6,484 Works

The need of an ethics of planetary sustainability

Andreas Losch
The concept of sustainability is widely acknowledged as a political guideline. Economic, ecological, social and cultural aspects of sustainability are already under discussion. Current space mining efforts demand that the discussion become a broader one about ‘planetary sustainability’, including the space surrounding Earth. To date, planetary sustainability has mainly been used with reference to Earth only and I will extend it here, elaborating on a similar NASA initiative. This article (1) sketches the contemporary economic–political...

Mobile Cloud Networking: Mobile Network, Compute, and Storage as One Service On-Demand

Thomas Bohnert, Georgios Karagiannis & Almerima Jamakovic
The Future Communication Architecture for Mobile Cloud Services: Mobile Cloud Networking (MCN) is a EU FP7 Large-scale Integrating Project (IP) funded by the European Commission. MCN project was launched in November 2012 for the period of 36 month. In total top-tier 19 partners from industry and academia commit to jointly establish the vision of Mobile Cloud Networking, to develop a fully cloud-based mobile communication and application platform.

The Distribution of Talent Across Contests

Marc Möller & Ghazala Azmat
Do the contests with the largest prizes attract the most-able contestants? To what extent do contestants avoid competition? In this paper, we show, theoretically and empirically, that the distribution of abilities plays a crucial role in determining contest choice. Complete sorting exists only when the proportion of high-ability contestants is sufficiently small. As this proportion increases, high-ability contestants shy away from competition and sorting decreases, such that, reverse sorting becomes a possibility. We test our...

Conversion, Factitious Disorder and Malingering: A Distinct Pattern or a Continuum?

Selma Aybek, Julien Bogousslavsky, Laurent Tatu & Silvio Galli
This chapter is aimed at highlighting the recent findings concerning physiopathology, diagnosis, and management of conversion, factitious disorder, and malingering. Conversion disorder is the unintentional production of neurological symptom, whereas malingering and factitious disorder represent the voluntary production of symptoms with internal or external incentives. They have a close history and this has been frequently confounded. Practitioners are often confronted to medically unexplained symptoms; they represent almost 30% of neurologist's consultation. The first challenge is...

Predictive factors and biomarkers for the 2-year outcome of uveitis in juvenile idiopathic arthritis: data from the Inception Cohort of Newly diagnosed patients with Juvenile Idiopathic Arthritis (ICON-JIA) study.

Claudia Sengler, Kirsten Minden, Arnd Heiligenhaus, Sabine Hoeft, Dirk Foell, Miha Lavric, Martina Niewerth, Christoph Tappeiner, Karoline Walscheid, Jens Klotsche & Ina Liedmann
Objective To define predictors for the 2-year outcome in terms of achieving inactivity, subsequent uveitis reactivation and occurrence of uveitis-related complications of JIA-associated uveitis. Methods Demographic and clinical parameters and serum samples of JIA-associated uveitis patients enrolled in ICON at ⩽1 year of JIA diagnosis were collected at study enrolment, every 3 months during the first year and subsequently every 6 months. Predictors for the 2-year outcome were evaluated by linear mixed models. Results Of...

Incidence of second primary cancers after radiotherapy combined with platinum and/or cetuximab in head and neck cancer patients.

Burim Sermaxhaj, Olgun Eliçin, Mohamed Shelan, Daniel Aebersold, Beat Bojaxhiu, Roland Giger & Daniel Rauch
PURPOSE The second primary cancer (SPC) incidence after treatment with platinum-based chemotherapy and cetuximab in combination with radiotherapy has not been previously reported. Our aim was to compare SPC risk following radiotherapy in combination with these agents for the treatment of head and neck squamous cell carcinoma (HNSCC). METHODS The charts of 296 cases treated for loco-regionally advanced HNSCC between 2009 and 2015 were retrospectively reviewed for patient, tumor, and procedural characteristics. All patients were...

Emerging aspects of microRNA interaction with TMPRSS2-ERG and endocrine therapy.

Martin Spahn, Sofia Karkampouna, Marianna Kruithof-De Julio, Eugenio Zoni & George Thalmann
Prostate cancer (PCa) is the most common malignancy detected in males and the second most common cause of cancer death in western countries. The development of the prostate gland, is finely regulated by androgens which modulate also its growth and function. Importantly, androgens exert a major role in PCa formation and progression and one of the hypothesized mechanism proposed has been linked to the chromosomal rearrangement of the androgen regulated gene TMPRSS2 with ERG. Androgens...

Tumor Heterogeneity in Lymphomas: A Different Breed.

