2,995 Works

Urinalysis in whole body exposure rodent studies (PMI)

Blaine Phillips & Ee Tsin Wong
The protocol describes the dipstick method for semi-quantitative urine analysis by visual reading.

Neutral Red Uptake Assay (NRU) in vitro cytotoxicity assay (Health Canada T-502)

Health Canada
The Health Canada T-502 protocol is applicable to the assessment of the cytotoxic potential of cigarette smoke or other types of related aerosols, including reduced-risks products. The method describes the cell preparation and treatment with different fractions of cigarette smoke, the uptake of neutral red dye by untreated and treated cells and the analysis of results.

Analytical procedure to measure TPM, Nicotine and Acrolein in aerosol fractions prepared for in vitro assays (PMI)

Lydia Gautier
Total particulate matter (TPM) and gas and vapor phase (GVP) are trapped from aerosol generated by THS 2.2 or cigarette. Nicotine is determined from TPM and acrolein from GVP fractions, respectively. These measurements are used as quality checks to evaluate the repeatability between the different batches of aerosol fractions generated for in vitro assays.

Characterization of the proteolytic activity in bronchoalveolar lavage fluid (BALF) (PMI)

Blaine Phillips, Patrice Leroy & Gregory Vuillaume
The bronchoalveolar lavage fluid (BALF) collected from mice can be analyzed in order to assess the inflammation status of the lungs after the exposure to toxicants. This protocol describes the methodology required to determine the activity of matrix metalloproteinases (MMPs) in the cell-free BALF supernatant.

Liver Histopathology and Histomorphometry (rodents, PMI)

Blaine Phillips & Ee Tsin Wong
Histopathology and histomorphometry characterization of liver tissue from rodents involved in inhalation toxicology studies

[Unilateral peromelia of the left pelvic limb in a Brown Swiss calf].

Alois Von Rotz, Aldona Pieńkowska-Schelling, Cord Drögemüller & Sonja Hofstetter
Congenital deformities of the limbs occur sporadically in various species, but the cause is often unclear. The clinically healthy female Brown Swiss calf presented here showed a congenital peromelia of the left hind limb. The affected limb is twisted, disproportional and the bones distally of the metatarsus are missing. Karyotyping and genome sequencing did not indicate on a genetic cause of the anomaly. An infection with the Schmallenberg virus could not be ruled out. Furthermore,...

Impact of Aneurysm Multiplicity on Treatment and Outcome After Aneurysmal Subarachnoid Hemorrhage.

Daniele Valsecchi, Johannes Goldberg, Andrea Ferrari, Rita Achermann, Schatlo Bawarjan, Heiner C Bucher, Donato D'Alonzo, Marco V Corniola, Serge Marbacher, Luigi Mariani, Martin A Seule, Christian Fung, Philippe Bijlenga, Jan-Karl Burkhardt, Martin N Stienen, Michel Roethlisberger, Daniel Schöni, Raphael Guzman, Daniel W Zumofen, Kristine A Blackham, Thomas Robert, Nicolai Maldaner & Rodolfo Maduri
BACKGROUND One-third of patients with aneurysmal subarachnoid hemorrhage (aSAH) have multiple intracranial aneurysms (MIA). OBJECTIVE To determine the predictors of outcome in aSAH patients with MIA compared to aSAH patients with a single intracranial aneurysm (SIA). METHODS The Swiss Study of Subarachnoid Hemorrhage dataset 2009-2014 was used to evaluate outcome in aSAH patients with MIA compared to patients with SIA with the aid of descriptive and multivariate regression analysis. The primary endpoints of this cohort...

Nature and Nurture: Brain Region-Specific Inheritance of Sleep Neurophysiology in Adolescence

Leila Tarokh, Peter Achermann, Christoph Hamann, Andjela Markovic, Thomas Rusterholz & Stefanie J Schmidt

Interrelationship between hemodynamics, brain volumes and outcome in Hypoplastic Left Heart Syndrome

Kristina Wetterling, Michael Hübler, Beatrice Latal, Dietmar Schranz, Bettina Reich, Oliver Kretschmar, Kristina N Heye, Ruth O Gorman Tuura, Ingrid Beck, Christian Jux, Hakan Aktintürk, Andreas Hahn & Walter Knirsch

Loss and Damage in the mountain cryosphere

Christine Jurt, Christian Huggel, Rachel James, Veruska Muccione, Reinhard Mechler & Mark Carey

In-hospital cost analysis of prostatic artery embolization compared to transurethral resection of the prostate: Post hoc analysis of a randomized controlled trial

Gautier Müllhaupt, Daniel S Engeler, Hans-Peter Schmid, Thomas M Kessler, Sabine Güsewell, Livio Mordasini, Dominik Abt, Patrick Betschart, Valentin Zumstein & Lukas Hechelhammer

In-depth peer review by anonymous panels of experts with predefined expertise criteria through an online platform.

Stephanie Boue
This protocol describes the conduct of in-depth peer review of study reports, data, and additional material by panels of experts, which are recruited and managed on an online platform by a third party, independent from the sponsor of the review.

