317 Works

Endoscopic Biopsy for Intra- and Paraventricular Tumors: Rates of Complications, Mortality, and Tumor Cell Dissemination

Michael R Gaab, Anna Katharina Krähenbühl, H W S W S Schroeder, Susanne Guhl & Jörg Baldauf
Background and Study Aim Intra- and paraventricular tumors are frequently associated with cerebrospinal fluid (CSF) pathway obstruction. Thus the aim of an endoscopic approach is to restore patency of the CSF pathways and to obtain a tumor biopsy. Because endoscopic tumor biopsy may increase tumor cell dissemination, this study sought to evaluate this risk. Patients, Materials, and Methods Forty-four patients who underwent endoscopic biopsies for ventricular or paraventricular tumors between 1993 and 2011 were included...

Higher macrophage superoxide anion production in coronary artery disease (CAD) patients with Type D personality

Claudia Hackl, Roland Von Känel, Petra H. Wirtz, Roland Wiest, Jean-Paul Schmid, Livia Thomas, Heinrich P. Mattle, Peggy Kübler, Marie-Luise Mono & Robert Rieben
BACKGROUND Type D personality (Type D) is an independent psychosocial risk factor for poor cardiac prognosis and increased mortality in patients with cardiovascular disease (CVD), but the involved mechanisms are poorly understood. Macrophages play a pivotal role in atherosclerosis, the process underlying coronary artery disease (CAD). We investigated macrophage superoxide anion production in production in CAD patients with and without Type D. METHODS AND RESULTS We studied 20 male CAD patients with Type D (M:66.7±9.9years)...

A live vaccine against Neospora caninum abortions in cattle

J P Dubey, Andrew Hemphill, Michael P Reichel, Dadín P Moore, Luis M Ortega-Mora & John T Ellis

Rearing group size determines social competence and brain structure in a cooperatively breeding cichlid

Alexander Kotrschal, Barbara Taborsky, Mathilde Bessert-Nettelbeck & Stefan Fischer
Social animals can greatly benefit from well-developed social skills. Because the frequency and diversity of social interactions often increase with the size of social groups, the benefits of advanced social skills can be expected to increase with group size. Variation in social skills often arises during ontogeny, depending on early social experience. Whether variation of social-group sizes affects development of social skills and related changes in brain structures remains unexplored. We investigated whether, in a...

Testing for allelopathy in invasive plants: it all depends on the substrate!

Oliver Bossdorf & Madalin Parepa
Invasive plants can affect native plants through competition or allelopathy, and researchers often use pot experiments as a tool to measure the strength of these interactions. Recently, such pot experiments provided inconsistent estimates of the impact and allelopathic potential of invasive knotweed, one of the world's most successful plant invaders. We suspected that the inconsistencies may be explained by the use of different substrates in different experiments. To test this, we conducted an experiment in...

Impact of body mass index on outcome in stroke patients treated with intravenous thrombolysis.

S T Engelter, P Vanacker, Hakan Sarikaya, A Zini, R Stark, G M De Marchis, A Wicht, G Kägi, L Poli, O Bill, A Pezzini, D J Seiffge, P A Lyrer, L H Bonati, N Peters, A Polymeris, P Michel, C Traenka, H Gensicke, P Costa, G Giovannini & L Vandelli
BACKGROUND AND PURPOSE The impact of body mass index (BMI) on outcome in stroke patients treated with intravenous thrombolysis (IVT) was investigated. METHODS In a multicentre IVT-register-based observational study, BMI with (i) poor 3-month outcome (i.e. modified Rankin Scale scores 3-6), (ii) death and (iii) symptomatic intracranial haemorrhage (sICH) based on criteria of the ECASS II trial was compared. BMI was used as a continuous and categorical variable distinguishing normal weight (reference group 18.5-24.9 kg/m(2)...

High resolution microscopy reveals an unusual architecture of the Plasmodium berghei endoplasmic reticulum.

Benoît Zuber, Gesine Kaiser, Mariana Isabel De Niz Hidalgo, Benoît Kornmann, Rebecca Limenitakis Stanway, Volker Heussler & Paul-Christian Burda
To fuel the tremendously fast replication of Plasmodium liver stage parasites, the endoplasmic reticulum (ER) must play a critical role as a major site of protein and lipid biosynthesis. In this study, we analysed the parasite's ER morphology and function. Previous studies exploring the parasite ER have mainly focused on the blood stage. Visualizing the Plasmodium berghei ER during liver stage development, we found that the ER forms an interconnected network throughout the parasite with...

