83,726 Works

RadOnc: An R Package for Analysis of Dose-Volume Histogram and Three-Dimensional Structural Data

Reid F. Thompson
Purpose/Objectives: Dose volume histogram (DVH) data are generally analyzed within the context of a treatment planning system (TPS) on a per-patient basis, with evaluation of single-plan or comparative dose distributions. However, TPS software generally cannot perform simultaneous comparative dosimetry among a cohort of patients. The same limitations apply to parallel analyses of three-dimensional structures and other clinical data. Materials/Methods: We developed a suite of tools ("RadOnc" package) using R statistical software to better compare pooled...

Recensione a Anilda Ibrahimi, "Non c’è dolcezza", Torino, Einaudi, 2012.

Silvia Camilotti
Si propone una recensione del romanzo "Non c'è dolcezza" (Einaudi 2012) di Anilda Ibrahimi, scrittrice di origine albanese, residente in Italia e autrice in lingua italiana. Nei suoi precedenti romanzi – "Rosso come una sposa" (Einaudi 2008) e "L'amore e gli stracci del tempo" (Einaudi 2009) – l'autrice pone l'attenzione sul conflitto balcanico e sulla storia albanese. Uno dei temi privilegiati nella sua scrittura è la condizione femminile nel suo paese natale: nei suoi romanzi...

Salve Domina. Hinweise auf lesende und schreibende Frauen im Römischen Reich

Josy Luginbühl
Während Darstellungen von lesenden und schreibenden Frauen in der römischen Antike nicht selten sind und auch in der Forschung schon mehrfach behandelt wurden, können sie nur sehr eingeschränkte Erkenntnisse über die effektive Fähigkeit zu lesen und zu schreiben liefern. Persönliche Gegenstände aus dem Fundmaterial wie Schreibgeräte oder beschriftete Gegenstände besitzen dagegen einen direkten Bezug zu ihren Besitzerinnen und erlauben so eine ganz andere Perspektive. Hinweise auf lesende und schreibende Frauen geben beispielsweise Grabbeigaben in Form...

The Distribution of Talent Across Contests

Marc Möller & Ghazala Azmat
Do the contests with the largest prizes attract the most-able contestants? To what extent do contestants avoid competition? In this paper, we show, theoretically and empirically, that the distribution of abilities plays a crucial role in determining contest choice. Complete sorting exists only when the proportion of high-ability contestants is sufficiently small. As this proportion increases, high-ability contestants shy away from competition and sorting decreases, such that, reverse sorting becomes a possibility. We test our...

Conversion, Factitious Disorder and Malingering: A Distinct Pattern or a Continuum?

Selma Aybek, Julien Bogousslavsky, Laurent Tatu & Silvio Galli
This chapter is aimed at highlighting the recent findings concerning physiopathology, diagnosis, and management of conversion, factitious disorder, and malingering. Conversion disorder is the unintentional production of neurological symptom, whereas malingering and factitious disorder represent the voluntary production of symptoms with internal or external incentives. They have a close history and this has been frequently confounded. Practitioners are often confronted to medically unexplained symptoms; they represent almost 30% of neurologist's consultation. The first challenge is...

Predictive factors and biomarkers for the 2-year outcome of uveitis in juvenile idiopathic arthritis: data from the Inception Cohort of Newly diagnosed patients with Juvenile Idiopathic Arthritis (ICON-JIA) study.

Claudia Sengler, Kirsten Minden, Arnd Heiligenhaus, Sabine Hoeft, Dirk Foell, Miha Lavric, Martina Niewerth, Christoph Tappeiner, Karoline Walscheid, Jens Klotsche & Ina Liedmann
Objective To define predictors for the 2-year outcome in terms of achieving inactivity, subsequent uveitis reactivation and occurrence of uveitis-related complications of JIA-associated uveitis. Methods Demographic and clinical parameters and serum samples of JIA-associated uveitis patients enrolled in ICON at ⩽1 year of JIA diagnosis were collected at study enrolment, every 3 months during the first year and subsequently every 6 months. Predictors for the 2-year outcome were evaluated by linear mixed models. Results Of...

Incidence of second primary cancers after radiotherapy combined with platinum and/or cetuximab in head and neck cancer patients.

Burim Sermaxhaj, Olgun Eliçin, Mohamed Shelan, Daniel Aebersold, Beat Bojaxhiu, Roland Giger & Daniel Rauch
PURPOSE The second primary cancer (SPC) incidence after treatment with platinum-based chemotherapy and cetuximab in combination with radiotherapy has not been previously reported. Our aim was to compare SPC risk following radiotherapy in combination with these agents for the treatment of head and neck squamous cell carcinoma (HNSCC). METHODS The charts of 296 cases treated for loco-regionally advanced HNSCC between 2009 and 2015 were retrospectively reviewed for patient, tumor, and procedural characteristics. All patients were...

Tumor Heterogeneity in Lymphomas: A Different Breed.

Christian Schürch, Birgit Federmann, Falko Fend & Leticia Quintanilla-Martinez
The facts that cancer represents tissues consisting of heterogeneous neoplastic, as well as reactive, cell populations and that cancers of the same histotype may show profound differences in clinical behavior have long been recognized. With the advent of new technologies and the demands of precision medicine, the investigation of tumor heterogeneity has gained much interest. An understanding of intertumoral heterogeneity in patients with the same disease entity is necessary to optimally guide personalized treatment. In...

Emerging aspects of microRNA interaction with TMPRSS2-ERG and endocrine therapy.

Martin Spahn, Sofia Karkampouna, Marianna Kruithof-De Julio, Eugenio Zoni & George Thalmann
Prostate cancer (PCa) is the most common malignancy detected in males and the second most common cause of cancer death in western countries. The development of the prostate gland, is finely regulated by androgens which modulate also its growth and function. Importantly, androgens exert a major role in PCa formation and progression and one of the hypothesized mechanism proposed has been linked to the chromosomal rearrangement of the androgen regulated gene TMPRSS2 with ERG. Androgens...

Comparison of Outcomes of Percutaneous MitraClip Versus Surgical Repair or Replacement for Degenerative Mitral Regurgitation in Octogenarians

Nicola Buzzatti, Francesco Maisano, Ottavio Alfieri, Azeem Latib, Giovanni La Canna, Maurizio Taramasso, Paolo Denti & Antonio Colombo

Evidence for atmospheric carbon injection during the end-Permian extinction

P A Hochuli, W M Kurschner, D Ware, N Goudemand, H Bucher, G Roohi, E Schneebeli-Hermann, H Weissert, K Ur-Rehman & S M Bernasconi

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