338 Works

Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.

S T Engelter, P Vanacker, Hakan Sarikaya, A Zini, R Stark, G M De Marchis, A Wicht, G Kägi, L Poli, O Bill, A Pezzini, D J Seiffge, P A Lyrer, L H Bonati, N Peters, A Polymeris, P Michel, C Traenka, H Gensicke, P Costa, G Giovannini & L Vandelli
BACKGROUND AND PURPOSE The impact of body mass index (BMI) on outcome in stroke patients treated with intravenous thrombolysis (IVT) was investigated. METHODS In a multicentre IVT-register-based observational study, BMI with (i) poor 3-month outcome (i.e. modified Rankin Scale scores 3-6), (ii) death and (iii) symptomatic intracranial haemorrhage (sICH) based on criteria of the ECASS II trial was compared. BMI was used as a continuous and categorical variable distinguishing normal weight (reference group 18.5-24.9 kg/m(2)...
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Canine Distemper Virus Fusion Activation: Critical Role of Residue E123 of CD150/SLAM.

Fanny Anne Bringolf, Silvan Röthlisberger, Andreas Zurbriggen, Francesco Origgi, Philippe Plattet, Mojtaba Khosravi, Maria Bieringer & Jürgen Schneider-Schaulies
UNLABELLED Measles virus (MeV) and canine distemper virus (CDV) possess tetrameric attachment proteins (H) and trimeric fusion proteins, which cooperate with either SLAM or nectin 4 receptors to trigger membrane fusion for cell entry. While the MeV H-SLAM cocrystal structure revealed the binding interface, two distinct oligomeric H assemblies were also determined. In one of the conformations, two SLAM units were sandwiched between two discrete H head domains, thus spotlighting two binding interfaces ("front" and...
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Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice.

Dominic Ritler, Andrew Hemphill, Adriana Aguado Martinez, Pablo Arnold Winzer, Joachim Müller, Vreni Balmer, David Arranz Solis, Isabel Hostettler, Luis Ortega-Mora & Vera Manser
The naphthoquinone buparvaquone is currently the only drug used against theileriosis. Here, the effects of buparvaquone were investigated in vitro and in an experimental mouse model for Neospora caninum infection. In 4-day proliferation assays, buparvaquone efficiently inhibited N. caninum tachyzoite replication (IC50 = 4.9 nM; IC100 = 100 nM). However, in the long term tachyzoites adapted and resumed proliferation in the presence of 100 nM buparvaquone after 20 days of cultivation. Parasiticidal activity was noted after 9 days of culture in 0.5 µM or...
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Species-specific stomatal response of trees to drought - a link to vegetation dynamics?

Roman Zweifel, Andreas Rigling & Matthias Dobbertin
Question: Is stomatal regulation specific for climate and tree species, and does it reveal species-specific responses to drought? Is there a link to vegetation dynamics? Location: Dry inner alpine valley, Switzerland Methods: Stomatal aperture (θE) of Pinus sylvestris, Quercus pubescens, Juniperus communis and Picea abies were continuously estimated by the ratio of measured branch sap flow rates to potential transpiration rates (adapted Penman-Monteith single leaf approach) at 10-min intervals over four seasons. Results: θE proved...
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Less Oxygen, Later Intubation and Reduced Respiratory Pressures for ELBW Infants from 1997 to 2011.

Mathias Nelle, Roland Gerull, T Arenz, H Küster, H Manser & Stephan Arenz
INTRODUCTION Evidence concerning delivery room management in extremely low birth weight infants (ELBW) has grown substantially within the last 20 years, leading to several guidelines and recommendations. However, it is unknown in which extent local treatment strategies have changed and if they reflect current recommendations. METHODS A detailed questionnaire about treatment strategies for ELBW infants was sent to all German neonatal intensive care units (NICUs) treating ELBW infants in 1997. A follow-up survey was conducted...
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Polaronic metal state at the LaAlO₃/SrTiO₃ interface

T. Schmitt, O. S. Barišić, C. Cancellieri, C. Faber, N. Nagaosa, Ulrich Johannes Aschauer, A. S. Mishchenko, A. Filippetti, V. A. Rogalev & V. N. Strocov
Interplay of spin, charge, orbital and lattice degrees of freedom in oxide heterostructures results in a plethora of fascinating properties, which can be exploited in new generations of electronic devices with enhanced functionalities. The paradigm example is the interface between the two band insulators LaAlO3 and SrTiO3 that hosts a two-dimensional electron system. Apart from the mobile charge carriers, this system exhibits a range of intriguing properties such as field effect, superconductivity and ferromagnetism, whose...
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Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination

Michelle Schorer, Thierry Monney, Andrew Hemphill, Ferial Alaeddine, Christophe Gouinaud, Norbert Müller, Joachim Müller & Karim Debache
Neospora caninum is an apicomplexan parasite that is capable of infecting, a wide range of tissues. The fact that Neospora represents an important abortion-causing parasite in cattle has transformed neosporosis research from an earlier, rather esoteric field, to a significant research topic, and considerable investments have been made in the last years to develop an efficacious vaccine or other means of intervention that would prevent infection and abortion due to N. caninum infection in cattle....
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The Relationship of Nitrate Reductase Activity to Uptake and Assimilation of Atmospheric 15NO2 -Nitrogen in Needles of Norway Spruce (Picea abies [L.] Karst.)

