4,027 Works

Portfolios - ein Beitrag zur Demokratisierung des Lernens und der Leistungsbeurteilung

F Winter & T Häcker

Ein Testfall für den Wissenschaftsstandort. Die Aufregung um den Wirtschaftsethiker Ulrich Thielmann

Andreas G Scherer, Anton Leist & Guido Palazzo

Ergänzungen zu \"Perlboote und Ammonshörner weltweit\"

H U Ernst & C Klug

Von offenen Aufträgen und anderem mehr

F Winter & A Pfau

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-NKVQNROMAN-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

Jérôme Klein
2-Phenylquinoxaline (107 mg, 519 μmol, 1.00 equiv), potassium persulfate (982 mg, 3.6 mmol, 7.00 equiv), and anhydrous methanol (25.0 mL) were sequentially added to a sealed vial. Then the solution was stirred at 110 °C for 6 h. Methylene chloride and distilled water were added and the aqueous layer was extracted three times with methylene chloride. The organic layers were combined and dried over Na2SO4. The solvent was removed under reduced pressure.

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-SPSSDDOTEZ-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

Jérôme Klein
Phosphoryl chloride (68.6 g, 41.8 mL, 447 mmol, 50.0 equiv) and N,N-dimethylformamide (10.0 mL) were added to 1,4-dihydroquinoxaline-2,3-dione (1.45 g, 8.94 mmol, 1.00 equiv) and the solution was heated to 100 °C for 2 h. The reaction was cooled to 21 °C and poured on ice and kept overnight. Methylene chloride and distilled water were added and the aqueous layer was extracted three times with methylene chloride. The organic layers were combined and dried over...

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-YBFFHQQKFL-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

Yannick Matt & Isabelle Wessely
In a closed vial, 1-azido-4-[tris(4-azidophenyl)methyl]benzene (226 mg, 466 μmol, 1.00 equiv), copper;sulfate;pentahydrate (11.7 mg, 46.9 μmol, 0.100 equiv), sodium;(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-olate (37.0 mg, 187 μmol, 0.400 equiv) and 5-ethynyl-2-$l^{1}-oxidanyl-1,1,3,3-tetramethylisoindole (601 mg, 2.80 mmol, 6.01 equiv) in 17 mL of a tBuOH/H2O-mixture (1:1) were stirred at 70 °C for 72 h. After cooling to room temperature 15 mL of methanol were added and the precipitate was filtered off, washed with 50 mL of water, 50 mL of methanol...

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-LRPLBHMNPS-UHFFFADPSC-NUHFF-MUHFF-NUHFF-ZZZ

Daniel Knoll
In a roundbottom flask, crude 4-(diphenylphosphinyl)-16-(4-(2’-pyridyl)­phen­yl)­­[2.2]para­cyclophane (420 mg, 0.770 mmol, 1.00 equiv.) and (tht)AuCl (381 mg, 0.770 mmol, 1.00 equiv.) were placed. The roundbottom flask was closed with a rubber septum and evacuated and backfilled with argon three times. Degassed DCM (7 mL) was added with a syringe. The mixture was stirred for 2 hours at r.t. in the dark. The solvent was removed under reduced pressure .

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-UANJEQXEUP-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

Janina Beck
Under argon atmosphere a 1 M solution of ceric ammonium nitrate (10.1 g, 18.5 mmol, 3.70 equiv.) in water was rapidly added to a 0.1 M solution of (1,4-dimethoxynaphthalen-2-yl)(2-bromophenyl)methanone (2.09 g, 5.63 mmol, 1.00 equiv.) in MeCN/CH2Cl2 (4:1) at -40 °C. The resulting reaction mixture was warmed to -20 °C over the course of 1 h and then poured into water. The aqueous phase was extracted with EtOAc and the combined organic phases were dried...

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-LQLVWTVLQD-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

Janina Beck
Under argon atmosphere a 1 M solution of ceric ammonium nitrate (620 mg, 1.12 mmol, 3.70 equiv.) in water was rapidly added to a 0.1 M solution of (2-bromo-4,5-dimethoxyphenyl)(1,4-dimethoxynaphthalen-2-yl)methanone (130 mg, 300 µmol, 1.00 equiv.) in MeCN/CH2Cl2 (4:1) at -40 °C. The resulting reaction mixture was warmed to -20 °C over the course of 1 h and then poured into water. The aqueous phase was extracted with EtOAc and the combined organic phases were dried...

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-BBXGNCLCSR-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

Janina Beck
In a crimp vial under argon atmosphere N-(4-bromo-3-(1,4-dioxo-1,4-dihydronaphthalene-2-carbonyl)phenyl)acetamide (119 mg, 300 µmol, 1.00 equiv.) was dissolved in dry CH2Cl2 (1 mL) and 2,3‑dimethylbuta-1,3-diene (0.10 mL, 73.9 mg, 900 µmol, 3.00 equiv.) was added. The reaction was stirred at 40 °C for 5 h until the consumption of the dienophile was completed as indicated by TLC. The solvent was removed under reduced pressure.

