2,088 Works

Inheritance of equine sarcoid disease in Franches-Montagnes horses.

Garance Anne Christen, Vinzenz Gerber, Dominik Burger, Christoph Koch & Gaudenz Dolf
The mode of inheritance for susceptibility to equine sarcoid disease (ES) remains unknown. The objectives of this study were to analyse a large sample of the Franches-Montagnes (FM) horse population and investigate the heritability and mode of inheritance for susceptibility to ES. Horses were clinically examined for the presence of sarcoid tumours. A standardized examination protocol and client questionnaire were used and a pedigree- and subsequent segregation-analysis for the ES trait performed. To investigate the...

Assoziation zwischen Hautgesundheit und Fellfarbe sowie weissen Abzeichen bei dreijährigen Freibergerpferden

Vinzenz Gerber, M. Federici, S. Klopfenstein, Dominik Burger & Marcus Doherr
In den letzten 30 Jahren hat sich der Anteil weisser Abzeichen in der Freibergerpopulation mehr als verdoppelt, was auch hinsichtlich der Gesundheit der Pferde kontrovers diskutiert wird. Ziel dieser Studie war es, den Einfluss der Fellfarbe und von weißen Abzeichen auf ausgewählte Hauterkrankungen und Hufhornveränderungen zu untersuchen. Zu diesem Zweck wurden 974 dreijährige Freibergerpferde im Rahmen der vom Zuchtverband organisierten Feld- und Stationstests klinisch untersucht. Bei 16.9% der Pferde wurden ein oder mehrere equine Sarkoide...

Synchronous and time-lagged effects between occupational self-efficacy and objective and subjective career success: Findings from a four-wave and 9-year longitudinal study

Andrea E. Abele & Daniel Spurk
We integrated research on the dimensionality of career success into social-cognitive career theory and explored the positive feedback loop between occupational self-efficacy and objective and subjective career success over time (self-efficacy → objective success → subjective success → self-efficacy). Furthermore, we theoretically accounted for synchronous and time-lagged effects, as well as indirect reciprocity between the variables. We tested the proposed model by means of longitudinal structural equation modeling in a 9-year four-wave panel design, by...

“Please do not leave any notes for the cleaning lady, as many do not speak English fluently”: policy, power and language brokering in a multilingual workplace.

Anne Schulter & Kellie Gonçalves
This article investigates the covert language policy and micro-language planning practices of one female Brazilian-American entrepreneur, Magda, within her multilingual cleaning company. Because Magda is plurilingual (Spolsky in Language policy. Cambridge University Press, Cambridge, 2004), she is able to draw on her metalinguistic awareness and multicompetence in order to facilitate communication between her working-class migrant employees and her English-speaking clients as well as engage in what we call “inter-employee brokering”. Magda’s position as the company’s...

The Influence of Self-efficacy and Compensatory Health Behavior in Bicycle Helmet Use

Monica Susanne Bachmann, Hansjörg Znoj, Nadine Messerli-Buergy, Irena Pjanic & Jürgen Barth
Individuals show compensatory health behavior (e.g. safer cycling without helmet) to compensate for risky behavior. Compensatory health behavior is facilitated by high self-efficacy. A total of 134 cyclists with different helmet wearing frequencies (occasionally (OH) or never helmet (NH)) were asked to fill out a questionnaire on their compensatory health behavior when cycling without a helmet and on their general self-efficacy. An interaction between self-efficacy and use of a helmet on compensatory health behavior was...

Conceptualizing the transfer of knowledge across cases in transdisciplinary research

Gertrude Hirsch Hadorn, Thomas Michael Breu, Carolina Adler, Christian Pohl & Urs Wiesmann
Transdisciplinary (TD) research is increasingly suggested as a means of tackling wicked problems by providing knowledge on solutions that serve as pathways towards sustainable development. In contrast to research striving for generalizable findings, TD research produces insights for a particular case and context. TD researchers, who build on other TD projects’ results, need to know under what conditions knowledge gained from their case can be transferred to and applied in another case and context. Knowledge...

Changes in cell proliferation, but not in vascularisation are characteristic for human endometrium in different reproductive failures--a pilot study

Anna T Grazul-Bilska, Thomas Strowitzki, Ariane Germeyer, Michael Von Wolff, Julia Jauckus & Tanuj Sharma
Reproductive failure, determined as recurrent spontaneous abortions (RSA) or recurrent implantation failure (RIF) in women is not well understood. Several factors, including embryo quality, and cellular and molecular changes in endometrium may contribute to the insufficient feto-maternal interaction resulting in reproductive failure. Prior clinical studies suggest an inadequate endometrial growth and development of the endometrium, leading to a lesser endometrial thickness.