Christian Brunold, Peter Von Ballmoos & Stefan Nussbaum
Using NO2, relations between nitrate reductase activity and stomatal conductance, N-uptake and N-glutamate were studied in the two youngest needles flushes of potted Norway spruce (Picea abies [L.] Karst.). There were linear correlations between the stomatal conductance and the N-uptake and between the N-uptake and nitrate reductase (E.C. 1.6.6.1/1.6.6.2) activity. The N labelling of free glutamate shows the assimilation of NO2 from the atmosphere in addition to the nitrogen from the soil. The portion of...
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Conducting commissioned research in neoliberal academia: The conditions evaluations impose on research practice

Ueli Hostettler & M. Richter
The article deals with the unease we experience during various commissioned research projects. On the one hand, as social scientists, we feel committed to conducting ‘good research’ that acknowledges quality criteria such as flexibility and transparency and in particular allows for musing and reflexivity to ‘discover’ new aspects of our research topic. On the other hand, we are situated in the context of present-day neoliberal academia. This means that our work is assessed according to...
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Mobilities, Entanglements, Transformations. Outline of a Research Project on Pottery Practices in Neolithic Wetland Sites of the Swiss Plateau

Caroline Heitz, Albert Hafner & Regine Barbara Stapfer
A large number of later Neolithic sites (3900–3500BC) in Switzerland, Southern Germany and Eastern France offer outstandingly well preserved archaeological materials from cultural layers. Due to the wide use of dendrochronology, settlement remains and artefact assemblages can now be placed into a precise and fixed chronological framework, thus presenting a unique case within prehistoric archaeology. In earlier research, chronological and regional units were constructed on the basis of pottery. These spacial and temporal units of...
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Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.

Elisabeth Oppliger Leibundgut, Michael A McDevitt, Gary Spitzer, Michael Daskalakis, Bart Burington, David S Snyder, Oliver G Ottmann, Gabriela M. Baerlocher, Monic Stuart, Alexander Röth & Olatoyosi Odenike
BACKGROUND Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits telomerase enzymatic activity. It has been shown to inhibit megakaryocytic proliferation in vitro in cells obtained from patients with essential thrombocythemia. In this phase 2 study, we investigated whether imetelstat could elicit hematologic and molecular responses in patients with essential thrombocythemia who had not had a response to or who had had unacceptable side effects from prior therapies. METHODS A total...
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Caregiver Responses to the Language Mixing of a Young Trilingual

Sarah Louise Chevalier
The situation once described by Hoffmann (1985), in which children grow up exposed to three languages from an early age, is a reality for an increasing number of families. In Europe – as elsewhere – greater mobility is leading to greater numbers of mixed-language couples (Piller 2002), and, by extension, multilingual families. For such families, questions concerning the acquisition and maintenance of three or more languages in a natural environment are of direct relevance. Researchers...
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Zukunftsentwicklung für Schneesportvereine und –verbände

Siegfried Nagel & Torsten Schlesinger
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Dauerausstellung, Museumsnacht, Leihgaben, virtuelle Ausstellungen

Heidy Greco-Kaufmann
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An (un) healthy poster: When environmental cues affect consumers’ food choices at vending machines

Claude Messner, Aline Stämpfli, Thomas A. Brunner & Sabrina Stöckli
Environmental cues can affect food decisions. There is growing evidence that environmental cues influence how much one consumes. This article demonstrates that environmental cues can similarly impact the healthiness of consumers’ food choices. Two field studies examined this effect with consumers of vending machine foods who were exposed to different posters. In field study 1, consumers with a health-evoking nature poster compared to a pleasure-evoking fun fair poster or no poster in their visual sight...
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Association between hepatitis B infection and elevated liver stiffness among HIV-infected adults in Lusaka, Zambia

Benjamin H Chi, Lloyd Mulenga, Roma Chilengi, Kalo Musukuma, Michael J Vinikoor, Gilles Wandeler, Mary-Ann Davies, Carolyn Bolton Moore, Matthias Egger & Alice Siyunda
OBJECTIVE To describe the liver disease epidemiology among HIV-infected individuals in Zambia. METHODS We recruited HIV-infected adults (≥18 years) at antiretroviral therapy initiation at two facilities in Lusaka. Using vibration controlled transient elastography we assessed liver stiffness, a surrogate for fibrosis/cirrhosis, and analyzed liver stiffness measurements (LSM) according to established thresholds (>7.0 kPa for significant fibrosis and >11.0 kPa for cirrhosis). All participants underwent standardized screening for potential causes of liver disease including chronic hepatitis...
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The Judiciary between Management and the Rule of Law - The general research findings

Andreas Lienhard & Daniel Kettiger
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Das Gefängnis als Forschungsfeld

Marina Richter, Ueli Hostettler & Roger Kirchhofer
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The Judiciary between Management and the Rule of Law - The general research findings

Andreas Lienhard & Daniel Kettiger
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Integration of space-borne DInSAR data in a multi-method monitoring concept for alpine mass movements

Elisa Benedetti, David Mosna, Christian Iasio, Robert Kenner, Benni Thiebes, Marcia Phillips, Giovanni Cuozzo, Michele Manunta, Giulia Chinellato, Volkmar Mair, Maria Grazia Visconti, Claudia Strada & Andreas Paul Zischg
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Geomorphology, Stratigraphy, and Radiocarbon Chronology of LlanquihueDrift in the Area of the Southern Lake District, Seno Reloncavi, and Isla Grande de Chiloe, Chile

Christian Schlüchter, D.R. Marchant, P.I. Moreno, C.J. Heusser, B.G. Andersen, Linda E. Heusser, T.V. Lowell & G.H. Denton
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Interhemispheric Linkage of Paleoclimate During the Last Glaciation

C. J. Heusser, B.G. Andersen, T.V. Lowel, Linda E. Heusser, G.H. Denton, P.I. Moreno, Christian Schlüchter & D.R. Marchant
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