Short-RInChIKey=SA-FUHFF-UHFFFADPSC-UKTGPOJWCW-UHFFFADPSC-NUHFF-NUHFF-NUHFF-ZZZ

Janina Beck
In a crimp vial under argon atmosphere 2‑(2‑bromo-5-methoxybenzoyl)naphthalene-1,4-dione (74.2 mg, 200 µmol, 1.00 equiv.) was dissolved in dry CH2Cl2 (1 mL) and 2,3-dimethylbuta-1,3-diene (0.12 mL, 82.2 mg, 1.00 mmol, 5.00 equiv.) was added. The reaction was stirred at 40 °C for 3 h until the consumption of the dienophile was completed as indicated by TLC. The solvent was removed under reduced pressure.

Capillary ultrastructure and mitochondrial volume density in skeletal muscle in relation to reduced exercise capacity of patients with intermittent claudication.

Corinna Malik, Adolfo Odriozola Quesada, Jens Bangsbo, Oliver Baum, Ylva Hellsten, Philip J Walker, Stefan A. Tschanz, Meegan Walker, Eleonora Torchetti, Franziska Graber, Christopher D Askew, Hans-Heinrich Hoppeler & Birgitte Hoier
Intermittent claudication (IC) is the most commonly reported symptom of peripheral arterial disease (PAD). Impaired limb blood flow is a major casual factor of lower exercise tolerance in PAD but cannot entirely explain it. We hypothesized that IC is associated with structural changes of the capillary-mitochondria interface that could contribute to the reduction of exercise tolerance in IC patients. Capillary and mitochondrial morphometry were performed after light and transmission electron microscopy using vastus lateralis muscle...

Effect of changed source/sink relations on proteolytic activities and on nitrogen mobilization in field-grown wheat (Triticum aestivum L.)

Urs Feller
Nitrogen mobilization and the pattern of proteolytic enzymes were investigated in leaves and glumes of field-grown winter wheat (Triticum aestivum L.) during maturation. Source/sink relations were changed by removal of the ear, the flag leaf or the lower leaves shortly after anthesis. Removal of the ear was most effective, resulting in delayed senescence of the flag leaf with the chlorophyll, aminopeptidase and carboxypeptidase activities remaining high in contrast to the control, whereas neutral endopeptidase activity...

Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics.

Brett Mc Kinnon, Konstantinos Nirgianakis, Michael Mueller, Vida Kocbek & Nick A. Bersinger
BACKGROUND Endometriosis, the growth of endometrial tissue outside the uterine cavity, is associated with chronic pelvic pain, subfertility and an increased risk of ovarian cancer. Current treatments include the surgical removal of the lesions or the induction of a hypoestrogenic state. However, a reappearance of the lesion after surgery is common and a hypoestrogenic state is less than optimal for women of reproductive age. Additional approaches are required. Endometriosis lesions exist in a unique microenvironment...

Index

Affiliation Bd. 81, Nr. 2 (2017)

Corpus-based analysis of the collocational profiles of the terms denoting the mentally challenged

Liana Markelova
The present study aims to trace the evolution of public attitude towards the mentally challenged by means of the corpus-based analysis. The raw data comes from the two of the BYU corpora: Global Web-Based English (GloWbE) and Corpus of Historical American English (COHA). The former is comprised of 1.8 million web pages from 20 English-speaking countries (Davies/Fuchs 2015: 1) and provides an opportunity to research at a cross-cultural level, whereas the latter, containing 400 million...

A dual PCR-based sequencing approach for the identification and discrimination of Echinococcus and Taenia taxa

Norbert Müller, Markus Spiliotis, Bruno Gottstein, Adriano Casulli, Irina Marinova, Francesca Gori, Amani Hizem, Ghalia Boubaker, Luis Enrique Jerez Puebla & Hamouda Babba
Reliable and rapid molecular tools for the genetic identification and differentiation of Echinococcus species and/or genotypes are crucial for studying spatial and temporal transmission dynamics. Here, we describe a novel dual PCR targeting regions in the small (rrnS) and large (rrnL) subunits of mitochondrial ribosomal RNA (rRNA) genes, which enables (i) the specific identification of species and genotypes of Echinococcus (rrnS + L-PCR) and/or (ii) the identification of a range of taeniid cestodes, including different...

Instability of the hip after anatomical re-alignment in patients with a slipped capital femoral epiphysis

Reinhold Ganz, A. Aprato, Theddy Slongo, Michael Leunig & A. Massé

Sozialgeschichte der Zuwanderung in die Stadt Bern 1850-1914

Christian Lüthi

Modifying the Glycome in Pigs for Xenotransplantation.

Robert Rieben & Peter J Cowan

Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs.

Robert Rieben, Ahmed Aziz Khattab, Pranitha Jayadev Kamat, Stephan Christen, Anjan Bongoni, Bernhard Meier & Stijn Vandenberghe
Calcium and iron overload participate in the mechanisms of ischemia/reperfusion (I/R) injury during myocardial infarction (MI). Calcium overload induces cardiomyocyte death by hypercontraction, while iron catalyses generation of reactive oxygen species (ROS). We therefore hypothesized that dexrazoxane, an intracellular metal chelator, would attenuate I/R injury. MI was induced in pigs by occlusion of the left anterior descending artery for 1 hour followed by 2 hours reperfusion. Thirty minutes before reperfusion either 5 mg/ml dexrazoxane (n...

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