53,366 Works

Advanced capillary-driven microfluidic chips for diagnostic applications

Martina Hitzbleck

Analysis of single-cell transcriptional profiles

Nan Papili Gao

Scale-down modeling of CHO fed-batch processes for monoclonal antibody production

Jochen Bastian Sieck

Self-assembled materials and supramolecular chemistry within microfluidic environments: From common thermodynamic states to non-equilibrium structures

Semih Sevim, Alessandro Sorrenti, Carlos Franco, Shuhei Furukawa, Salvador Pané, Andrew De Mello & Josep Puigmartí-Luis
Chemical Society Reviews, 47 (11)

Decrease in 230Th in the Amundsen Basin since 2007: far-field effect of increased scavenging on the shelf?

Ole Valk, Michiel M. Rutgers Van Der Loeff, Walter Geibert, Sandra Gdaniec, S. Bradley Moran, Kate Lepore, Robert L. Edwards, Yanbin Lu, Viena Puigcorbé, Nuria Casacuberta, Ronja Paffrath, William Smethie & Matthieu Roy-Barman
This study provides dissolved and particulate 230Th and 232Th results as well as particulate 234Th data collected during expeditions to the central Arctic Ocean (GEOTRACES, an international project to identify processes and quantify fluxes that control the distributions of trace elements; sections GN04 and GIPY11). Constructing a time series of dissolved 230Th from 1991 to 2015 enables the identification of processes that control the temporal development of 230Th distributions in the Amundsen Basin. After 2007,...

Low Amplitude Boom-and-Bust Cycles Define the Septoria Nodorum Blotch Interaction

Huyen T.T. Phan, Darcy A.B. Jones, Kasia Rybak, Kejal N. Dodhia, Francisco J. Lopez-Ruiz, Romain Valade, Lilian Gout, Marc-Henri Lebrun, Patrick C. Brunner, Richard P. Oliver & Kar-Chun Tan
Introduction: Septoria nodorum blotch (SNB) is a complex fungal disease of wheat caused by the Dothideomycete fungal pathogen Parastagonospora nodorum. The fungus infects through the use of necrotrophic effectors (NEs) that cause necrosis on hosts carrying matching dominant susceptibility genes. The Western Australia (WA) wheatbelt is a SNB “hot spot” and experiences significant under favorable conditions. Consequently, SNB has been a major target for breeders in WA for many years. Materials and Methods: In this...

Global Changes in Urban Vegetation Cover

Daniel R. Richards & Richard N. Belcher
Urban vegetation provides many ecosystem services that make cities more liveable for people. As the world continues to urbanise, the vegetation cover in urban areas is changing rapidly. Here we use Google Earth Engine to map vegetation cover in all urban areas larger than 15 km2 in 2000 and 2015, which covered 390,000 km2 and 490,000 km2 respectively. In 2015, urban vegetation covered a substantial area, equivalent to the size of Belarus. Proportional vegetation cover...

Microfluidic Systems for the Synthesis and Spectroscopic Analysis of Nanomaterials

Richard M. Maceiczyk

CALISTA: Clustering and LINEAGE Inference in Single-Cell Transcriptional Analysis

Nan Papili Gao, Thomas Hartmann, Tao Fang & Rudiyanto Gunawan
We present Clustering and Lineage Inference in Single-Cell Transcriptional Analysis (CALISTA), a numerically efficient and highly scalable toolbox for an end-to-end analysis of single-cell transcriptomic profiles. CALISTA includes four essential single-cell analyses for cell differentiation studies, including single-cell clustering, reconstruction of cell lineage specification, transition gene identification, and cell pseudotime ordering, which can be applied individually or in a pipeline. In these analyses, we employ a likelihood-based approach where single-cell mRNA counts are described by...

Hybrid deep fault detection and isolation: Combining deep neural networks and system performance models

Manuel Arias Chao, Chetan Kulkarni, Kai Goebel & Olga Fink
With the increased availability of condition monitoring data on the one hand and the increased complexity of explicit system physics-based models on the other hand, the application of data-driven approaches for fault detection and isolation has recently grown. While detection accuracy of such approaches is generally very good, their performance on fault isolation often suffers from the fact that fault conditions affect a large portion of the measured signals thereby masking the fault source. To...

Theodizee oder die Ambivalenz Gottes

Peter Brüesch

The Advocacy Planning and the Civil Rights Movement in the United States: The Architects’ Renewal Committee and the Democratization of Urban Planning

Marianna Charitonidou
This paper takes as its point of departure advocacy planning approaches’ consideration that urban renewal is incompatible with any kind of socially effective urban planning. It focuses on analysing the Architects’ Renewal Committee in Harlem (ARCH), the first organisation solely devoted to advocacy planning in the United States, and places particular emphasis on the critiques of urban renewal strategies in the late 1960s in the North-Eastern American context, and on the emergence of groups that...

