Effect of sulfated oligosaccharides (heparin and fucoidan) on the oligomerization of stromal cell-derived factor-1Soraya Fermas, Florence Gonnet, Angela Sutton, Nathalie Charnaux, Barbara Mulloy, Yuguo Du, Françoise Baleux & Régis Daniel
We investigate the dimerization of SDF-1 in microM concentration and in the presence of sulfated oligosaccharides, using affinity capillary electrophoresis (ACE) hyphenated to electrospray ionization-mass spectrometry (ESI/MS). Chemokine stromal cell-derived factor-1 (SDF-1) is a potent chemoattractant involved in leukocyte trafficking and metastasis. Heparan sulfate on the cell surface binds SDF-1 and may modulate its function as a coreceptor of this chemokine. A major effect of the glycosaminoglycan binding may be on the quaternary structure of...
International Zurich Seminar on Communications - Proceedings
Differential roles of ROR gamma-t in the development of NKp46+ spleen (LTIL) cells and NKp46+ NK cells in gut and skinDamien Chaussabel, Elena Tomasello, Eric Vivier, Carmelo Luci, Ana Reynders & Ivaylo Ivanov
Natural killer (NK) cells are NKp46+CD3- lymphocytes that can perform granule-dependent cytotoxicity and produce interferon-gamma, when isolated from blood, lymphoid organs, lung, liver and uterus. Here we identify in dermis, gut lamina propria and cryptopatches, very distinct populations of NKp46+CD3- cells with reduced ability to degranulate and to produce interferon-gamma. In gut, the transcription factor RORgamma-t and CD127 (IL-7R alpha) defined a novel subset of NKp46+CD3- that is reminiscent of lymphoid tissue inducer (LTi)-like cells....
What's the control in studies measuring the effect of computer aided detection (CAD) on observer performance?Jeffrey Hoffmeister
Purpose Methods and Materials Results Conclusion References Personal Information
Transcription profiling of Caenorhabditis elegans after an exposure of 4 hours to the fungal pathogen Drechmeria coniospora, and a post exposure of 24 hours. This experiment has been deposited in the Array Express database under reference number E-MEXP-768.
Transcription profiling of Caenorhabditis elegans 12 hours and 24 hours post exposure to fungal pathogen, Drechmeria coniosporaJonathan Ewbank
Transcriptome study of Caenorhabditis elegans animals 12 hours and 24 hours post exposure to fungal pathogen, Drechmeria coniospora. This experiment has been deposited in the Array Express database under reference number E-MEXP-479.
25th European Photovoltaic Solar Energy Conference and Exhibition / 5th World Conference on Photovoltaic Energy Conversion, 6-10 September 2010, Valencia, Spain; 1871-1874
Natural Killer (NK) cells are lymphocytes of the innate immune system that recognize and induce the lysis of a variety of target cells, including virally-infected cells, tumor cells, and allogenic cells without prior specific sensitization. In addition, NK cells elaborate a variety of regulatory cytokines including IFNg, TGFß1, TNFa, IL-1bß, IL-10, G-CSF, and GM-CSF and CC-chemokines, such as RANTES, MIP-1a and MIP-1bß which are involved in the elimination of intracellular pathogens in vivo, as well...
Deciphering Transcriptional Regulatory Networks that Control Differentiation, Identity and Proliferation of Murine ES and T CellsPierre Ferrier & Jean-Christophe Andrau
We are interested in transcription factor binding patterns both in murine ES cells and in differentiated T cells. Among others we study genome wide recruitment of RNA poymerase II, TBP, polycomb and other TFs in these cells using either chip on chip or ChIPseq approaches.
Learning objectives Main References Personal Information
Microgravity has a dramatic impact on human physiology, illustrated in particular with skeletal muscle impairment. A thorough understanding of the mechanisms leading to loss of muscle mass and structural disorders is necessary for the definition of efficient clinical and spaceflight countermeasures. We investigated the effects of long-term bed rest on transcriptome of soleus (SOL) and vastus lateralis (VL) muscles in healthy women (BRC group, n=8), and the potential beneficial impact of protein supplementation (BRN group,...
Rotation with winter cover crops is a fundamental practice for sustainable agricultural systems. Cover crops can have significant positive effects on soil health and are an important tool for soil organic matter management. In this research a double cropping system is based on a winter (field pea-Pisum sativum L.) and two bio-energy summer crops (Helianthus annuus L. and Zea mays L.) harvested in the same year, for bio-energy production. Two field experiments were carried out...
Peer-reviewed journal article
Previous reports have defined three subsets of mouse NK cells on the basis of the expression of CD27 and CD11b. The developmental relationship between these subsets was unclear. To address this issue, we evaluated the overall proximity between mouse NK cell subsets defined by CD27 and CD11b expression using pangenomic gene expression profiling. The results suggest that CD27+CD11b-, CD27+CD11b+ and CD27-CD11b+ correspond to three different intermediates stages of NK cell development. This experiment has been...
Spatial localisation of metabolites was investigated on one representative fruit for each cultivar by direct 1H-NMR profiling of juice or GC-EI-TOF-MS profiling of tissue extracts collected from different locations in the fruit flesh. This experiment has been deposited in the MeRy-B database, a plant metabolomics platform allowing the storage and visualisation of Nuclear Magnetic Resonance (NMR) metabolic profiles from plants (http://www.cbib.u-bordeaux2.fr/MERYB/).
Caenorhabditis elegans is a widely used invertebrate model organism. We are using C. elegans to dissect the molecular basis of host-pathogen interactions. We are investigating host innate immune defences. There is mounting evidence that resistance to infection in the nematode involves both a dedicated antimicrobial response and a more general reaction to infection-associated cellular stress. Our studies indicate that multiple signal pathways cooperate to control the expression of antimicrobial peptides and proteins. We are starting...
Suppose one has access to oracles generating samples from two unknown probability distributions $p$ and $q$ on some $N$-element set. How many samples does one need to test whether the two distributions are close or far from each other in the $L_1$-norm? This and related questions have been extensively studied during the last years in the field of property testing. In the present paper we study quantum algorithms for testing properties of distributions. It is...
European Society of Radiology5,059
German Medical Science4,402
ETH Zürich Research Collection1,250
WIP - Renewable Energies1,209
ETA-Florence Renewable Energies441
Bibliothek des Wissenschaftsparks Albert Einstein79
Archaeology Data Service38
DESY - Deutsches Elektronen-Synchrotron37
INIST/CNRS Institut de l'Information Scientifique et Technique22