92,047 Works

Mechanism of action of the trastuzumab biosimilar CT-P6

Sun Ah Jeong, Jung Min Choi, Jun Mo Park, Jun Young Lee, So Jung Lee, Su Yeon Lee, Si Yeon Lee, Yoon A Park, Hee Jeong Jeong, Yoo Cheol Song, Sung Hwan Kim & Shin Jae Chang
Objectives: Therapeutic monoclonal antibody biosimilars are expected to help reduce the sizeable economic burden of targeted treatments. Trastuzumab (Herceptin®), a recombinant humanized monoclonal antibody that binds to the extracellular domain of HER2, is approved for use in HER2-overexpressing breast cancer (in both the adjuvant and metastatic settings) and HER2-positive gastric cancer. CT-P6 (Herzuma®) is a biosimilar of trastuzumab, designed to bind with high affinity and specificity to the same HER2 epitope as the reference product....

Mechanism of action of the trastuzumab biosimilar CT-P6

Sun Ah Jeong, Jung Min Choi, Jun Mo Park, Jun Young Lee, So Jung Lee, Su Yeon Lee, Si Yeon Lee, Yoon A Park, Hee Jeong Jeong, Yoo Cheol Song, Sung Hwan Kim & Shin Jae Chang
Objectives: Therapeutic monoclonal antibody biosimilars are expected to help reduce the sizeable economic burden of targeted treatments. Trastuzumab (Herceptin®), a recombinant humanized monoclonal antibody that binds to the extracellular domain of HER2, is approved for use in HER2-overexpressing breast cancer (in both the adjuvant and metastatic settings) and HER2-positive gastric cancer. CT-P6 (Herzuma®) is a biosimilar of trastuzumab, designed to bind with high affinity and specificity to the same HER2 epitope as the reference product....

Defining the toxicity of current regimens for extranodal NK/T cell lymphoma: a systematic review and metaproportion

Vadim S. Pokrovsky & Denis Vinnikov
Objectives: The aim of this study is to compare the toxicity profiles of SMILE versus less intense L-asparaginase-containing regimens, CCRT or “sandwich” RT+CT regimens. Methods: PRISMA protocol was used to search Pubmed and Embase for studies of treatment regimens for extranodal NK/T-cell lymphoma, nasal type (ENKTL) in English published before March 2018. Pooled data were grouped into five categories: A) CHOP-like regimens; B) Gemcitabine-based regimens; C) SMILE-like regimens; D) Concurrent and “sandwich” RT + CT;...

Defining the toxicity of current regimens for extranodal NK/T cell lymphoma: a systematic review and metaproportion

Vadim S. Pokrovsky & Denis Vinnikov
Objectives: The aim of this study is to compare the toxicity profiles of SMILE versus less intense L-asparaginase-containing regimens, CCRT or “sandwich” RT+CT regimens. Methods: PRISMA protocol was used to search Pubmed and Embase for studies of treatment regimens for extranodal NK/T-cell lymphoma, nasal type (ENKTL) in English published before March 2018. Pooled data were grouped into five categories: A) CHOP-like regimens; B) Gemcitabine-based regimens; C) SMILE-like regimens; D) Concurrent and “sandwich” RT + CT;...

Major effects on blood-retina barrier passage by minor alterations in design of polybutylcyanoacrylate nanoparticles

Qing You, Talea Hopf, Werner Hintz, Stefan Rannabauer, Nadine Voigt, B. Van Wachem, Petra Henrich-Noack & Bernhard A. Sabel
Because the blood-brain barrier (BBB) is an obstacle for drug-delivery, carrier systems such as polybutylcyanoacrylate (PBCA) nanoparticles (NPs) have been studied. Yet, little is known of how physiochemical features such as size, surfactants and surface charge influence BBB passage in vivo. We now used a rat model of in vivo imaging of the retina - which is brain tissue and can reflect the situation at the BBB - to study how size and surface charge...

Major effects on blood-retina barrier passage by minor alterations in design of polybutylcyanoacrylate nanoparticles

Qing You, Talea Hopf, Werner Hintz, Stefan Rannabauer, Nadine Voigt, B. Van Wachem, Petra Henrich-Noack & Bernhard A. Sabel
Because the blood-brain barrier (BBB) is an obstacle for drug-delivery, carrier systems such as polybutylcyanoacrylate (PBCA) nanoparticles (NPs) have been studied. Yet, little is known of how physiochemical features such as size, surfactants and surface charge influence BBB passage in vivo. We now used a rat model of in vivo imaging of the retina - which is brain tissue and can reflect the situation at the BBB - to study how size and surface charge...