Christian Schürch, Birgit Federmann, Falko Fend & Leticia Quintanilla-Martinez
The facts that cancer represents tissues consisting of heterogeneous neoplastic, as well as reactive, cell populations and that cancers of the same histotype may show profound differences in clinical behavior have long been recognized. With the advent of new technologies and the demands of precision medicine, the investigation of tumor heterogeneity has gained much interest. An understanding of intertumoral heterogeneity in patients with the same disease entity is necessary to optimally guide personalized treatment. In...

Impact of cumulative SBP and serious adverse events on efficacy of intensive blood pressure treatment: a randomized clinical trial.

Lyda Z Rojas, Shahzad Ahmad, Oscar H Franco, Cornelia M Van Duijn, Oscar L Rueda-Ochoa, Maryam Kavousi, Jaap W Deckers, Mohammad A Ikram & Dimitris Rizopoulos
BACKGROUND Intensive blood pressure lowering is increasingly gaining attention. In addition to higher baseline blood pressure, cumulative SBP, visit-to-visit variability, and treatment-induced serious adverse events (SAEs) could impact treatment efficacy over time. Our aim was to assess the impact of cumulative SBP and SAEs on intensive hypertension treatment efficacy in the Systolic Blood Pressure Intervention Trial (SPRINT) population during follow-up. METHODS Secondary analysis of the SPRINT study: a randomized, controlled, open-label trial including 102 clinical...

Bovine dilated cardiomyopathy: Almost forgotten but still present

Corinne Gurtner, Mireille Meylan, Cord Drögemüller & Anna-Katharina Riedi
Nach einer Häufung von Fällen der bovinen dilatativen Kardiomyopathie (BDCMP) in den 1980er-Jahren nahm deren Prävalenz dank klassischer zuchthygienischer Ausschlussmassnahmen stetig ab. Die hier beschriebenen Fälle zeigen, dass die rezessiv vererbte Krankheit in der Schweizer Rinderpopulation, wenn auch selten, nach wie vor vorhanden ist. Mittels eines vor einigen Jahren entwickelten direkten Gentests kann eine klinische Verdachtsdiagnose eindeutig bestätigt werden. Seit Ende 2016 werden Anlageträger in der Schweiz offiziell gekennzeichnet. Zur Zeit tragen rund 2% aller...

Russische Oper in Italien am Beginn des 20. Jahrhunderts. Rezeption, Theoriedebatte und neue Perspektiven

Vincenzina Ottomano
This article examines the impact of the early dissemination of Russian Opera in the cultural life and the musical thought of Italy between the second half of the 19th century and the beginning of the 20th century. At the same time, it deals with the theory that Italy embraced Russian Opera in order to solve his own problems in building a national identity and it reflects the wider historiographical debates over the concept of cultural...

Antimicrobial susceptibility patterns of blood culture isolates from foals in Switzerland.

Andreas Thomann, Vinzenz Gerber, Nathalie Elisa Fouché & Vincent Perreten
INTRODUCTION We report blood culture results of 43 foals admitted to an equine hospital for medical or surgical disorders and determine minimal inhibitory concentrations (MIC) of different antibiotics. Eleven foals had a positive blood culture result despite prior administration of antibiotics in 10 of these animals. MIC values above EUCAST and/or CLSI breakpoints were identified in coagulase-negative staphylococci, methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium. Gram-negative isolates were less frequently identified and did not appear...

[Unilateral peromelia of the left pelvic limb in a Brown Swiss calf].

Alois Von Rotz, Aldona Pieńkowska-Schelling, Cord Drögemüller & Sonja Hofstetter
Congenital deformities of the limbs occur sporadically in various species, but the cause is often unclear. The clinically healthy female Brown Swiss calf presented here showed a congenital peromelia of the left hind limb. The affected limb is twisted, disproportional and the bones distally of the metatarsus are missing. Karyotyping and genome sequencing did not indicate on a genetic cause of the anomaly. An infection with the Schmallenberg virus could not be ruled out. Furthermore,...

Impact of Aneurysm Multiplicity on Treatment and Outcome After Aneurysmal Subarachnoid Hemorrhage.

Daniele Valsecchi, Johannes Goldberg, Andrea Ferrari, Rita Achermann, Schatlo Bawarjan, Heiner C Bucher, Donato D'Alonzo, Marco V Corniola, Serge Marbacher, Luigi Mariani, Martin A Seule, Christian Fung, Philippe Bijlenga, Jan-Karl Burkhardt, Martin N Stienen, Michel Roethlisberger, Daniel Schöni, Raphael Guzman, Daniel W Zumofen, Kristine A Blackham, Thomas Robert, Nicolai Maldaner & Rodolfo Maduri
BACKGROUND One-third of patients with aneurysmal subarachnoid hemorrhage (aSAH) have multiple intracranial aneurysms (MIA). OBJECTIVE To determine the predictors of outcome in aSAH patients with MIA compared to aSAH patients with a single intracranial aneurysm (SIA). METHODS The Swiss Study of Subarachnoid Hemorrhage dataset 2009-2014 was used to evaluate outcome in aSAH patients with MIA compared to patients with SIA with the aid of descriptive and multivariate regression analysis. The primary endpoints of this cohort...

