4,344 Works

Dūr-Šarru-ukīn, die Festung Sargons: Schaltzentrale eines Weltreiches

Mirko Novák

Physical Activity and Risk of Bleeding in Elderly Patients Taking Anticoagulants.

Marc Husmann, D Aujesky, Joseph Osterwalder, Kurt Jaeger, Markus Aschwanden, P M Frey, Beat Frauchiger, N Rodondi, Christian M Matter, M Méan, Martin Banyai, N Kucher, Marc Righini, Anne Angelillo, Michael Egloff, A Limacher & Hans-Jürg Beer
BACKGROUND Although the possibility of bleeding during anticoagulant treatment may limit patients from taking part in physical activity, the association between physical activity and anticoagulation-related bleeding is uncertain. OBJECTIVES To determine whether physical activity is associated with bleeding in elderly patients taking anticoagulants. PATIENTS/METHODS In a prospective multicenter cohort study of 988 patients aged ≥65 years receiving anticoagulants for venous thromboembolism, we assessed patients' self-reported physical activity level. The primary outcome was the time to...

Patho-genetics of Clostridium chauvoei

Laurent Falquet & Joachim Frey
The genomic sequence of Clostridium chauvoei, the etiological agent of blackleg, a severe disease of ruminants with high mortality specified by a myonecrosis reveals a chromosome of 2.8 million base-pairs and a cryptic plasmid of 5.5 kilo base-pairs. The chromosome contains the main pathways like glycolysis/gluconeogenesis, sugar metabolism, purine and pyrimidine metabolisms, but the notable absence of genes of the citric acid cycle and deficient or partially deficient amino acid metabolism for Histidine, Tyrosine, Phenylalanine,...

A stratigraphic framework for abrupt climatic changes during the Last Glacial period based on three synchronized Greenland ice-core records: refining and extending the INTIMATE event stratigraphy

Henrik B. Clausen, Trevor Popp, Susanne L. Buchardt, Joe J. Wheatley, Matthias Bigler, Joel B. Pedro, Hubertus Fischer, Thomas Blunier, J. John Lowe, Simon P. Blockley, Jørgen Peder Steffensen, Sigfus J. Johnsen, Ivana Cvijanovic, Myriam Guillevic, Wim Z. Hoek, Dorthe Dahl-Jensen, Sune O. Rasmussen, Paul Vallelonga, Mike J.C. Walker, Vasileios Gkinis, Inger K. Seierstad, Mai Winstrup, Anders M. Svensson & Bo M. Vinther
Due to their outstanding resolution and well-constrained chronologies, Greenland ice-core records provide a master record of past climatic changes throughout the Last Interglacial–Glacial cycle in the North Atlantic region. As part of the INTIMATE (INTegration of Ice-core, MArine and TErrestrial records) project, protocols have been proposed to ensure consistent and robust correlation between different records of past climate. A key element of these protocols has been the formal definition and ordinal numbering of the sequence...

Hope as a resource for self-directed career management: Investigatiing mediating effects on proactive career behaviors, life and job satisfaction

Andreas Hirschi
ABSTRACT Hope is increasingly recognized as an important psychological resource for career development, yet the empirical research on its functioning in this domain is sparse. This paper describes an investigation of how dispositional hope is related to career decidedness, career planning, and career self-efficacy beliefs and whether these more proximal career attitudes mediate the effects of hope on proactive career behaviors, life satisfaction, and job satisfaction. This investigation was conducted using two independent samples of...

Fractional flow reserve-guided PCI.

Bernard De Bruyne, William F Fearon & Peter Jüni

Maximal acceleration of calcium release refractoriness by β-adrenergic stimulation requires dual activation of protein kinase A and CaMKII in mouse ventricular myocytes

Eric A. Sobie, Ernst Niggli, Ardo Illaste & Eva Poláková
Time-dependent refractoriness of calcium (Ca2+) release in cardiac myocytes is an important factor in determining whether pro-arrhythmic release patterns develop. At the subcellular level of the Ca2+ spark, recent studies have suggested that recovery of spark amplitude is controlled by local sarcoplasmic reticulum (SR) refilling whereas refractoriness of spark triggering depends on both refilling and the sensitivity of the ryanodine receptor (RyR) release channels that produce sparks. Here we studied regulation of Ca2+ spark refractoriness...

Tritrichomonas foetus: Prevalence study in naturally mating bulls in Switzerland

Christoph Bernasconi, M.G. Doherr, Caroline Frey, F. Janett, C. Iten, Brigitte Hentrich, Bruno Gottstein, Cornelia Spycher, Norbert Müller, Andreas Thomann & Michèle Bodmer
Switzerland is officially free from bovine Tritrichomonas foetus. While bulls used for artificial insemination (AI) are routinely examined for this pathogen, bulls engaged in natural mating, as well as aborted fetuses, are only very sporadically investigated, indicating that the disease awareness for bovine tritrichomoniasis is low. Natural mating in cattle is becoming increasingly popular in Switzerland. Accordingly, a re-introduction/re-occurrence of T. foetus in cattle seems possible either via resurgence from a yet unknown bovine reservoir,...