Wharton’s jelly stem cell-derived extracellular vesicles drive neural progenitor cells towards oligodendroglial identity

Gierin Florence Thomi, Marialuigia Spinelli, Daniel Surbek, Martin Müller, Byron Oppliger, Marianne Jörger Messerli, Andreina Schoeberlein & Valérie Haesler

Palynostratigraphic investigation and luminescence dating of the Galgenmoos section and implications for the chronology of the last glacial cycle in the northern Alpine Foreland of Switzerland

Frank Preusser, Christian Schlüchter, B. U. Müller & Samuel Wegmüller
Im Profil Huttwil-Galgenmoos liegt an der Basis ein über 2 Meter mächtiges Torfpaket, das von sandig-siltigen Sedimenten überschüttet wurde. Die klastischen Hangablagerungen fallen zeitlich in das Mittelwürm bzw. in den Übergangsbereich Hochwürm/Spätglazial. In den Torfen selber lassen sich zwei bewaldete Koniferen-Interstadiale ausgliedern. Das jüngere Interstadial wird nach palynostratigraphischen Befunden und Datierungen mit Infrarot Stimulierter Lumineszenz (IRSL) in das frühe Mittelwürm gestellt. Für das ältere Interstadial ergibt sich eine deutliche Diskrepanz zwischen den beiden verwendeten Untersuchungsmethoden....

A Tomato Tocopherol-Binding Protein Sheds Light on Intracellular α-Tocopherol Metabolism in Plants.

Claire Bréhélin, Magdalena Rossi, Viola Previtali, Luisa Bermúdez, Achim Stocker, Talía Del Pozo, Bruno Silvestre Lira, Pia Guadalupe Dominguez, Rigel Salinas Gamboa, Leandro Quadrana, Laura Pérez-Flores, Irene Boos, Saleh Alseekh, Mads Hartving Clausen, Maurício González, Cecilia Romanò, Andreas Hemmerle, Alisdair Robert Fernie, Fernando Carrari, Diego Demarco, Ramón Asis, Fabiana De Godoy, Christophe Rothan & Juliana Almeida
Tocopherols are non-polar compounds synthesized in the plastids, which function as major antioxidants of the plant cells and are essential in the human diet. Both the intermediates and final products of the tocopherol biosynthetic pathway must cross plastid membranes to reach their sites of action. So far, no protein with tocopherol binding activity has been reported in plants. Here, we demonstrated that the tomato SlTBP protein is targeted to chloroplasts and able to bind α-tocopherol....

Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice.

Dominic Ritler, Andrew Hemphill, Adriana Aguado Martinez, Pablo Arnold Winzer, Joachim Müller, Vreni Balmer, David Arranz Solis, Isabel Hostettler, Luis Ortega-Mora & Vera Manser
The naphthoquinone buparvaquone is currently the only drug used against theileriosis. Here, the effects of buparvaquone were investigated in vitro and in an experimental mouse model for Neospora caninum infection. In 4-day proliferation assays, buparvaquone efficiently inhibited N. caninum tachyzoite replication (IC50 = 4.9 nM; IC100 = 100 nM). However, in the long term tachyzoites adapted and resumed proliferation in the presence of 100 nM buparvaquone after 20 days of cultivation. Parasiticidal activity was noted after 9 days of culture in 0.5 µM or...

Role of ST-Segment Resolution in Patients With ST-Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention (from the 5-Year Outcomes of the EXAMINATION [Evaluation of the Xience-V Stent in Acute Myocardial Infarction] Trial).

Alberto Pernigotti, Salvatore Brugaletta, Patrick W Serruys, Vicente Mainar, Pilar Jiménez-Quevedo, Josep Gomez-Lara, Marco Valgimigli, Nicolás Vazquez, Giosafat Spitaleri, Peter Den Heijer, Andrés Iñiguez, Giancarla Scalone, Antonio Serra, Elisabetta Moscarella, Angel Cequier, Maurizio Tespili, Armando Bethencourt, Luis Ortega-Paz, Manel Sabaté & Gianluca Campo
In patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI), lack of ST-segment resolution (STR) is associated with poor prognosis at short- and long-term follow-up. The aim of this study was to evaluate the role of STR on very long-term outcomes in patients with STEMI treated with pPCI included in the EXAMINATION (Evaluation of the Xience-V Stent in Acute Myocardial Infarction) trial. Patients were stratified according to the presence of...

Species-specific stomatal response of trees to drought - a link to vegetation dynamics?

Roman Zweifel, Andreas Rigling & Matthias Dobbertin
Question: Is stomatal regulation specific for climate and tree species, and does it reveal species-specific responses to drought? Is there a link to vegetation dynamics? Location: Dry inner alpine valley, Switzerland Methods: Stomatal aperture (θE) of Pinus sylvestris, Quercus pubescens, Juniperus communis and Picea abies were continuously estimated by the ratio of measured branch sap flow rates to potential transpiration rates (adapted Penman-Monteith single leaf approach) at 10-min intervals over four seasons. Results: θE proved...

