148,251 Works

Dendritic cells and antiviral defenses

Marc Dalod
The goal of our research is to identify new molecular pathways regulating the biology of DC subsets or more generally innate immune responses to viral infection. The model used is murine cytomegalovirus (MCMV) infection. The specific aims are 1) to determine the molecular bases regulating in vivo differentiation and anti-viral functions of DC subsets, 2) to investigate further NK cell anti-viral and immunoregulatory functions during viral infection, and 3) to identify viral molecules and cellular...

Comparison of mouse dendritic cell subsets by genome-wide expression profiling

Marc Dalod, Robbins Scott, Doulaye Dembele, Philippe Kastner & Susan Chan
Spleen or lymph node resident DCs are subdivided into conventional DC (cDC) subsets (CD11b and CD8alpha in mouse; BDCA1 and BDCA3 in man) and plasmacytoid DCs (pDCs). It is currently unclear if these various DC populations belong to a unique hematopoietic lineage and if the subsets identified in the mouse and human systems are evolutionary homologs. To bring novel insights into these questions, we sought conserved genetic signatures for these DCs through the analysis of...

Cartographie et spectroscopie des propriétés mécaniques à l'échelle du nanomètre par spectrométrie acoustique locale à fréquence variable

Emmanuel Dupas
This work aims at completing the development of local mechanical spectroscopy as initiated by F. Oulevey during his thesis. More precisely, the measurement of the amplitude and phase lag of the strain as a function of the applied stress frequency bas to be settled. Parallel to the development of the technical aspects making such an acquisition possible, the model used to analyze the measured quantities is modified in order to describe the studied system more...

Comprehensive Review of Pleistocene Volcanics of Italy Using Classical Geochemical-Petrological Discriminant Diagrams

Dogan Meral, Dogan A. Umran, Tibaldi Alessandro, Yesilyurt-Yenice F. Irem, Alaygut Dogan, Ozbay S. Serhat & Akkus Murat

Effect of sulfated oligosaccharides (heparin and fucoidan) on the oligomerization of stromal cell-derived factor-1

Soraya Fermas, Florence Gonnet, Angela Sutton, Nathalie Charnaux, Barbara Mulloy, Yuguo Du, Françoise Baleux & Régis Daniel
We investigate the dimerization of SDF-1 in microM concentration and in the presence of sulfated oligosaccharides, using affinity capillary electrophoresis (ACE) hyphenated to electrospray ionization-mass spectrometry (ESI/MS). Chemokine stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant involved in leukocyte trafficking and metastasis. Heparan sulfate on the cell surface binds SDF-1 and may modulate its function as a coreceptor of this chemokine. A major effect of the glycosaminoglycan binding may be on the quaternary structure of...

Robustness and Recovery in Train Scheduling - a Case Study from DSB S-tog a/s

Mads Hofman, Line Madsen, Julie Jespersen Groth, Jens Clausen & Jesper Larsen
This paper presents a simulation model to study the robustness of timetables of DSB S-tog a/s, the city rail of Copenhagen. Dealing with rush hour scenarios only, the simulation model investigates the effects of disturbances on the S-tog network. Several timetables are analyzed with respect to robustness. Some of these are used in operation and some are generated for the purpose of investigating timetables with specific alternative characteristics.

Suz12 ChIP-on-chip of mouse embryonic stem cell

Pierre Cauchy, Touati Benoukraf, Romain Fenouil, Frédéric Koch, Jean-Christophe Andrau & Pierre Ferrier
We aim to identify target sequences of suz12, a member of the polycomb group proteins (PcG) PRC2 (polycomb repressive complex 2). We study the role played by this polycomb complex on genetic plasticity during embryonic development in undifferentiated mouse embryonic stem cells (day 8). Suz12 is required for trimethylation of the tail of histone H3 on lysine 27 (H3K27me3). This epigenetic modification of chromatin induces dynamic repression of many target genes involved in developmental pathways....

Spatial localisation of metabolites in the Charentais melon fruit

Benoit Biais, J William Allwood, Catherine Deborde, Yun Xu, Mickael Maucourt, Bertrand Beauvoit, Warwick B Dunn, Daniel Jacob, Royston Goodacre, Dominique Rolin & Annick Moing
Spatial localisation of metabolites was investigated on one representative fruit for each cultivar by direct 1H-NMR profiling of juice or GC-EI-TOF-MS profiling of tissue extracts collected from different locations in the fruit flesh. This experiment has been deposited in the MeRy-B database, a plant metabolomics platform allowing the storage and visualisation of Nuclear Magnetic Resonance (NMR) metabolic profiles from plants (http://www.cbib.u-bordeaux2.fr/MERYB/).

Finding Induced Subgraphs via Minimal Triangulations

Fedor V. Fomin & Yngve Villanger
Potential maximal cliques and minimal separators are combinatorial objects which were introduced and studied in the realm of minimal triangulation problems including Minimum Fill-in and Treewidth. We discover unexpected applications of these notions to the field of moderate exponential algorithms. In particular, we show that given an n-vertex graph G together with its set of potential maximal cliques, and an integer t, it is possible in time the number of potential maximal cliques times $O(n^{O(t)})$...