Self-initiated expatriates and their career success

Jürgen Deller, Andreas Hirschi & Lan Cao
Purpose This paper aims to provide conceptual clarity by distinguishing self‐initiated expatriates (SIEs) from company‐assigned expatriates (AEs), and skilled migrants; most importantly, it introduces an overarching conceptual framework based on career capital theory to explain SIEs’ career success. Design/methodology/approach This conceptual framework is based on a review of the relevant literature on SIE, expatriation, career studies, cross‐cultural studies, migration, and other related areas. Findings Protean career attitude, career networks, and cultural intelligence are identified as...

Upper Mesopotamia in the Mittani Period

Mirko Novák

Envisioning sustainable water futures in a transdisciplinary learning process: combining normative, explorative, and participatory scenario approaches

Stephan Rist & Flurina Schneider
Competing water demands for household consumption as well as the production of food, energy, and other uses pose challenges for water supply and sustainable development in many parts of the world. Designing creative strategies and learning processes for sustainable water governance is thus of prime importance. While this need is uncontested, suitable approaches still have to be found. In this article we present and evaluate a conceptual approach to scenario building aimed at transdisciplinary learning...

Quality of care after acute coronary syndromes in a prospective cohort with reasons for non-prescription of recommended medications

Christian M Matter, David Carballo, Jacques Cornuz, Nicolas Rodondi, Pierre Vogt, Stephan Windecker, John-Paul Vader, Sebastian Carballo, Reto Auer, Roland Klingenberg, Thomas Felix Lüscher, Baris Gencer, David Nanchen, Lorenz Räber, Peter Jüni & François Mach
BACKGROUND Adherence to guidelines is associated with improved outcomes of patients with acute coronary syndrome (ACS). Clinical registries developed to assess quality of care at discharge often do not collect the reasons for non-prescription for proven efficacious preventive medication in Continental Europe. In a prospective cohort of patients hospitalized for an ACS, we aimed at measuring the rate of recommended treatment at discharge, using pre-specified quality indicators recommended in cardiologic guidelines and including systematic collection...

Evaluation of apoptotic cell death in normal and chondrodystrophic canine intervertebral discs

Marcus Doherr, Simone Forterre, David Spreng, Franck Forterre, Andreas Zurbriggen & Marie Klauser

Nonverbale Synchronisation in Dyaden: ein Vergleich von kooperativen und kompetitiven Interaktionen

Georg Rees
Nonverbales Verhalten spielt in zwischenmenschlichen Interaktionen eine bedeutende Rolle. Es beeinflusst mutmaßlich den Verlauf eines Gesprächs, die Beziehung zwischen den Interaktionspartnern und die reziproke Sympathie. Trotz dieser immensen Bedeutung wird nonverbales Verhalten von den Beteiligten meist nicht bewusst wahrgenommen. Die vorliegende Arbeit widmet sich diesem wirkungsvollen Phänomen und vergleicht nonverbales Verhalten in kooperativen und kompetitiven Interaktionsbedingungen. Im Fokus der Experimentalstudie steht die nonverbale Synchronisation. Diese bezieht sich auf den dynamischen, quantitativen Aspekt der Koordination nonverbalen...

Molecular beacons with a homo-DNA stem: improving target selectivity

Dae-Ro Ahn, Christian J. Leumann & Caroline Crey-Desbiolles
Molecular beacons (MBs) are stem-loop DNA probes used for identifying and reporting the presence and localization of nucleic acid targets in vitro and in vivo via target-dependent dequenching of fluorescence. A drawback of conventional MB design is present in the stem sequence that is necessary to keep the MBs in a closed conformation in the absence of a target, but that can participate in target binding in the open (target-on) conformation, giving rise to the...

Baseline hypovitaminosis D is not associated with poor clinical outcomes in osteoarticular infections

R L Barrack, V J Fraser, H M Babcock, J W S Lewis, Jonas Marschall & D K Warren
OBJECTIVES Although vitamin D is recognized as an important factor in bone health, its role in osteoarticular infections is unclear. We hypothesized that low vitamin D (25-hydroxycholecalciferol) levels are associated with a lower likelihood of treatment success in osteoarticular infections. METHODS This was a retrospective cohort study of patients with orthopedic infections who had a 25-hydroxycholecalciferol level drawn when their infection was diagnosed. Outcomes were determined at early (3-6 months) and late (≥6 months) follow-up...

Multi-channel search for squarks and gluinos in sqrts=7 TeV pp collisions with the ATLAS detector

Sigve Haug, Antonio Ereditato, Andreas Battaglia, Marco Agustoni, Collaboration ATLAS, Hans Peter Beck, Valentina Gallo, Tobias Kruker, Claudia Borer, Lukas Marti, Gianfranco Sciacca, Basil Schneider, Sonja Kabana, Michael Weber, Lucian Ancu & Klaus-Peter Pretzl
A search for supersymmetric particles in final states with zero, one, and two leptons, with and without jets identified as originating from b-quarks, in 4.7 fb(-1) of root s = 7 TeV pp collisions produced by the Large Hadron Collider and recorded by the ATLAS detector is presented. The search uses a set of variables carrying information on the event kinematics transverse and parallel to the beam line that are sensitive to several topologies expected...