Resting state morphology predicts the effect of theta burst stimulation in false belief reasoning

Charlotte Hartwright
Anonymized meta-data for the article, "Resting state morphology predicts the effect of theta burst stimulation in false belief reasoning: ventrolateral prefrontal cortex in false belief reasoning".

An applied methodology for stakeholder identification in transdisciplinary research

Heleen Claringbould, Julia Leventon, Luuk Fleskens & Gudrun Schwilch

Ausländerinnen und Ausländer im geschlossenen Strafvollzug: eine ethnologische Gefängnisstudie

Ueli Hostettler & Christin Achermann

Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?

Conrad Von Schubert, Andrew Hemphill, Cristina Fragoso, Erik Betzig, Wesley Legant, Isabel Roditi, Dong Li & Simon Imhof
Diverse structures facilitate direct exchange of proteins between cells, including plasmadesmata in plants and tunnelling nanotubes in bacteria and higher eukaryotes. Here we describe a new mechanism of protein transfer, flagellar membrane fusion, in the unicellular parasite Trypanosoma brucei. When fluorescently tagged trypanosomes were co-cultured, a small proportion of double-positive cells were observed. The formation of double-positive cells was dependent on the presence of extracellular calcium and was enhanced by placing cells in medium supplemented...

Conducting commissioned research in neoliberal academia: The conditions evaluations impose on research practice

Ueli Hostettler & M. Richter
The article deals with the unease we experience during various commissioned research projects. On the one hand, as social scientists, we feel committed to conducting ‘good research’ that acknowledges quality criteria such as flexibility and transparency and in particular allows for musing and reflexivity to ‘discover’ new aspects of our research topic. On the other hand, we are situated in the context of present-day neoliberal academia. This means that our work is assessed according to...

Web-based 3D-visualization of the DrugBank chemical space

Mahendra Awale & Jean-Louis Reymond
BACKGROUND Similarly to the periodic table for elements, chemical space offers an organizing principle for representing the diversity of organic molecules, usually in the form of multi-dimensional property spaces that are subjected to dimensionality reduction methods to obtain 3D-spaces or 2D-maps suitable for visual inspection. Unfortunately, tools to look at chemical space on the internet are currently very limited. RESULTS Herein we present webDrugCS, a web application freely available at www.gdb.unibe.ch to visualize DrugBank (www.drugbank.ca,...

The Judiciary between Management and the Rule of Law - The general research findings

Andreas Lienhard & Daniel Kettiger

Das Gefängnis als Forschungsfeld

Marina Richter, Ueli Hostettler & Roger Kirchhofer

The Judiciary between Management and the Rule of Law - The general research findings

Andreas Lienhard & Daniel Kettiger

High prevalence of hereditary thrombotic thrombocytopenic purpura in Central Norway: from clinical observation to evidence.

R Brudevold, Bernhard Lämmle, A S Von Krogh, Johanna Anna Kremer Hovinga, P Quist-Paulsen, Ø O Langseth, A Waage, Carlo Rodolfo Largiadèr, G E Tjønnfjord & K Thorstensen
BACKGROUND Hereditary thrombotic thrombocytopenic purpura (TTP) caused by ADAMTS13 mutations is a rare, but serious condition. The prevalence is unknown, but seems to be high in Norway. OBJECTIVES To identify all patients with hereditary TTP in Central Norway and to investigate the prevalence of hereditary TTP and the population frequencies of two common ADAMTS13 mutations. Patients/Methods Patients were identified in a cross-sectional study within Central Norway Health Region by means of three different search strategies....

Indications and pitfalls of sutureless aortic valves: recommendations are welcome.

Thierry Carrel

Telomerase Inhibitor Imetelstat in Essential Thrombocythemia and Myelofibrosis.

Gabriela M. Baerlocher, Bart Burington & David S Snyder

Detecting single-target changes in multiple object tracking: The case of peripheral vision

Christian Vater, Ralf Kredel & Ernst-Joachim Hossner
In the current study it is investigated whether peripheral vision can be used to monitor multi-ple moving objects and to detect single-target changes. For this purpose, in Experiment 1, a modified MOT setup with a large projection and a constant-position centroid phase had to be checked first. Classical findings regarding the use of a virtual centroid to track multiple ob-jects and the dependency of tracking accuracy on target speed could be successfully replicat-ed. Thereafter, the...

Bauern in theatralen Aktionsräumen: Verlachenswert, vorbildlich, revolutionär

Heidy Greco-Kaufmann

Sinneslust und Eschatologie in Renward Cysats Convivii Process

Heidy Greco-Kaufmann

Bivalirudin in Acute Coronary Syndromes. Authors reply.

Andrea Santucci & Marco Valgimigli

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