Microfluidic Tools and Techniques for Artificial Cell Engineering

Dirk Van Swaay

Silicon and zinc biogeochemical cycles coupled through the Southern Ocean

Derek Vance, Susan H. Little, Gregory F. De Souza, Samar Khatiwala, Maeve C. Lohan & Rob Middag
Nature Geoscience, 10 (3)

The Aesthetics of Travel in the Thought of Architects: Urban Space in Movement as a New Perceptual Regime and the Dynamics of Landscape

Marianna Charitonidou
The automobile, since its invention, has reshaped our conceptions of space, revolutionizing the way architects perceive the city and contributing significantly to the transformation of the relationship between architecture and the city. The paper will explore the theories and methods most suitable for understanding how the automobile has transformed the architects’ perception of urban conditions. It will investigate which visual means and artefacts are most efficient for comprehending the snapshot aesthetics, understood as the rapid,...

Integrated microfluidics for high-content biological analysis

Xiaobao Cao

Micro-scale fluorescence in situ hybridization

Deborah Huber
In this thesis, we aimed to leverage some of the unique hydrodynamic properties of fluidics to make fluorescence in situ hybridization (FISH) assays more efficient, and to elucidate the underlying physical mechanisms surrounding this important class of cytogenetic techniques. Hydrodynamic phenomena are ubiquitous in living organisms and can be used to manipulate cells or emulate physiological microenvironments experienced in vivo. Hydrodynamic effects influence multiple cellular properties and processes, including cell morphology, intracellular processes, cell-cell signalling...

Inertial Microfluidics: Self-Assembly of Particles & Applications in Flow Cytometry

Anandkumar Rane

Biogeophysical impacts of forestation in Europe: first results from the LUCAS (Land Use and Climate Across Scales) regional climate model intercomparison

Edouard Léopold Davin, Diana Rechid, Marcus Breil, Rita M. Cardoso, Erika Coppola, Peter Hoffmann, Lisa L. Jach, Eleni Katragkou, Nathalie De Noblet-Ducoudré, Kai Radtke, Mario Raffa, Pedro M.M. Soares, Giannis Sofiadis, Susanna Strada, Gustav Strandberg, Merja H. Tölle, Kirsten Warrach-Sagi & Volker Wulfmeyer
The Land Use and Climate Across Scales Flagship Pilot Study (LUCAS FPS) is a coordinated community effort to improve the integration of land use change (LUC) in regional climate models (RCMs) and to quantify the biogeophysical effects of LUC on local to regional climate in Europe. In the first phase of LUCAS, nine RCMs are used to explore the biogeophysical impacts of re-/afforestation over Europe: two idealized experiments representing respectively a non-forested and a maximally...

Microfluidic Step Emulsification: From Fundamental Understanding to the Fabrication of Functional Materials

Alessandro Ofner
Microfluidics offers a fascinating playground to manipulate liquids. As a manipulating tool, it enables, for example, the production of size-controlled droplets. A large-volume production of monodisperse droplets is essential for industrial applications, as it allows for templating functional materials, such as microparticles, microcapsules, or porous structures. The monodispersity achieved through this technique enables precise control over droplet volumes, arrangement of droplets into periodic structures, and tailored release of microencapsulated substances. These features offer several benefits...

Synthesis of biomaterials utilizing microfluidic technology

Xiaohong Wang, Jinfeng Liu, Peizhou Wang, Andrew De Mello, Lingyan Feng, Xiaoli Zhu, Weijia Wen, Rimantas Kodzius & Xiuqing Gong
Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extremely small volumes of fluids is accompanied by additional benefits, most notably, rapid and efficient mass and heat transfer. In addition, reactions performed within microfluidic systems are highly controlled, meaning that many advanced materials, with...

Mechanical behaviour of composite calcium phosphate–titanium cranial implants: Effects of loading rate and design

Susanne Lewin, Jonas Åberg, Dominique Neuhaus, Stephen J. Ferguson, Caroline Öhman-Mägi, Benedikt Helgason & Cecilia Persson
Cranial implants are used to repair bone defects following neurosurgery or trauma. At present, there is a lack of data on their mechanical response, particularly in impact loading. The aim of the present study was to assess the mechanical response of a recently developed composite calcium phosphate–titanium (CaP–Ti) implant at quasi-static and impact loading rates. Two different designs were tested, referred to as Design 1 (D1) and Design 2 (D2). The titanium structures in the...

Development of a Microfluidic Platform for Ageing Research on Caenorhabditis Elegans

Tomasz Koprowski

Continuous Reaction and Separation of IgG

Nicole Ulmer
Biopharmaceuticals are the fastest growing eld in the pharmaceutical sector. Among them, sca olds derived from the classical biopharmaceuticals, such as antibody drug conjugates, antibody fragments and PEGylated proteins, gain increasing attention. These are often derived from an already available product with the aim to give it new functionalities. This reaction is done in a step subsequent to the protein expression in cells. While continuous integrated biomanufacturing is an intensely discussed topic for the production...

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