Major metabolites of Charentais melon flesh

Benoit Biais, J William Allwood, Catherine Deborde, Yun Xu, Mickael Maucourt, Bertrand Beauvoit, Warwick B Dunn, Daniel Jacob, Royston Goodacre, Dominique Rolin & Annick Moing
The major metabolites of melon flesh of three F1 hybrid cultivars (Cézanne, Escrito and Hugo) of Charentais melon (Cucumis melo L.) were analysed by quantitative 1H-NMR of polar extracts. This experiment has been deposited in the MeRy-B database, a plant metabolomics platform allowing the storage and visualisation of Nuclear Magnetic Resonance (NMR) metabolic profiles from plants (http://www.cbib.u-bordeaux2.fr/MERYB/).

Stable and Reproducible Na Doping for CIS/CIGS Solar Cells Using MoNa Sputtering Targets

N. Reinfried, J. Winkler, C. Linke, C. Adelhelm, H. Köstenbauer, L. Klaiber & S. Nishiwaki
25th European Photovoltaic Solar Energy Conference and Exhibition / 5th World Conference on Photovoltaic Energy Conversion, 6-10 September 2010, Valencia, Spain; 3353-3356

Role of Ikaros in hematopoietic cell development

Philippe Kastner
The hematopoietic cell-specific transcription factor Ikaros functions as a key regulator of lymphocyte differentiation and a tumor suppressor in T cells. The Ikaros gene encodes a zinc-finger transcription factor required during early lymphocyte development. We study Ikaros function in lymphocyte cell lineage using mice bearing a hypomorphic mutation in the ikzf1 (Ikaros) locus (IkL/L).

Differential roles of ROR gamma-t in the development of NKp46+ spleen (LTIL) cells and NKp46+ NK cells in gut and skin

Damien Chaussabel, Elena Tomasello, Eric Vivier, Carmelo Luci, Ana Reynders & Ivaylo Ivanov
Natural killer (NK) cells are NKp46+CD3- lymphocytes that can perform granule-dependent cytotoxicity and produce interferon-gamma, when isolated from blood, lymphoid organs, lung, liver and uterus. Here we identify in dermis, gut lamina propria and cryptopatches, very distinct populations of NKp46+CD3- cells with reduced ability to degranulate and to produce interferon-gamma. In gut, the transcription factor RORgamma-t and CD127 (IL-7R alpha) defined a novel subset of NKp46+CD3- that is reminiscent of lymphoid tissue inducer (LTi)-like cells....

Strategies to Improve Cyanine Dye Multi Layer Organic Solar Cells

R. Hany, B. Fan, F. Araujo De Castro, J. Heier, W. Kylberg & F. Nüesch
25th European Photovoltaic Solar Energy Conference and Exhibition / 5th World Conference on Photovoltaic Energy Conversion, 6-10 September 2010, Valencia, Spain; 297-302

A Novel Approach to Biomass Gasification in a Downdraft Gasifier

Y. Muilu, K. Pieniniemi, U.-P. Granö & U. Lassi
The purpose of the HighBio is to study input and output flows of the wood chips gasification process in pilot-scale gasifiers. Solid wood based biomass is used as a fuel in the gasification process. It is heated with the amount of air which is insufficient for total combustion in the gasifier, i.e. it gasifies the biomass to a mixture of carbon monoxide and hydrogen both 15-20 vol-% (synthesis gas). Pyrolysis equipment consists of the downdraft...

Evaluation of MALDI-TOF Mass spectrometry detection of DNA noncovalent complexes with basic polypeptides or polyamines

Peran Terrier, Jeanine Tortajada, Gregoire Zin & Wiliam Buchmann
In this work, MALDI-MS was evaluated as a method for the study of noncovalent complexes involving DNA and basic polypeptides (penta-L-arginine, penta-L-lysine) or polyamines (polypropylenimine dendrimers, linear and branched polyethylenimines).

Industrialization of the Laser Diffusion Process: Innovative Concepts for Increased Production Throughput

P. Oesterlin, U. Jäger, H.-U. Zuehlke & A. Büchel
25th European Photovoltaic Solar Energy Conference and Exhibition / 5th World Conference on Photovoltaic Energy Conversion, 6-10 September 2010, Valencia, Spain; 2074-2077

The Team Orienteering Problem: Formulations and Branch-Cut and Price

Marcus Poggi, Henrique Viana & Eduardo Uchoa
The Team Orienteering Problem is a routing problem on a graph with durations associated to the arcs and profits assigned to visiting the vertices. A fixed number of identical vehicles, with a limited total duration for their routes, is given. The total profit gathered by all routes is to be maximized. We devise an extended formulation where edges are indexed by the time they are placed in the route. A new class of inequalities, min...

Performance of Miniature Silicon Solar Cells

N.S. Ngwe & A. Blakers
25th European Photovoltaic Solar Energy Conference and Exhibition / 5th World Conference on Photovoltaic Energy Conversion, 6-10 September 2010, Valencia, Spain; 1744-1747

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