An in vitro toxicity evaluation of gold-, PLLA- and PCL-coated silica nanoparticles in neuronal cells for nanoparticle-assisted laser-tissue soldering.

Franziska Koch, Martin Frenz, Meike Mevissen, Uwe Pieles, Anja-Maria Möller & Kathrin Kühni
The uptake of silica (Si) and gold (Au) nanoparticles (NPs) engineered for laser-tissue soldering in the brain was investigated using microglial cells and undifferentiated and differentiated SH-SY5Y cells. It is not known what effects NPs elicit once entering the brain. Cellular uptake, cytotoxicity, apoptosis, and the potential induction of oxidative stress by means of depletion of glutathione levels were determined after NP exposure at concentrations of 10(3) and 10(9)NPs/ml. Au-, silica poly (ε-caprolactone) (Si-PCL-) and...

Psychological refractory period in introverts and extraverts

Stefan J. Troche, Rebekka Indermühle & Thomas H. Rammsayer

La narrazione dell’Oriente e la svolta letteraria di Cristina Trivulzio Belgiojoso: il testo-laboratorio dei \"Souvenirs dans l’exil\"

Flavia Caporuscio
L’articolo analizza la svolta letteraria di Cristina Trivulzio Belgiojoso individuando nei "Souvenirs dans l’exil" (1850) il testo di transito che documenta una tappa fondamentale nell’evoluzione della scrittura dell’autrice. L’opera, che nasce come una raccolta di lettere inviate dall’esilio all’amica francese Caroline Jaubert, esibisce una scrittura ibrida, contrassegnata da una commistione di generi sapientemente organizzati all’interno della cornice formale della lettera privata, e si configura come un vero e proprio testo-laboratorio che presenta manifestamente al lettore...

Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs.

Sonja Haertle, Valeri Zakhartchenko, Eckhard Wolf, Bruno Reichart, Andreas Blutke, Ruediger Wanke, Nikolai Klymiuk, Wiebke Baars, Hiroshi Nagashima, Robert Rieben, Elisabeth Kemter, Jan-Michael Abicht, David Ayares, Annegret Wuensch, Andrea Baehr, Mayuko Kurome, Barbara Kessler, Claudius Faber, Reinhard Schwinzer & Anjan Bongoni
BACKGROUND Among other mismatches between human and pig, incompatibilities in the blood coagulation systems hamper the xenotransplantation of vascularized organs. The provision of the porcine endothelium with human thrombomodulin (hTM) is hypothesized to overcome the impaired activation of protein C by a heterodimer consisting of human thrombin and porcine TM. METHODS We evaluated regulatory regions of the THBD gene, optimized vectors for transgene expression, and generated hTM expressing pigs by somatic cell nuclear transfer. Genetically...

The career satisfaction scale: Longitudinal measurement invariance and latent growth analysis

Andrea E. Abele, Daniel Spurk & Judith Volmer
The present research analyses the adequacy of the widely used Career Satisfaction Scale (CSS; Greenhaus, Parasuraman, & Wormley, 1990) for measuring change over time. We used data of a sample of 1,273 professionals over a 5-year time period. First, we tested longitudinal measurement invariance of the CSS. Second, we analysed changes in career satisfaction by means of multiple indicator latent growth modelling (MLGM). Results revealed that the CSS can be reliably used in mean change...

In search of the internal structure of the processes underlying interval timing in the sub-second and the second range: A confirmatory factor analysis approach

Stefan J. Troche & Thomas H. Rammsayer
One of the earliest accounts of duration perception by Karl von Vierordt implied a common process underlying the timing of intervals in the sub-second and the second range. To date, there are two major explanatory approaches for the timing of brief intervals: the Common Timing Hypothesis and the Distinct Timing Hypothesis. While the common timing hypothesis also proceeds from a unitary timing process, the distinct timing hypothesis suggests two dissociable, independent mechanisms for the timing...

The dual impact of gender and the influence of timing of parenthood on men’s and women’s career development: Longitudinal findings

Andrea E. Abele & Daniel Spurk
This study investigated the impact of gender, the gender-related self-concept (agency and communion), and the timing of parenthood on objective career success of 1,015 highly educated professionals. Hypotheses derived from a dual-impact model of gender and career-related processes were tested in a 5-wave longitudinal study over a time span of 10 years starting with participants’ career entry. In line with our hypotheses we found that the communal component of the gender self-concept had an impact...

Response of myocardial oxygenation to breathing manoeuvres and adenosine infusion

Dominik Günsch, Matthias G Friedrich & Kady Anne Fischer
AIMS: Testing for inducible myocardial ischaemia is one of the most important diagnostic procedures and has a strong impact on clinical decision-making. Current standard protocols are typically limited by the required infusion of vasodilatory substances. Recent data indicate that changes of myocardial oxygenation induced by hyperventilation and breath-holds can be monitored by oxygenation-sensitive (OS) cardiovascular magnetic resonance (CMR) and may be useful for assessing coronary vascular function. As tests using breathing manoeuvres may be safer,...

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