Inseratekampagne zur No-Billag-Initiative. Zwischenstand vom 21.02.2018

Marc Bühlmann & Anja Heidelberger
Die Auswertung von Année Politique Suisse zur Abstimmung vom 04.03.2018, rund eine Woche vor dem Urnengang, zeigt eine durchschnittlich starke Kampagne mit deutlichen regionalen Unterschieden.

Posterior Approach and Spinal Cord Release for 360° Repair of Dural Defects in Spontaneous Intracranial Hypotension.

Eike Immo Piechowiak, Andreas Raabe, Wouter I Schievink, Christian Fung, Jürgen Beck, Jan Gralla, Kathleen Seidel & Christian Thomas Ulrich
BACKGROUND Spinal cerebrospinal fluid (CSF) leaks are the cause of spontaneous intracranial hypotension (SIH). OBJECTIVE To propose a surgical strategy, stratified according to anatomic location of the leak, for sealing all CSF leaks around the 360° circumference of the dura through a single tailored posterior approach. METHODS All consecutive SIH patients undergoing spinal surgery were included. The anatomic site of the leak was exactly localized. We used a tailored hemilaminotomy and intraoperative neurophysiological monitoring (IOM)...

Fanconi-Bickel-Syndrom: eine bislang unerkannte Erbkrankheit beim Braunvieh

F Seefried, Manuela Hanna Stettler, Martina Andrea Dettwiler, Mireille Meylan, Iwan Locher, Cord Drögemüller & Sara Joller
Dieser Fallbericht beschreibt eine neue Erbkrankheit beim Braunvieh in der Schweiz. Diese auch beim Deutschen Fleckvieh als FH2 vorkommende Krankheit entspricht einer beim Menschen als Fanconi-Bickel-Syndrom bekannten Glykogenspeicherkrankheit. Sie wird durch Mutationen im SLC2A2 Gen verursacht, das für den Glukosetransporter GLUT2 kodiert. Ein Original Braunviehkalb mit homozygotem Genotyp für die FH2-assoziierte SLC2A2 Leserasterverschiebung wird vorgestellt. Die klinische Untersuchung des Kalbes zeigte ein verzögertes Wachstum, Polyurie und Polydipsie sowie schlechte Fell- und Klauenhornqualität. Die pathologische Untersuchung...

Hall effect in the coma of 67P/Churyumov–Gerasimenko

N Fougere, Y Shou, K C Hansen, Z Huang, G Tóth, Kathrin Altwegg, V Tenishev, M R Combi, T I Gombosi, X Jia & Martin Rubin
Magnetohydrodynamics simulations have been carried out in studying the solar wind and cometary plasma interactions for decades. Various plasma boundaries have been simulated and compared well with observations for comet 1P/Halley. The Rosetta mission, which studies comet 67P/Churyumov–Gerasimenko, challenges our understanding of the solar wind and comet interactions. The Rosetta Plasma Consortium observed regions of very weak magnetic field outside the predicted diamagnetic cavity. In this paper, we simulate the inner coma with the Hall...

Unresolved Problems with the "I", the "A" and the "T": Logical and Psychometric Critique of the Implicit Association Test (IAT)

Matthias Blümke, Klaus Fiedler & Claude Messner
The Implicit Association Test (IAT) had already gained the status of a prominent assessment procedure before its psychometric properties and underlying task structure were understood. The present critique addresses five major problems that arise when the IAT is used for diagnostic inferences: (1) the asymmetry of causal and diagnostic inferences; (2) the viability of the underlying association model; (3) the lack of a testable model underlying IAT-based inferences; (4) the difficulties of interpreting difference scores;...

Cerebral microembolism in the critically ill with acute kidney injury (COMET-AKI trial): study protocol for a randomized controlled clinical trial.

Joerg C. Schefold, Beatrice Kobel, Dominik E Uehlinger, Gabor Erdös, Stephan Jakob, Frank Stüber, Monika Pia Stucki, Roland Wiest & Niklaus Fankhauser
BACKGROUND Microembolism is a frequent pathological event during extracorporeal renal replacement therapy (RRT). Some previous data indicate that microemboli are generated in patients who are undergoing RRT and that these may contribute to increased cerebrovascular and neurocognitive morbidity in patients with end-stage renal disease. The current trial aims to quantify the microembolic load and respective qualitative composition that effectively reaches the intracerebral circulation in critically ill patients treated with different RRT modalities for acute kidney...

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