Managing limb pain using virtual reality: a systematic review of clinical and experimental studies

Priscilla G. Wittkopf, Donna M. Lloyd & Mark I. Johnson
Purpose: The aim of this systematic review was to assess the effect of virtual representation of body parts on pain perception in patients with pain and in pain-free participants exposed to experimentally induced pain. Methods: Databases searched: Medline, PsycInfo, CINAHL, and Web of Science. Studies investigating participants with clinical pain or those who were pain free and exposed to experimentally induced pain were analysed separately. Results: Eighteen clinical studies and seven experimental studies were included....

Effects of exercise on the physical fitness level of adults with intellectual disability: a systematic review

Sara Bouzas, Carlos Ayán & R. Iván Martínez-Lemos
Purpose: To systematically review the existing scientific evidence regarding the effects of physical exercise on the fitness level of people with intellectual disabilities. Methods: Following the checklist of the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, the PubMed, CINAHL, SPORTDiscus, and Scopus databases were searched using specific keywords up to January 2018. The methodological quality of the studies found was rated by the means of specific scales according to their specific design. Results:...

Managing limb pain using virtual reality: a systematic review of clinical and experimental studies

Priscilla G. Wittkopf, Donna M. Lloyd & Mark I. Johnson
Purpose: The aim of this systematic review was to assess the effect of virtual representation of body parts on pain perception in patients with pain and in pain-free participants exposed to experimentally induced pain. Methods: Databases searched: Medline, PsycInfo, CINAHL, and Web of Science. Studies investigating participants with clinical pain or those who were pain free and exposed to experimentally induced pain were analysed separately. Results: Eighteen clinical studies and seven experimental studies were included....

Effects of exercise on the physical fitness level of adults with intellectual disability: a systematic review

Sara Bouzas, R. Iván Martínez-Lemos & Carlos Ayán
Purpose: To systematically review the existing scientific evidence regarding the effects of physical exercise on the fitness level of people with intellectual disabilities. Methods: Following the checklist of the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, the PubMed, CINAHL, SPORTDiscus, and Scopus databases were searched using specific keywords up to January 2018. The methodological quality of the studies found was rated by the means of specific scales according to their specific design. Results:...

Risk factors for hospitalizations and readmissions among individuals with sickle cell disease: results of a U.S. survey study

Robert M. Cronin, Jane S. Hankins, Jeannie Byrd, Brandi M. Pernell, Adetola Kassim, Patricia Adams-Graves, Alexis Thompson, Karen Kalinyak, Michael DeBaun & Marsha Treadwell
Objective: Hospital admissions are significant events in the care of individuals with sickle cell disease (SCD) due to associated costs and potential for quality of life compromise. Methods: This cross-sectional cohort study evaluated risk factors for admissions and readmissions between October 2014 and March 2016 in adults with SCD (n = 201) and caregivers of children with SCD (n = 330) at six centres across the U.S. Survey items assessed social determinants of health (e.g....

Risk factors for hospitalizations and readmissions among individuals with sickle cell disease: results of a U.S. survey study

Robert M. Cronin, Jane S. Hankins, Jeannie Byrd, Brandi M. Pernell, Adetola Kassim, Patricia Adams-Graves, Alexis Thompson, Karen Kalinyak, Michael DeBaun & Marsha Treadwell
Objective: Hospital admissions are significant events in the care of individuals with sickle cell disease (SCD) due to associated costs and potential for quality of life compromise. Methods: This cross-sectional cohort study evaluated risk factors for admissions and readmissions between October 2014 and March 2016 in adults with SCD (n = 201) and caregivers of children with SCD (n = 330) at six centres across the U.S. Survey items assessed social determinants of health (e.g....

Cross-sectional physician survey on the use of minimal residual disease testing in the management of pediatric and adult patients with acute lymphoblastic leukemia

Christopher Kim, Kara Delaney, Michelle McNamara, Victoria Chia & Vadim Romanov
Objectives: Minimal residual disease (MRD) is a strong prognostic factor in acute lymphoblastic leukemia (ALL), which progresses quickly and is fatal within months if untreated. This study explored use of MRD testing in adult and pediatric B-cell ALL patients, and academic versus community settings. Methods: A survey was administered to US-based hematologists/oncologists currently managing ≥5 B-cell ALL patients and using MRD tests. Descriptive analyses (frequencies and percentages) and Pearson’s chi square testing assessed any differences...