Effectiveness of Contour Augmentation with Guided Bone Regeneration: 10-Year Results.

Ramona Buser, Urs Belser, Lira Rahman, Vivianne Chappuis, Daniel Albin Buser & Simone Janner
In aesthetic sites, the integrity of the facial bone wall dimension in the anterior maxilla is jeopardized by physiologic and structural changes postextraction. An effective regenerative protocol is key to reestablish and maintain the hard and soft tissue dimensions over time. The present prospective case series study examined the effectiveness of early implant placement with simultaneous contour augmentation through guided bone regeneration with a 2-layer composite graft in postextraction single-tooth sites over an observation period...

Less Oxygen, Later Intubation and Reduced Respiratory Pressures for ELBW Infants from 1997 to 2011.

Mathias Nelle, Roland Gerull, T Arenz, H Küster, H Manser & Stephan Arenz
INTRODUCTION Evidence concerning delivery room management in extremely low birth weight infants (ELBW) has grown substantially within the last 20 years, leading to several guidelines and recommendations. However, it is unknown in which extent local treatment strategies have changed and if they reflect current recommendations. METHODS A detailed questionnaire about treatment strategies for ELBW infants was sent to all German neonatal intensive care units (NICUs) treating ELBW infants in 1997. A follow-up survey was conducted...

Optical In-Situ Monitor Breadbord System

N. Lievre, J. Utzmann, Jean-Noël Pittet, Lionel Séraphin Charles Métrailler, G. Vives, Jiri Silha, T. Flohrer & L. Ferreira
The aim of the ESA GSTP activity „Optical In-Situ Monitor“ is to design and test a breadboard of a space-based space debris camera and to develop and test its end-to-end processing chain. The corresponding future flight model shall be used for the detection of small-sized (down to 1 mm) space debris in LEO as well as larger objects in GEO. It is intended to be flown on a platform in sun-synchronous orbit near the terminator...

Polymorphisms in MIR27A Associated with Early-Onset Toxicity in Fluoropyrimidine-Based Chemotherapy

Johanna Sistonen, Steven M Offer, Carlo Rodolfo Largiadèr, Markus Joerger, Robert B Diasio & Ursula Amstutz
PURPOSE The microRNA miR-27a was recently shown to directly regulate dihydropyrimidine dehydrogenase (DPD), the key enzyme in fluoropyrimidine catabolism. A common polymorphism (rs895819A>G) in the miR-27a genomic region (MIR27A) was associated with reduced DPD activity in healthy volunteers, but the clinical relevance of this effect is still unknown. Here, we assessed the association of MIR27A germline variants with early-onset fluoropyrimidine toxicity. EXPERIMENTAL DESIGN MIR27A was sequenced in 514 patients with cancer receiving fluoropyrimidine-based chemotherapy. Associations...

Vertical mobility around the high-alpine Schnidejoch Pass. Indications of Neolithic and Bronze Age pastoralism in the Swiss Alps from paleoecological and archaeological sources.

Albert Hafner & Christoph Schwörer
Since 2003 a melting ice field on the Schnidejoch Pass (2756 m a.s.l.) has yielded several hundred objects from the Neolithic period, the Bronze and Iron Ages and from Roman and early medieval times. The oldest finds date from the beginning of the 5th millennium BC, whilst the most recent artefacts date from around AD 1000. Most of the objects belong to the Neolithic period and the Bronze Age and are of organic origin. A...

Good Intents, but Low Impacts: Diverging Importance of Motivational and Socioeconomic Determinants Explaining Pro-Environmental Behavior, Energy Use, and Carbon Footprint

Stephanie Moser & Silke Kleinhückelkotten
Earlier research has yielded contradictory results as to the main drivers of environmentally significant behavior. Intent-oriented research has stressed the importance of motivational aspects, while impact-oriented research has drawn attention to people’s socio-economic status. In this study, we investigated the diverging role of a pro-environmental stance under these two research perspectives. Data from a German survey (N = 1,012) enabled assessment of per capita energy use, and individual carbon footprints (impact-related measures), proenvironmental behavior (an...

Polaronic metal state at the LaAlO₃/SrTiO₃ interface

T. Schmitt, O. S. Barišić, C. Cancellieri, C. Faber, N. Nagaosa, Ulrich Johannes Aschauer, A. S. Mishchenko, A. Filippetti, V. A. Rogalev & V. N. Strocov
Interplay of spin, charge, orbital and lattice degrees of freedom in oxide heterostructures results in a plethora of fascinating properties, which can be exploited in new generations of electronic devices with enhanced functionalities. The paradigm example is the interface between the two band insulators LaAlO3 and SrTiO3 that hosts a two-dimensional electron system. Apart from the mobile charge carriers, this system exhibits a range of intriguing properties such as field effect, superconductivity and ferromagnetism, whose...

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