Shotgun lipidomics analysis of mouse lung tissues (PMI)

Oksana Lavrynenko, Sophie Dijon & Bjorn Titz
This protocol describes how to determine the lipidomics profile of mouse lung cryosections using BUME extraction followed by shotgun analysis.

Body Weight Determination (rodents, PMI)

Blaine Phillips
Measurement of body weight in mice at regular intervals during exposure.

Analysis of indoor air constituents: nicotine and 3-ethenylpyridine (PMI)

Maya Mitova, Catherine Goujon-Ginglinger & Camille Cluse
The protocol describes the quantification of gas-phase tobacco specific markers, nicotine and 3-ethenylpyridine (3-EP).

Analysis of indoor air constituents: carbonyls (PMI)

Maya Mitova, Catherine Goujon-Ginglinger & Camille Cluse
The protocol describes the quantification of formaldehyde, acetaldehyde, acrolein, and crotonaldehyde that are marker constituents in Environmental Tobacco Smoke (ETS).

Analysis of indoor air constituents: volatile organic compounds (VOCs, PMI)

Maya Mitova, Catherine Goujon-Ginglinger & Camille Cluse
The protocol describes the quantification of five volatile organic compounds (VOCs), 1.3-butadiene, acrylonitrile, benzene, isoprene, and toluene that are marker constituents in Environmental Tobacco Smoke (ETS).

Analysis of indoor air constituents: carbon monoxide (CO), nitrogen monoxide (NO) and nitrogen oxides (NOx) (PMI)

Maya Mitova, Catherine Goujon-Ginglinger & Camille Cluse
The protocol describes required steps to operate two sensors for online quantification of respectively carbon monoxide (CO), Nitrogen monoxide (NO) and Nitrogen oxides (NOx) that are gas markers in Environmental Tobacco Smoke (ETS).

Height-specific blood pressure cutoffs for screening elevated and high blood pressure in children and adolescents: an International Study.

Arnaud Chiolero, Mohammad Esmaeil Motlagh, Alicja Krzyżaniak, Habiba Ben Romdhane, Lidia Ostrowska-Nawarycz, Mostafa Qorbani, Neha Kajale, Shashi Chiplonkar, Hajer Aounallah-Skhiri, Tadeusz Nawarycz, Liu Yang, Barbara Stawińska-Witoszyńska, Yaping Hou, Hae Soon Kim, Anuradha Khadilkar, Bo Xi, Min Zhao, Gelayol Ardalan, Pierre Traissac, Roya Kelishadi, Małgorzata Krzywińska-Wiewiorowska, Vaman Khadilkar, Jalila El Ati, Lavanya Parthasarathy, Mieczysław Litwin … & Pascal Bovet
Pediatric blood pressure (BP) reference tables are generally based on sex, age, and height and tend to be cumbersome to use in routine clinical practice. In this study, we aimed to develop a new, height-specific simple BP table according to the international child BP reference table based on sex, age and height and to evaluate its performance using international data. We validated the simple table in a derivation cohort that included 58,899 children and adolescents...

PMI's REXC study – Questionnaires

Christelle Haziza, Guillaume de La Bourdonnaye, Dimitra Skiada, Jacek Ancerewicz, Gizelle Baker, Patrick Picavet & Frank Lüdicke
In this clinical reduced exposure study with 5 days in a confinement setting (REX-C), questionnaires were used to assess nicotine dependence: Fagerström Test for Nicotine Dependence [FTND], revised version), assessment of cough (on a VAS), product evaluation (MCEQ), urge-to-smoke symptoms (QSU-brief), withdrawal symptoms (MNWS questionnaire, revised version), and the impact of using the HST device on smoking experience in terms of ritual disruption (HST questionnaire). All questionnaires used in this study were either available as...

Composite resins preparation and assessment

Xiaoyi Zhao, Filippo Zanetti, Shoaib Majeed, Jie Pan, Hans Malmstrom, Manuel Peitsch, Julia Hoeng & Yanfang Ren
This protocol describes the steps necessary to prepare composite resins discs and to assess their color, gloss, and surface roughness.

Analysis of indoor air constituents: RSP, UVPM, FPM and Solanesol (PMI)

Maya Mitova, Catherine Goujon-Ginglinger & Camille Cluse
The protocol describes the quantification of Respirable Suspended Particles (RSP), ultraviolet particulate matter (UVPM), fluorescent particulate matter (FPM), and solanesol that are marker constituents in Environmental Tobacco Smoke (ETS).

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-AXGWEHWIGI-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

Robin Bär
A 1 M thiophenol solution in diethyl ether (165 mg, 1.50 mL, 1.5 mmol, 2.87 equiv) was added to the propellane solution (1.00 mL) and the mixture was stirred for 15 min at 21 °C. The solution was diluted with 10 mL of pentane and was washed with 10 mL of a 1 M NaOH solution. The organic layer was dried by the addition of Na2SO4. The mixture was filtered through a glass funnel and...

Registration Year

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