma quassioides

Chang Liu, Rong-Rong Cheng, Zhu-Zhen Han, Ying-Bo Yang, Yue Zhou, Li Yang & Zheng-Tao Wang
Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2–9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents.

A new ionone derivative from the leaves of Picrasma quassioides

Chang Liu, Rong-Rong Cheng, Zhu-Zhen Han, Ying-Bo Yang, Yue Zhou, Li Yang & Zheng-Tao Wang
Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2–9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents.

Four new C20-diterpenoid alkaloids from Aconitum rotundifolium

Ji-Fa Zhang, Yu Li, Feng Gao, Lian-Hai Shan & Xian-Li Zhou
Four new C20-diterpenoid alkaloids, rotundifosines D-G (1–4), along with eight known ones (5–12) were isolated from the whole plant of Aconitum rotundifolium Kar. & Kir. The structures of the compounds were elucidated on the basis of spectroscopic analyses, including HR-ESI-MS and 1D, 2D NMR. Rotundifosine F (3) is a rare C20-diterpenoid alkaloid with quaternary ammonium salt. Alkaloids 1–4, 5, 6, 9, and 12 were evaluated for cytotoxicity against MCF-7, HCT-116 and HepG2 human cancer cell...

A new menthane-type monoterpenoid from fermented Illigera aromatica with Clonostachys rogersoniana 828H2

Jian-Wei Dong, Le Cai, Xue-Jiao Li, Ya-Xian Shi, Jia-Peng Wang, Rui-Feng Mei & Zhong-Tao Ding
A new menthane-type monoterpenoid, illigerate E (1), as well as two known ones, (1R*,3R*,4S*,6R*)-6,8-dihydroxymenthol (2) and cis-4-hydroxy-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclohexene-1-one (3), were isolated from fermented Illigera aromatica with Clonostachys rogersoniana 828H2. Their structures were identified by HRESIMS and 1D/2D NMR spectra. Their inhibitory effects of NO production in RAW 264.7 macrophages were estimated.

A new menthane-type monoterpenoid from fermented Illigera aromatica with Clonostachys rogersoniana 828H2

Jian-Wei Dong, Le Cai, Xue-Jiao Li, Ya-Xian Shi, Jia-Peng Wang, Rui-Feng Mei & Zhong-Tao Ding
A new menthane-type monoterpenoid, illigerate E (1), as well as two known ones, (1R*,3R*,4S*,6R*)-6,8-dihydroxymenthol (2) and cis-4-hydroxy-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclohexene-1-one (3), were isolated from fermented Illigera aromatica with Clonostachys rogersoniana 828H2. Their structures were identified by HRESIMS and 1D/2D NMR spectra. Their inhibitory effects of NO production in RAW 264.7 macrophages were estimated.

Sesquiterpenoids from the roots of Croton crassifolius

Jin-Long Tian, Chen-Xi Li, Xin-Yue Shang, Xue-Wen Hou, Yan Zhang, Ling-Zhi Li, Xiao-Xiao Huang & Shao-Jiang Song
Phytochemical investigation of Croton crassifolius roots afforded five sesquiterpenes (1–5), including two new sesquiterpenes 6S-hydroxy-cyperenoic acid (1) and crassifterpenoid A (5), together with three known compounds (2–4). The structures of the new compounds were determined by comprehensive spectroscopic methods, and their absolute configurations were determined by quantum chemical ECD calculation. Crassifterpenoid A (5) is the first germacrane-type sesquiterpene isolated from C. crassifolius, which enriched the diversity of chemical constituents in Croton crassifolius. In addition, the...

A new labdane-type diterpenoid from Leonurus japonicus

Min-Hong Jiang, Yue Hu, Lin Jiao, Pan Dong, Sheng Yin, Zhi-Min Zhao, De-Po Yang & Dong-Mei Wang
Five fractions prepared from the crude extract of Leonurus japonicus were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (1), and nine known ones (2–10) along with a seco-labdane (11) were isolated from the aerial parts of Leonurus japonicus. The structure elucidation was primarily based on comprehensive spectroscopic analyses, including HRESIMS, IR, and 1D and 2D NMR methods. Compound 4 (6β-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one) exhibited potential cytotoxicity against HeLa cell...

Three new polyketides from Ascotricha sp. ZJ-M-5 by the OSMAC strategy

Ya-Jing Dong, Guo-Mei Hou, Bin Lin, Dan-Yi Li & Zhan-Lin Li
Three new compounds, ascotrichols A-B (1–2) and ascotrichrone A (3), along with two known isocoumarin derivatives (4–5), were isolated from the solid culture of a sea mud-derived fungus, Ascotricha sp. ZJ-M-5 on rice media. The structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR data, and the absolute configurations were determined by electronic circular dichroism and biogenetic correlation.

A new labdane-type diterpenoid from Leonurus japonicus

Min-Hong Jiang, Yue Hu, Lin Jiao, Pan Dong, Sheng Yin, Zhi-Min Zhao, De-Po Yang & Dong-Mei Wang
Five fractions prepared from the crude extract of Leonurus japonicus were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (1), and nine known ones (2–10) along with a seco-labdane (11) were isolated from the aerial parts of Leonurus japonicus. The structure elucidation was primarily based on comprehensive spectroscopic analyses, including HRESIMS, IR, and 1D and 2D NMR methods. Compound 4 (6β-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one) exhibited potential cytotoxicity against HeLa cell...

Three new polyketides from Ascotricha sp. ZJ-M-5 by the OSMAC strategy

Ya-Jing Dong, Guo-Mei Hou, Bin Lin, Dan-Yi Li & Zhan-Lin Li
Three new compounds, ascotrichols A-B (1–2) and ascotrichrone A (3), along with two known isocoumarin derivatives (4–5), were isolated from the solid culture of a sea mud-derived fungus, Ascotricha sp. ZJ-M-5 on rice media. The structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR data, and the absolute configurations were determined by electronic circular dichroism and biogenetic correlation.

Acylphloroglucinols as kinase inhibitors from Sargassum nigrifoloides

Cheng-Shi Jiang, Yin-Yin Wang, Jin-Tong Song & Jin-Hai Yu
Three new acylphloroglucinols (1–3) and four known biosynthetically related analogs (4–7) were isolated from the ethanol extract of a brown alga Sargassum nigrifoloides. Structures for 1–7 were characterized via detailed spectroscopic analyses especially 2D NMR data. Screening of these compounds in Alzheimer’s diseases-related bioassays revealed moderate inhibitory activities against two therapeutically important kinases, CDK5 and GSK3β. A preliminary structure–activity relationship was also discussed.

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