Cross-sectional physician survey on the use of minimal residual disease testing in the management of pediatric and adult patients with acute lymphoblastic leukemia

Christopher Kim, Kara Delaney, Michelle McNamara, Victoria Chia & Vadim Romanov
Objectives: Minimal residual disease (MRD) is a strong prognostic factor in acute lymphoblastic leukemia (ALL), which progresses quickly and is fatal within months if untreated. This study explored use of MRD testing in adult and pediatric B-cell ALL patients, and academic versus community settings. Methods: A survey was administered to US-based hematologists/oncologists currently managing ≥5 B-cell ALL patients and using MRD tests. Descriptive analyses (frequencies and percentages) and Pearson’s chi square testing assessed any differences...

The origin of imprinting defects in Temple syndrome and comparison with other imprinting disorders

Jasmin Beygo, Claudia Mertel, Sabine Kaya, Gabriele Gillessen-Kaesbach, Thomas Eggermann, Bernhard Horsthemke & Karin Buiting
Temple syndrome (TS14) is a rare imprinting disorder caused by genetic and epigenetic alterations on chromosome 14q32. A subset of these patients shows an imprinting defect (ID) where the paternal allele harbors a maternal epigenotype thus silencing the paternally expressed genes and leading to an increased expression of the maternally expressed genes. We investigated the grandparental origin of the incorrectly imprinted chromosome 14 in a cohort of 13 TS14 ID patients and their families. In...

The origin of imprinting defects in Temple syndrome and comparison with other imprinting disorders

Jasmin Beygo, Claudia Mertel, Sabine Kaya, Gabriele Gillessen-Kaesbach, Thomas Eggermann, Bernhard Horsthemke & Karin Buiting
Temple syndrome (TS14) is a rare imprinting disorder caused by genetic and epigenetic alterations on chromosome 14q32. A subset of these patients shows an imprinting defect (ID) where the paternal allele harbors a maternal epigenotype thus silencing the paternally expressed genes and leading to an increased expression of the maternally expressed genes. We investigated the grandparental origin of the incorrectly imprinted chromosome 14 in a cohort of 13 TS14 ID patients and their families. In...

Managing employees’ depression from the employees’, co-workers’ and employers’ perspectives. An integrative review

Cecilie N. Thisted, Merete Labriola, Claus Vinther Nielsen, Sanne T. Kristiansen, Janni Strøm & Merete B. Bjerrum
Purpose: To synthesize evidence on factors promoting or hindering work participation (WP) of employees with depression from the employees’, co-workers’ and employers’ perspectives, as well as an additional focus on the influence of the employee’s occupation. Methods: An integrative review was conducted. Pre-defined eligibility criteria guided study selection. Articles were critically appraised using tools developed by Joanna Briggs and Mixed Methods Appraisal Tool. Findings were analysed and synthesised using qualitative inductive content analysis. Results: Seventeen...

Determinants of patient satisfaction in outpatient musculoskeletal physiotherapy: a systematic, qualitative meta-summary, and meta-synthesis

Giacomo Rossettini, Teresa Maria Latini, Alvisa Palese, Susan M. Jack, Diego Ristori, Serena Gonzatto & Marco Testa
Purpose: To identify and synthesise patient-identified factors that influence satisfaction with outpatient musculoskeletal physiotherapy (O-MSK). Methods: A systematic, qualitative meta-summary and meta-synthesis was conducted by accessing six electronic databases: CINAHL, Embase, MEDLINE, Scopus, Web of Science, and Wiley Online Library, from inception to March 2017. Additional studies were identified by using a “berry-picking” method. Search limits were: primary studies; English language; and involving human subjects. Qualitative peer-reviewed articles describing patient satisfaction in O-MSK were eligible...

Managing employees’ depression from the employees’, co-workers’ and employers’ perspectives. An integrative review

Cecilie N. Thisted, Merete Labriola, Claus Vinther Nielsen, Sanne T. Kristiansen, Janni Strøm & Merete B. Bjerrum
Purpose: To synthesize evidence on factors promoting or hindering work participation (WP) of employees with depression from the employees’, co-workers’ and employers’ perspectives, as well as an additional focus on the influence of the employee’s occupation. Methods: An integrative review was conducted. Pre-defined eligibility criteria guided study selection. Articles were critically appraised using tools developed by Joanna Briggs and Mixed Methods Appraisal Tool. Findings were analysed and synthesised using qualitative inductive content analysis. Results: Seventeen...

Determinants of patient satisfaction in outpatient musculoskeletal physiotherapy: a systematic, qualitative meta-summary, and meta-synthesis

Giacomo Rossettini, Teresa Maria Latini, Alvisa Palese, Susan M. Jack, Diego Ristori, Serena Gonzatto & Marco Testa
Purpose: To identify and synthesise patient-identified factors that influence satisfaction with outpatient musculoskeletal physiotherapy (O-MSK). Methods: A systematic, qualitative meta-summary and meta-synthesis was conducted by accessing six electronic databases: CINAHL, Embase, MEDLINE, Scopus, Web of Science, and Wiley Online Library, from inception to March 2017. Additional studies were identified by using a “berry-picking” method. Search limits were: primary studies; English language; and involving human subjects. Qualitative peer-reviewed articles describing patient satisfaction in O-MSK were eligible...

Defining quality indicators for heart failure in general practice

Marie Smets, Miek Smeets, Steve Van Den Bulck, Stefan Janssens, Bert Aertgeerts & Bert Vaes
Background: Quality indicators (QIs) are used to measure and evaluate quality of care. However, QIs to evaluate care for HF patients in general practice in Belgium are lacking. Therefore, this study aimed to determine which QIs, rooted in the electronic health record (EHR), are useful to monitor quality of care for patients with HF in general practice. Methods: The RAND/UCLA appropriateness method (a modified Delphi method) was used to define these assigned QIs. First, a...

Defining quality indicators for heart failure in general practice

Marie Smets, Miek Smeets, Steve Van Den Bulck, Stefan Janssens, Bert Aertgeerts & Bert Vaes
Background: Quality indicators (QIs) are used to measure and evaluate quality of care. However, QIs to evaluate care for HF patients in general practice in Belgium are lacking. Therefore, this study aimed to determine which QIs, rooted in the electronic health record (EHR), are useful to monitor quality of care for patients with HF in general practice. Methods: The RAND/UCLA appropriateness method (a modified Delphi method) was used to define these assigned QIs. First, a...

Treatment patterns in anticoagulant therapy in patients with newly diagnosed atrial fibrillation in Belgium: results from the GARFIELD-AF registry

Frank Cools, Bart Wollaert, Geert Vervoort, Stefan Verstraete, Joeri Voet, Kurt Hermans, Alex Heyse, Axel De Wolf, Geert Hollanders, Tim Boussy, Wim Anné, Jan Vercammen, Dirk Faes, Michel Beutels, Georges Mairesse, Philippe Purnode, Ivan Blankoff, Peter Vandergoten, Luc Capiau, Jagan Allu, Jean-Pierre Bassand & Gloria Kayani
Background: AF, anticoagulation, NOACs, changing patterns of prescription. Methods: We describe baseline data and treatment patterns of patients recruited in Belgium in the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF). Recruitment began when novel oral anticoagulants (NOACs) were introduced and provides a unique picture of changing treatment patterns over time. 1713 patients with a new (≤6 weeks duration) diagnosis of non-valvular atrial fibrillation (NVAF) and at least one investigator-defined stroke risk factor were recruited...

Treatment patterns in anticoagulant therapy in patients with newly diagnosed atrial fibrillation in Belgium: results from the GARFIELD-AF registry

Frank Cools, Bart Wollaert, Geert Vervoort, Stefan Verstraete, Joeri Voet, Kurt Hermans, Alex Heyse, Axel De Wolf, Geert Hollanders, Tim Boussy, Wim Anné, Jan Vercammen, Dirk Faes, Michel Beutels, Georges Mairesse, Philippe Purnode, Ivan Blankoff, Peter Vandergoten, Luc Capiau, Jagan Allu, Jean-Pierre Bassand & Gloria Kayani
Background: AF, anticoagulation, NOACs, changing patterns of prescription. Methods: We describe baseline data and treatment patterns of patients recruited in Belgium in the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF). Recruitment began when novel oral anticoagulants (NOACs) were introduced and provides a unique picture of changing treatment patterns over time. 1713 patients with a new (≤6 weeks duration) diagnosis of non-valvular atrial fibrillation (NVAF) and at least one investigator-defined stroke risk factor were recruited...

Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes

Risto O. Juvonen, Mira Ahinko, Juhani Huuskonen, Hannu Raunio & Olli T. Pentikäinen
Cytochrome P450 (CYP) enzymes constitute an essential xenobiotic metabolizing system that regulates the elimination of lipophilic compounds from the body. Convenient and affordable assays for CYP enzymes are important for assessing these metabolic pathways.In this study, 10 novel profluorescent coumarin derivatives with various substitutions at carbons 3, 6 and 7 were developed. Molecular modeling indicated that 3-phenylcoumarin offers an excellent scaffold for the development of selective substrate compounds for various human CYP forms, as they...

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  • 2018
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    92,047